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Science 298 (5594): 830-834

Copyright © 2002 by the American Association for the Advancement of Science

Timing Requirements for Insulin/IGF-1 Signaling in C. elegans

Andrew Dillin,* Douglas K. Crawford, Cynthia Kenyondagger

The insulin/IGF-1 (where IGF-1 is insulin-like growth factor-1) signaling pathway influences longevity, reproduction, and diapause in many organisms. Because of the fundamental importance of this system in animal physiology, we asked when during the animal's life it is required to regulate these different processes. We find that in Caenorhabditis elegans, the pathway acts during adulthood, to relatively advanced ages, to influence aging. In contrast, it regulates diapause during development. In addition, the pathway controls longevity and reproduction independently of one another. Together our findings show that life-span regulation can be dissociated temporally from phenotypes that might seem to decrease the quality of life.

Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94143-0448, USA.
*   Present address: Molecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA.

dagger    To whom correspondence should be addressed. E-mail: ckenyon{at}

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