Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.
Treatment of Ischemic Brain Damage by Perturbing NMDA Receptor- PSD-95 Protein Interactions
Michelle Aarts,1*Yitao Liu,234*Lidong Liu,234Shintaro Besshoh,5Mark Arundine,1James W. Gurd,5Yu-Tian Wang,234Michael W. Salter,36Michael Tymianski167
N-methyl-D-aspartate
receptors (NMDARs) mediate ischemic brain damage but also
mediate essential neuronal excitation. To treatstroke without blocking
NMDARs, we transduced neurons with peptidesthat disrupted the
interaction of NMDARs with the postsynapticdensity protein PSD-95.
This procedure dissociated NMDARs fromdownstream neurotoxic signaling
without blocking synaptic activityor calcium influx. The peptides,
when applied either before or1 hour after an insult, protected
cultured neurons from excitotoxicity,reduced focal ischemic brain
damage in rats, and improved theirneurological function. This approach
circumvents the negativeconsequences associated with blocking NMDARs
and may constitutea practical stroke therapy.
1 Toronto Western Hospital Research Institute,
11-416 MC-PAV, 399 Bathurst Street, Toronto, Ontario M5T 2S8, Canada.
2 Divisions of Laboratory Medicine and Pathobiology,
3 Programme in Brain and Behaviour, Hospital
for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8,
Canada.
4 Brain Research Center and Department of
Medicine, Vancouver Hospital and Health Sciences Center, University of
British Columbia, Vancouver, British Columbia V6T 1Z3, Canada.
5 Centre for the Neurobiology of Stress, Division of
Life Sciences, University of Toronto at Scarborough, Toronto, Ontario
M1C 1A3, Canada.
6 Department of Physiology,
7 Department of Surgery, University of Toronto,
Toronto, Ontario M5S 1A8, Canada.
*
These authors contributed equally to this report.
To whom correspondence should be addressed.
E-mail: mike_t{at}uhnres.utoronto.ca,
mike.salter{at}utoronto.ca
The editors suggest the following Related Resources on Science sites:
The nNOS-p38MAPK Pathway Is Mediated by NOS1AP during Neuronal Death.
L.-L. Li, V. Ginet, X. Liu, O. Vergun, M. Tuittila, M. Mathieu, C. Bonny, J. Puyal, A. C. Truttmann, and M. J. Courtney (2013)
J. Neurosci.
33, 8185-8201
|Abstract »|Full Text »|PDF »
Critical Role of Increased PTEN Nuclear Translocation in Excitotoxic and Ischemic Neuronal Injuries.
S. Zhang, C. Taghibiglou, K. Girling, Z. Dong, S.-Z. Lin, W. Lee, W.-c. Shyu, and Y. T. Wang (2013)
J. Neurosci.
33, 7997-8008
|Abstract »|Full Text »|PDF »
Genetic Deletion of NP1 Prevents Hypoxic-Ischemic Neuronal Death Via Reducing AMPA Receptor Synaptic Localization in Hippocampal Neurons.
Phosphorylation and Feedback Regulation of Metabotropic Glutamate Receptor 1 by Calcium/Calmodulin-Dependent Protein Kinase II.
D.-Z. Jin, M.-L. Guo, B. Xue, E. E. Fibuch, E. S. Choe, L.-M. Mao, and J. Q. Wang (2013)
J. Neurosci.
33, 3402-3412
|Abstract »|Full Text »|PDF »
Peptide Inhibitors Disrupt the Serotonin 5-HT2C Receptor Interaction with Phosphatase and Tensin Homolog to Allosterically Modulate Cellular Signaling and Behavior.
N. C. Anastasio, S. R. Gilbertson, M. J. Bubar, A. Agarkov, S. J. Stutz, Y. Jeng, N. M. Bremer, T. D. Smith, R. G. Fox, S. E. Swinford, et al. (2013)
J. Neurosci.
33, 1615-1630
|Abstract »|Full Text »|PDF »
Reviving Neuroprotection Using a New Approach: Targeting Postsynaptic Density-95 to Arrest Glutamate Excitotoxicity.
S. I. Savitz and W.-R. Schabitz (2012)
Stroke
43, 3411-3412
|Full Text »|PDF »
Neuroprotective Effects of Reactive Oxygen Species Mediated by BDNF-Independent Activation of TrkB.
Lanthionine Synthetase C-like Protein 1 Interacts with and Inhibits Cystathionine {beta}-Synthase: A TARGET FOR NEURONAL ANTIOXIDANT DEFENSE.
W.-x. Zhong, Y.-b. Wang, L. Peng, X.-z. Ge, J. Zhang, S.-s. Liu, X.-n. Zhang, Z.-h. Xu, Z. Chen, and J.-h. Luo (2012)
J. Biol. Chem.
287, 34189-34201
|Abstract »|Full Text »|PDF »
A Translational Paradigm for the Preclinical Evaluation of the Stroke Neuroprotectant Tat-NR2B9c in Gyrencephalic Nonhuman Primates.
D. J. Cook, L. Teves, and M. Tymianski (2012)
Science Translational Medicine
4, 154ra133
|Abstract »|Full Text »|PDF »
Glycine Exerts Dual Roles in Ischemic Injury Through Distinct Mechanisms.
W. Yao, F. Ji, Z. Chen, N. Zhang, S.-Q. Ren, X.-Y. Zhang, S.-Y. Liu, and W. Lu (2012)
Stroke
43, 2212-2220
|Abstract »|Full Text »|PDF »
Hydrogen Sulfide Induced Disruption of Na+ Homeostasis in the Cortex.
D. Chao, X. He, Y. Yang, G. Balboni, S. Salvadori, D. H. Kim, and Y. Xia (2012)
Toxicol. Sci.
128, 198-208
|Abstract »|Full Text »|PDF »
Mechanisms underlying the impairment of hippocampal long-term potentiation and memory in experimental Parkinson's disease.
C. Costa, C. Sgobio, S. Siliquini, A. Tozzi, M. Tantucci, V. Ghiglieri, M. Di Filippo, V. Pendolino, A. de Iure, M. Marti, et al. (2012)
Brain
135, 1884-1899
|Abstract »|Full Text »|PDF »
N-Methyl-D-aspartate (NMDA) Receptor Composition Modulates Dendritic Spine Morphology in Striatal Medium Spiny Neurons.
C. Vastagh, F. Gardoni, V. Bagetta, J. Stanic, E. Zianni, C. Giampa, B. Picconi, P. Calabresi, and M. Di Luca (2012)
J. Biol. Chem.
287, 18103-18114
|Abstract »|Full Text »|PDF »
Comparative Impact of Voltage-Gated Calcium Channels and NMDA Receptors on Mitochondria-Mediated Neuronal Injury.
R. I. Stanika, I. Villanueva, G. Kazanina, S. B. Andrews, and N. B. Pivovarova (2012)
J. Neurosci.
32, 6642-6650
|Abstract »|Full Text »|PDF »
Opposing Roles of Synaptic and Extrasynaptic NMDA Receptor Signaling in Cocultured Striatal and Cortical Neurons.
A. M. Kaufman, A. J. Milnerwood, M. D. Sepers, A. Coquinco, K. She, L. Wang, H. Lee, A. M. Craig, M. Cynader, and L. A. Raymond (2012)
J. Neurosci.
32, 3992-4003
|Abstract »|Full Text »|PDF »
Copper-dependent regulation of NMDA receptors by cellular prion protein: implications for neurodegenerative disorders.
A high-affinity, dimeric inhibitor of PSD-95 bivalently interacts with PDZ1-2 and protects against ischemic brain damage.
A. Bach, B. H. Clausen, M. Moller, B. Vestergaard, C. N. Chi, A. Round, P. L. Sorensen, K. B. Nissen, J. S. Kastrup, M. Gajhede, et al. (2012)
PNAS
109, 3317-3322
|Abstract »|Full Text »|PDF »
Distribution of KAI-9803, a Novel {delta}-Protein Kinase C Inhibitor, after Intravenous Administration to Rats.
Y. Miyaji, S. Walter, L. Chen, A. Kurihara, T. Ishizuka, M. Saito, K. Kawai, and O. Okazaki (2011)
Drug Metab. Dispos.
39, 1946-1953
|Abstract »|Full Text »|PDF »
Oxygen/Glucose Deprivation Induces a Reduction in Synaptic AMPA Receptors on Hippocampal CA3 Neurons Mediated by mGluR1 and Adenosine A3 Receptors.
S. H. Dennis, N. Jaafari, H. Cimarosti, J. G. Hanley, J. M. Henley, and J. R. Mellor (2011)
J. Neurosci.
31, 11941-11952
|Abstract »|Full Text »|PDF »
Palmitoyl Acyltransferase zD17 Mediates Neuronal Responses in Acute Ischemic Brain Injury by Regulating JNK Activation in a Signaling Module.
Mechanism underlying selective regulation of G protein-gated inwardly rectifying potassium channels by the psychostimulant-sensitive sorting nexin 27.
B. Balana, I. Maslennikov, W. Kwiatkowski, K. M. Stern, L. Bahima, S. Choe, and P. A. Slesinger (2011)
PNAS
108, 5831-5836
|Abstract »|Full Text »|PDF »
Inhibition of Amyloid-{beta} (A{beta}) Peptide-Binding Alcohol Dehydrogenase-A{beta} Interaction Reduces A{beta} Accumulation and Improves Mitochondrial Function in a Mouse Model of Alzheimer's Disease.
J. Yao, H. Du, S. Yan, F. Fang, C. Wang, L.-F. Lue, L. Guo, D. Chen, D. M. Stern, F. J. Gunn Moore, et al. (2011)
J. Neurosci.
31, 2313-2320
|Abstract »|Full Text »|PDF »
Synaptic Localization and Activity of ADAM10 Regulate Excitatory Synapses through N-Cadherin Cleavage.
M. Malinverno, M. Carta, R. Epis, E. Marcello, C. Verpelli, F. Cattabeni, C. Sala, C. Mulle, M. Di Luca, and F. Gardoni (2010)
J. Neurosci.
30, 16343-16355
|Abstract »|Full Text »|PDF »
Dynamic and specific interaction between synaptic NR2-NMDA receptor and PDZ proteins.
L. Bard, M. Sainlos, D. Bouchet, S. Cousins, L. Mikasova, C. Breillat, F. A. Stephenson, B. Imperiali, D. Choquet, and L. Groc (2010)
PNAS
107, 19561-19566
|Abstract »|Full Text »|PDF »
Blocking ADAM10 synaptic trafficking generates a model of sporadic Alzheimer's disease.
R. Epis, E. Marcello, F. Gardoni, C. Vastagh, M. Malinverno, C. Balducci, A. Colombo, B. Borroni, H. Vara, M. Dell'Agli, et al. (2010)
Brain
133, 3323-3335
|Abstract »|Full Text »|PDF »
Distinct Levels of Dopamine Denervation Differentially Alter Striatal Synaptic Plasticity and NMDA Receptor Subunit Composition.
V. Paille, B. Picconi, V. Bagetta, V. Ghiglieri, C. Sgobio, M. Di Filippo, M. T. Viscomi, C. Giampa, F. R. Fusco, F. Gardoni, et al. (2010)
J. Neurosci.
30, 14182-14193
|Abstract »|Full Text »|PDF »
Regulation of AMPA Receptor Currents by Mitochondrial ATP-Sensitive K+ Channels in Anoxic Turtle Neurons.
Deciphering the Kinetic Binding Mechanism of Dimeric Ligands Using a Potent Plasma-stable Dimeric Inhibitor of Postsynaptic Density Protein-95 as an Example.
C. N. Chi, A. Bach, M. Gottschalk, A. S. Kristensen, K. Stromgaard, and P. Jemth (2010)
J. Biol. Chem.
285, 28252-28260
|Abstract »|Full Text »|PDF »
Effective Post-insult Neuroprotection by a Novel Ca2+/ Calmodulin-dependent Protein Kinase II (CaMKII) Inhibitor.
R. S. Vest, H. O'Leary, S. J. Coultrap, M. S. Kindy, and K. U. Bayer (2010)
J. Biol. Chem.
285, 20675-20682
|Abstract »|Full Text »|PDF »
CaMKII "Autonomy" Is Required for Initiating But Not for Maintaining Neuronal Long-Term Information Storage.
I. Buard, S. J. Coultrap, R. K. Freund, Y.-S. Lee, M. L. Dell'Acqua, A. J. Silva, and K. U. Bayer (2010)
J. Neurosci.
30, 8214-8220
|Abstract »|Full Text »|PDF »
The DREAM Protein Negatively Regulates the NMDA Receptor through Interaction with the NR1 Subunit.
Y. Zhang, P. Su, P. Liang, T. Liu, X. Liu, X.-Y. Liu, B. Zhang, T. Han, Y.-B. Zhu, D.-M. Yin, et al. (2010)
J. Neurosci.
30, 7575-7586
|Abstract »|Full Text »|PDF »
Phosphorylation of N-Methyl-D-Aspartic Acid Receptor-Associated Neuronal Nitric Oxide Synthase Depends on Estrogens and Modulates Hypothalamic Nitric Oxide Production during the Ovarian Cycle.
J. Parkash, X. d'Anglemont de Tassigny, N. Bellefontaine, C. Campagne, D. Mazure, V. Buee-Scherrer, and V. Prevot (2010)
Endocrinology
151, 2723-2735
|Abstract »|Full Text »|PDF »
Identification of a small-molecule inhibitor of the PICK1 PDZ domain that inhibits hippocampal LTP and LTD.
T. S. Thorsen, K. L. Madsen, N. Rebola, M. Rathje, V. Anggono, A. Bach, I. S. Moreira, N. Stuhr-Hansen, T. Dyhring, D. Peters, et al. (2010)
PNAS
107, 413-418
|Abstract »|Full Text »|PDF »
Interaction of Postsynaptic Density Protein-95 with NMDA Receptors Influences Excitotoxicity in the Yeast Artificial Chromosome Mouse Model of Huntington's Disease.
J. Fan, C. M. Cowan, L. Y. J. Zhang, M. R. Hayden, and L. A. Raymond (2009)
J. Neurosci.
29, 10928-10938
|Abstract »|Full Text »|PDF »
Cell-surface thiols affect cell entry of disulfide-conjugated peptides.
S. Aubry, F. Burlina, E. Dupont, D. Delaroche, A. Joliot, S. Lavielle, G. Chassaing, and S. Sagan (2009)
FASEB J
23, 2956-2967
|Abstract »|Full Text »|PDF »
A nonfibrin macromolecular cofactor for tPA-mediated plasmin generation following cellular injury.
A. L. Samson, R. J. Borg, B. Niego, C. H. Y. Wong, P. J. Crack, T. Yongqing, and R. L. Medcalf (2009)
Blood
114, 1937-1946
|Abstract »|Full Text »|PDF »
Extrasynaptic NMDA Receptors Couple Preferentially to Excitotoxicity via Calpain-Mediated Cleavage of STEP.
J. Xu, P. Kurup, Y. Zhang, S. M. Goebel-Goody, P. H. Wu, A. H. Hawasli, M. L. Baum, J. A. Bibb, and P. J. Lombroso (2009)
J. Neurosci.
29, 9330-9343
|Abstract »|Full Text »|PDF »
Posttranslational Modification of Constitutive Nitric Oxide Synthase in the Penis.
B. Musicki, A. E. Ross, H. C. Champion, A. L. Burnett, and T. J. Bivalacqua (2009) 30, 352-362
|Abstract »|Full Text »|PDF »
Coupling diverse routes of calcium entry to mitochondrial dysfunction and glutamate excitotoxicity.
R. I. Stanika, N. B. Pivovarova, C. A. Brantner, C. A. Watts, C. A. Winters, and S. B. Andrews (2009)
PNAS
106, 9854-9859
|Abstract »|Full Text »|PDF »
p21-Activated kinase mediates rapid estradiol-negative feedback actions in the reproductive axis.
Z. Zhao, C. Park, M. A. McDevitt, C. Glidewell-Kenney, P. Chambon, J. Weiss, J. L. Jameson, and J. E. Levine (2009)
PNAS
106, 7221-7226
|Abstract »|Full Text »|PDF »
Decreased NR2B Subunit Synaptic Levels Cause Impaired Long-Term Potentiation But Not Long-Term Depression.
F. Gardoni, D. Mauceri, M. Malinverno, F. Polli, C. Costa, A. Tozzi, S. Siliquini, B. Picconi, F. Cattabeni, P. Calabresi, et al. (2009)
J. Neurosci.
29, 669-677
|Abstract »|Full Text »|PDF »
Specific Targeting of Pro-Death NMDA Receptor Signals with Differing Reliance on the NR2B PDZ Ligand.
F. X. Soriano, M.-A. Martel, S. Papadia, A. Vaslin, P. Baxter, C. Rickman, J. Forder, M. Tymianski, R. Duncan, M. Aarts, et al. (2008)
J. Neurosci.
28, 10696-10710
|Abstract »|Full Text »|PDF »
Neuroprotection by Cell Permeable TAT-mGluR1 Peptide in Ischemia: Synergy between Carrier and Cargo Sequences.
Wei Xu, Miou Zhou, and M. Baudry (2008)
Neuroscientist
14, 409-414
|Abstract »|PDF »
Effectiveness of PSD95 Inhibitors in Permanent and Transient Focal Ischemia in the Rat.
H.-S. Sun, T. A. Doucette, Y. Liu, Y. Fang, L. Teves, M. Aarts, C. L. Ryan, P. B. Bernard, A. Lau, J. P. Forder, et al. (2008)
Stroke
39, 2544-2553
|Abstract »|Full Text »|PDF »
Postsynaptic Density-95 (PSD-95) and Calcineurin Control the Sensitivity of N-Methyl-D-aspartate Receptors to Calpain Cleavage in Cortical Neurons.
Traumatic brain injury: Can the consequences be stopped?.
E. Park PhD, J. D. Bell BSc, and A. J. Baker MD (2008)
Can. Med. Assoc. J.
178, 1163-1170
|Abstract »|Full Text »|PDF »
Key role of tissue plasminogen activator in neurovascular coupling.
L. Park, E. F. Gallo, J. Anrather, G. Wang, E. H. Norris, J. Paul, S. Strickland, and C. Iadecola (2008)
PNAS
105, 1073-1078
|Abstract »|Full Text »|PDF »
Kalirin-7 Is an Essential Component of both Shaft and Spine Excitatory Synapses in Hippocampal Interneurons.
X.-M. Ma, Y. Wang, F. Ferraro, R. E. Mains, and B. A. Eipper (2008)
J. Neurosci.
28, 711-724
|Abstract »|Full Text »|PDF »
R. Meller, S. J. Thompson, T. A. Lusardi, A. N. Ordonez, M. D. Ashley, V. Jessick, W. Wang, D. J. Torrey, D. C. Henshall, P. R. Gafken, et al. (2008)
J. Neurosci.
28, 50-59
|Abstract »|Full Text »|PDF »
The Dichotomy of NMDA Receptor Signaling.
S. Papadia and G. E. Hardingham (2007)
Neuroscientist
13, 572-579
|Abstract »|PDF »
Dual Mechanism of a Natural CaMKII Inhibitor.
R. S. Vest, K. D. Davies, H. O'Leary, J. D. Port, and K. U. Bayer (2007)
Mol. Biol. Cell
18, 5024-5033
|Abstract »|Full Text »|PDF »
Compartmentalized NMDA receptor signalling to survival and death.
PDZ Protein Interactions Underlying NMDA Receptor-Mediated Excitotoxicity and Neuroprotection by PSD-95 Inhibitors.
H. Cui, A. Hayashi, H.-S. Sun, M. P. Belmares, C. Cobey, T. Phan, J. Schweizer, M. W. Salter, Y. T. Wang, R. A. Tasker, et al. (2007)
J. Neurosci.
27, 9901-9915
|Abstract »|Full Text »|PDF »
Glycogen Synthase Kinase 3 Regulates N-Methyl-D-aspartate Receptor Channel Trafficking and Function in Cortical Neurons.
Coupling of Neuronal Nitric Oxide Synthase to NMDA Receptors via Postsynaptic Density-95 Depends on Estrogen and Contributes to the Central Control of Adult Female Reproduction.
X. d'Anglemont de Tassigny, C. Campagne, B. Dehouck, D. Leroy, G. R. Holstein, J.-C. Beauvillain, V. Buee-Scherrer, and V. Prevot (2007)
J. Neurosci.
27, 6103-6114
|Abstract »|Full Text »|PDF »
Physical interaction between the serotonin transporter and neuronal nitric oxide synthase underlies reciprocal modulation of their activity.
B. Chanrion, C. Mannoury la Cour, F. Bertaso, M. Lerner-Natoli, M. Freissmuth, M. J. Millan, J. Bockaert, and P. Marin (2007)
PNAS
104, 8119-8124
|Abstract »|Full Text »|PDF »
Synergistic Neuroprotection by Bis(7)-tacrine via Concurrent Blockade of N-Methyl-D-aspartate Receptors and Neuronal Nitric-Oxide Synthase.
W. Li, J. Xue, C. Niu, H. Fu, C. S. C. Lam, J. Luo, H. H. N. Chan, H. Xue, K. K. W. Kan, N. T. K. Lee, et al. (2007)
Mol. Pharmacol.
71, 1258-1267
|Abstract »|Full Text »|PDF »
NMDA Receptor Subunits Have Differential Roles in Mediating Excitotoxic Neuronal Death Both In Vitro and In Vivo.
Y. Liu, T. P. Wong, M. Aarts, A. Rooyakkers, L. Liu, T. W. Lai, D. C. Wu, J. Lu, M. Tymianski, A. M. Craig, et al. (2007)
J. Neurosci.
27, 2846-2857
|Abstract »|Full Text »|PDF »
Status Epilepticus-Induced Somatostatinergic Hilar Interneuron Degeneration Is Regulated by Striatal Enriched Protein Tyrosine Phosphatase.
Y.-S. Choi, S. L. Lin, B. Lee, P. Kurup, H.-Y. Cho, J. R. Naegele, P. J. Lombroso, and K. Obrietan (2007)
J. Neurosci.
27, 2999-3009
|Abstract »|Full Text »|PDF »
HIV-tat induces formation of an LRP-PSD-95- NMDAR-nNOS complex that promotes apoptosis in neurons and astrocytes.
E. A. Eugenin, J. E. King, A. Nath, T. M. Calderon, R. S. Zukin, M. V. L. Bennett, and J. W. Berman (2007)
PNAS
104, 3438-3443
|Abstract »|Full Text »|PDF »
Synapse-Associated Protein-97 Mediates {alpha}-Secretase ADAM10 Trafficking and Promotes Its Activity.
E. Marcello, F. Gardoni, D. Mauceri, S. Romorini, A. Jeromin, R. Epis, B. Borroni, F. Cattabeni, C. Sala, A. Padovani, et al. (2007)
J. Neurosci.
27, 1682-1691
|Abstract »|Full Text »|PDF »
Transient Receptor Potential Channels of the Melastatin Family and Ischemic Responses of Central Neurons.
An Antagonist of Dishevelled Protein-Protein Interaction Suppresses {beta}-Catenin-Dependent Tumor Cell Growth.
N. Fujii, L. You, Z. Xu, K. Uematsu, J. Shan, B. He, I. Mikami, L. R. Edmondson, G. Neale, J. Zheng, et al. (2007)
Cancer Res.
67, 573-579
|Abstract »|Full Text »|PDF »
Intracellular protein interaction mapping with FRET hybrids.
X. You, A. W. Nguyen, A. Jabaiah, M. A. Sheff, K. S. Thorn, and P. S. Daugherty (2006)
PNAS
103, 18458-18463
|Abstract »|Full Text »|PDF »
Opposite Effects of PSD-95 and MPP3 PDZ Proteins on Serotonin 5-Hydroxytryptamine2C Receptor Desensitization and Membrane Stability.
S. Gavarini, C. Becamel, C. Altier, P. Lory, J. Poncet, J. Wijnholds, J. Bockaert, and P. Marin (2006)
Mol. Biol. Cell
17, 4619-4631
|Abstract »|Full Text »|PDF »
NR2B Subunit Exerts a Critical Role in Postischemic Synaptic Plasticity.
B. Picconi, A. Tortiglione, I. Barone, D. Centonze, F. Gardoni, P. Gubellini, P. Bonsi, A. Pisani, G. Bernardi, M. Di Luca, et al. (2006)
Stroke
37, 1895-1901
|Abstract »|Full Text »|PDF »
A critical interaction between NR2B and MAGUK in L-DOPA induced dyskinesia..
F. Gardoni, B. Picconi, V. Ghiglieri, F. Polli, V. Bagetta, G. Bernardi, F. Cattabeni, M. Di Luca, and P. Calabresi (2006)
J. Neurosci.
26, 2914-2922
|Abstract »|Full Text »|PDF »
Neuroprotection against ischaemic brain injury by a GluR6-9c peptide containing the TAT protein transduction sequence.
D.-S. Pei, X.-T. Wang, Y. Liu, Y.-F. Sun, Q.-H. Guan, W. Wang, J.-Z. Yan, Y.-Y. Zong, T.-L. Xu, and G.-Y. Zhang (2006)
Brain
129, 465-479
|Abstract »|Full Text »|PDF »
Hypoxia-inducible Factor Prolyl 4-Hydroxylase Inhibition: A TARGET FOR NEUROPROTECTION IN THE CENTRAL NERVOUS SYSTEM.
A. Siddiq, I. A. Ayoub, J. C. Chavez, L. Aminova, S. Shah, J. C. LaManna, S. M. Patton, J. R. Connor, R. A. Cherny, I. Volitakis, et al. (2005)
J. Biol. Chem.
280, 41732-41743
|Abstract »|Full Text »|PDF »
Nucleus Accumbens Long-Term Depression and the Expression of Behavioral Sensitization.
K. Brebner, T. P. Wong, L. Liu, Y. Liu, P. Campsall, S. Gray, L. Phelps, A. G. Phillips, and Y. T. Wang (2005)
Science
310, 1340-1343
|Abstract »|Full Text »|PDF »
Mitochondrial Nitric Oxide Mediates Decreased Vulnerability of Hippocampal Neurons from Immature Animals to NMDA.
S. Zou, L. Li, L. Pei, B. Vukusic, H. H. M. Van Tol, F. J. S. Lee, Q. Wan, and F. Liu (2005)
J. Neurosci.
25, 4385-4395
|Abstract »|Full Text »|PDF »
TRPM7 and Ischemic CNS Injury.
M. M. Aarts and M. Tymianski (2005)
Neuroscientist
11, 116-123
|Abstract »|PDF »
Apoptosis-Inducing Factor Is a Key Factor in Neuronal Cell Death Propagated by BAX-Dependent and BAX-Independent Mechanisms.
E. C. C. Cheung, L. Melanson-Drapeau, S. P. Cregan, J. L. Vanderluit, K. L. Ferguson, W. C. McIntosh, D. S. Park, S. A. L. Bennett, and R. S. Slack (2005)
J. Neurosci.
25, 1324-1334
|Abstract »|Full Text »|PDF »
N-methyl-D-aspartate Receptor Subtypes: Multiple Roles in Excitotoxicity and Neurological Disease.
E. A. Waxman and D. R. Lynch (2005)
Neuroscientist
11, 37-49
|Abstract »|PDF »
The PSD95-nNOS interface: a target for inhibition of excitotoxic p38 stress-activated protein kinase activation and cell death.
J. Cao, J. I. Viholainen, C. Dart, H. K. Warwick, M. L. Leyland, and M. J. Courtney (2005)
J. Cell Biol.
168, 117-126
|Abstract »|Full Text »|PDF »
A Novel Ca2+-Independent Signaling Pathway to Extracellular Signal-Regulated Protein Kinase by Coactivation of NMDA Receptors and Metabotropic Glutamate Receptor 5 in Neurons.
L. Yang, L. Mao, Q. Tang, S. Samdani, Z. Liu, and J. Q. Wang (2004)
J. Neurosci.
24, 10846-10857
|Abstract »|Full Text »|PDF »
Differential Mechanisms of Nitric Oxide- and Peroxynitrite-Induced Cell Death.
J. T. A. Meij, C. L. Haselton, K. L. Hillman, D. Muralikrishnan, M. Ebadi, and L. Yu (2004)
Mol. Pharmacol.
66, 1043-1053
|Abstract »|Full Text »|PDF »
Vulnerability of Central Neurons to Secondary Insults after In Vitro Mechanical Stretch.
M. Arundine, M. Aarts, A. Lau, and M. Tymianski (2004)
J. Neurosci.
24, 8106-8123
|Abstract »|Full Text »|PDF »
Protein Kinase C {delta} Mediates Cerebral Reperfusion Injury In Vivo.
R. Bright, A. P. Raval, J. M. Dembner, M. A. Perez-Pinzon, G. K. Steinberg, M. A. Yenari, and D. Mochly-Rosen (2004)
J. Neurosci.
24, 6880-6888
|Abstract »|Full Text »|PDF »
Selective inhibition of calcineurin-NFAT signaling by blocking protein-protein interaction with small organic molecules.
M. H. A. Roehrl, S. Kang, J. Aramburu, G. Wagner, A. Rao, and P. G. Hogan (2004)
PNAS
101, 7554-7559
|Abstract »|Full Text »|PDF »
ABAD Directly Links A{beta} to Mitochondrial Toxicity in Alzheimer's Disease.
J. W. Lustbader, M. Cirilli, C. Lin, H. W. Xu, K. Takuma, N. Wang, C. Caspersen, X. Chen, S. Pollak, M. Chaney, et al. (2004)
Science
304, 448-452
|Abstract »|Full Text »|PDF »
Bidirectional Regulation of Neuronal Nitric-oxide Synthase Phosphorylation at Serine 847 by the N-Methyl-D-aspartate Receptor.
G. A. Rameau, L.-Y. Chiu, and E. B. Ziff (2004)
J. Biol. Chem.
279, 14307-14314
|Abstract »|Full Text »|PDF »
N-Methyl-D-aspartate Receptors: Subunit Assembly and Trafficking to the Synapse.
K. Prybylowski and R. J. Wenthold (2004)
J. Biol. Chem.
279, 9673-9676
|Full Text »|PDF »
3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Inhibitors Protect Cortical Neurons from Excitotoxicity.
A. Zacco, J. Togo, K. Spence, A. Ellis, D. Lloyd, S. Furlong, and T. Piser (2003)
J. Neurosci.
23, 11104-11111
|Abstract »|Full Text »|PDF »
Developmental Decrease in NMDA Receptor Desensitization Associated with Shift to Synapse and Interaction with Postsynaptic Density-95.
B. Li, Y. Otsu, T. H. Murphy, and L. A. Raymond (2003)
J. Neurosci.
23, 11244-11254
|Abstract »|Full Text »|PDF »
Neonatal Hypoxia-Ischemia Differentially Upregulates MAGUKs and Associated Proteins in PSD-93-Deficient Mouse Brain.
X. Jiang, D. Mu, R. A. Sheldon, D. V. Glidden, and D. M. Ferriero (2003)
Stroke
34, 2958-2963
|Abstract »|Full Text »|PDF »
Synaptic PDZ Domain-mediated Protein Interactions Are Disrupted by Inhalational Anesthetics.
M. Fang, Y.-X. Tao, F. He, M. Zhang, C. F. Levine, P. Mao, F. Tao, C.-L. Chou, S. Sadegh-Nasseri, and R. A. Johns (2003)
J. Biol. Chem.
278, 36669-36675
|Abstract »|Full Text »|PDF »
Expression of Polyglutamine-expanded Huntingtin Induces Tyrosine Phosphorylation of N-Methyl-D-aspartate Receptors.
C. Song, Y. Zhang, C. G. Parsons, and Y. F. Liu (2003)
J. Biol. Chem.
278, 33364-33369
|Abstract »|Full Text »|PDF »
The Neuroscientist Comments: Ischemic Neuroprotection via Perturbation of NMDA Receptor-PSD-95 Interactions.
