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Science 298 (5595): 1029-1033

Copyright © 2002 by the American Association for the Advancement of Science

Cytoprotective Role of Ca2+- Activated K+ Channels in the Cardiac Inner Mitochondrial Membrane

Wenhong Xu,1 Yongge Liu,2 Sheng Wang,2 Todd McDonald,3 Jennifer E. Van Eyk,3 Agnieszka Sidor,1 Brian O'Rourke1*

Ion channels on the mitochondrial inner membrane influence cell function in specific ways that can be detrimental or beneficial to cell survival. At least one type of potassium (K+) channel, the mitochondrial adenosine triphosphate-sensitive K+ channel (mitoKATP), is an important effector of protection against necrotic and apoptotic cell injury after ischemia. Here another channel with properties similar to the surface membrane calcium-activated K+ channel was found on the mitochondrial inner membrane (mitoKCa) of guinea pig ventricular cells. MitoKCa significantly contributed to mitochondrial K+ uptake of the myocyte, and an opener of mitoKCa protected hearts against infarction.

1 Institute of Molecular Cardiobiology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
2 Maryland Research Laboratories, Otsuka Maryland Research Institute, Rockville, MD 20850, USA.
3 Department of Physiology, Queen's University, Kingston, Ontario, K7L 3N6 Canada.
*   To whom correspondence should be addressed. E-mail: bor{at}jhmi.edu.



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