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Science 298 (5596): 1245-1248

Copyright © 2002 by the American Association for the Advancement of Science

The Neurotrophin Receptor p75NTR as a Positive Modulator of Myelination

José M. Cosgaya,* Jonah R. Chan,* Eric M. Shooterdagger

Schwann cells in developing and regenerating peripheral nerves express elevated levels of the neurotrophin receptor p75NTR. Neurotrophins are key mediators of peripheral nervous system myelination. Our results show that myelin formation is inhibited in the absence of functional p75NTR and enhanced by blocking TrkC activity. Moreover, the enhancement of myelin formation by endogenous brain-derived neurotrophic factor is mediated by the p75NTR receptor, whereas TrkC receptors are responsible for neurotrophin-3 inhibition. Thus p75NTR and TrkC receptors have opposite effects on myelination.

Department of Neurobiology, Stanford University School of Medicine, 299 Campus Drive, Fairchild Building, Stanford, CA 94305, USA.
*   These authors contributed equally to this work.

dagger    To whom correspondence should be addressed. E-mail: eshooter{at}cmgm.stanford.edu



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