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Science 298 (5597): 1418-1421

Copyright © 2002 by the American Association for the Advancement of Science

On the Origin of Interictal Activity in Human Temporal Lobe Epilepsy in Vitro

Ivan Cohen,1 Vincent Navarro,24 Stéphane Clemenceau,13 Michel Baulac,12 Richard Miles1*

The origin and mechanisms of human interictal epileptic discharges remain unclear. Here, we describe a spontaneous, rhythmic activity initiated in the subiculum of slices from patients with temporal lobe epilepsy. Synchronous events were similar to interictal discharges of patient electroencephalograms. They were suppressed by antagonists of either glutamatergic or gamma -aminobutyric acid (GABA)-ergic signaling. The network of neurons discharging during population events comprises both subicular interneurons and a subgroup of pyramidal cells. In these pyramidal cells, GABAergic synaptic events reversed at depolarized potentials. Depolarizing GABAergic responses in neurons downstream to the sclerotic CA1 region contribute to human interictal activity.

1 EMI 0224, CHU Pitié-Salpêtrière, Université Paris VI, 75013 Paris, France.
2 Epilepsy Unit,
3 Department of Neurosurgery,
4 CNRS UPR640, Hôpital Pitié-Salpêtrière AP-HP, 75013, Paris, France.
*   To whom correspondence should be addressed. E-mail: rmiles{at}biomedicale.univ-paris5.fr.



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