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Science 298 (5600): 1912-1934

Copyright © 2002 by the American Association for the Advancement of Science

The Protein Kinase Complement of the Human Genome

G. Manning,1* D. B. Whyte,1 R. Martinez,1 T. Hunter,2 S. Sudarsanam13

We have catalogued the protein kinase complement of the human genome (the "kinome") using public and proprietary genomic, complementary DNA, and expressed sequence tag (EST) sequences. This provides a starting point for comprehensive analysis of protein phosphorylation in normal and disease states, as well as a detailed view of the current state of human genome analysis through a focus on one large gene family. We identify 518 putative protein kinase genes, of which 71 have not previously been reported or described as kinases, and we extend or correct the protein sequences of 56 more kinases. New genes include members of well-studied families as well as previously unidentified families, some of which are conserved in model organisms. Classification and comparison with model organism kinomes identified orthologous groups and highlighted expansions specific to human and other lineages. We also identified 106 protein kinase pseudogenes. Chromosomal mapping revealed several small clusters of kinase genes and revealed that 244 kinases map to disease loci or cancer amplicons.

1 SUGEN Inc., 230 East Grand Avenue, South San Francisco, CA 94080, USA.
2 Salk Institute, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA.
3 Genomics and Biotechnology, Pharmacia Corporation, 230 East Grand Avenue, South San Francisco, CA 94080, USA.
*   To whom correspondence should be addressed. E-mail: gerard-manning{at}sugen.com

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Serine/Threonine Protein Kinase Stk Is Required for Virulence, Stress Response, and Penicillin Tolerance in Streptococcus pyogenes.
J. Bugrysheva, B. J. Froehlich, J. A. Freiberg, and J. R. Scott (2011)
Infect. Immun. 79, 4201-4209
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