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Maintenance of Serological Memory by Polyclonal Activation of Human Memory B Cells
Nadia L. Bernasconi,*Elisabetta Traggiai,*Antonio Lanzavecchia
Production of antibodies can last for a lifetime, through
mechanisms that remain poorly understood. Here, we show that humanmemory B lymphocytes proliferate and differentiate into plasmacells in
response to polyclonal stimuli, such as bystander T cellhelp and CpG
DNA. Furthermore, plasma cells secreting antibodiesto recall antigens
are produced in vivo at levels proportionalto the frequency of
specific memory B cells, even several yearsafter antigenic
stimulation. Although antigen boosting leads toa transient increase in
specific antibody levels, ongoing polyclonalactivation of memory B
cells offers a means to maintain serologicalmemory for a human
lifetime.
Institute for Research in Biomedicine, Via Vela 6, CH 6500 Bellinzona, Switzerland.
*
These authors contributed equally to this work.
To whom correspondence should be addressed. E-mail:
lanzavecchia{at}irb.unisi.ch
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J. Immunol.
180, 5283-5290
|Abstract »|Full Text »|PDF »
Maintenance of the plasma cell pool is independent of memory B cells.
A. Ahuja, S. M. Anderson, A. Khalil, and M. J. Shlomchik (2008)
PNAS
105, 4802-4807
|Abstract »|Full Text »|PDF »
The Magnitude of the Antibody and Memory B Cell Responses during Priming with a Protein-Polysaccharide Conjugate Vaccine in Human Infants Is Associated with the Persistence of Antibody and the Intensity of Booster Response.
G. B. Rohner, M. D. Snape, D. F. Kelly, T. John, A. Morant, L.-M. Yu, A. Borkowski, F. Ceddia, R. Borrow, C.-A. Siegrist, et al. (2008)
J. Immunol.
180, 2165-2173
|Abstract »|Full Text »|PDF »
CpG Drives Human Transitional B Cells to Terminal Differentiation and Production of Natural Antibodies.
F. Capolunghi, S. Cascioli, E. Giorda, M. M. Rosado, A. Plebani, C. Auriti, G. Seganti, R. Zuntini, S. Ferrari, M. Cagliuso, et al. (2008)
J. Immunol.
180, 800-808
|Abstract »|Full Text »|PDF »
Increased survival is a selective feature of human circulating antigen-induced plasma cells synthesizing high-affinity antibodies.
I. Gonzalez-Garcia, B. Rodriguez-Bayona, F. Mora-Lopez, A. Campos-Caro, and J. A. Brieva (2008)
Blood
111, 741-749
|Abstract »|Full Text »|PDF »
