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Science 299 (5614): 1898-1902

Copyright © 2003 by the American Association for the Advancement of Science

Discrete Coding of Reward Probability and Uncertainty by Dopamine Neurons

Christopher D. Fiorillo,* Philippe N. Tobler, Wolfram Schultz

Uncertainty is critical in the measure of information and in assessing the accuracy of predictions. It is determined by probability P, being maximal at P = 0.5 and decreasing at higher and lower probabilities. Using distinct stimuli to indicate the probability of reward, we found that the phasic activation of dopamine neurons varied monotonically across the full range of probabilities, supporting past claims that this response codes the discrepancy between predicted and actual reward. In contrast, a previously unobserved response covaried with uncertainty and consisted of a gradual increase in activity until the potential time of reward. The coding of uncertainty suggests a possible role for dopamine signals in attention-based learning and risk-taking behavior.

Institute of Physiology, University of Fribourg, CH-1700 Fribourg, Switzerland, and Department of Anatomy, University of Cambridge, Downing Street, Cambridge CB2 3DY, UK.
*   To whom correspondence should be addressed. E-mail: cdf28{at}cam.ac.uk



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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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J. Neurosci. 30, 11447-11457
   Abstract »    Full Text »    PDF »
Temporally Extended Dopamine Responses to Perceptually Demanding Reward-Predictive Stimuli.
K. Nomoto, W. Schultz, T. Watanabe, and M. Sakagami (2010)
J. Neurosci. 30, 10692-10702
   Abstract »    Full Text »    PDF »
The Effects of COMT (Val108/158Met) and DRD4 (SNP -521) Dopamine Genotypes on Brain Activations Related to Valence and Magnitude of Rewards.
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Full Text »    PDF »
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   Abstract »    PDF »
Contextual Novelty Changes Reward Representations in the Striatum.
M. Guitart-Masip, N. Bunzeck, K. E. Stephan, R. J. Dolan, and E. Duzel (2010)
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   Abstract »    Full Text »    PDF »
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J. Neurosci. 30, 534-544
   Abstract »    Full Text »    PDF »
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J. Dickhaut, A. Rustichini, and V. Smith (2009)
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   Abstract »    Full Text »    PDF »
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B. Abler, R. Hahlbrock, A. Unrath, G. Gron, and J. Kassubek (2009)
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   Abstract »    Full Text »    PDF »
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E. van Duuren, G. van der Plasse, J. Lankelma, R. N. J. M. A. Joosten, M. G. P. Feenstra, and C. M. A. Pennartz (2009)
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   Abstract »    Full Text »    PDF »
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G. Xue, Z. Lu, I. P. Levin, J. A. Weller, X. Li, and A. Bechara (2009)
Cereb Cortex 19, 1019-1027
   Abstract »    Full Text »    PDF »
Stimulus-outcome learnability differentially activates anterior cingulate and hippocampus at feedback processing.
P. F. Rodriguez (2009)
Learn. Mem. 16, 324-331
   Abstract »    Full Text »    PDF »
The Hippocampus Codes the Uncertainty of Cue-Outcome Associations: An Intracranial Electrophysiological Study in Humans.
G. Vanni-Mercier, F. Mauguiere, J. Isnard, and J.-C. Dreher (2009)
J. Neurosci. 29, 5287-5294
   Abstract »    Full Text »    PDF »
D1/D5 Modulation of Synaptic NMDA Receptor Currents.
J. A. Varela, S. J. Hirsch, D. Chapman, L. S. Leverich, and R. W. Greene (2009)
J. Neurosci. 29, 3109-3119
   Abstract »    Full Text »    PDF »
Encoding of Probabilistic Rewarding and Aversive Events by Pallidal and Nigral Neurons.
M. Joshua, A. Adler, B. Rosin, E. Vaadia, and H. Bergman (2009)
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   Abstract »    Full Text »    PDF »
Variation in dopamine genes influences responsivity of the human reward system.
J.-C. Dreher, P. Kohn, B. Kolachana, D. R. Weinberger, and K. F. Berman (2009)
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   Abstract »    Full Text »    PDF »
The role of the striatum in aversive learning and aversive prediction errors.
M. R Delgado, J. Li, D. Schiller, and E. A Phelps (2008)
Phil Trans R Soc B 363, 3787-3800
   Abstract »    Full Text »    PDF »
Explicit neural signals reflecting reward uncertainty.
W. Schultz, K. Preuschoff, C. Camerer, M. Hsu, C. D Fiorillo, P. N Tobler, and P. Bossaerts (2008)
Phil Trans R Soc B 363, 3801-3811
   Abstract »    Full Text »    PDF »
Neuroethology of reward and decision making.
K. K Watson and M. L Platt (2008)
Phil Trans R Soc B 363, 3825-3835
   Abstract »    Full Text »    PDF »
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M. Joshua, A. Adler, R. Mitelman, E. Vaadia, and H. Bergman (2008)
J. Neurosci. 28, 11673-11684
   Abstract »    Full Text »    PDF »
A Local Circuit Model of Learned Striatal and Dopamine Cell Responses under Probabilistic Schedules of Reward.
C. O. Tan and D. Bullock (2008)
J. Neurosci. 28, 10062-10074
   Abstract »    Full Text »    PDF »
Age-related changes in midbrain dopaminergic regulation of the human reward system.
J.-C. Dreher, A. Meyer-Lindenberg, P. Kohn, and K. F. Berman (2008)
PNAS 105, 15106-15111
   Abstract »    Full Text »    PDF »
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N. J. Diederich and C. G. Goetz (2008)
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   Abstract »    Full Text »    PDF »
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S. Kobayashi and W. Schultz (2008)
J. Neurosci. 28, 7837-7846
   Abstract »    Full Text »    PDF »
Toward a Mechanistic Understanding of Human Decision Making: Contributions of Functional Neuroimaging.
J. P. O'Doherty and P. Bossaerts (2008)
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   Abstract »    Full Text »    PDF »
Motor Adaptation as a Process of Reoptimization.
J. Izawa, T. Rane, O. Donchin, and R. Shadmehr (2008)
J. Neurosci. 28, 2883-2891
   Abstract »    Full Text »    PDF »
Expected Value, Reward Outcome, and Temporal Difference Error Representations in a Probabilistic Decision Task.
E. T. Rolls, C. McCabe, and J. Redoute (2008)
Cereb Cortex 18, 652-663
   Abstract »    Full Text »    PDF »
BOLD Responses Reflecting Dopaminergic Signals in the Human Ventral Tegmental Area.
K. D'Ardenne, S. M. McClure, L. E. Nystrom, and J. D. Cohen (2008)
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   Abstract »    Full Text »    PDF »
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F. Krueger, K. McCabe, J. Moll, N. Kriegeskorte, R. Zahn, M. Strenziok, A. Heinecke, and J. Grafman (2007)
PNAS 104, 20084-20089
   Abstract »    Full Text »    PDF »
History- and Current Instruction-Based Coding of Forthcoming Behavioral Outcomes in the Striatum.
H. Yamada, N. Matsumoto, and M. Kimura (2007)
J Neurophysiol 98, 3557-3567
   Abstract »    Full Text »    PDF »
Lateral Habenula Stimulation Inhibits Rat Midbrain Dopamine Neurons through a GABAA Receptor-Mediated Mechanism.
H. Ji and P. D. Shepard (2007)
J. Neurosci. 27, 6923-6930
   Abstract »    Full Text »    PDF »
Processing of Temporal Unpredictability in Human and Animal Amygdala.
C. Herry, D. R. Bach, F. Esposito, F. Di Salle, W. J. Perrig, K. Scheffler, A. Luthi, and E. Seifritz (2007)
J. Neurosci. 27, 5958-5966
   Abstract »    Full Text »    PDF »
Gene gene interaction associated with neural reward sensitivity.
J. Yacubian, T. Sommer, K. Schroeder, J. Glascher, R. Kalisch, B. Leuenberger, D. F. Braus, and C. Buchel (2007)
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   Abstract »    Full Text »    PDF »

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