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Requirement for CD4 T Cell Help in Generating Functional CD8 T Cell Memory
Devon J. Shedlock,Hao Shen*
Although primary CD8 responses to acute infections are independent
of CD4 help, it is unknown whether a similar situationapplies to
secondary responses. We show that depletion of CD4cells during the
recall response has minimal effect, whereas depletionduring the
priming phase leads to reduced responses by memoryCD8 cells to
reinfection. Memory CD8 cells generated in CD4+/+ mice
responded normally when transferred into CD4/ hosts,
whereas memory CD8 cells generated in CD4/ mice mounted
defective recall responses in CD4+/+ adoptive hosts. These
results demonstrate a previously undescribedrole for CD4 help in the
development of functional CD8 memory.
Department of Microbiology, University of Pennsylvania School of
Medicine, Philadelphia, PA 19104, USA.
*
To whom correspondence should be addressed at the Department of
Microbiology, University of Pennsylvania School of Medicine,3610 Hamilton Walk, Philadelphia, PA 19104-6076, USA. E-mail:hshen{at}mail.med.upenn.edu
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Impact of Cytotoxic-T-Lymphocyte Memory Induction without Virus-Specific CD4+ T-Cell Help on Control of a Simian Immunodeficiency Virus Challenge in Rhesus Macaques.
T. Tsukamoto, A. Takeda, T. Yamamoto, H. Yamamoto, M. Kawada, and T. Matano (2009)
J. Virol.
83, 9339-9346
|Abstract »|Full Text »|PDF »
CD4+ T Cell Help Has an Epitope-Dependent Impact on CD8+ T Cell Memory Inflation during Murine Cytomegalovirus Infection.
C. M. Snyder, A. Loewendorf, E. L. Bonnett, M. Croft, C. A. Benedict, and A. B. Hill (2009)
J. Immunol.
183, 3932-3941
|Abstract »|Full Text »|PDF »
Kinetics and Phenotype of Vaccine-Induced CD8+ T-Cell Responses to Toxoplasma gondii.
K. A. Jordan, E. H. Wilson, E. D. Tait, B. A. Fox, D. S. Roos, D. J. Bzik, F. Dzierszinski, and C. A. Hunter (2009)
Infect. Immun.
77, 3894-3901
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Human Immunodeficiency Virus Type 1 Escapes from Interleukin-2-Producing CD4+ T-Cell Responses without High-Frequency Fixation of Mutations.
R. B. Jones, F.-Y. Yue, X. X. J. Gu, D. V. Hunter, S. Mujib, G. Gyenes, R. D. Mason, R. Mohamed, K. S. MacDonald, C. Kovacs, et al. (2009)
J. Virol.
83, 8722-8732
|Abstract »|Full Text »|PDF »
Strong Ability of Nef-Specific CD4+ Cytotoxic T Cells To Suppress Human Immunodeficiency Virus Type 1 (HIV-1) Replication in HIV-1-Infected CD4+ T Cells and Macrophages.
N. Zheng, M. Fujiwara, T. Ueno, S. Oka, and M. Takiguchi (2009)
J. Virol.
83, 7668-7677
|Abstract »|Full Text »|PDF »
Immunity to Murine Prostatic Tumors: Continuous Provision of T-Cell Help Prevents CD8 T-Cell Tolerance and Activates Tumor-Infiltrating Dendritic Cells.
K. A. Shafer-Weaver, S. K. Watkins, M. J. Anderson, L. J. Draper, A. Malyguine, W. G. Alvord, N. M. Greenberg, and A. A. Hurwitz (2009)
Cancer Res.
69, 6256-6264
|Abstract »|Full Text »|PDF »
Functional Unresponsiveness and Replicative Senescence of Myeloid Leukemia Antigen-specific CD8+ T Cells After Allogeneic Stem Cell Transplantation.
G. L. Beatty, J. S. Smith, R. Reshef, K. P. Patel, T. A. Colligon, B. A. Vance, N. V. Frey, F. B. Johnson, D. L. Porter, and R. H. Vonderheide (2009)
Clin. Cancer Res.
15, 4944-4953
|Abstract »|Full Text »|PDF »
A Vital Role for Interleukin-21 in the Control of a Chronic Viral Infection.
M. J. Cayabyab, B. Korioth-Schmitz, Y. Sun, A. Carville, H. Balachandran, A. Miura, K. R. Carlson, A. P. Buzby, B. F. Haynes, W. R. Jacobs, et al. (2009)
J. Virol.
83, 5505-5513
|Abstract »|Full Text »|PDF »
Polyfunctional CD4+ T-Cell Induction in Neutralizing Antibody-Triggered Control of Simian Immunodeficiency Virus Infection.
T. Yamamoto, N. Iwamoto, H. Yamamoto, T. Tsukamoto, T. Kuwano, A. Takeda, M. Kawada, Y. Tsunetsugu-Yokota, and T. Matano (2009)
J. Virol.
83, 5514-5524
|Abstract »|Full Text »|PDF »
Comparison of Human and Rhesus Macaque T-Cell Responses Elicited by Boosting with NYVAC Encoding Human Immunodeficiency Virus Type 1 Clade C Immunogens.
P. Mooij, S. S. Balla-Jhagjhoorsingh, N. Beenhakker, P. van Haaften, I. Baak, I. G. Nieuwenhuis, S. Heidari, H. Wolf, M.-J. Frachette, K. Bieler, et al. (2009)
J. Virol.
83, 5881-5889
|Abstract »|Full Text »|PDF »
Chronic Antigen Stimulation Alone Is Sufficient to Drive CD8+ T Cell Exhaustion.
C. M. Bucks, J. A. Norton, A. C. Boesteanu, Y. M. Mueller, and P. D. Katsikis (2009)
J. Immunol.
182, 6697-6708
|Abstract »|Full Text »|PDF »
CD4+ T Cells Are Required for the Priming of CD8+ T Cells following Infection with Herpes Simplex Virus Type 1.
N. K. Rajasagi, S. H. Kassim, C. M. Kollias, X. Zhao, R. Chervenak, and S. R. Jennings (2009)
J. Virol.
83, 5256-5268
|Abstract »|Full Text »|PDF »
Cognate CD4 help is essential for the reactivation and expansion of CD8 memory T cells directed against the hematopoietic cell-specific dominant minor histocompatibility antigen, H60.
S. J. Ryu, K. M. Jung, H. S. Yoo, T. W. Kim, S. Kim, J. Chang, and E. Y. Choi (2009)
Blood
113, 4273-4280
|Abstract »|Full Text »|PDF »
Th-1 polarization is regulated by dendritic-cell comparison of MHC class I and class II antigens.
W. K. Decker, D. Xing, S. Li, S. N. Robinson, H. Yang, D. Steiner, K. V. Komanduri, and E. J. Shpall (2009)
Blood
113, 4213-4223
|Abstract »|Full Text »|PDF »
Depletion of CD4 T cells enhances immunotherapy for neuroblastoma after syngeneic HSCT but compromises development of antitumor immune memory.
Identification of a particular HIV-specific CD8+ T-cell subset with a CD27+ CD45RO-/RA+ phenotype and memory characteristics after initiation of HAART during acute primary HIV infection.
C. Lecuroux, I. Girault, A. Urrutia, J.-M. Doisne, C. Deveau, C. Goujard, L. Meyer, M. Sinet, and A. Venet (2009)
Blood
113, 3209-3217
|Abstract »|Full Text »|PDF »
Recall Responses by Helpless Memory CD8+ T Cells Are Restricted by the Up-Regulation of PD-1.
S. Fuse, C.-Y. Tsai, M. J. Molloy, S. R. Allie, W. Zhang, H. Yagita, and E. J. Usherwood (2009)
J. Immunol.
182, 4244-4254
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Characterization of the Class I-Restricted gp100 Melanoma Peptide-stimulated Primary Immune Response in Tumor-Free Vaccine-draining Lymph Nodes and Peripheral Blood.
E. B. Walker, W. Miller, D. Haley, K. Floyd, B. Curti, and W. J. Urba (2009)
Clin. Cancer Res.
15, 2541-2551
|Abstract »|Full Text »|PDF »
Characterization of a CD44/CD122int Memory CD8 T Cell Subset Generated under Sterile Inflammatory Conditions.
F.-M. Mbitikon-Kobo, M. Vocanson, M.-C. Michallet, M. Tomkowiak, A. Cottalorda, G. S. Angelov, C.-A. Coupet, S. Djebali, A. Marcais, B. Dubois, et al. (2009)
J. Immunol.
182, 3846-3854
|Abstract »|Full Text »|PDF »
Antigen Processing and MHC-II Presentation by Dermal and Tumor-Infiltrating Dendritic Cells.
Requirement of B Cells for Generating CD4+ T Cell Memory.
J. K. Whitmire, M. S. Asano, S. M. Kaech, S. Sarkar, L. G. Hannum, M. J. Shlomchik, and R. Ahmed (2009)
J. Immunol.
182, 1868-1876
|Abstract »|Full Text »|PDF »
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