Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.
Subscribe

Logo for

Science 300 (5617): 339-342

Copyright © 2003 by the American Association for the Advancement of Science

Defective CD8 T Cell Memory Following Acute Infection Without CD4 T Cell Help

Joseph C. Sun, Michael J. Bevan*

The CD8+ cytotoxic T cell response to pathogens is thought to be CD4+ helper T cell independent because infectious agents provide their own inflammatory signals. Mice that lack CD4+ T cells mount a primary CD8 response to Listeria monocytogenes equal to that of wild-type mice and rapidly clear the infection. However, protective memory to a challenge is gradually lost in the former animals. Memory CD8+ T cells from normal mice can respond rapidly, but memory CD8+ T cells that are generated without CD4 help are defective in their ability to respond to secondary encounters with antigen. The results highlight a previously undescribed role for CD4 help in promoting protective CD8 memory development.

Department of Immunology and the Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195, USA.
*   To whom correspondence should be addressed: E-mail: mbevan{at}u.washington.edu

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Cytomegalovirus-specific T cells are primed early after cord blood transplant but fail to control virus in vivo.
S. M. McGoldrick, M. E. Bleakley, A. Guerrero, C. J. Turtle, T. N. Yamamoto, S. E. Pereira, C. S. Delaney, and S. R. Riddell (2013)
Blood 121, 2796-2803
   Abstract »    Full Text »    PDF »
Phase I Trial of Recombinant Modified Vaccinia Ankara Encoding Epstein-Barr Viral Tumor Antigens in Nasopharyngeal Carcinoma Patients.
E. P. Hui, G. S. Taylor, H. Jia, B. B. Y. Ma, S. L. Chan, R. Ho, W.-L. Wong, S. Wilson, B. F. Johnson, C. Edwards, et al. (2013)
Cancer Res. 73, 1676-1688
   Abstract »    Full Text »    PDF »
Functional Characterization of T Cell Populations in a Mouse Model of Chronic Obstructive Pulmonary Disease.
B. L. Eppert, B. W. Wortham, J. L. Flury, and M. T. Borchers (2013)
J. Immunol. 190, 1331-1340
   Abstract »    Full Text »    PDF »
Influenza-induced, helper-independent CD8+ T cell responses use CD40 costimulation at the late phase of the primary response.
S. G. K. Seah, J. L. Brady, E. M. Carrington, W. C. Ng, R. M. Sutherland, M. S. Hancock, N. L. La Gruta, L. E. Brown, S. J. Turner, A. M. Lew, et al. (2013)
J. Leukoc. Biol. 93, 145-154
   Abstract »    Full Text »    PDF »
Vaccine-Elicited CD8+ T Cells Protect against Respiratory Syncytial Virus Strain A2-Line19F-Induced Pathogenesis in BALB/c Mice.
S. Lee, K. L. Stokes, M. G. Currier, K. Sakamoto, N. W. Lukacs, E. Celis, and M. L. Moore (2012)
J. Virol. 86, 13016-13024
   Abstract »    Full Text »    PDF »
Dynamics of CD4+ T Cell Responses against Listeria monocytogenes.
F. Graw, K. S. Weber, P. M. Allen, and A. S. Perelson (2012)
J. Immunol. 189, 5250-5256
   Abstract »    Full Text »    PDF »
Transient Enhanced IL-2R Signaling Early during Priming Rapidly Amplifies Development of Functional CD8+ T Effector-Memory Cells.
I. Castro, M. J. Dee, and T. R. Malek (2012)
J. Immunol. 189, 4321-4330
   Abstract »    Full Text »    PDF »
The T-Cell Response to HIV.
B. Walker and A. McMichael (2012)
Cold Spring Harb Perspect Med 2, a007054
   Abstract »    Full Text »    PDF »
TCR Bias and HLA Cross-Restriction Are Strategies of Human Brain-Infiltrating JC Virus-Specific CD4+ T Cells during Viral Infection.
S. Yousef, R. Planas, K. Chakroun, S. Hoffmeister-Ullerich, T. M. C. Binder, T. H. Eiermann, R. Martin, and M. Sospedra (2012)
J. Immunol. 189, 3618-3630
   Abstract »    Full Text »    PDF »
CD4+ T Cell-Dependent IFN-{gamma} Production by CD8+ Effector T Cells in Mycobacterium tuberculosis Infection.
T. D. Bold and J. D. Ernst (2012)
J. Immunol. 189, 2530-2536
   Abstract »    Full Text »    PDF »
Stability and Function of Secondary Th1 Memory Cells Are Dependent on the Nature of the Secondary Stimulus.
C. Kim, D. C. Jay, and M. A. Williams (2012)
J. Immunol. 189, 2348-2355
   Abstract »    Full Text »    PDF »
Chronic Exposure to Staphylococcal Superantigen Elicits a Systemic Inflammatory Disease Mimicking Lupus.
V. R. Chowdhary, A. Y. Tilahun, C. R. Clark, J. P. Grande, and G. Rajagopalan (2012)
J. Immunol. 189, 2054-2062
   Abstract »    Full Text »    PDF »
Direct in vivo evidence of CD4+ T cell requirement for CTL response and memory via pMHC-I targeting and CD40L signaling.
K. A. Ahmed, L. Wang, M. A. Munegowda, S. J. Mulligan, J. R. Gordon, P. Griebel, and J. Xiang (2012)
J. Leukoc. Biol. 92, 289-300
   Abstract »    Full Text »    PDF »
Pten Loss in CD4 T Cells Enhances Their Helper Function but Does Not Lead to Autoimmunity or Lymphoma.
D. R. Soond, F. Garcon, D. T. Patton, J. Rolf, M. Turner, C. Scudamore, O. A. Garden, and K. Okkenhaug (2012)
J. Immunol. 188, 5935-5943
   Abstract »    Full Text »    PDF »
Distinct CD4+ helper T cells involved in primary and secondary responses to infection.
K. S. Weber, Q.-J. Li, S. P. Persaud, J. D. Campbell, M. M. Davis, and P. M. Allen (2012)
PNAS 109, 9511-9516
   Abstract »    Full Text »    PDF »
Synergistic CD40 signaling on APCs and CD8 T cells drives efficient CD8 response and memory differentiation.
S. Meunier, L. Rapetti, L. Beziaud, C. Pontoux, A. Legrand, and C. Tanchot (2012)
J. Leukoc. Biol. 91, 859-869
   Abstract »    Full Text »    PDF »
Type II membrane protein CD69 regulates the formation of resting T-helper memory.
K. Shinoda, K. Tokoyoda, A. Hanazawa, K. Hayashizaki, S. Zehentmeier, H. Hosokawa, C. Iwamura, H. Koseki, D. J. Tumes, A. Radbruch, et al. (2012)
PNAS 109, 7409-7414
   Abstract »    Full Text »    PDF »
CD27 Stimulation Promotes the Frequency of IL-7 Receptor-Expressing Memory Precursors and Prevents IL-12-Mediated Loss of CD8+ T Cell Memory in the Absence of CD4+ T Cell Help.
H. Dong, N. A. Franklin, D. J. Roberts, H. Yagita, M. J. Glennie, and T. N. J. Bullock (2012)
J. Immunol. 188, 3829-3838
   Abstract »    Full Text »    PDF »
MHC Class Ib-Restricted CD8 T Cells Differ in Dependence on CD4 T Cell Help and CD28 Costimulation over the Course of Mouse Polyomavirus Infection.
A. R. Hofstetter, M. L. Ford, L. C. Sullivan, J. J. Wilson, A. Hadley, A. G. Brooks, and A. E. Lukacher (2012)
J. Immunol. 188, 3071-3079
   Abstract »    Full Text »    PDF »
CD4 T Cells Promote CD8 T Cell Immunity at the Priming and Effector Site during Viral Encephalitis.
T. W. Phares, S. A. Stohlman, M. Hwang, B. Min, D. R. Hinton, and C. C. Bergmann (2012)
J. Virol. 86, 2416-2427
   Abstract »    Full Text »    PDF »
Simultaneous Targeting of Toll- and Nod-Like Receptors Induces Effective Tumor-Specific Immune Responses.
J. Garaude, A. Kent, N. van Rooijen, and J. M. Blander (2012)
Science Translational Medicine 4, 120ra16
   Abstract »    Full Text »    PDF »
HTLV-1 bZIP factor impairs cell-mediated immunity by suppressing production of Th1 cytokines.
K. Sugata, Y. Satou, J.-i. Yasunaga, H. Hara, K. Ohshima, A. Utsunomiya, M. Mitsuyama, and M. Matsuoka (2012)
Blood 119, 434-444
   Abstract »    Full Text »    PDF »
Alphavirus-Induced Encephalomyelitis: Antibody-Secreting Cells and Viral Clearance from the Nervous System.
T. U. Metcalf and D. E. Griffin (2011)
J. Virol. 85, 11490-11501
   Abstract »    Full Text »    PDF »
Development of Memory-Like Autoregulatory CD8+ T Cells Is CD4+ T Cell Dependent.
A. Shameli, X. Clemente-Casares, J. Wang, and P. Santamaria (2011)
J. Immunol. 187, 2859-2866
   Abstract »    Full Text »    PDF »
Mutations in a Dominant Nef Epitope of Simian Immunodeficiency Virus Diminish TCR:Epitope Peptide Affinity but not Epitope Peptide:MHC Class I Binding.
E. M. Cale, H. S. Bazick, T. A. Rianprakaisang, S. M. Alam, and N. L. Letvin (2011)
J. Immunol. 187, 3300-3313
   Abstract »    Full Text »    PDF »
IL-15 ex vivo overcomes CD4+ T cell deficiency for the induction of human antigen-specific CD8+ T cell responses.
H. Yu, A. Tawab-Amiri, A. Dzutsev, M. Sabatino, K. Aleman, R. Yarchoan, M. Terabe, Y. Sui, and J. A. Berzofsky (2011)
J. Leukoc. Biol. 90, 205-214
   Abstract »    Full Text »    PDF »
CD4+ T cells support cytotoxic T lymphocyte priming by controlling lymph node input.
Y. Kumamoto, L. M. Mattei, S. Sellers, G. W. Payne, and A. Iwasaki (2011)
PNAS 108, 8749-8754
   Abstract »    Full Text »    PDF »
Prolonged Antitumor NK Cell Reactivity Elicited by CXCL10-Expressing Dendritic Cells Licensed by CD40L+CD4+ Memory T Cells.
K. Shimizu, M. Asakura, and S.-i. Fujii (2011)
J. Immunol. 186, 5927-5937
   Abstract »    Full Text »    PDF »
Epitope-Specific CD8+ T Lymphocytes Cross-Recognize Mutant Simian Immunodeficiency Virus (SIV) Sequences but Fail To Contain Very Early Evolution and Eventual Fixation of Epitope Escape Mutations during SIV Infection.
E. M. Cale, P. Hraber, E. E. Giorgi, W. Fischer, T. Bhattacharya, T. Leitner, W. W. Yeh, C. Gleasner, L. D. Green, C. S. Han, et al. (2011)
J. Virol. 85, 3746-3757
   Abstract »    Full Text »    PDF »
Conventional Dendritic Cells Are Required for the Activation of Helper-Dependent CD8 T Cell Responses to a Model Antigen After Cutaneous Vaccination with Lentiviral Vectors.
H. D. Goold, D. Escors, T. J. Conlan, R. Chakraverty, and C. L. Bennett (2011)
J. Immunol. 186, 4565-4572
   Abstract »    Full Text »    PDF »
Vaccination against Lymphocytic Choriomeningitis Virus Infection in MHC Class II-Deficient Mice.
P. J. Holst, J. P. Christensen, and A. R. Thomsen (2011)
J. Immunol. 186, 3997-4007
   Abstract »    Full Text »    PDF »
White Paper on Adoptive Cell Therapy for Cancer with Tumor-Infiltrating Lymphocytes: A Report of the CTEP Subcommittee on Adoptive Cell Therapy.
J. Weber, M. Atkins, P. Hwu, L. Radvanyi, M. Sznol, C. Yee, and on behalf of the Immunotherapy Task Force of the N (2011)
Clin. Cancer Res. 17, 1664-1673
   Abstract »    Full Text »    PDF »
Possession of HLA Class II DRB1*1303 Associates with Reduced Viral Loads in Chronic HIV-1 Clade C and B Infection.
B. Julg, E. S. Moodley, Y. Qi, D. Ramduth, S. Reddy, Z. Mncube, X. Gao, P. J. Goulder, R. Detels, T. Ndung'u, et al. (2011)
The Journal of Infectious Disease 203, 803-809
   Abstract »    Full Text »    PDF »
Intrinsic IL-21 Signaling Is Critical for CD8 T Cell Survival and Memory Formation in Response to Vaccinia Viral Infection.
P. Novy, X. Huang, W. J. Leonard, and Y. Yang (2011)
J. Immunol. 186, 2729-2738
   Abstract »    Full Text »    PDF »
Recent Developments in Cancer Vaccines.
K. Palucka, H. Ueno, and J. Banchereau (2011)
J. Immunol. 186, 1325-1331
   Abstract »    Full Text »    PDF »
HIV-1-Specific Interleukin-21+ CD4+ T Cell Responses Contribute to Durable Viral Control through the Modulation of HIV-Specific CD8+ T Cell Function.
M. F. Chevalier, B. Julg, A. Pyo, M. Flanders, S. Ranasinghe, D. Z. Soghoian, D. S. Kwon, J. Rychert, J. Lian, M. I. Muller, et al. (2011)
J. Virol. 85, 733-741
   Abstract »    Full Text »    PDF »
Persistent Survival of Prevalent Clonotypes within an Immunodominant HIV Gag-Specific CD8+ T Cell Response.
D. J. van Bockel, D. A. Price, M. L. Munier, V. Venturi, T. E. Asher, K. Ladell, H. Y. Greenaway, J. Zaunders, D. C. Douek, D. A. Cooper, et al. (2011)
J. Immunol. 186, 359-371
   Abstract »    Full Text »    PDF »
CD8+ Enriched "Young" Tumor Infiltrating Lymphocytes Can Mediate Regression of Metastatic Melanoma.
M. E. Dudley, C. A. Gross, M. M. Langhan, M. R. Garcia, R. M. Sherry, J. C. Yang, G. Q. Phan, U. S. Kammula, M. S. Hughes, D. E. Citrin, et al. (2010)
Clin. Cancer Res. 16, 6122-6131
   Abstract »    Full Text »    PDF »
Delineating the role of CD4+ T cells in the activation of human cytomegalovirus-specific immune responses following immunization with Ad-gBCMVpoly vaccine: implications for vaccination of immunocompromised individuals.
J. Zhong and R. Khanna (2010)
J. Gen. Virol. 91, 2994-3001
   Abstract »    Full Text »    PDF »
IL-17A-Producing {gamma}{delta}T Cells Promote CTL Responses against Listeria monocytogenes Infection by Enhancing Dendritic Cell Cross-Presentation.
S. Xu, Y. Han, X. Xu, Y. Bao, M. Zhang, and X. Cao (2010)
J. Immunol. 185, 5879-5887
   Abstract »    Full Text »    PDF »
Th Cells Act Via Two Synergistic Pathways To Promote Antiviral CD8+ T Cell Responses.
M. Wiesel, N. Joller, A.-K. Ehlert, J. Crouse, R. Sporri, M. F. Bachmann, and A. Oxenius (2010)
J. Immunol. 185, 5188-5197
   Abstract »    Full Text »    PDF »
CD4+ T Cells Are Not Required for the Induction of Dengue Virus-Specific CD8+ T Cell or Antibody Responses but Contribute to Protection after Vaccination.
L. E. Yauch, T. R. Prestwood, M. M. May, M. M. Morar, R. M. Zellweger, B. Peters, A. Sette, and S. Shresta (2010)
J. Immunol. 185, 5405-5416
   Abstract »    Full Text »    PDF »
Induction of Homologous Rather than Heterologous Antigen-Specific CD4 T Cell Responses Is Critical for Functional CD8 T Cell Responses in Mice Transgenic for a Foreign Antigen.
N. Sabarth, L. Chamberlain, S. Brett, J. Tite, and J. Craigen (2010)
J. Immunol. 185, 4590-4601
   Abstract »    Full Text »    PDF »
T Cell Immunity in Acute HIV-1 Infection.
H. Streeck and D. F. Nixon (2010)
The Journal of Infectious Disease 202, S302-S308
   Abstract »    Full Text »    PDF »
Prolonged Antigen Storage Endows Merocytic Dendritic Cells with Enhanced Capacity To Prime Anti-Tumor Responses in Tumor-Bearing Mice.
R. A. Reboulet, C. M. Hennies, Z. Garcia, S. Nierkens, and E. M. Janssen (2010)
J. Immunol. 185, 3337-3347
   Abstract »    Full Text »    PDF »
Homeostatic Turnover of Virus-Specific Memory CD8 T Cells Occurs Stochastically and Is Independent of CD4 T Cell Help.
D. K. Choo, K. Murali-Krishna, R. Anita, and R. Ahmed (2010)
J. Immunol. 185, 3436-3444
   Abstract »    Full Text »    PDF »
Early events governing memory CD8+ T-cell differentiation.
J. J. Obar and L. Lefrancois (2010)
Int. Immunol. 22, 619-625
   Abstract »    Full Text »    PDF »
The Role of CD80/CD86 in Generation and Maintenance of Functional Virus-Specific CD8+ T Cells in Mice Infected with Lymphocytic Choriomeningitis Virus.
M. Grujic, C. Bartholdy, M. Remy, D. D. Pinschewer, J. P. Christensen, and A. R. Thomsen (2010)
J. Immunol. 185, 1730-1743
   Abstract »    Full Text »    PDF »
Early Signals during CD8+ T Cell Priming Regulate the Generation of Central Memory Cells.
J. J. Obar and L. Lefrancois (2010)
J. Immunol. 185, 263-272
   Abstract »    Full Text »    PDF »
Distinct Roles for IL-2 and IL-15 in the Differentiation and Survival of CD8+ Effector and Memory T Cells.
D. M. Mitchell, E. V. Ravkov, and M. A. Williams (2010)
J. Immunol. 184, 6719-6730
   Abstract »    Full Text »    PDF »
Essential role of the Wnt pathway effector Tcf-1 for the establishment of functional CD8 T cell memory.
G. Jeannet, C. Boudousquie, N. Gardiol, J. Kang, J. Huelsken, and W. Held (2010)
PNAS 107, 9777-9782
   Abstract »    Full Text »    PDF »
Dendritic cell targeted HIV gag protein vaccine provides help to a DNA vaccine including mobilization of protective CD8+ T cells.
G. Nchinda, D. Amadu, C. Trumpfheller, O. Mizenina, K. Uberla, and R. M. Steinman (2010)
PNAS 107, 4281-4286
   Abstract »    Full Text »    PDF »
CD70 expression by dendritic cells plays a critical role in the immunogenicity of CD40-independent, CD4+ T cell-dependent, licensed CD8+ T cell responses.
K. E. Van Deusen, R. Rajapakse, and T. N. J. Bullock (2010)
J. Leukoc. Biol. 87, 477-485
   Abstract »    Full Text »    PDF »
Mechanisms of control of acute Friend virus infection by CD4+ T helper cells and their functional impairment by regulatory T cells.
S. R. Nair, G. Zelinskyy, S. Schimmer, N. Gerlach, G. Kassiotis, and U. Dittmer (2010)
J. Gen. Virol. 91, 440-451
   Abstract »    Full Text »    PDF »
CD4+ T cell regulation of CD25 expression controls development of short-lived effector CD8+ T cells in primary and secondary responses.
J. J. Obar, M. J. Molloy, E. R. Jellison, T. A. Stoklasek, W. Zhang, E. J. Usherwood, and L. Lefrancois (2010)
PNAS 107, 193-198
   Abstract »    Full Text »    PDF »
Early CD4+ T Cell Help Prevents Partial CD8+ T Cell Exhaustion and Promotes Maintenance of Herpes Simplex Virus 1 Latency.
G. M. Frank, A. J. Lepisto, M. L. Freeman, B. S. Sheridan, T. L. Cherpes, and R. L. Hendricks (2010)
J. Immunol. 184, 277-286
   Abstract »    Full Text »    PDF »
TLR2 Engagement on Dendritic Cells Promotes High Frequency Effector and Memory CD4 T Cell Responses.
S. S. Chandran, D. Verhoeven, J. R. Teijaro, M. J. Fenton, and D. L. Farber (2009)
J. Immunol. 183, 7832-7841
   Abstract »    Full Text »    PDF »
Activation-Induced CD154 Expression Abrogates Tolerance Induced by Apoptotic Cells.
P. Gurung, T. A. Kucaba, T. A. Ferguson, and T. S. Griffith (2009)
J. Immunol. 183, 6114-6123
   Abstract »    Full Text »    PDF »
Partial CD4 Depletion Reduces Regulatory T Cells Induced by Multiple Vaccinations and Restores Therapeutic Efficacy.
M. G. LaCelle, S. M. Jensen, and B. A. Fox (2009)
Clin. Cancer Res. 15, 6881-6890
   Abstract »    Full Text »    PDF »
Myeloma cell line-derived, pooled heat shock proteins as a universal vaccine for immunotherapy of multiple myeloma.
J. Qian, S. Hong, S. Wang, L. Zhang, L. Sun, M. Wang, J. Yang, L. W. Kwak, J. Hou, and Q. Yi (2009)
Blood 114, 3880-3889
   Abstract »    Full Text »    PDF »
The Size of the Viral Inoculum Contributes to the Outcome of Hepatitis B Virus Infection.
S. Asabe, S. F. Wieland, P. K. Chattopadhyay, M. Roederer, R. E. Engle, R. H. Purcell, and F. V. Chisari (2009)
J. Virol. 83, 9652-9662
   Abstract »    Full Text »    PDF »
Highly Efficient Antiviral CD8+ T-Cell Induction by Peptides Coupled to the Surfaces of Liposomes.
A. Takagi, M. Matsui, S. Ohno, H. Duan, O. Moriya, N. Kobayashi, H. Oda, M. Mori, A. Kobayashi, M. Taneichi, et al. (2009)
Clin. Vaccine Immunol. 16, 1383-1392
   Abstract »    Full Text »    PDF »
Impact of Cytotoxic-T-Lymphocyte Memory Induction without Virus-Specific CD4+ T-Cell Help on Control of a Simian Immunodeficiency Virus Challenge in Rhesus Macaques.
T. Tsukamoto, A. Takeda, T. Yamamoto, H. Yamamoto, M. Kawada, and T. Matano (2009)
J. Virol. 83, 9339-9346
   Abstract »    Full Text »    PDF »
CD4+ T Cell Help Has an Epitope-Dependent Impact on CD8+ T Cell Memory Inflation during Murine Cytomegalovirus Infection.
C. M. Snyder, A. Loewendorf, E. L. Bonnett, M. Croft, C. A. Benedict, and A. B. Hill (2009)
J. Immunol. 183, 3932-3941
   Abstract »    Full Text »    PDF »
Kinetics and Phenotype of Vaccine-Induced CD8+ T-Cell Responses to Toxoplasma gondii.
K. A. Jordan, E. H. Wilson, E. D. Tait, B. A. Fox, D. S. Roos, D. J. Bzik, F. Dzierszinski, and C. A. Hunter (2009)
Infect. Immun. 77, 3894-3901
   Abstract »    Full Text »    PDF »
Human Immunodeficiency Virus Type 1 Escapes from Interleukin-2-Producing CD4+ T-Cell Responses without High-Frequency Fixation of Mutations.
R. B. Jones, F.-Y. Yue, X. X. J. Gu, D. V. Hunter, S. Mujib, G. Gyenes, R. D. Mason, R. Mohamed, K. S. MacDonald, C. Kovacs, et al. (2009)
J. Virol. 83, 8722-8732
   Abstract »    Full Text »    PDF »
Differential Effects of Dendritic Cell Transfer on Airway Hyperresponsiveness and Inflammation.
T. Koya, H. Matsuda, S. Matsubara, N. Miyahara, A. Dakhama, K. Takeda, and E. W. Gelfand (2009)
41, 271-280
   Abstract »    Full Text »    PDF »
Functional Unresponsiveness and Replicative Senescence of Myeloid Leukemia Antigen-specific CD8+ T Cells After Allogeneic Stem Cell Transplantation.
G. L. Beatty, J. S. Smith, R. Reshef, K. P. Patel, T. A. Colligon, B. A. Vance, N. V. Frey, F. B. Johnson, D. L. Porter, and R. H. Vonderheide (2009)
Clin. Cancer Res. 15, 4944-4953
   Abstract »    Full Text »    PDF »
A Matter of Timing: Unsynchronized Antigen Expression and Antigen Presentation Diminish Secondary T Cell Responses.
M. Elnekave, M. Bivas-Benita, G. O. Gillard, P. Sircar, and A.-H. Hovav (2009)
J. Immunol. 183, 1013-1021
   Abstract »    Full Text »    PDF »
A Vital Role for Interleukin-21 in the Control of a Chronic Viral Infection.
J. S. Yi, M. Du, and A. J. Zajac (2009)
Science 324, 1572-1576
   Abstract »    Full Text »    PDF »
Recombinant Mycobacterium bovis BCG Prime-Recombinant Adenovirus Boost Vaccination in Rhesus Monkeys Elicits Robust Polyfunctional Simian Immunodeficiency Virus-Specific T-Cell Responses.
M. J. Cayabyab, B. Korioth-Schmitz, Y. Sun, A. Carville, H. Balachandran, A. Miura, K. R. Carlson, A. P. Buzby, B. F. Haynes, W. R. Jacobs, et al. (2009)
J. Virol. 83, 5505-5513
   Abstract »    Full Text »    PDF »
Polyfunctional CD4+ T-Cell Induction in Neutralizing Antibody-Triggered Control of Simian Immunodeficiency Virus Infection.
T. Yamamoto, N. Iwamoto, H. Yamamoto, T. Tsukamoto, T. Kuwano, A. Takeda, M. Kawada, Y. Tsunetsugu-Yokota, and T. Matano (2009)
J. Virol. 83, 5514-5524
   Abstract »    Full Text »    PDF »
Functionally Distinct LAG-3 and PD-1 Subsets on Activated and Chronically Stimulated CD8 T Cells.
J. F. Grosso, M. V. Goldberg, D. Getnet, T. C. Bruno, H.-R. Yen, K. J. Pyle, E. Hipkiss, D. A. A. Vignali, D. M. Pardoll, and C. G. Drake (2009)
J. Immunol. 182, 6659-6669
   Abstract »    Full Text »    PDF »
Chronic Antigen Stimulation Alone Is Sufficient to Drive CD8+ T Cell Exhaustion.
C. M. Bucks, J. A. Norton, A. C. Boesteanu, Y. M. Mueller, and P. D. Katsikis (2009)
J. Immunol. 182, 6697-6708
   Abstract »    Full Text »    PDF »
CD4+ T Cells Are Required for the Priming of CD8+ T Cells following Infection with Herpes Simplex Virus Type 1.
N. K. Rajasagi, S. H. Kassim, C. M. Kollias, X. Zhao, R. Chervenak, and S. R. Jennings (2009)
J. Virol. 83, 5256-5268
   Abstract »    Full Text »    PDF »
Critical Roles of NK and CD8+ T Cells in Central Nervous System Listeriosis.
T. Hayashi, S. Nagai, H. Fujii, Y. Baba, E. Ikeda, T. Kawase, and S. Koyasu (2009)
J. Immunol. 182, 6360-6368
   Abstract »    Full Text »    PDF »
Cognate CD4 help is essential for the reactivation and expansion of CD8 memory T cells directed against the hematopoietic cell-specific dominant minor histocompatibility antigen, H60.
S. J. Ryu, K. M. Jung, H. S. Yoo, T. W. Kim, S. Kim, J. Chang, and E. Y. Choi (2009)
Blood 113, 4273-4280
   Abstract »    Full Text »    PDF »
Identification of a particular HIV-specific CD8+ T-cell subset with a CD27+ CD45RO-/RA+ phenotype and memory characteristics after initiation of HAART during acute primary HIV infection.
C. Lecuroux, I. Girault, A. Urrutia, J.-M. Doisne, C. Deveau, C. Goujard, L. Meyer, M. Sinet, and A. Venet (2009)
Blood 113, 3209-3217
   Abstract »    Full Text »    PDF »
Recall Responses by Helpless Memory CD8+ T Cells Are Restricted by the Up-Regulation of PD-1.
S. Fuse, C.-Y. Tsai, M. J. Molloy, S. R. Allie, W. Zhang, H. Yagita, and E. J. Usherwood (2009)
J. Immunol. 182, 4244-4254
   Abstract »    Full Text »    PDF »
Characterization of the Class I-Restricted gp100 Melanoma Peptide-stimulated Primary Immune Response in Tumor-Free Vaccine-draining Lymph Nodes and Peripheral Blood.
E. B. Walker, W. Miller, D. Haley, K. Floyd, B. Curti, and W. J. Urba (2009)
Clin. Cancer Res. 15, 2541-2551
   Abstract »    Full Text »    PDF »
Postthymic maturation influences the CD8 T cell response to antigen.
L. E. Makaroff, D. W. Hendricks, R. E. Niec, and P. J. Fink (2009)
PNAS 106, 4799-4804
   Abstract »    Full Text »    PDF »
Characterization of a CD44/CD122int Memory CD8 T Cell Subset Generated under Sterile Inflammatory Conditions.
F.-M. Mbitikon-Kobo, M. Vocanson, M.-C. Michallet, M. Tomkowiak, A. Cottalorda, G. S. Angelov, C.-A. Coupet, S. Djebali, A. Marcais, B. Dubois, et al. (2009)
J. Immunol. 182, 3846-3854
   Abstract »    Full Text »    PDF »
Requirement of B Cells for Generating CD4+ T Cell Memory.
J. K. Whitmire, M. S. Asano, S. M. Kaech, S. Sarkar, L. G. Hannum, M. J. Shlomchik, and R. Ahmed (2009)
J. Immunol. 182, 1868-1876
   Abstract »    Full Text »    PDF »
CD8{beta} knockout mice mount normal anti-viral CD8+ T cell responses--but why?.
G. S. Angelov, P. Guillaume, and I. F. Luescher (2009)
Int. Immunol. 21, 123-135
   Abstract »    Full Text »    PDF »
IMMUNOLOGY: Ex Uno Plura.
S. Feau and S. P. Schoenberger (2009)
Science 323, 466-467
   Abstract »    Full Text »    PDF »
Memory-like CD8+ and CD4+ T cells cooperate to break peripheral tolerance under lymphopenic conditions.
C. Le Saout, S. Mennechet, N. Taylor, and J. Hernandez (2008)
PNAS 105, 19414-19419
   Abstract »    Full Text »    PDF »
In vivo Expansion, Persistence, and Function of Peptide Vaccine-Induced CD8 T Cells Occur Independently of CD4 T Cells.
D. Assudani, H.-I. Cho, N. DeVito, N. Bradley, and E. Celis (2008)
Cancer Res. 68, 9892-9899
   Abstract »    Full Text »    PDF »
Cutting Edge: CD4+ T Cell-Derived IL-2 Is Essential for Help-Dependent Primary CD8+ T Cell Responses.
E. B. Wilson and A. M. Livingstone (2008)
J. Immunol. 181, 7445-7448
   Abstract »    Full Text »    PDF »
Self-Antigen Prevents CD8 T Cell Effector Differentiation by CD134 and CD137 Dual Costimulation.
S. Bandyopadhyay, M. Long, H. Z. Qui, A. T. Hagymasi, A. M. Slaiby, M. A. Mihalyo, H. L. Aguila, R. S. Mittler, A. T. Vella, and A. J. Adler (2008)
J. Immunol. 181, 7728-7737
   Abstract »    Full Text »    PDF »
Deficiency of HIV-Gag-Specific T Cells in Early Childhood Correlates with Poor Viral Containment.
S. Huang, J. Dunkley-Thompson, Y. Tang, E. A. Macklin, J. Steel-Duncan, I. Singh-Minott, E. G. Ryland, M. Smikle, B. D. Walker, C. D. C. Christie, et al. (2008)
J. Immunol. 181, 8103-8111
   Abstract »    Full Text »    PDF »
Early Interferon Therapy for Hepatitis C Virus Infection Rescues Polyfunctional, Long-Lived CD8+ Memory T Cells.
G. Badr, N. Bedard, M. S. Abdel-Hakeem, L. Trautmann, B. Willems, J.-P. Villeneuve, E. K. Haddad, R. P. Sekaly, J. Bruneau, and N. H. Shoukry (2008)
J. Virol. 82, 10017-10031
   Abstract »    Full Text »    PDF »
Enumeration of Cytotoxic CD8 T Cells Ex Vivo during the Response to Listeria monocytogenes Infection.
D. M. W. Zaiss, A. J. A. M. Sijts, and T. R. Mosmann (2008)
Infect. Immun. 76, 4609-4614
   Abstract »    Full Text »    PDF »
Primary CD8+ T-Cell Response to Soluble Ovalbumin Is Improved by Chloroquine Treatment In Vivo.
B. Garulli, M. G. Stillitano, V. Barnaba, and M. R. Castrucci (2008)
Clin. Vaccine Immunol. 15, 1497-1504
   Abstract »    Full Text »    PDF »
DNA vaccination induces WT1-specific T-cell responses with potential clinical relevance.
C. Chaise, S. L. Buchan, J. Rice, J. Marquet, H. Rouard, M. Kuentz, G. E. Vittes, V. Molinier-Frenkel, J.-P. Farcet, H. J. Stauss, et al. (2008)
Blood 112, 2956-2964
   Abstract »    Full Text »    PDF »
Systemic Targeting of CpG-ODN to the Tumor Microenvironment with Anti-neu-CpG Hybrid Molecule and T Regulatory Cell Depletion Induces Memory Responses in BALB-neuT Tolerant Mice.
S. Sharma, A. L. Dominguez, S. Z. Manrique, F. Cavallo, S. Sakaguchi, and J. Lustgarten (2008)
Cancer Res. 68, 7530-7540
   Abstract »    Full Text »    PDF »
Antigen Persistence Is Required for Dendritic Cell Licensing and CD8+ T Cell Cross-Priming.
H. Jusforgues-Saklani, M. Uhl, N. Blachere, F. Lemaitre, O. Lantz, P. Bousso, D. Braun, J. J. Moon, and M. L. Albert (2008)
J. Immunol. 181, 3067-3076
   Abstract »    Full Text »    PDF »
Cutting Edge: Chromatin Remodeling as a Molecular Basis for the Enhanced Functionality of Memory CD8 T Cells.
J. K. Northrop, A. D. Wells, and H. Shen (2008)
J. Immunol. 181, 865-868
   Abstract »    Full Text »    PDF »

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882