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Peroxiredoxin Evolution and the Regulation of Hydrogen Peroxide Signaling
Zachary A. Wood,1*
Leslie B. Poole,2
P. Andrew Karplus1
Abstract:
Eukaryotic 2-Cys peroxiredoxins (2-Cys Prxs) not only act asantioxidants, but also appear to regulate hydrogen peroxide–mediatedsignal transduction. We showthat bacterial 2-Cys Prxs are muchless sensitive to oxidative inactivation than are eukaryotic2-Cys Prxs. By identifying two sequence motifs unique to thesensitive 2-Cys Prxs and comparing the crystal structure ofa bacterial 2-Cys Prx at 2.2 angstrom resolution with otherPrx structures, we define the structural origins of sensitivity.We suggest this adaptation allows 2-Cys Prxs to act as floodgates,keeping resting levels of hydrogen peroxide low, while permittinghigher levels during signal transduction.
1 Department of Biochemistry and Biophysics, Oregon State University, Corvallis, OR 97333, USA. 2 Department of Biochemistry, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.
* Present address: Institute of Molecular Biology, Howard HughesMedical Institute, University of Oregon, Eugene, OR 97403, USA.
To whom correspondence should be addressed. E-mail: karplusp{at}ucs.orst.edu
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PNAS
102, 8875-8880
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Substrate Specificity, Localization, and Essential Role of the Glutathione Peroxidase-type Tryparedoxin Peroxidases in Trypanosoma brucei.
T. Schlecker, A. Schmidt, N. Dirdjaja, F. Voncken, C. Clayton, and R. L. Krauth-Siegel (2005)
J. Biol. Chem.
280, 14385-14394
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Crystal Structure of Human SCO1: IMPLICATIONS FOR REDOX SIGNALING BY A MITOCHONDRIAL CYTOCHROME c OXIDASE "ASSEMBLY" PROTEIN.
J. C. Williams, C. Sue, G. S. Banting, H. Yang, D. M. Glerum, W. A. Hendrickson, and E. A. Schon (2005)
J. Biol. Chem.
280, 15202-15211
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Hydrogen peroxide generated extracellularly by receptor-ligand interaction facilitates cell signaling.
G. J. DeYulia Jr., J. M. Carcamo, O. Borquez-Ojeda, C. C. Shelton, and D. W. Golde (2005)
PNAS
102, 5044-5049
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The Mitochondrial Type II Peroxiredoxin F Is Essential for Redox Homeostasis and Root Growth of Arabidopsis thaliana under Stress.
I. Finkemeier, M. Goodman, P. Lamkemeyer, A. Kandlbinder, L. J. Sweetlove, and K.-J. Dietz (2005)
J. Biol. Chem.
280, 12168-12180
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Mitochondria as integrators of information in an early-evolving animal: insights from a triterpenoid metabolite.
N. W Blackstone, M. M Kelly, V. Haridas, and J. U Gutterman (2005)
Proc R Soc B
272, 527-531
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Reduction of Cysteine Sulfinic Acid by Sulfiredoxin Is Specific to 2-Cys Peroxiredoxins.
H. A. Woo, W. Jeong, T.-S. Chang, K. J. Park, S. J. Park, J. S. Yang, and S. G. Rhee (2005)
J. Biol. Chem.
280, 3125-3128
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Peroxiredoxin-linked Detoxification of Hydroperoxides in Toxoplasma gondii.
Contribution of the Helicobacter pylori Thiol Peroxidase Bacterioferritin Comigratory Protein to Oxidative Stress Resistance and Host Colonization.
G. Wang, A. A. Olczak, J. P. Walton, and R. J. Maier (2005)
Infect. Immun.
73, 378-384
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Characterization of Mammalian Sulfiredoxin and Its Reactivation of Hyperoxidized Peroxiredoxin through Reduction of Cysteine Sulfinic Acid in the Active Site to Cysteine.
T.-S. Chang, W. Jeong, H. A. Woo, S. M. Lee, S. Park, and S. G. Rhee (2004)
J. Biol. Chem.
279, 50994-51001
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Reversible oxidation and inactivation of the tumor suppressor PTEN in cells stimulated with peptide growth factors.
J. Kwon, S.-R. Lee, K.-S. Yang, Y. Ahn, Y. J. Kim, E. R. Stadtman, and S. G. Rhee (2004)
PNAS
101, 16419-16424
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Leishmania major Elongation Factor 1B Complex Has Trypanothione S-Transferase and Peroxidase Activity.
T. J. Vickers, S. Wyllie, and A. H. Fairlamb (2004)
J. Biol. Chem.
279, 49003-49009
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Genetic Dissection of the Phospholipid Hydroperoxidase Activity of Yeast Gpx3 Reveals Its Functional Importance.
A. M. Avery, S. A. Willetts, and S. V. Avery (2004)
J. Biol. Chem.
279, 46652-46658
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Cytosolic Thioredoxin Peroxidase I and II Are Important Defenses of Yeast against Organic Hydroperoxide Insult: CATALASES AND PEROXIREDOXINS COOPERATE IN THE DECOMPOSITION OF H2O2 BY YEAST.
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