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Despite its implications for higher order functions of the brain,little is currently known about the molecular basis of left-rightasymmetry of the brain. Here we report that synaptic distributionof N-methyl-D-aspartate (NMDA) receptor GluR2 (NR2B) subunitsin the adult mouse hippocampus is asymmetrical between the leftand right and between the apical and basal dendrites of singleneurons. These asymmetrical allocations of 2 subunits differentiatethe properties of NMDA receptors and synaptic plasticity betweenthe left and right hippocampus. These results provide a molecularbasis for the structural and functional asymmetry of the maturebrain.
1 Department of Molecular Biology, Graduate School of Medical Science, Kyushu University, Fukuoka 812-8582, Japan. 2 Division of Cerebral Structure, National Institute for Physiological Sciences, School of Life Science, The Graduate University for Advanced Studies, Okazaki 444-8585, Japan. 3 Department of Biology, Faculty of Sciences, Kyushu University, Fukuoka 812-8581, Japan. 4 CREST Japan Science and Technology Corporation, Kawaguchi, Japan.
Neuronal major histocompatibility complex class I molecules are implicated in the generation of asymmetries in hippocampal circuitry.
A. Kawahara, S. Kurauchi, Y. Fukata, J. Martinez-Hernandez, T. Yagihashi, Y. Itadani, R. Sho, T. Kajiyama, N. Shinzato, K. Narusuye, et al. (2013)
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Lateralization of observational fear learning at the cortical but not thalamic level in mice.