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Triggering the Interferon Antiviral Response Through an IKK-Related Pathway
Sonia Sharma,*
Benjamin R. tenOever,*
Nathalie Grandvaux,*
Guo-Ping Zhou,
Rongtuan Lin,
John Hiscott
Abstract:
Rapid induction of type I interferon expression, a central eventin establishing the innate antiviral response, requires cooperativeactivation of numerous transcription factors. Although signalingpathways that activate the transcription factors nuclear factorB and ATF-2/c-Jun have been well characterized, activation ofthe interferon regulatory factors IRF-3 and IRF-7 has remaineda critical missing link in understanding interferon signaling.We report here that the IB kinase (IKK)–related kinasesIKK and TANK-binding kinase 1 are components of the virus-activatedkinase that phosphorylate IRF-3 and IRF-7. These studies illustratean essential role for an IKK-related kinase pathway in triggeringthe host antiviral response to viral infection.
Lady Davis Institute for Medical Research–Jewish General Hospital, Departments of Microbiology and Immunology and Medicine, McGill University, Montreal, Quebec H3T 1E2, Canada.
To whom correspondence should be addressed at the Lady Davis Institute for Medical Research, 3755 Cote Ste. Catherine, Montreal, Quebec H3T 1E2, Canada. E-mail: john.hiscott{at}mcgill.ca (J.H.); rongtuan.lin{at}mcgill.ca (R.L.)
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Pathogen Recognition and Inflammatory Signaling in Innate Immune Defenses.
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TANK-Binding Kinase-1 Plays an Important Role during In Vitro and In Vivo Type I IFN Responses to DNA Virus Infections.
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|Abstract »|Full Text »|PDF »
Influenza B mutant viruses with truncated NS1 proteins grow efficiently in Vero cells and are immunogenic in mice.
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Synergistic benefit in inflammatory arthritis by targeting I{kappa}B kinase {epsilon} and interferon {beta}.
M Corr, D L Boyle, L Ronacher, N Flores, and G S Firestein (2009)
Ann Rheum Dis
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|Abstract »|Full Text »|PDF »
Hematopoietic cell-derived interferon controls viral replication and virus-induced disease.
P. A. Lang, L. Cervantes-Barragan, A. Verschoor, A. A. Navarini, M. Recher, M. Pellegrini, L. Flatz, A. Bergthaler, K. Honda, B. Ludewig, et al. (2009)
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|Abstract »|Full Text »|PDF »
Epstein-Barr Virus LF2: an Antagonist to Type I Interferon.
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|Abstract »|Full Text »|PDF »
John Hiscott
B and ATF-2/c-Jun have been well characterized, activation of the interferon regulatory factors IRF-3 and IRF-7 has remained a critical missing link in understanding interferon signaling. We report here that the I
and TANK-binding kinase 1 are components of the virus-activated kinase that phosphorylate IRF-3 and IRF-7. These studies illustrate an essential role for an IKK-related kinase pathway in triggering the host antiviral response to viral infection. 
To whom correspondence should be addressed at the Lady Davis Institute for Medical Research, 3755 Cote Ste. Catherine, Montreal, Quebec H3T 1E2, Canada. E-mail: 
