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Science 300 (5623): 1295-1297

Copyright © 2003 by the American Association for the Advancement of Science

Recruitment of HIV and Its Receptors to Dendritic Cell-T Cell Junctions

David McDonald,1 Li Wu,2 Stacy M. Bohks,3 Vineet N. KewalRamani,2 Derya Unutmaz,3 Thomas J. Hope1*

Abstract: Monocyte-derived dendritic cells (MDDCs) can efficiently bind and transfer HIV infectivity without themselves becoming infected. Using live-cell microscopy, we found that HIV was recruited to sites of cell contact in MDDCs. Analysis of conjugates between MDDCs and T cells revealed that, in the absence of antigen-specific signaling, the HIV receptors CD4, CCR5, and CXCR4 on the T cell were recruited to the interface while the MDDCs concentrated HIV to the same region. We propose that contact between dendritic cells and T cells facilitates transmission of HIV by locally concentrating virus, receptor, and coreceptor during the formation of an infectious synapse.

1 Department of Microbiology and Immunology, University of Illinois, Chicago, IL 60612, USA.
2 HIV Drug Resistance Program, National Cancer Institute at Frederick, Frederick, MD 21702, USA.
3 Department of Microbiology and Immunology, Vanderbilt University, Nashville, TN 37232, USA.

* To whom correspondence should be addressed. E-mail: thope{at}

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Maturation of Blood-Derived Dendritic Cells Enhances Human Immunodeficiency Virus Type 1 Capture and Transmission.
N. Izquierdo-Useros, J. Blanco, I. Erkizia, M. T. Fernandez-Figueras, F. E. Borras, M. Naranjo-Gomez, M. Bofill, L. Ruiz, B. Clotet, and J. Martinez-Picado (2007)
J. Virol. 81, 7559-7570
   Abstract »    Full Text »    PDF »
Dendritic Cells Infected with vpr-Positive Human Immunodeficiency Virus Type 1 Induce CD8+ T-Cell Apoptosis via Upregulation of Tumor Necrosis Factor Alpha.
B. Majumder, N. J. Venkatachari, E. A. Schafer, M. L. Janket, and V. Ayyavoo (2007)
J. Virol. 81, 7388-7399
   Abstract »    Full Text »    PDF »
Activated CD34-Derived Langerhans Cells Mediate Transinfection with Human Immunodeficiency Virus.
K. M. Fahrbach, S. M. Barry, S. Ayehunie, S. Lamore, M. Klausner, and T. J. Hope (2007)
J. Virol. 81, 6858-6868
   Abstract »    Full Text »    PDF »
IgG Opsonization of HIV Impedes Provirus Formation in and Infection of Dendritic Cells and Subsequent Long-Term Transfer to T Cells.
D. Wilflingseder, Z. Banki, E. Garcia, M. Pruenster, G. Pfister, B. Muellauer, D. S. Nikolic, C. Gassner, C. G. Ammann, M. P. Dierich, et al. (2007)
J. Immunol. 178, 7840-7848
   Abstract »    Full Text »    PDF »
In macrophages, HIV-1 assembles into an intracellular plasma membrane domain containing the tetraspanins CD81, CD9, and CD53.
M. Deneka, A. Pelchen-Matthews, R. Byland, E. Ruiz-Mateos, and M. Marsh (2007)
J. Cell Biol. 177, 329-341
   Abstract »    Full Text »    PDF »
Dendritic Cell-Mediated trans-Enhancement of Human Immunodeficiency Virus Type 1 Infectivity Is Independent of DC-SIGN.
C. Boggiano, N. Manel, and D. R. Littman (2007)
J. Virol. 81, 2519-2523
   Abstract »    Full Text »    PDF »
Preferential Infection of Dendritic Cells during Human Immunodeficiency Virus Type 1 Infection of Blood Leukocytes.
P. U. Cameron, A. J. Handley, D. C. Baylis, A. E. Solomon, N. Bernard, D. F. J. Purcell, and S. R. Lewin (2007)
J. Virol. 81, 2297-2306
   Abstract »    Full Text »    PDF »
CD4 Coexpression Regulates DC-SIGN-Mediated Transmission of Human Immunodeficiency Virus Type 1.
J.-H. Wang, A. M. Janas, W. J. Olson, V. N. KewalRamani, and L. Wu (2007)
J. Virol. 81, 2497-2507
   Abstract »    Full Text »    PDF »
Relevance of DC-SIGN in DC-induced T cell proliferation.
K. Gijzen, P. J. Tacken, A. Zimmerman, B. Joosten, I. J. M. de Vries, C. G. Figdor, and R. Torensma (2007)
J. Leukoc. Biol. 81, 729-740
   Abstract »    Full Text »    PDF »
Involvement of Src and Syk Tyrosine Kinases in HIV-1 Transfer from Dendritic Cells to CD4+ T Lymphocytes.
C. Gilbert, C. Barat, R. Cantin, and M. J. Tremblay (2007)
J. Immunol. 178, 2862-2871
   Abstract »    Full Text »    PDF »
Efficient Capture of Antibody Neutralized HIV-1 by Cells Expressing DC-SIGN and Transfer to CD4+ T Lymphocytes.
T. van Montfort, A. A. Nabatov, T. B. H. Geijtenbeek, G. Pollakis, and W. A. Paxton (2007)
J. Immunol. 178, 3177-3185
   Abstract »    Full Text »    PDF »
Leukocyte-specific protein 1 interacts with DC-SIGN and mediates transport of HIV to the proteasome in dendritic cells.
A. L. Smith, L. Ganesh, K. Leung, J. Jongstra-Bilen, J. Jongstra, and G. J. Nabel (2007)
J. Exp. Med. 204, 421-430
   Abstract »    Full Text »    PDF »
T-Cell inactivation and immunosuppressive activity induced by HIV gp41 via novel interacting motif.
I. Bloch, F. J. Quintana, D. Gerber, T. Cohen, I. R. Cohen, and Y. Shai (2007)
FASEB J 21, 393-401
   Abstract »    Full Text »    PDF »
Inefficient Human Immunodeficiency Virus Replication in Mobile Lymphocytes.
M. Sourisseau, N. Sol-Foulon, F. Porrot, F. Blanchet, and O. Schwartz (2007)
J. Virol. 81, 1000-1012
   Abstract »    Full Text »    PDF »
APOBEC3G/3F mediates intrinsic resistance of monocyte-derived dendritic cells to HIV-1 infection.
M. Pion, A. Granelli-Piperno, B. Mangeat, R. Stalder, R. Correa, R. M. Steinman, and V. Piguet (2006)
J. Exp. Med. 203, 2887-2893
   Abstract »    Full Text »    PDF »

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