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Science 300 (5623): 1295-1297

Copyright © 2003 by the American Association for the Advancement of Science

Recruitment of HIV and Its Receptors to Dendritic Cell-T Cell Junctions

David McDonald,1 Li Wu,2 Stacy M. Bohks,3 Vineet N. KewalRamani,2 Derya Unutmaz,3 Thomas J. Hope1*

Abstract: Monocyte-derived dendritic cells (MDDCs) can efficiently bind and transfer HIV infectivity without themselves becoming infected. Using live-cell microscopy, we found that HIV was recruited to sites of cell contact in MDDCs. Analysis of conjugates between MDDCs and T cells revealed that, in the absence of antigen-specific signaling, the HIV receptors CD4, CCR5, and CXCR4 on the T cell were recruited to the interface while the MDDCs concentrated HIV to the same region. We propose that contact between dendritic cells and T cells facilitates transmission of HIV by locally concentrating virus, receptor, and coreceptor during the formation of an infectious synapse.

1 Department of Microbiology and Immunology, University of Illinois, Chicago, IL 60612, USA.
2 HIV Drug Resistance Program, National Cancer Institute at Frederick, Frederick, MD 21702, USA.
3 Department of Microbiology and Immunology, Vanderbilt University, Nashville, TN 37232, USA.

* To whom correspondence should be addressed. E-mail: thope{at}uic.edu

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   Abstract »    Full Text »    PDF »
Relevance of DC-SIGN in DC-induced T cell proliferation.
K. Gijzen, P. J. Tacken, A. Zimmerman, B. Joosten, I. J. M. de Vries, C. G. Figdor, and R. Torensma (2007)
J. Leukoc. Biol. 81, 729-740
   Abstract »    Full Text »    PDF »
Involvement of Src and Syk Tyrosine Kinases in HIV-1 Transfer from Dendritic Cells to CD4+ T Lymphocytes.
C. Gilbert, C. Barat, R. Cantin, and M. J. Tremblay (2007)
J. Immunol. 178, 2862-2871
   Abstract »    Full Text »    PDF »
Efficient Capture of Antibody Neutralized HIV-1 by Cells Expressing DC-SIGN and Transfer to CD4+ T Lymphocytes.
T. van Montfort, A. A. Nabatov, T. B. H. Geijtenbeek, G. Pollakis, and W. A. Paxton (2007)
J. Immunol. 178, 3177-3185
   Abstract »    Full Text »    PDF »
Leukocyte-specific protein 1 interacts with DC-SIGN and mediates transport of HIV to the proteasome in dendritic cells.
A. L. Smith, L. Ganesh, K. Leung, J. Jongstra-Bilen, J. Jongstra, and G. J. Nabel (2007)
J. Exp. Med. 204, 421-430
   Abstract »    Full Text »    PDF »
T-Cell inactivation and immunosuppressive activity induced by HIV gp41 via novel interacting motif.
I. Bloch, F. J. Quintana, D. Gerber, T. Cohen, I. R. Cohen, and Y. Shai (2007)
FASEB J 21, 393-401
   Abstract »    Full Text »    PDF »
Inefficient Human Immunodeficiency Virus Replication in Mobile Lymphocytes.
M. Sourisseau, N. Sol-Foulon, F. Porrot, F. Blanchet, and O. Schwartz (2007)
J. Virol. 81, 1000-1012
   Abstract »    Full Text »    PDF »
APOBEC3G/3F mediates intrinsic resistance of monocyte-derived dendritic cells to HIV-1 infection.
M. Pion, A. Granelli-Piperno, B. Mangeat, R. Stalder, R. Correa, R. M. Steinman, and V. Piguet (2006)
J. Exp. Med. 203, 2887-2893
   Abstract »    Full Text »    PDF »
HIV Induces Maturation of Monocyte-Derived Dendritic Cells and Langerhans Cells.
A. N. Harman, J. Wilkinson, C. R. Bye, L. Bosnjak, J. L. Stern, M. Nicholle, J. Lai, and A. L. Cunningham (2006)
J. Immunol. 177, 7103-7113
   Abstract »    Full Text »    PDF »
The immunoregulatory effects of HIV-1 Nef on dendritic cells and the pathogenesis of AIDS.
M. G. Quaranta, B. Mattioli, L. Giordani, and M. Viora (2006)
FASEB J 20, 2198-2208
   Abstract »    Full Text »    PDF »
HIV interactions with dendritic cells: has our focus been too narrow?.
H. Donaghy, J. Wilkinson, and A. L. Cunningham (2006)
J. Leukoc. Biol. 80, 1001-1012
   Abstract »    Full Text »    PDF »
DC-SIGN and CLEC-2 Mediate Human Immunodeficiency Virus Type 1 Capture by Platelets.
C. Chaipan, E. J. Soilleux, P. Simpson, H. Hofmann, T. Gramberg, A. Marzi, M. Geier, E. A. Stewart, J. Eisemann, A. Steinkasserer, et al. (2006)
J. Virol. 80, 8951-8960
   Abstract »    Full Text »    PDF »
Role of N-Acetylglucosamine within Core Lipopolysaccharide of Several Species of Gram-Negative Bacteria in Targeting the DC-SIGN (CD209).
P. Zhang, S. Snyder, P. Feng, P. Azadi, S. Zhang, S. Bulgheresi, K. E. Sanderson, J. He, J. Klena, and T. Chen (2006)
J. Immunol. 177, 4002-4011
   Abstract »    Full Text »    PDF »
Opposing roles of dendritic cell subsets in HIV-1 infection.
J. Stebbing and M. Bower (2006)
Blood 108, 1785-1786
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Opposing roles of blood myeloid and plasmacytoid dendritic cells in HIV-1 infection of T cells: transmission facilitation versus replication inhibition.
F. Groot, T. M. M. van Capel, M. L. Kapsenberg, B. Berkhout, and E. C. de Jong (2006)
Blood 108, 1957-1964
   Abstract »    Full Text »    PDF »

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