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Science 300 (5625): 1527-1528

Copyright © 2003 by the American Association for the Advancement of Science

Interleukin-4 and Interleukin-13 Signaling Connections Maps

Ann E. Kelly-Welch,1 Erica M. Hanson,1 Mark R. Boothby,2 Achsah D. Keegan1*

Abstract: Cytokines are inflammatory mediators important in responding to pathogens and other foreign challenges. Interleukin-4 (IL-4) and IL-13 are two cytokines produced by T helper type 2 cells, mast cells, and basophils. In addition to their physiological roles, these cytokines are also implicated in pathological conditions such as asthma and allergy. IL-4 can stimulate two receptors, type I and type II, whereas IL-13 signaling is mediated only by the type II receptor (see the STKE Connections Maps). These cytokines activate the Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling cascades, which may contribute to allergic responses. In addition, stimulation of the phosphatidylinositol 3-kinase (PI3K) pathway through recruitment of members of the insulin receptor substrate family may contribute to survival and proliferation.

1 Department of Immunology, Holland Laboratory, American Red Cross, Rockville, MD 20855, and the Institute for Biomedical Sciences, George Washington Medical Center, Washington, DC 20037, USA.
2 Department of Microbiology, Vanderbilt University, Nashville, TN 37232, USA.

* To whom correspondence should be addressed. E-mail: keegana{at}usa.redcross.org

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