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Science 301 (5632): 513-517

Copyright © 2003 by the American Association for the Advancement of Science

VDAC2 Inhibits BAK Activation and Mitochondrial Apoptosis

Emily H.-Y. Cheng,1 Tatiana V. Sheiko,2 Jill K. Fisher,1 William J. Craigen,2 Stanley J. Korsmeyer1*

Abstract: The multidomain proapoptotic molecules BAK or BAX are required to initiate the mitochondrial pathway of apoptosis. How cells maintain the potentially lethal proapoptotic effector BAK in a monomeric inactive conformation at mitochondria is unknown. In viable cells, we found BAK complexed with mitochondrial outer-membrane protein VDAC2, a VDAC isoform present in low abundance that interacts specifically with the inactive conformer of BAK. Cells deficient in VDAC2, but not cells lacking the more abundant VDAC1, exhibited enhanced BAK oligomerization and were more susceptible to apoptotic death. Conversely, overexpression of VDAC2 selectively prevented BAK activation and inhibited the mitochondrial apoptotic pathway. Death signals activate "BH3-only" molecules such as tBID, BIM, or BAD, which displace VDAC2 from BAK, enabling homo-oligomerization of BAK and apoptosis. Thus, VDAC2, an isoform restricted to mammals, regulates the activity of BAK and provides a connection between mitochondrial physiology and the core apoptotic pathway.

1 Howard Hughes Medical Institute, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA. 2 Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030–3498, USA.

* To whom correspondence should be addressed. E-mail: stanley_korsmeyer{at}dfci.harvard.edu

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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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M. Ott, E. Norberg, K. M. Walter, P. Schreiner, C. Kemper, D. Rapaport, B. Zhivotovsky, and S. Orrenius (2007)
J. Biol. Chem. 282, 27633-27639
   Abstract »    Full Text »    PDF »
Bak regulates mitochondrial morphology and pathology during apoptosis by interacting with mitofusins.
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
Mitochondrial Membrane Permeabilization in Cell Death.
G. Kroemer, L. Galluzzi, and C. Brenner (2007)
Physiol Rev 87, 99-163
   Abstract »    Full Text »    PDF »
Bcl-2 family members and apoptosis, taken to heart.
A. B. Gustafsson and R. A. Gottlieb (2007)
Am J Physiol Cell Physiol 292, C45-C51
   Abstract »    Full Text »    PDF »
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J. M. Taylor, D. Quilty, L. Banadyga, and M. Barry (2006)
J. Biol. Chem. 281, 39728-39739
   Abstract »    Full Text »    PDF »
Chaperone-mediated coupling of endoplasmic reticulum and mitochondrial Ca2+ channels.
G. Szabadkai, K. Bianchi, P. Varnai, D. De Stefani, M. R. Wieckowski, D. Cavagna, A. I. Nagy, T. Balla, and R. Rizzuto (2006)
J. Cell Biol. 175, 901-911
   Abstract »    Full Text »    PDF »
A Membrane-targeted BID BCL-2 Homology 3 Peptide Is Sufficient for High Potency Activation of BAX in Vitro.
K. J. Oh, S. Barbuto, K. Pitter, J. Morash, L. D. Walensky, and S. J. Korsmeyer (2006)
J. Biol. Chem. 281, 36999-37008
   Abstract »    Full Text »    PDF »
Evidence against Calcium as a Mediator of Mitochondrial Dysfunction during Apoptosis Induced by Arachidonic Acid and Other Free Fatty Acids.
R. C. Maia, C. A. Culver, and S. M. Laster (2006)
J. Immunol. 177, 6398-6404
   Abstract »    Full Text »    PDF »
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H. Okamoto, J. Li, A. O. Vortmeyer, H. Jaffe, Y.-S. Lee, S. Glasker, T.-S. Sohn, W. Zeng, B. Ikejiri, M. A. Proescholdt, et al. (2006)
Cancer Res. 66, 10199-10204
   Abstract »    Full Text »    PDF »
Hunting Interactomes of a Membrane Protein: Obtaining the Largest Set of Voltage-Dependent Anion Channel-Interacting Protein Epitopes.
I. Roman, J. Figys, G. Steurs, and M. Zizi (2006)
Mol. Cell. Proteomics 5, 1667-1680
   Abstract »    Full Text »    PDF »
The mitochondrial protein Bak is pivotal for gliotoxin-induced apoptosis and a critical host factor of Aspergillus fumigatus virulence in mice.
J. Pardo, C. Urban, E. M. Galvez, P. G. Ekert, U. Muller, J. Kwon-Chung, M. Lobigs, A. Mullbacher, R. Wallich, C. Borner, et al. (2006)
J. Cell Biol. 174, 509-519
   Abstract »    Full Text »    PDF »
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N. Li, R. Guo, W. Li, J. Shao, S. Li, K. Zhao, X. Chen, N. Xu, S. Liu, and Y. Lu (2006)
Carcinogenesis 27, 1222-1231
   Abstract »    Full Text »    PDF »
Proapoptotic BAX and BAK modulate the unfolded protein response by a direct interaction with IRE1alpha..
C. Hetz, P. Bernasconi, J. Fisher, A.-H. Lee, M. C. Bassik, B. Antonsson, G. S. Brandt, N. N. Iwakoshi, A. Schinzel, L. H. Glimcher, et al. (2006)
Science 312, 572-576
   Abstract »    Full Text »    PDF »
Inhibition of the phosphatidylinositol 3-kinase/Akt pathway sensitizes MDA-MB468 human breast cancer cells to cerulenin-induced apoptosis..
X. Liu, Y. Shi, V. L. Giranda, and Y. Luo (2006)
Mol. Cancer Ther. 5, 494-501
   Abstract »    Full Text »    PDF »
Genetic Demonstration That the Plasma Membrane Maxianion Channel and Voltage-dependent Anion Channels Are Unrelated Proteins.
R. Z. Sabirov, T. Sheiko, H. Liu, D. Deng, Y. Okada, and W. J. Craigen (2006)
J. Biol. Chem. 281, 1897-1904
   Abstract »    Full Text »    PDF »
The Vaccinia Virus F1L Protein Interacts with the Proapoptotic Protein Bak and Inhibits Bak Activation.
S. T. Wasilenko, L. Banadyga, D. Bond, and M. Barry (2005)
J. Virol. 79, 14031-14043
   Abstract »    Full Text »    PDF »
MAP-1 is a mitochondrial effector of Bax.
K. O. Tan, N. Y. Fu, S. K. Sukumaran, S.-L. Chan, J. H. Kang, K. L. Poon, B. S. Chen, and V. C. Yu (2005)
PNAS 102, 14623-14628
   Abstract »    Full Text »    PDF »
Mutually Exclusive Subsets of BH3-Only Proteins Are Activated by the p53 and c-Jun N-Terminal Kinase/c-Jun Signaling Pathways during Cortical Neuron Apoptosis Induced by Arsenite.
H. K. Wong, M. Fricker, A. Wyttenbach, A. Villunger, E. M. Michalak, A. Strasser, and A. M. Tolkovsky (2005)
Mol. Cell. Biol. 25, 8732-8747
   Abstract »    Full Text »    PDF »
WT1 Induces Apoptosis through Transcriptional Regulation of the Proapoptotic Bcl-2 Family Member Bak.
D. J. Morrison, M. A. English, and J. D. Licht (2005)
Cancer Res. 65, 8174-8182
   Abstract »    Full Text »    PDF »
Transcripts from a human primordial follicle cDNA library.
M. D. Serafica, T. Goto, and A. O. Trounson (2005)
Hum. Reprod. 20, 2074-2091
   Abstract »    Full Text »    PDF »
BH3-only proteins in control: specificity regulates MCL-1 and BAK-mediated apoptosis.
C. Gelinas and E. White (2005)
Genes & Dev. 19, 1263-1268
   Full Text »    PDF »
Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins.
S. N. Willis, L. Chen, G. Dewson, A. Wei, E. Naik, J. I. Fletcher, J. M. Adams, and D. C.S. Huang (2005)
Genes & Dev. 19, 1294-1305
   Abstract »    Full Text »    PDF »
Bax-dependent Regulation of Bak by Voltage-dependent Anion Channel 2.
D. Chandra, G. Choy, P. T. Daniel, and D. G. Tang (2005)
J. Biol. Chem. 280, 19051-19061
   Abstract »    Full Text »    PDF »
Oligomeric Bax Is a Component of the Putative Cytochrome c Release Channel MAC, Mitochondrial Apoptosis-induced Channel.
L. M. Dejean, S. Martinez-Caballero, L. Guo, C. Hughes, O. Teijido, T. Ducret, F. Ichas, S. J. Korsmeyer, B. Antonsson, E. A. Jonas, et al. (2005)
Mol. Biol. Cell 16, 2424-2432
   Abstract »    Full Text »    PDF »
Newcomers in the process of mitochondrial permeabilization.
S. Lucken-Ardjomande and J.-C. Martinou (2005)
J. Cell Sci. 118, 473-483
   Abstract »    Full Text »    PDF »
Conformational Changes in BID, a Pro-apoptotic BCL-2 Family Member, upon Membrane Binding: A SITE-DIRECTED SPIN LABELING STUDY.
K. J. Oh, S. Barbuto, N. Meyer, R.-S. Kim, R. J. Collier, and S. J. Korsmeyer (2005)
J. Biol. Chem. 280, 753-767
   Abstract »    Full Text »    PDF »
Proapoptotic BAX and BAK regulate the type 1 inositol trisphosphate receptor and calcium leak from the endoplasmic reticulum.
S. A. Oakes, L. Scorrano, J. T. Opferman, M. C. Bassik, M. Nishino, T. Pozzan, and S. J. Korsmeyer (2005)
PNAS 102, 105-110
   Abstract »    Full Text »    PDF »
(-)-Gossypol acts directly on the mitochondria to overcome Bcl-2- and Bcl-XL-mediated apoptosis resistance.
C. L. Oliver, M. B. Miranda, S. Shangary, S. Land, S. Wang, and D. E. Johnson (2005)
Mol. Cancer Ther. 4, 23-31
   Abstract »    Full Text »    PDF »
Mitochondrial Proteomic Analysis of a Cell Line Model of Familial Amyotrophic Lateral Sclerosis.
K. Fukada, F. Zhang, A. Vien, N. R. Cashman, and H. Zhu (2004)
Mol. Cell. Proteomics 3, 1211-1223
   Abstract »    Full Text »    PDF »
The Mitochondrial Death Pathway and Cardiac Myocyte Apoptosis.
M. T. Crow, K. Mani, Y.-J. Nam, and R. N. Kitsis (2004)
Circ. Res. 95, 957-970
   Abstract »    Full Text »    PDF »
Global Analysis of Host Cell Gene Expression Late during Cytomegalovirus Infection Reveals Extensive Dysregulation of Cell Cycle Gene Expression and Induction of Pseudomitosis Independent of US28 Function.
L. Hertel and E. S. Mocarski (2004)
J. Virol. 78, 11988-12011
   Abstract »    Full Text »    PDF »
Voltage-dependent Anion Channel-1 (VDAC-1) Contributes to ATP Release and Cell Volume Regulation in Murine Cells.
S. F. Okada, W. K. O'Neal, P. Huang, R. A. Nicholas, L. E. Ostrowski, W. J. Craigen, E. R. Lazarowski, and R. C. Boucher (2004)
J. Gen. Physiol. 124, 513-526
   Abstract »    Full Text »    PDF »
BAD Is a Pro-survival Factor Prior to Activation of Its Pro-apoptotic Function.
S. Y. Seo, Y.-b. Chen, I. Ivanovska, A. M. Ranger, S. J. Hong, V. L. Dawson, S. J. Korsmeyer, D. S. Bellows, Y. Fannjiang, and J. M. Hardwick (2004)
J. Biol. Chem. 279, 42240-42249
   Abstract »    Full Text »    PDF »
Proapoptotic N-truncated BCL-xL protein activates endogenous mitochondrial channels in living synaptic terminals.
E. A. Jonas, J. A. Hickman, M. Chachar, B. M. Polster, T. A. Brandt, Y. Fannjiang, I. Ivanovska, G. Basanez, K. W. Kinnally, J. Zimmerberg, et al. (2004)
PNAS 101, 13590-13595
   Abstract »    Full Text »    PDF »
Bax Does Not Directly Participate in the Ca2+-induced Permeability Transition of Isolated Mitochondria.
U. De Marchi, S. Campello, I. Szabo, F. Tombola, J.-C. Martinou, and M. Zoratti (2004)
J. Biol. Chem. 279, 37415-37422
   Abstract »    Full Text »    PDF »
A Caspase-8-independent Signaling Pathway Activated by Fas Ligation Leads to Exposure of the Bak N Terminus.
L. Zhang, S. Shimizu, K. Sakamaki, S. Yonehara, and Y. Tsujimoto (2004)
J. Biol. Chem. 279, 33865-33874
   Abstract »    Full Text »    PDF »
The Pathophysiology of Mitochondrial Cell Death.
D. R. Green and G. Kroemer (2004)
Science 305, 626-629
   Abstract »    Full Text »    PDF »
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W. Q. Li, Q. Jiang, A. R. Khaled, J. R. Keller, and S. K. Durum (2004)
J. Biol. Chem. 279, 29160-29166
   Abstract »    Full Text »    PDF »
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R. Aiello, A. Messina, B. Schiffler, R. Benz, G. Tasco, R. Casadio, and V. De Pinto (2004)
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K.-D. Hinsch, V. De Pinto, V. A. Aires, X. Schneider, A. Messina, and E. Hinsch (2004)
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   Abstract »    Full Text »    PDF »
Neuroactive Steroid Interactions with Voltage-Dependent Anion Channels: Lack of Relationship to GABAA Receptor Modulation and Anesthesia.
R. Darbandi-Tonkabon, B. D. Manion, W. R. Hastings, W. J. Craigen, G. Akk, J. R. Bracamontes, Y. He, T. V. Sheiko, J. H. Steinbach, S. J. Mennerick, et al. (2004)
J. Pharmacol. Exp. Ther. 308, 502-511
   Abstract »    Full Text »    PDF »
The Voltage-dependent Anion Channel Is the Target for a New Class of Inhibitors of the Mitochondrial Permeability Transition Pore.
A. M. Cesura, E. Pinard, R. Schubenel, V. Goetschy, A. Friedlein, H. Langen, P. Polcic, M. A. Forte, P. Bernardi, and J. A. Kemp (2003)
J. Biol. Chem. 278, 49812-49818
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DNA damage response and MCL-1 destruction initiate apoptosis in adenovirus-infected cells.
A. Cuconati, C. Mukherjee, D. Perez, and E. White (2003)
Genes & Dev. 17, 2922-2932
   Abstract »    Full Text »    PDF »
Ways of dying: multiple pathways to apoptosis.
J. M. Adams (2003)
Genes & Dev. 17, 2481-2495
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