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Science 301 (5632): 525-527

Copyright © 2003 by the American Association for the Advancement of Science

Melanopsin Is Required for Non-Image-Forming Photic Responses in Blind Mice

Satchidananda Panda,1,2* Ignacio Provencio,4* Daniel C. Tu,5* Susana S. Pires,1 Mark D. Rollag,4 Ana Maria Castrucci,4,7 Mathew T. Pletcher,1,2 Trey K. Sato,1,2 Tim Wiltshire,1 Mary Andahazy,1 Steve A. Kay,2 Russell N. Van Gelder,5,6 John B. Hogenesch1,3{dagger}

Abstract: Although mice lacking rod and cone photoreceptors are blind, they retain many eye-mediated responses to light, possibly through photosensitive retinal ganglion cells. These cells express melanopsin, a photopigment that confers this photosensitivity. Mice lacking melanopsin still retain nonvisual photoreception, suggesting that rods and cones could operate in this capacity. We observed that mice with both outer-retinal degeneration and a deficiency in melanopsin exhibited complete loss of photoentrainment of the circadian oscillator, pupillary light responses, photic suppression of arylalkylamine-N-acetyltransferase transcript, and acute suppression of locomotor activity by light. This indicates the importance of both nonvisual and classical visual photoreceptor systems for nonvisual photic responses in mammals.

1 Genomics Institute of the Novartis Research Foundation, 10675 John J. Hopkins Drive, San Diego, CA 92121, USA. 2 Department of Cell Biology, 3 Department of Neuropharmacology, Scripps Research Institute, 10550 North Torrey Pines Road, San Diego, CA 92037, USA. 4 Department of Anatomy, Physiology, and Genetics, Uniformed Services University, 4301 Jones Bridge Road, Bethesda, MD 20814, USA. 5 Department of Ophthalmology and Visual Sciences, 6 Department of Molecular Biology and Pharmacology, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO 63110, USA. 7 Department of Physiology, Biosciences Institute, University of São Paulo, Rua do Matão, travessa 14, 05508-900, São Paulo, Brazil.

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* These authors contributed equally to this work.

{dagger} To whom correspondence should be addressed. E-mail: hogenesch{at}gnf.org


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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    PDF »
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   Abstract »    PDF »
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   Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    PDF »
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   Abstract »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    PDF »
Light-Evoked Calcium Responses of Isolated Melanopsin-Expressing Retinal Ganglion Cells.
A. T. E. Hartwick, J. R. Bramley, J. Yu, K. T. Stevens, C. N. Allen, W. H. Baldridge, P. J. Sollars, and G. E. Pickard (2007)
J. Neurosci. 27, 13468-13480
   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    PDF »
Melanopsin-Dependent Nonvisual Responses: Evidence for Photopigment Bistability In Vivo.
L. S. Mure, C. Rieux, S. Hattar, and H. M. Cooper (2007)
J Biol Rhythms 22, 411-424
   Abstract »    PDF »
Responses of Suprachiasmatic Nucleus Neurons to Light and Dark Adaptation: Relative Contributions of Melanopsin and Rod Cone Inputs.
E. Drouyer, C. Rieux, R. A. Hut, and H. M. Cooper (2007)
J. Neurosci. 27, 9623-9631
   Abstract »    Full Text »    PDF »
Synaptic Contact between Melanopsin-Containing Retinal Ganglion Cells and Rod Bipolar Cells.
J. Ostergaard, J. Hannibal, and J. Fahrenkrug (2007)
Invest. Ophthalmol. Vis. Sci. 48, 3812-3820
   Abstract »    Full Text »    PDF »
Synaptic influences on rat ganglion-cell photoreceptors.
K. Y. Wong, F. A. Dunn, D. M. Graham, and D. M. Berson (2007)
J. Physiol. 582, 279-296
   Abstract »    Full Text »    PDF »
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Y. Zhu, D. C. Tu, D. Denner, T. Shane, C. M. Fitzgerald, and R. N. Van Gelder (2007)
Invest. Ophthalmol. Vis. Sci. 48, 1268-1275
   Abstract »    Full Text »    PDF »
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S. Doyle and M. Menaker (2007)
Cold Spring Harb Symp Quant Biol 72, 499-508
   Abstract »    PDF »
Multiple Photoreceptors Contribute to Nonimage-forming Visual Functions Predominantly through Melanopsin-containing Retinal Ganglion Cells.
A.D. Guler, C.M. Altimus, J.L. Ecker, and S. Hattar (2007)
Cold Spring Harb Symp Quant Biol 72, 509-515
   Abstract »    PDF »
Sleep and Circadian Rhythms in Humans.
C. A. Czeisler and J. J. Gooley (2007)
Cold Spring Harb Symp Quant Biol 72, 579-597
   Abstract »    PDF »
Diversity of zebrafish peripheral oscillators revealed by luciferase reporting.
M. Kaneko, N. Hernandez-Borsetti, and G. M. Cahill (2006)
PNAS 103, 14614-14619
   Abstract »    Full Text »    PDF »
Monoamine oxidase A knockout mice exhibit impaired nicotine preference but normal responses to novel stimuli.
S. Agatsuma, M. Lee, H. Zhu, K. Chen, J. C. Shih, I. Seif, and N. Hiroi (2006)
Hum. Mol. Genet. 15, 2721-2731
   Abstract »    Full Text »    PDF »
DARPP-32 Involvement in the Photic Pathway of the Circadian System.
L. Yan, J. M. Bobula, P. Svenningsson, P. Greengard, and R. Silver (2006)
J. Neurosci. 26, 9434-9438
   Abstract »    Full Text »    PDF »
Chromophore regeneration: Melanopsin does its own thing.
R. J. Lucas (2006)
PNAS 103, 10153-10154
   Full Text »    PDF »
Inner retinal photoreception independent of the visual retinoid cycle.
D. C. Tu, L. A. Owens, L. Anderson, M. Golczak, S. E. Doyle, M. McCall, M. Menaker, K. Palczewski, and R. N. Van Gelder (2006)
PNAS 103, 10426-10431
   Abstract »    Full Text »    PDF »
Nonvisual light responses in the Rpe65 knockout mouse: Rod loss restores sensitivity to the melanopsin system.
S. E. Doyle, A. M. Castrucci, M. McCall, I. Provencio, and M. Menaker (2006)
PNAS 103, 10432-10437
   Abstract »    Full Text »    PDF »
Melanopsin-expressing retinal ganglion cells are more injury-resistant in a chronic ocular hypertension model..
R. S. Li, B.-Y. Chen, D. K. Tay, H. H. L. Chan, M.-L. Pu, and K.-F. So (2006)
Invest. Ophthalmol. Vis. Sci. 47, 2951-2958
   Abstract »    Full Text »    PDF »
Immunohistochemical evidence of a melanopsin cone in human retina..
O. Dkhissi-Benyahya, C. Rieux, R. A. Hut, and H. M. Cooper (2006)
Invest. Ophthalmol. Vis. Sci. 47, 1636-1641
   Abstract »    Full Text »    PDF »
Impact of behavior on central and peripheral circadian clocks in the common vole Microtus arvalis, a mammal with ultradian rhythms.
D. R. van der Veen, N. L. Minh, P. Gos, M. Arneric, M. P. Gerkema, and U. Schibler (2006)
PNAS 103, 3393-3398
   Abstract »    Full Text »    PDF »
Intrinsically photosensitive retinal ganglion cells detect light with a vitamin A-based photopigment, melanopsin.
Y. Fu, H. Zhong, M.-H. H. Wang, D.-G. Luo, H.-W. Liao, H. Maeda, S. Hattar, L. J. Frishman, and K.-W. Yau (2005)
PNAS 102, 10339-10344
   Abstract »    Full Text »    PDF »
Illumination of the Melanopsin Signaling Pathway.
S. Panda, S. K. Nayak, B. Campo, J. R. Walker, J. B. Hogenesch, and T. Jegla (2005)
Science 307, 600-604
   Abstract »    Full Text »    PDF »
Rhabdomeric phototransduction initiated by the vertebrate photopigment melanopsin.
M. C. Isoldi, M. D. Rollag, A. M. d. L. Castrucci, and I. Provencio (2005)
PNAS 102, 1217-1221
   Abstract »    Full Text »    PDF »
Effect of Vitamin A Depletion on Nonvisual Phototransduction Pathways in Cryptochromeless Mice.
C. L. Thompson, C. P. Selby, R. N. Van Gelder, W. S. Blaner, J. Lee, L. Quadro, K. Lai, M. E. Gottesman, and A. Sancar (2004)
J Biol Rhythms 19, 504-517
   Abstract »    PDF »
Multipotent Retinal Progenitors Express Developmental Markers, Differentiate into Retinal Neurons, and Preserve Light-Mediated Behavior.
H. J. Klassen, T. F. Ng, Y. Kurimoto, I. Kirov, M. Shatos, P. Coffey, and M. J. Young (2004)
Invest. Ophthalmol. Vis. Sci. 45, 4167-4173
   Abstract »    Full Text »    PDF »
Melanopsin Is Expressed in PACAP-Containing Retinal Ganglion Cells of the Human Retinohypothalamic Tract.
J. Hannibal, P. Hindersson, J. Ostergaard, B. Georg, S. Heegaard, P. J. Larsen, and J. Fahrenkrug (2004)
Invest. Ophthalmol. Vis. Sci. 45, 4202-4209
   Abstract »    Full Text »    PDF »
Selective deficits in the circadian light response in mice lacking PACAP.
C. S. Colwell, S. Michel, J. Itri, W. Rodriguez, J. Tam, V. Lelievre, Z. Hu, and J. A. Waschek (2004)
Am J Physiol Regulatory Integrative Comp Physiol 287, R1194-R1201
   Abstract »    Full Text »    PDF »
Classical Photoreceptors Regulate Melanopsin mRNA Levels in the Rat Retina.
K. Sakamoto, C. Liu, and G. Tosini (2004)
J. Neurosci. 24, 9693-9697
   Abstract »    Full Text »    PDF »
Finding New Clock Components: Past and Future.
J. S. Takahashi (2004)
J Biol Rhythms 19, 339-347
   Abstract »    PDF »
Clock Gene Evolution and Functional Divergence.
E. Tauber, K. S. Last, P. J.W. Olive, and C. P. Kyriacou (2004)
J Biol Rhythms 19, 445-458
   Abstract »    PDF »
Nonvisual Photoreception in the Chick Iris.
D. C. Tu, M. L. Batten, K. Palczewski, and R. N. Van Gelder (2004)
Science 306, 129-131
   Abstract »    Full Text »    PDF »
Blue light and the circadian clock.
R N Van Gelder and M A Mainster (2004)
Br J Ophthalmol 88, 1353
   Full Text »    PDF »
Regulation of the Mammalian Circadian Clock by Cryptochrome.
A. Sancar (2004)
J. Biol. Chem. 279, 34079-34082
   Full Text »    PDF »
Efficacy of a single sequence of intermittent bright light pulses for delaying circadian phase in humans.
C. Gronfier, K. P. Wright Jr., R. E. Kronauer, M. E. Jewett, and C. A. Czeisler (2004)
Am J Physiol Endocrinol Metab 287, E174-E181
   Abstract »    Full Text »    PDF »
Retinal Circadian Clocks and Control of Retinal Physiology.
C. B. Green and J. C. Besharse (2004)
J Biol Rhythms 19, 91-102
   Abstract »    PDF »
Lecithin-retinol Acyltransferase Is Essential for Accumulation of All-trans-Retinyl Esters in the Eye and in the Liver.
M. L. Batten, Y. Imanishi, T. Maeda, D. C. Tu, A. R. Moise, D. Bronson, D. Possin, R. N. Van Gelder, W. Baehr, and K. Palczewski (2004)
J. Biol. Chem. 279, 10422-10432
   Abstract »    Full Text »    PDF »
Opsin Photoisomerases in the Chick Retina and Pineal Gland: Characterization, Localization, and Circadian Regulation.
M. J. Bailey and V. M. Cassone (2004)
Invest. Ophthalmol. Vis. Sci. 45, 769-775
   Abstract »    Full Text »    PDF »
Clean Thoughts about Dirty Genes.
R. N. van Gelder and J. B. Hogenesch (2004)
J Biol Rhythms 19, 3-9
   Abstract »    PDF »
Nocturnal Activity in a Diurnal Rodent (Arvicanthis Niloticus): The Importance of Masking.
U. Redlin and N. Mrosovsky (2004)
J Biol Rhythms 19, 58-67
   Abstract »    PDF »
Phenotype Matters: Identification of Light-Responsive Cells in the Mouse Suprachiasmatic Nucleus.
I. N. Karatsoreos, L. Yan, J. LeSauter, and R. Silver (2004)
J. Neurosci. 24, 68-75
   Abstract »    Full Text »    PDF »
Molecular Mechanism of Mammalian Circadian Clock.
Y. Isojima, N. Okumura, and K. Nagai (2003)
J. Biochem. 134, 777-784
   Abstract »    Full Text »    PDF »
Chicktacking Pineal Clock.
T. Okano and Y. Fukada (2003)
J. Biochem. 134, 791-797
   Abstract »    Full Text »    PDF »
Seeing More Clearly: Recent Advances in Understanding Retinal Circuitry.
S. He, W. Dong, Q. Deng, S. Weng, and W. Sun (2003)
Science 302, 408-411
   Abstract »    Full Text »    PDF »

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