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Science 301 (5634): 850-853

Copyright © 2003 by the American Association for the Advancement of Science

Detection of Sweet and Umami Taste in the Absence of Taste Receptor T1r3

Sami Damak,1* Minqing Rong,1,2* Keiko Yasumatsu,3 Zaza Kokrashvili,1 Vijaya Varadarajan,1 Shiying Zou,1 Peihua Jiang,1 Yuzo Ninomiya,3 Robert F. Margolskee1,2{dagger}

Abstract: The tastes of sugars (sweet) and glutamate (umami) are thought to be detected by T1r receptors expressed in taste cells. Molecular genetics and heterologous expression implicate T1r2 plus T1r3 as a sweet-responsive receptor,and T1r1 plus T1r3,as well as a truncated form of the type 4 metabotropic glutamate receptor (taste-mGluR4),as umami-responsive receptors. Here,we show that mice lacking T1r3 showed no preference for artificial sweeteners and had diminished but not abolished behavioral and nerve responses to sugars and umami compounds. These results indicate that T1r3-independent sweet- and umami-responsive receptors and/or pathways exist in taste cells.

1 Department of Biophysics and Physiology, Mount Sinai School of Medicine, Box 1677, 1425 Madison Avenue, New York, NY 10029, USA.
2 Howard Hughes Medical Institute, Mount Sinai School of Medicine, Box 1677, 1425 Madison Avenue, New York, NY 10029, USA.
3 Section of Oral Neuroscience, Kyushu University 3-1-1, Maidashi, Higashi-ku, Fukuoka 812–8582, Japan.

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* These authors contributed equally to this work.

{dagger} To whom correspondence should be addressed. E-mail: bob{at}inka.mssm.edu


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