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Science 302 (5643): 293-296

Copyright © 2003 by the American Association for the Advancement of Science

A Neurexin-Related Protein, BAM-2, Terminates Axonal Branches in C. elegans

Antonio Colavita*, and Marc Tessier-Lavigne{dagger}{ddagger}

Abstract: Neuronal axons connect to multiple target cells through the formation of collateral branches, but the mechanisms that regulate this process are largely unknown. We show that BAM-2, a neurexin-related transmembrane protein, is required for development of VC motoneuron branches in the worm Caenorhabditis elegans. Expression analysis and ectopic expression experiments suggest that BAM-2 functions as a branch termination cue and reveal a mechanism for selective control of branches that sprout off a primary axon.

Department of Biological Sciences, Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA.

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* Present address: Ottawa Health Research Institute (Neurosciences), 451 Smyth Road, Ottawa, Ontario K1H 8M5, Canada.

{dagger} Present address: Genentech, 1 DNA Way, South San Francisco, CA 94080, USA

{ddagger} To whom correspondence should be addressed. E-mail: marctl{at}gene.com


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