Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Logo for

Science 302 (5643): 293-296

Copyright © 2003 by the American Association for the Advancement of Science

A Neurexin-Related Protein, BAM-2, Terminates Axonal Branches in C. elegans

Antonio Colavita*, and Marc Tessier-Lavigne{dagger}{ddagger}

Abstract: Neuronal axons connect to multiple target cells through the formation of collateral branches, but the mechanisms that regulate this process are largely unknown. We show that BAM-2, a neurexin-related transmembrane protein, is required for development of VC motoneuron branches in the worm Caenorhabditis elegans. Expression analysis and ectopic expression experiments suggest that BAM-2 functions as a branch termination cue and reveal a mechanism for selective control of branches that sprout off a primary axon.

Department of Biological Sciences, Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA.

Back to Top

* Present address: Ottawa Health Research Institute (Neurosciences), 451 Smyth Road, Ottawa, Ontario K1H 8M5, Canada.

{dagger} Present address: Genentech, 1 DNA Way, South San Francisco, CA 94080, USA

{ddagger} To whom correspondence should be addressed. E-mail: marctl{at}

Molecular Control of Axon Branching.
P. M. Bilimoria and A. Bonni (2013)
Neuroscientist 19, 16-24
   Abstract »    Full Text »    PDF »
The N-Glycanase png-1 Acts to Limit Axon Branching during Organ Formation in Caenorhabditis elegans.
N. Habibi-Babadi, A. Su, C. E. de Carvalho, and A. Colavita (2010)
J. Neurosci. 30, 1766-1776
   Abstract »    Full Text »    PDF »
The Caenorhabditis elegans vulva: A post-embryonic gene regulatory network controlling organogenesis.
T. O. Ririe, J. S. Fernandes, and P. W. Sternberg (2008)
PNAS 105, 20095-20099
   Abstract »    Full Text »    PDF »
Netrin-1 Induces Axon Branching in Developing Cortical Neurons by Frequency-Dependent Calcium Signaling Pathways.
F. Tang and K. Kalil (2005)
J. Neurosci. 25, 6702-6715
   Abstract »    Full Text »    PDF »
Transcriptional network underlying Caenorhabditis elegans vulval development.
T. Inoue, M. Wang, T. O. Ririe, J. S. Fernandes, and P. W. Sternberg (2005)
PNAS 102, 4972-4977
   Abstract »    Full Text »    PDF »

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882