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Science 302 (5644): 442-445

Copyright © 2003 by the American Association for the Advancement of Science

Diffusion Dynamics of Glycine Receptors Revealed by Single-Quantum Dot Tracking

Maxime Dahan,1*{dagger} Sabine Lévi,2* Camilla Luccardini,1 Philippe Rostaing,2 Béatrice Riveau,2 Antoine Triller2{dagger}

Abstract: Semiconductor quantum dots (QDs) are nanometer-sized fluorescent probes suitable for advanced biological imaging. We used QDs to track individual glycine receptors (GlyRs) and analyze their lateral dynamics in the neuronal membrane of living cells for periods ranging from milliseconds to minutes. We characterized multiple diffusion domains in relation to the synaptic, perisynaptic, or extrasynaptic GlyR localization. The entry of GlyRs into the synapse by diffusion was observed and further confirmed by electron microscopy imaging of QD-tagged receptors.

1 Laboratoire Kastler Brossel, CNRS UMR 8552, Ecole Normale Supérieure and Université Pierre et Marie Curie, 24 rue Lhomond, 75005 Paris, France.
2 Biologie Cellulaire de la Synapse, INSERM U497, Ecole Normale Supérieure, 46 rue d'Ulm, 75005 Paris, France.

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* These authors contributed equally to this work.

{dagger} To whom correspondence should be addressed. E-mail: maxime.dahan{at}lkb.ens.fr (M.D.); triller{at}wotan.ens.fr (A.T.)

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