Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Logo for

Science 302 (5646): 885-889

Copyright © 2003 by the American Association for the Advancement of Science

Derepression of BDNF Transcription Involves Calcium-Dependent Phosphorylation of MeCP2

Wen G. Chen,1,2 Qiang Chang,3 Yingxi Lin,1 Alexander Meissner,3,4 Anne E. West,1 Eric C. Griffith,1 Rudolf Jaenisch,3,4 Michael E. Greenberg1,2*

Abstract: Mutations in MeCP2, which encodes a protein that has been proposed to function as a global transcriptional repressor, are the cause of Rett syndrome (RT T), an X-linked progressive neurological disorder. Although the selective inactivation of MeCP2 in neurons is sufficient to confer a Rett-like phenotype in mice, the specific functions of MeCP2 in postmitotic neurons are not known. We find that MeCP2 binds selectively to BDNF promoter III and functions to repress expression of the BDNF gene. Membrane depolarization triggers the calcium-dependent phosphorylation and release of MeCP2 from BDNF promoter III, thereby facilitating transcription. These studies indicate that MeCP2 plays a key role in the control of neuronal activity–dependent gene regulation and suggest that the deregulation of this process may underlie the pathology of RT T.

1 Division of Neuroscience, Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.
2 Program in Biological and Biomedical Sciences, Harvard Medical School, Boston, MA 02115, USA.
3 Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.
4 Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.

* To whom correspondence should be addressed. E-mail: Michael.Greenberg{at}

Mild expression differences of MECP2 influencing aggressive social behavior.
M. Tantra, C. Hammer, A. Kastner, L. Dahm, M. Begemann, C. Bodda, K. Hammerschmidt, I. Giegling, B. Stepniak, A. Castillo Venzor, et al. (2014)
EMBO Mol Med.
   Abstract »    Full Text »    PDF »
Transcriptional regulation in pluripotent stem cells by methyl CpG-binding protein 2 (MeCP2).
Y. Tanaka, K.-Y. Kim, M. Zhong, X. Pan, S. M. Weissman, and I.-H. Park (2014)
Hum. Mol. Genet. 23, 1045-1055
   Abstract »    Full Text »    PDF »
MeCP2: a novel Huntingtin interactor.
K. N. McFarland, M. N. Huizenga, S. B. Darnell, G. R. Sangrey, O. Berezovska, J.-H. J. Cha, T. F. Outeiro, and G. Sadri-Vakili (2014)
Hum. Mol. Genet. 23, 1036-1044
   Abstract »    Full Text »    PDF »
Environment and Brain Plasticity: Towards an Endogenous Pharmacotherapy.
A. Sale, N. Berardi, and L. Maffei (2014)
Physiol Rev 94, 189-234
   Abstract »    Full Text »    PDF »
Deep Sequencing and High-Resolution Imaging Reveal Compartment-Specific Localization of Bdnf mRNA in Hippocampal Neurons.
T. J. Will, G. Tushev, L. Kochen, B. Nassim-Assir, I. J. Cajigas, S. tom Dieck, and E. M. Schuman (2013)
Science Signaling 6, rs16
   Abstract »    Full Text »    PDF »
Dendritic Arborization and Spine Dynamics Are Abnormal in the Mouse Model of MECP2 Duplication Syndrome.
M. Jiang, R. T. Ash, S. A. Baker, B. Suter, A. Ferguson, J. Park, J. Rudy, S. P. Torsky, H.-T. Chao, H. Y. Zoghbi, et al. (2013)
J. Neurosci. 33, 19518-19533
   Abstract »    Full Text »    PDF »
Genome-wide loss of 5-hmC is a novel epigenetic feature of Huntington's disease.
F. Wang, Y. Yang, X. Lin, J.-Q. Wang, Y.-S. Wu, W. Xie, D. Wang, S. Zhu, Y.-Q. Liao, Q. Sun, et al. (2013)
Hum. Mol. Genet. 22, 3641-3653
   Abstract »    Full Text »    PDF »
Phencyclidine-Induced Decrease of Synaptic Connectivity via Inhibition of BDNF Secretion in Cultured Cortical Neurons.
N. Adachi, T. Numakawa, E. Kumamaru, C. Itami, S. Chiba, Y. Iijima, M. Richards, R. Katoh-Semba, and H. Kunugi (2013)
Cereb Cortex 23, 847-858
   Abstract »    Full Text »    PDF »
Epigenetic mechanisms in the development and maintenance of dopaminergic neurons.
H. J. van Heesbeen, S. Mesman, J. V. Veenvliet, and M. P. Smidt (2013)
Development 140, 1159-1169
   Abstract »    Full Text »    PDF »
Epigenetics and Psychostimulant Addiction.
H. D. Schmidt, J. F. McGinty, A. E. West, and G. Sadri-Vakili (2013)
Cold Spring Harb Perspect Med 3, a012047
   Abstract »    Full Text »    PDF »
Different Roles of BDNF in Nucleus Accumbens Core versus Shell during the Incubation of Cue-Induced Cocaine Craving and Its Long-Term Maintenance.
X. Li, M. R. DeJoseph, J. H. Urban, A. Bahi, J.-L. Dreyer, G. E. Meredith, K. A. Ford, C. R. Ferrario, J. A. Loweth, and M. E. Wolf (2013)
J. Neurosci. 33, 1130-1142
   Abstract »    Full Text »    PDF »
Reduced axonal localization of a Caps2 splice variant impairs axonal release of BDNF and causes autistic-like behavior in mice.
T. Sadakata, Y. Shinoda, M. Oka, Y. Sekine, Y. Sato, C. Saruta, H. Miwa, M. Tanaka, S. Itohara, and T. Furuichi (2012)
PNAS 109, 21104-21109
   Abstract »    Full Text »    PDF »
Activity-dependent BDNF release and TRPC signaling is impaired in hippocampal neurons of Mecp2 mutant mice.
W. Li, G. Calfa, J. Larimore, and L. Pozzo-Miller (2012)
PNAS 109, 17087-17092
   Abstract »    Full Text »    PDF »
Paternal social enrichment effects on maternal behavior and offspring growth.
R. Mashoodh, B. Franks, J. P. Curley, and F. A. Champagne (2012)
PNAS 109, 17232-17238
   Abstract »    Full Text »    PDF »
MeCP2 Phosphorylation Is Required for Modulating Synaptic Scaling through mGluR5.
X. Zhong, H. Li, and Q. Chang (2012)
J. Neurosci. 32, 12841-12847
   Abstract »    Full Text »    PDF »
Nuclear Calcium Signaling Controls Methyl-CpG-binding Protein 2 (MeCP2) Phosphorylation on Serine 421 following Synaptic Activity.
B. Buchthal, D. Lau, U. Weiss, J.-M. Weislogel, and H. Bading (2012)
J. Biol. Chem. 287, 30967-30974
   Abstract »    Full Text »    PDF »
Phosphorylation of Distinct Sites in MeCP2 Modifies Cofactor Associations and the Dynamics of Transcriptional Regulation.
M. L. Gonzales, S. Adams, K. W. Dunaway, and J. M. LaSalle (2012)
Mol. Cell. Biol. 32, 2894-2903
   Abstract »    Full Text »    PDF »
Dysregulation of BDNF-TrkB Signaling in Developing Hippocampal Neurons by Pb2+: Implications for an Environmental Basis of Neurodevelopmental Disorders.
K. H. Stansfield, J. R. Pilsner, Q. Lu, R. O. Wright, and T. R. Guilarte (2012)
Toxicol. Sci. 127, 277-295
   Abstract »    Full Text »    PDF »
Methyl CpG-binding Protein Isoform MeCP2_e2 Is Dispensable for Rett Syndrome Phenotypes but Essential for Embryo Viability and Placenta Development.
M. Itoh, C. G. T. Tahimic, S. Ide, A. Otsuki, T. Sasaoka, S. Noguchi, M. Oshimura, Y.-i. Goto, and A. Kurimasa (2012)
J. Biol. Chem. 287, 13859-13867
   Abstract »    Full Text »    PDF »
Pharmacological interference with the glucocorticoid system influences symptoms and lifespan in a mouse model of Rett syndrome.
S. Braun, D. Kottwitz, and U. A. Nuber (2012)
Hum. Mol. Genet. 21, 1673-1680
   Abstract »    Full Text »    PDF »
Brain-Derived Neurotrophic Factor and Neuropsychiatric Disorders.
A. E. Autry and L. M. Monteggia (2012)
Pharmacol. Rev. 64, 238-258
   Abstract »    Full Text »    PDF »
7,8-dihydroxyflavone exhibits therapeutic efficacy in a mouse model of Rett syndrome.
R. A. Johnson, M. Lam, A. M. Punzo, H. Li, B. R. Lin, K. Ye, G. S. Mitchell, and Q. Chang (2012)
J Appl Physiol 112, 704-710
   Abstract »    Full Text »    PDF »
Algorithmic Approach for Methyl-CpG Binding Protein 2 (MECP2) Gene Testing in Patients With Neurodevelopmental Disabilities.
J. N. Sanmann, G. B. Schaefer, B. A. Buehler, and W. G. Sanger (2012)
J Child Neurol 27, 346-354
   Abstract »    Full Text »    PDF »
Synaptic Dysfunction in Neurodevelopmental Disorders Associated with Autism and Intellectual Disabilities.
H. Y. Zoghbi and M. F. Bear (2012)
Cold Spring Harb Perspect Biol 4, a009886
   Abstract »    Full Text »    PDF »
A Mouse Model for MeCP2 Duplication Syndrome: MeCP2 Overexpression Impairs Learning and Memory and Synaptic Transmission.
E. S. Na, E. D. Nelson, M. Adachi, A. E. Autry, M. A. Mahgoub, E. T. Kavalali, and L. M. Monteggia (2012)
J. Neurosci. 32, 3109-3117
   Abstract »    Full Text »    PDF »
A TrkB Small Molecule Partial Agonist Rescues TrkB Phosphorylation Deficits and Improves Respiratory Function in a Mouse Model of Rett Syndrome.
D. A. Schmid, T. Yang, M. Ogier, I. Adams, Y. Mirakhur, Q. Wang, S. M. Massa, F. M. Longo, and D. M. Katz (2012)
J. Neurosci. 32, 1803-1810
   Abstract »    Full Text »    PDF »
Epigenetic Mechanisms: Critical Contributors to Long-Term Memory Formation.
F. D. Lubin, S. Gupta, R. R. Parrish, N. M. Grissom, and R. L. Davis (2011)
Neuroscientist 17, 616-632
   Abstract »    PDF »
Calcium Signaling in Synapse-to-Nucleus Communication.
A. M. Hagenston and H. Bading (2011)
Cold Spring Harb Perspect Biol 3, a004564
   Abstract »    Full Text »    PDF »
Dissociation of antidepressant-like activity of escitalopram and nortriptyline on behaviour and hippocampal BDNF expression in female rats.
A. C. Hansson, R. Rimondini, M. Heilig, A. A. Mathe, and W. H. Sommer (2011)
J Psychopharmacol 25, 1378-1387
   Abstract »    Full Text »    PDF »
Loss of Methyl-CpG-Binding Domain Protein 2 Enhances Endothelial Angiogenesis and Protects Mice Against Hind-Limb Ischemic Injury.
X. Rao, J. Zhong, S. Zhang, Y. Zhang, Q. Yu, P. Yang, M.-H. Wang, D. J. Fulton, H. Shi, Z. Dong, et al. (2011)
Circulation 123, 2964-2974
   Abstract »    Full Text »    PDF »
Complexities of Rett Syndrome and MeCP2.
R. C. Samaco and J. L. Neul (2011)
J. Neurosci. 31, 7951-7959
   Full Text »    PDF »
Neuronal Activity-Regulated Gene Transcription in Synapse Development and Cognitive Function.
A. E. West and M. E. Greenberg (2011)
Cold Spring Harb Perspect Biol 3, a005744
   Abstract »    Full Text »    PDF »
Neurons show distinctive DNA methylation profile and higher interindividual variations compared with non-neurons.
K. Iwamoto, M. Bundo, J. Ueda, M. C. Oldham, W. Ukai, E. Hashimoto, T. Saito, D. H. Geschwind, and T. Kato (2011)
Genome Res. 21, 688-696
   Abstract »    Full Text »    PDF »
Epigenetic regulation of the calcitonin gene-related peptide gene in trigeminal glia.
K.-Y. Park, J. R. Fletcher, A. C. Raddant, and A. F. Russo (2011)
Cephalalgia 31, 614-624
   Abstract »    Full Text »    PDF »
The Implications of DNA Methylation for Toxicology: Toward Toxicomethylomics, the Toxicology of DNA Methylation.
M. Szyf (2011)
Toxicol. Sci. 120, 235-255
   Abstract »    Full Text »    PDF »
Identification of cis-Elements and Transcription Factors Regulating Neuronal Activity-Dependent Transcription of Human BDNF Gene.
P. Pruunsild, M. Sepp, E. Orav, I. Koppel, and T. Timmusk (2011)
J. Neurosci. 31, 3295-3308
   Abstract »    Full Text »    PDF »
Chromatin and DNA methylation dynamics during retinoic acid-induced RET gene transcriptional activation in neuroblastoma cells.
T. Angrisano, S. Sacchetti, F. Natale, A. Cerrato, R. Pero, S. Keller, S. Peluso, B. Perillo, V. E. Avvedimento, A. Fusco, et al. (2011)
Nucleic Acids Res. 39, 1993-2006
   Abstract »    Full Text »    PDF »
A Novel Mutation in the MECP2 Gene in a Korean Patient with Rett Syndrome.
E. Y. Lee, H.-J. Chung, C.-S. Ki, J.-H. Yoo, and J. R. Choi (2011)
Ann. Clin. Lab. Sci. 41, 93-96
   Abstract »    Full Text »    PDF »
Experimental models of Rett syndrome based on Mecp2 dysfunction.
G. Calfa, A. K. Percy, and L. Pozzo-Miller (2011)
Experimental Biology and Medicine 236, 3-19
   Abstract »    Full Text »    PDF »
Nicotinamide adenine dinucleotide (NAD)-regulated DNA methylation alters CCCTC-binding factor (CTCF)/cohesin binding and transcription at the BDNF locus.
J. Chang, B. Zhang, H. Heath, N. Galjart, X. Wang, and J. Milbrandt (2010)
PNAS 107, 21836-21841
   Abstract »    Full Text »    PDF »
Genome-wide analysis reveals methyl-CpG-binding protein 2-dependent regulation of microRNAs in a mouse model of Rett syndrome.
H. Wu, J. Tao, P. J. Chen, A. Shahab, W. Ge, R. P. Hart, X. Ruan, Y. Ruan, and Y. E. Sun (2010)
PNAS 107, 18161-18166
   Abstract »    Full Text »    PDF »
Diminished Activity-Dependent Brain-Derived Neurotrophic Factor Expression Underlies Cortical Neuron Microcircuit Hypoconnectivity Resulting from Exposure to Mutant Huntingtin Fragments.
L. Gambazzi, O. Gokce, T. Seredenina, E. Katsyuba, H. Runne, H. Markram, M. Giugliano, and R. Luthi-Carter (2010)
J. Pharmacol. Exp. Ther. 335, 13-22
   Abstract »    Full Text »    PDF »
MeCP2 Binds Cooperatively to Its Substrate and Competes with Histone H1 for Chromatin Binding Sites.
R. P. Ghosh, R. A. Horowitz-Scherer, T. Nikitina, L. S. Shlyakhtenko, and C. L. Woodcock (2010)
Mol. Cell. Biol. 30, 4656-4670
   Abstract »    Full Text »    PDF »
Cocaine-Induced Chromatin Remodeling Increases Brain-Derived Neurotrophic Factor Transcription in the Rat Medial Prefrontal Cortex, Which Alters the Reinforcing Efficacy of Cocaine.
G. Sadri-Vakili, V. Kumaresan, H. D. Schmidt, K. R. Famous, P. Chawla, F. M. Vassoler, R. P. Overland, E. Xia, C. E. Bass, E. F. Terwilliger, et al. (2010)
J. Neurosci. 30, 11735-11744
   Abstract »    Full Text »    PDF »
Epigenetic Regulation of BDNF Expression via the Scaffolding Protein RACK1.
D.-Y. He, J. Neasta, and D. Ron (2010)
J. Biol. Chem. 285, 19043-19050
   Abstract »    Full Text »    PDF »
Elevated expression of MeCP2 in cardiac and skeletal tissues is detrimental for normal development.
M. Alvarez-Saavedra, L. Carrasco, S. Sura-Trueba, V. Demarchi Aiello, K. Walz, J. X. Neto, and J. I. Young (2010)
Hum. Mol. Genet. 19, 2177-2190
   Abstract »    Full Text »    PDF »
Alleviating Transcriptional Inhibition of the Norepinephrine Slc6a2 Transporter Gene in Depolarized Neurons.
H. KN, R. Bayles, G. D. Ciccotosto, S. Maxwell, R. Cappai, G. J. Pelka, P. P. L. Tam, J. Christodoulou, and A. El-Osta (2010)
J. Neurosci. 30, 1494-1501
   Abstract »    Full Text »    PDF »
Methyl-CpG-binding protein 2 is phosphorylated by homeodomain-interacting protein kinase 2 and contributes to apoptosis.
G. Bracaglia, B. Conca, A. Bergo, L. Rusconi, Z. Zhou, M. E. Greenberg, N. Landsberger, S. Soddu, and C. Kilstrup-Nielsen (2009)
EMBO Rep. 10, 1327-1333
   Abstract »    Full Text »    PDF »
Synaptic Circuit Abnormalities of Motor-Frontal Layer 2/3 Pyramidal Neurons in an RNA Interference Model of Methyl-CpG-Binding Protein 2 Deficiency.
L. Wood, N. W. Gray, Z. Zhou, M. E. Greenberg, and G. M. G. Shepherd (2009)
J. Neurosci. 29, 12440-12448
   Abstract »    Full Text »    PDF »
Regulation of heterochromatin remodelling and myogenin expression during muscle differentiation by FAK interaction with MBD2.
S.-W. Luo, C. Zhang, B. Zhang, C.-H. Kim, Y.-Z. Qiu, Q.-S. Du, L. Mei, and W.-C. Xiong (2009)
EMBO J. 28, 2568-2582
   Abstract »    Full Text »    PDF »
DNA hypomethylation restricted to the murine forebrain induces cortical degeneration and impairs postnatal neuronal maturation.
L. K. Hutnick, P. Golshani, M. Namihira, Z. Xue, A. Matynia, X. W. Yang, A. J. Silva, F. E. Schweizer, and G. Fan (2009)
Hum. Mol. Genet. 18, 2875-2888
   Abstract »    Full Text »    PDF »
Mouse models of MeCP2 disorders share gene expression changes in the cerebellum and hypothalamus.
S. Ben-Shachar, M. Chahrour, C. Thaller, C. A. Shaw, and H. Y. Zoghbi (2009)
Hum. Mol. Genet. 18, 2431-2442
   Abstract »    Full Text »    PDF »
Remodelling of the respiratory network in a mouse model of Rett syndrome depends on brain-derived neurotrophic factor regulated slow calcium buffering.
S. L. Mironov, E. Skorova, N. Hartelt, L. A. Mironova, M. T. Hasan, and S. Kugler (2009)
J. Physiol. 587, 2473-2485
   Abstract »    Full Text »    PDF »
Rett Syndrome Astrocytes Are Abnormal and Spread MeCP2 Deficiency through Gap Junctions.
I. Maezawa, S. Swanberg, D. Harvey, J. M. LaSalle, and L.-W. Jin (2009)
J. Neurosci. 29, 5051-5061
   Abstract »    Full Text »    PDF »
The common BDNF polymorphism may be a modifier of disease severity in Rett syndrome.
B. B. Zeev, A. Bebbington, G. Ho, H. Leonard, N. de Klerk, E. Gak, M. Vecksler, and J. Christodoulou (2009)
Neurology 72, 1242-1247
   Abstract »    Full Text »    PDF »
MeCP2-Mediated Transcription Repression in the Basolateral Amygdala May Underlie Heightened Anxiety in a Mouse Model of Rett Syndrome.
M. Adachi, A. E. Autry, H. E. Covington III, and L. M. Monteggia (2009)
J. Neurosci. 29, 4218-4227
   Abstract »    Full Text »    PDF »
The yin and yang of MeCP2 phosphorylation.
H.-T. Chao and H. Y. Zoghbi (2009)
PNAS 106, 4577-4578
   Full Text »    PDF »
P2X4-Receptor-Mediated Synthesis and Release of Brain-Derived Neurotrophic Factor in Microglia Is Dependent on Calcium and p38-Mitogen-Activated Protein Kinase Activation.
T. Trang, S. Beggs, X. Wan, and M. W. Salter (2009)
J. Neurosci. 29, 3518-3528
   Abstract »    Full Text »    PDF »
Partial reversal of Rett Syndrome-like symptoms in MeCP2 mutant mice.
D. Tropea, E. Giacometti, N. R. Wilson, C. Beard, C. McCurry, D. D. Fu, R. Flannery, R. Jaenisch, and M. Sur (2009)
PNAS 106, 2029-2034
   Abstract »    Full Text »    PDF »
Reciprocal co-regulation of EGR2 and MECP2 is disrupted in Rett syndrome and autism.
S. E. Swanberg, R. P. Nagarajan, S. Peddada, D. H. Yasui, and J. M. LaSalle (2009)
Hum. Mol. Genet. 18, 525-534
   Abstract »    Full Text »    PDF »
Mutations in the MECP2 Gene Are Not a Major Cause of Rett Syndrome-Like or Related Neurodevelopmental Phenotype in Male Patients.
M. Santos, T. Temudo, T. Kay, I. Carrilho, A. Medeira, H. Cabral, R. Gomes, M. T. Lourencco, M. Venancio, E. Calado, et al. (2009)
J Child Neurol 24, 49-55
   Abstract »    PDF »
BDNF splice variants from the second promoter cluster support cell survival of differentiated neuroblastoma upon cytotoxic stress.
B. Gabriele and T. Enrico (2009)
J. Cell Sci. 122, 36-43
   Abstract »    Full Text »    PDF »
Yin Yang 1 Is a Critical Repressor of Matrix Metalloproteinase-9 Expression in Brain Neurons.
M. Rylski, R. Amborska, K. Zybura, B. Mioduszewska, P. Michaluk, J. Jaworski, and L. Kaczmarek (2008)
J. Biol. Chem. 283, 35140-35153
   Abstract »    Full Text »    PDF »
MECP2 genomic structure and function: insights from ENCODE.
J. Singh, A. Saxena, J. Christodoulou, and D. Ravine (2008)
Nucleic Acids Res. 36, 6035-6047
   Abstract »    Full Text »    PDF »
CDKL5 Expression Is Modulated during Neuronal Development and Its Subcellular Distribution Is Tightly Regulated by the C-terminal Tail.
L. Rusconi, L. Salvatoni, L. Giudici, I. Bertani, C. Kilstrup-Nielsen, V. Broccoli, and N. Landsberger (2008)
J. Biol. Chem. 283, 30101-30111
   Abstract »    Full Text »    PDF »
Epigenetic Regulation of bdnf Gene Transcription in the Consolidation of Fear Memory.
F. D. Lubin, T. L. Roth, and J. D. Sweatt (2008)
J. Neurosci. 28, 10576-10586
   Abstract »    Full Text »    PDF »
A set of differentially expressed miRNAs, including miR-30a-5p, act as post-transcriptional inhibitors of BDNF in prefrontal cortex.
N. Mellios, H.-S. Huang, A. Grigorenko, E. Rogaev, and S. Akbarian (2008)
Hum. Mol. Genet. 17, 3030-3042
   Abstract »    Full Text »    PDF »
Histone Deacetylase Inhibitors Decrease Cocaine But Not Sucrose Self-Administration in Rats.
P. Romieu, L. Host, S. Gobaille, G. Sandner, D. Aunis, and J. Zwiller (2008)
J. Neurosci. 28, 9342-9348
   Abstract »    Full Text »    PDF »
Rett Syndrome-causing Mutations in Human MeCP2 Result in Diverse Structural Changes That Impact Folding and DNA Interactions.
R. P. Ghosh, R. A. Horowitz-Scherer, T. Nikitina, L. M. Gierasch, and C. L. Woodcock (2008)
J. Biol. Chem. 283, 20523-20534
   Abstract »    Full Text »    PDF »
The loss of methyl-CpG binding protein 1 leads to autism-like behavioral deficits.
A. M. Allan, X. Liang, Y. Luo, C. Pak, X. Li, K. E. Szulwach, D. Chen, P. Jin, and X. Zhao (2008)
Hum. Mol. Genet. 17, 2047-2057
   Abstract »    Full Text »    PDF »
MeCP2, a Key Contributor to Neurological Disease, Activates and Represses Transcription.
M. Chahrour, S. Y. Jung, C. Shaw, X. Zhou, S. T. C. Wong, J. Qin, and H. Y. Zoghbi (2008)
Science 320, 1224-1229
   Abstract »    Full Text »    PDF »
The p.Val66Met polymorphism in the BDNF gene protects against early seizures in Rett syndrome.
J. Nectoux, N. Bahi-Buisson, I. Guellec, J. Coste, N. D. Roux, H. Rosas, M. Tardieu, J. Chelly, and T. Bienvenu (2008)
Neurology 70, 2145-2151
   Abstract »    Full Text »    PDF »
Relationship between DNA Methylation States and Transcription of Individual Isoforms Encoded by the Protocadherin-{alpha} Gene Cluster.
M. Kawaguchi, T. Toyama, R. Kaneko, T. Hirayama, Y. Kawamura, and T. Yagi (2008)
J. Biol. Chem. 283, 12064-12075
   Abstract »    Full Text »    PDF »
MeCP2-dependent repression of an imprinted miR-184 released by depolarization.
T. Nomura, M. Kimura, T. Horii, S. Morita, H. Soejima, S. Kudo, and I. Hatada (2008)
Hum. Mol. Genet. 17, 1192-1199
   Abstract »    Full Text »    PDF »
Ca2+-Operated Transcriptional Networks: Molecular Mechanisms and In Vivo Models.
B. Mellstrom, M. Savignac, R. Gomez-Villafuertes, and J. R. Naranjo (2008)
Physiol Rev 88, 421-449
   Abstract »    Full Text »    PDF »
Analysis of protein domains and Rett syndrome mutations indicate that multiple regions influence chromatin-binding dynamics of the chromatin-associated protein MECP2 in vivo.
A. Kumar, S. Kamboj, B. M. Malone, S. Kudo, J. L. Twiss, K. J. Czymmek, J. M. LaSalle, and N. C. Schanen (2008)
J. Cell Sci. 121, 1128-1137
   Abstract »    Full Text »    PDF »
Salicylate Alters the Expression of Calcium Response Transcription Factor 1 in the Cochlea: Implications for Brain-Derived Neurotrophic Factor Transcriptional Regulation.
W. Singer, R. Panford-Walsh, D. Watermann, O. Hendrich, U. Zimmermann, I. Kopschall, K. Rohbock, and M. Knipper (2008)
Mol. Pharmacol. 73, 1085-1091
   Abstract »    Full Text »    PDF »
BHLHB2 Controls Bdnf Promoter 4 Activity and Neuronal Excitability.
X. Jiang, F. Tian, Y. Du, N. G. Copeland, N. A. Jenkins, L. Tessarollo, X. Wu, H. Pan, X.-Z. Hu, K. Xu, et al. (2008)
J. Neurosci. 28, 1118-1130
   Abstract »    Full Text »    PDF »
Temporal and epigenetic regulation of neurodevelopmental plasticity.
N. D Allen (2008)
Phil Trans R Soc B 363, 23-38
   Abstract »    Full Text »    PDF »
Activity-Dependent Suppression of Miniature Neurotransmission through the Regulation of DNA Methylation.
E. D. Nelson, E. T. Kavalali, and L. M. Monteggia (2008)
J. Neurosci. 28, 395-406
   Abstract »    Full Text »    PDF »
Integrated epigenomic analyses of neuronal MeCP2 reveal a role for long-range interaction with active genes.
D. H. Yasui, S. Peddada, M. C. Bieda, R. O. Vallero, A. Hogart, R. P. Nagarajan, K. N. Thatcher, P. J. Farnham, and J. M. LaSalle (2007)
PNAS 104, 19416-19421
   Abstract »    Full Text »    PDF »
Brain-Derived Neurotrophic Factor Expression and Respiratory Function Improve after Ampakine Treatment in a Mouse Model of Rett Syndrome.
M. Ogier, H. Wang, E. Hong, Q. Wang, M. E. Greenberg, and D. M. Katz (2007)
J. Neurosci. 27, 10912-10917
   Abstract »    Full Text »    PDF »
Evidence of Endogenous Mu Opioid Receptor Regulation by Epigenetic Control of the Promoters.
C. K. Hwang, K. Y. Song, C. S. Kim, H. S. Choi, X.-H. Guo, P.-Y. Law, L.-N. Wei, and H. H. Loh (2007)
Mol. Cell. Biol. 27, 4720-4736
   Abstract »    Full Text »    PDF »
A Role for Transcriptional Repressor Methyl-CpG-Binding Protein 2 and Plasticity-Related Gene Serum- and Glucocorticoid-Inducible Kinase 1 in the Induction of Inflammatory Pain States.
S. M. Geranton, C. Morenilla-Palao, and S. P. Hunt (2007)
J. Neurosci. 27, 6163-6173
   Abstract »    Full Text »    PDF »
Mbd2 Contributes to DNA Methylation-Directed Repression of the Xist Gene.
H. Barr, A. Hermann, J. Berger, H.-H. Tsai, K. Adie, A. Prokhortchouk, B. Hendrich, and A. Bird (2007)
Mol. Cell. Biol. 27, 3750-3757
   Abstract »    Full Text »    PDF »
Interaction between chromatin proteins MECP2 and ATRX is disrupted by mutations that cause inherited mental retardation.
X. Nan, J. Hou, A. Maclean, J. Nasir, M. J. Lafuente, X. Shu, S. Kriaucionis, and A. Bird (2007)
PNAS 104, 2709-2714
   Abstract »    Full Text »    PDF »
The Transcription Factor Nerve Growth Factor-Inducible Protein A Mediates Epigenetic Programming: Altering Epigenetic Marks by Immediate-Early Genes.
I. C. G. Weaver, A. C. D'Alessio, S. E. Brown, I. C. Hellstrom, S. Dymov, S. Sharma, M. Szyf, and M. J. Meaney (2007)
J. Neurosci. 27, 1756-1768
   Abstract »    Full Text »    PDF »
Partial rescue of MeCP2 deficiency by postnatal activation of MeCP2.
E. Giacometti, S. Luikenhuis, C. Beard, and R. Jaenisch (2007)
PNAS 104, 1931-1936
   Abstract »    Full Text »    PDF »
Chimeric DNA methyltransferases target DNA methylation to specific DNA sequences and repress expression of target genes.
F. Li, M. Papworth, M. Minczuk, C. Rohde, Y. Zhang, S. Ragozin, and A. Jeltsch (2007)
Nucleic Acids Res. 35, 100-112
   Abstract »    Full Text »    PDF »

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882