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Science 302 (5646): 890-893

Copyright © 2003 by the American Association for the Advancement of Science

DNA Methylation-Related Chromatin Remodeling in Activity-Dependent Bdnf Gene Regulation

Keri Martinowich,1,2 Daisuke Hattori,3* Hao Wu,2* Shaun Fouse,4* Fei He,2 Yan Hu,4 Guoping Fan,1,4{dagger} Yi E. Sun1,2{dagger}

Abstract: In conjunction with histone modifications, DNA methylation plays critical roles in gene silencing through chromatin remodeling. Changes in DNA methylation perturb neuronal function, and mutations in a methyl-CpG–binding protein, MeCP2, are associated with Rett syndrome. We report that increased synthesis of brain-derived neurotrophic factor (BDNF) in neurons after depolarization correlates with a decrease in CpG methylation within the regulatory region of the Bdnf gene. Moreover, increased Bdnf transcription involves dissociation of the MeCP2–histone deacetylase–mSin3A repression complex from its promoter. Our findings suggest that DNA methylation–related chromatin remodeling is important for activity-dependent gene regulation that may be critical for neural plasticity.

1 Neuroscience Interdepartmental Program, UCLA School of Medicine, 760 Westwood Plaza, Los Angeles, CA 90095, USA.
2 Departments of Molecular and Medical Pharmacology and Psychiatry and Behavioral Sciences, UCLA School of Medicine, 760 Westwood Plaza, Los Angeles, CA 90095, USA.
3 University of California, Los Angeles (UCLA) ACCESS program, UCLA School of Medicine, 760 Westwood Plaza, Los Angeles, CA 90095, USA.
4 Department of Human Genetics, UCLA School of Medicine, 760 Westwood Plaza, Los Angeles, CA 90095, USA.

* These authors contributed equally to the work.

{dagger} To whom correspondence should be addressed. E-mail: ysun{at}mednet.ucla.edu (Y.E.S.); gfan{at}mednet.ucla.edu (G.F.)


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   Abstract »    Full Text »    PDF »
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J. Neurosci. 30, 1494-1501
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J. Neurosci. 29, 12440-12448
   Abstract »    Full Text »    PDF »
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L. K. Hutnick, P. Golshani, M. Namihira, Z. Xue, A. Matynia, X. W. Yang, A. J. Silva, F. E. Schweizer, and G. Fan (2009)
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   Abstract »    Full Text »    PDF »
Mouse models of MeCP2 disorders share gene expression changes in the cerebellum and hypothalamus.
S. Ben-Shachar, M. Chahrour, C. Thaller, C. A. Shaw, and H. Y. Zoghbi (2009)
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   Abstract »    Full Text »    PDF »
Rett Syndrome Astrocytes Are Abnormal and Spread MeCP2 Deficiency through Gap Junctions.
I. Maezawa, S. Swanberg, D. Harvey, J. M. LaSalle, and L.-W. Jin (2009)
J. Neurosci. 29, 5051-5061
   Abstract »    Full Text »    PDF »
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B. B. Zeev, A. Bebbington, G. Ho, H. Leonard, N. de Klerk, E. Gak, M. Vecksler, and J. Christodoulou (2009)
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   Abstract »    Full Text »    PDF »
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J. Neurosci. 29, 4218-4227
   Abstract »    Full Text »    PDF »
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H. Wu and Y. E. Sun (2009)
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   Abstract »    Full Text »    PDF »
The yin and yang of MeCP2 phosphorylation.
H.-T. Chao and H. Y. Zoghbi (2009)
PNAS 106, 4577-4578
   Full Text »    PDF »
Phosphorylation of MeCP2 at Serine 80 regulates its chromatin association and neurological function.
J. Tao, K. Hu, Q. Chang, H. Wu, N. E. Sherman, K. Martinowich, R. J. Klose, C. Schanen, R. Jaenisch, W. Wang, et al. (2009)
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   Abstract »    Full Text »    PDF »
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D. K. Ma, M.-H. Jang, J. U. Guo, Y. Kitabatake, M.-l. Chang, N. Pow-anpongkul, R. A. Flavell, B. Lu, G.-l. Ming, and H. Song (2009)
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S. E. Swanberg, R. P. Nagarajan, S. Peddada, D. H. Yasui, and J. M. LaSalle (2009)
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   Abstract »    Full Text »    PDF »
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M. Santos, T. Temudo, T. Kay, I. Carrilho, A. Medeira, H. Cabral, R. Gomes, M. T. Lourencco, M. Venancio, E. Calado, et al. (2009)
J Child Neurol 24, 49-55
   Abstract »    PDF »
BDNF splice variants from the second promoter cluster support cell survival of differentiated neuroblastoma upon cytotoxic stress.
B. Gabriele and T. Enrico (2009)
J. Cell Sci. 122, 36-43
   Abstract »    Full Text »    PDF »
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M. Rylski, R. Amborska, K. Zybura, B. Mioduszewska, P. Michaluk, J. Jaworski, and L. Kaczmarek (2008)
J. Biol. Chem. 283, 35140-35153
   Abstract »    Full Text »    PDF »
Epigenetics in the Nervous System.
Y. Jiang, B. Langley, F. D. Lubin, W. Renthal, M. A. Wood, D. H. Yasui, A. Kumar, E. J. Nestler, S. Akbarian, and A. C. Beckel-Mitchener (2008)
J. Neurosci. 28, 11753-11759
   Abstract »    Full Text »    PDF »
MECP2 genomic structure and function: insights from ENCODE.
J. Singh, A. Saxena, J. Christodoulou, and D. Ravine (2008)
Nucleic Acids Res. 36, 6035-6047
   Abstract »    Full Text »    PDF »
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L. Rusconi, L. Salvatoni, L. Giudici, I. Bertani, C. Kilstrup-Nielsen, V. Broccoli, and N. Landsberger (2008)
J. Biol. Chem. 283, 30101-30111
   Abstract »    Full Text »    PDF »
Epigenetic Regulation of bdnf Gene Transcription in the Consolidation of Fear Memory.
F. D. Lubin, T. L. Roth, and J. D. Sweatt (2008)
J. Neurosci. 28, 10576-10586
   Abstract »    Full Text »    PDF »
A set of differentially expressed miRNAs, including miR-30a-5p, act as post-transcriptional inhibitors of BDNF in prefrontal cortex.
N. Mellios, H.-S. Huang, A. Grigorenko, E. Rogaev, and S. Akbarian (2008)
Hum. Mol. Genet. 17, 3030-3042
   Abstract »    Full Text »    PDF »
Rett Syndrome-causing Mutations in Human MeCP2 Result in Diverse Structural Changes That Impact Folding and DNA Interactions.
R. P. Ghosh, R. A. Horowitz-Scherer, T. Nikitina, L. M. Gierasch, and C. L. Woodcock (2008)
J. Biol. Chem. 283, 20523-20534
   Abstract »    Full Text »    PDF »
The loss of methyl-CpG binding protein 1 leads to autism-like behavioral deficits.
A. M. Allan, X. Liang, Y. Luo, C. Pak, X. Li, K. E. Szulwach, D. Chen, P. Jin, and X. Zhao (2008)
Hum. Mol. Genet. 17, 2047-2057
   Abstract »    Full Text »    PDF »
MeCP2, a Key Contributor to Neurological Disease, Activates and Represses Transcription.
M. Chahrour, S. Y. Jung, C. Shaw, X. Zhou, S. T. C. Wong, J. Qin, and H. Y. Zoghbi (2008)
Science 320, 1224-1229
   Abstract »    Full Text »    PDF »
Relationship between DNA Methylation States and Transcription of Individual Isoforms Encoded by the Protocadherin-{alpha} Gene Cluster.
M. Kawaguchi, T. Toyama, R. Kaneko, T. Hirayama, Y. Kawamura, and T. Yagi (2008)
J. Biol. Chem. 283, 12064-12075
   Abstract »    Full Text »    PDF »
MeCP2-dependent repression of an imprinted miR-184 released by depolarization.
T. Nomura, M. Kimura, T. Horii, S. Morita, H. Soejima, S. Kudo, and I. Hatada (2008)
Hum. Mol. Genet. 17, 1192-1199
   Abstract »    Full Text »    PDF »
Ca2+-Operated Transcriptional Networks: Molecular Mechanisms and In Vivo Models.
B. Mellstrom, M. Savignac, R. Gomez-Villafuertes, and J. R. Naranjo (2008)
Physiol Rev 88, 421-449
   Abstract »    Full Text »    PDF »
Analysis of protein domains and Rett syndrome mutations indicate that multiple regions influence chromatin-binding dynamics of the chromatin-associated protein MECP2 in vivo.
A. Kumar, S. Kamboj, B. M. Malone, S. Kudo, J. L. Twiss, K. J. Czymmek, J. M. LaSalle, and N. C. Schanen (2008)
J. Cell Sci. 121, 1128-1137
   Abstract »    Full Text »    PDF »
Is folic acid good for everyone?.
A D. Smith, Y.-I. Kim, and H. Refsum (2008)
Am J Clin Nutr 87, 517-533
   Abstract »    Full Text »    PDF »
BHLHB2 Controls Bdnf Promoter 4 Activity and Neuronal Excitability.
X. Jiang, F. Tian, Y. Du, N. G. Copeland, N. A. Jenkins, L. Tessarollo, X. Wu, H. Pan, X.-Z. Hu, K. Xu, et al. (2008)
J. Neurosci. 28, 1118-1130
   Abstract »    Full Text »    PDF »
Activity-Dependent Suppression of Miniature Neurotransmission through the Regulation of DNA Methylation.
E. D. Nelson, E. T. Kavalali, and L. M. Monteggia (2008)
J. Neurosci. 28, 395-406
   Abstract »    Full Text »    PDF »
Integrated epigenomic analyses of neuronal MeCP2 reveal a role for long-range interaction with active genes.
D. H. Yasui, S. Peddada, M. C. Bieda, R. O. Vallero, A. Hogart, R. P. Nagarajan, K. N. Thatcher, P. J. Farnham, and J. M. LaSalle (2007)
PNAS 104, 19416-19421
   Abstract »    Full Text »    PDF »
Brain-Derived Neurotrophic Factor Expression and Respiratory Function Improve after Ampakine Treatment in a Mouse Model of Rett Syndrome.
M. Ogier, H. Wang, E. Hong, Q. Wang, M. E. Greenberg, and D. M. Katz (2007)
J. Neurosci. 27, 10912-10917
   Abstract »    Full Text »    PDF »
Evidence of Endogenous Mu Opioid Receptor Regulation by Epigenetic Control of the Promoters.
C. K. Hwang, K. Y. Song, C. S. Kim, H. S. Choi, X.-H. Guo, P.-Y. Law, L.-N. Wei, and H. H. Loh (2007)
Mol. Cell. Biol. 27, 4720-4736
   Abstract »    Full Text »    PDF »
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S. M. Geranton, C. Morenilla-Palao, and S. P. Hunt (2007)
J. Neurosci. 27, 6163-6173
   Abstract »    Full Text »    PDF »
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H. Barr, A. Hermann, J. Berger, H.-H. Tsai, K. Adie, A. Prokhortchouk, B. Hendrich, and A. Bird (2007)
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   Abstract »    Full Text »    PDF »
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FXYD1 is an MeCP2 target gene overexpressed in the brains of Rett syndrome patients and Mecp2-null mice.
V. Deng, V. Matagne, F. Banine, M. Frerking, P. Ohliger, S. Budden, J. Pevsner, G. A. Dissen, L. S. Sherman, and S. R. Ojeda (2007)
Hum. Mol. Genet. 16, 640-650
   Abstract »    Full Text »    PDF »
DNA Methyltransferase Inhibitors Coordinately Induce Expression of the Human Reelin and Glutamic Acid Decarboxylase 67 Genes.
M. Kundakovic, Y. Chen, E. Costa, and D. R. Grayson (2007)
Mol. Pharmacol. 71, 644-653
   Abstract »    Full Text »    PDF »
Interaction between chromatin proteins MECP2 and ATRX is disrupted by mutations that cause inherited mental retardation.
X. Nan, J. Hou, A. Maclean, J. Nasir, M. J. Lafuente, X. Shu, S. Kriaucionis, and A. Bird (2007)
PNAS 104, 2709-2714
   Abstract »    Full Text »    PDF »
The Transcription Factor Nerve Growth Factor-Inducible Protein A Mediates Epigenetic Programming: Altering Epigenetic Marks by Immediate-Early Genes.
I. C. G. Weaver, A. C. D'Alessio, S. E. Brown, I. C. Hellstrom, S. Dymov, S. Sharma, M. Szyf, and M. J. Meaney (2007)
J. Neurosci. 27, 1756-1768
   Abstract »    Full Text »    PDF »
Partial rescue of MeCP2 deficiency by postnatal activation of MeCP2.
E. Giacometti, S. Luikenhuis, C. Beard, and R. Jaenisch (2007)
PNAS 104, 1931-1936
   Abstract »    Full Text »    PDF »
Autism-lessons from the X chromosome.
E. J. Marco and D. H. Skuse (2006)
Soc Cogn Affect Neurosci 1, 183-193
   Abstract »    Full Text »    PDF »
Enhanced anxiety and stress-induced corticosterone release are associated with increased Crh expression in a mouse model of Rett syndrome.
B. E. McGill, S. F. Bundle, M. B. Yaylaoglu, J. P. Carson, C. Thaller, and H. Y. Zoghbi (2006)
PNAS 103, 18267-18272
   Abstract »    Full Text »    PDF »

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