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Science 302 (5647): 1049-1053

Copyright © 2003 by the American Association for the Advancement of Science

Enhanced Fitness Conferred by Naturally Occurring Variation in the Circadian Clock

Todd P. Michael,1 Patrice A. Salomé,1 Hannah J. Yu,1 Taylor R. Spencer,1 Emily L. Sharp,1 Mark A. McPeek,1 José M. Alonso,2* Joseph R. Ecker,2 C. Robertson McClung1{dagger}

Abstract: Natural variation in clock parameters is necessary for the circadian clock to contribute to organismal fitness over a broad geographic range. Considerable variation is evident in the period, phase, and amplitude of 150 Arabidopsis accessions, and the period length is correlated with the day length at the latitude of origin, implying the adaptive significance of correctly regulated circadian timing. Quantitative trait loci analysis of recombinant inbred lines indicates that multiple loci interact to determine period, phase, and amplitude. The loss-of-function analysis of each member of the ARABIDOPSIS PSEUDO-RESPONSE REGULATOR family suggests that they are candidates for clock quantitative trait loci.

1 Dartmouth College, Department of Biological Sciences, Hanover, NH 03755, USA.
2 Plant Biology Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA.

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* Present address: Department of Genetics, Box 7614, North Carolina State University, Raleigh, NC 27695, USA.

{dagger} To whom correspondence should be addressed. E-mail: mcclung{at}dartmouth.edu


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