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Science 302 (5648): 1212-1215

Copyright © 2003 by the American Association for the Advancement of Science

CLIP Identifies Nova-Regulated RNA Networks in the Brain

Jernej Ule,1,2* Kirk B. Jensen,1,2* Matteo Ruggiu,1,2 Aldo Mele,1,2 Aljaz Ule,3 Robert B. Darnell1,2{dagger}

Abstract: Nova proteins are neuron-specific antigens targeted in paraneoplastic opsoclonus myoclonus ataxia (POMA), an autoimmune neurologic disease characterized by abnormal motor inhibition.Nova proteins regulate neuronal pre-messenger RNA splicing by directly binding to RNA.To identify Nova RNA targets, we developed a method to purify protein-RNA complexes from mouse brain with the use of ultraviolet cross-linking and immunoprecipitation (CLIP).Thirty-four transcripts were identified multiple times by Nova CLIP.Three-quarters of these encode proteins that function at the neuronal synapse, and one-third are involved in neuronal inhibition.Splicing targets confirmed in Nova–/– mice include c-Jun N-terminal kinase 2, neogenin, and gephyrin; the latter encodes a protein that clusters inhibitory {gamma}-aminobutyric acid and glycine receptors, two previously identified Nova splicing targets.Thus, CLIP reveals that Nova coordinately regulates a biologically coherent set of RNAs encoding multiple components of the inhibitory synapse, an observation that may relate to the cause of abnormal motor inhibition in POMA.

1 Howard Hughes Medical Institute, Rockefeller University, New York, NY 10021, USA.
2 Laboratory of Molecular Neuro-Oncology, Rockefeller University, New York, NY 10021, USA.
3 Center for Research in Experimental Economics and Political Decision-Making, University of Amsterdam, 1018 WB Amsterdam, Netherlands.

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* These authors contributed equally to this work.

{dagger} To whom correspondence should be addressed. E-mail: darnelr{at}mail.rockefeller.edu

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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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J. R. Sanford, X. Wang, M. Mort, N. VanDuyn, D. N. Cooper, S. D. Mooney, H. J. Edenberg, and Y. Liu (2009)
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   Abstract »    Full Text »    PDF »
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A. di Penta, V. Mercaldo, F. Florenzano, S. Munck, M. T. Ciotti, F. Zalfa, D. Mercanti, M. Molinari, C. Bagni, and T. Achsel (2009)
J. Cell Biol. 184, 423-435
   Abstract »    Full Text »    PDF »
Retinoic acid-gated sequence-specific translational control by RAR{alpha}.
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   Abstract »    Full Text »    PDF »
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Endocr. Rev. 29, 513-534
   Abstract »    Full Text »    PDF »
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M. P. van der Brug, J. Blackinton, J. Chandran, L.-Y. Hao, A. Lal, K. Mazan-Mamczarz, J. Martindale, C. Xie, R. Ahmad, K. J. Thomas, et al. (2008)
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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Z. Wang and C. B. Burge (2008)
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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H. Zhu, M. N. Hinman, R. A. Hasman, P. Mehta, and H. Lou (2008)
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   Abstract »    Full Text »    PDF »
Jernej Ule: An RNA runaway success.
R. Williams (2008)
J. Cell Biol. 180, 448-449
   Full Text »    PDF »
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M. J. Moore and P. A. Silver (2008)
RNA 14, 197-203
   Abstract »    Full Text »    PDF »
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C. J. David and J. L. Manley (2008)
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   Full Text »    PDF »
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C. Ben-Dov, B. Hartmann, J. Lundgren, and J. Valcarcel (2008)
J. Biol. Chem. 283, 1229-1233
   Abstract »    Full Text »    PDF »
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H. Kuroyanagi, G. Ohno, S. Mitani, and M. Hagiwara (2007)
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   Abstract »    Full Text »    PDF »
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R. B. Voelker and J. A. Berglund (2007)
Genome Res. 17, 1023-1033
   Abstract »    Full Text »    PDF »
Cis-acting determinants of asymmetric, cytoplasmic RNA transport.
A. Jambhekar and J. L. DeRisi (2007)
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   Abstract »    Full Text »    PDF »
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M. Gabut, J. Dejardin, J. Tazi, and J. Soret (2007)
Mol. Cell. Biol. 27, 3087-3097
   Abstract »    Full Text »    PDF »
Alternative splicing and bioinformatic analysis of human U12-type introns.
W.-C. Chang, Y.-C. Chen, K.-M. Lee, and W.-Y. Tarn (2007)
Nucleic Acids Res. 35, 1833-1841
   Abstract »    Full Text »    PDF »
The RNA-binding protein Rrm4 is essential for polarity in Ustilago maydis and shuttles along microtubules.
P. Becht, J. Konig, and M. Feldbrugge (2006)
J. Cell Sci. 119, 4964-4973
   Abstract »    Full Text »    PDF »
A Nuclear Function of Hu Proteins as Neuron-specific Alternative RNA Processing Regulators.
H. Zhu, R. A. Hasman, V. A. Barron, G. Luo, and H. Lou (2006)
Mol. Biol. Cell 17, 5105-5114
   Abstract »    Full Text »    PDF »
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I. Paarmann, B. Schmitt, B. Meyer, M. Karas, and H. Betz (2006)
J. Biol. Chem. 281, 34918-34925
   Abstract »    Full Text »    PDF »
A three-hybrid screen identifies mRNAs controlled by a regulatory protein.
D. Seay, B. Hook, K. Evans, and M. Wickens (2006)
RNA 12, 1594-1600
   Abstract »    Full Text »    PDF »
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Y. Wang, E. O. Gracheva, J. Richmond, T. Kawano, J. M. Couto, J. A. Calarco, V. Vijayaratnam, Y. Jin, and M. Zhen (2006)
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   Abstract »    Full Text »    PDF »
Genomic localization of RNA binding proteins reveals links between pre-mRNA processing and transcription.
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   Abstract »    Full Text »    PDF »
Identification of RNA-binding proteins that regulate FGFR2 splicing through the use of sensitive and specific dual color fluorescence minigene assays.
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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J. Ohlson, M. Enstero, B.-M. Sjoberg, and M. Ohman (2005)
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   Abstract »    Full Text »    PDF »
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Y. S. Cho, N. Iguchi, J. Yang, M. A. Handel, and N. B. Hecht (2005)
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   Abstract »    Full Text »    PDF »
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Mol. Cell. Biol. 25, 7580-7591
   Abstract »    Full Text »    PDF »
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J. C. Darnell, C. E. Fraser, O. Mostovetsky, G. Stefani, T. A. Jones, S. R. Eddy, and R. B. Darnell (2005)
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   Abstract »    Full Text »    PDF »

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