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Science 302 (5650): 1575-1577

Copyright © 2003 by the American Association for the Advancement of Science

Notch-Mediated Restoration of Regenerative Potential to Aged Muscle

Irina M. Conboy,1 Michael J. Conboy,1 Gayle M. Smythe,1 Thomas A. Rando1,2*

Abstract: A hallmark of aging is diminished regenerative potential of tissues, but the mechanism of this decline is unknown. Analysis of injured muscle revealed that, with age, resident precursor cells (satellite cells) had a markedly impaired propensity to proliferate and to produce myoblasts necessary for muscle regeneration. This was due to insufficient up-regulation of the Notch ligand Delta and, thus, diminished activation of Notch in aged, regenerating muscle. Inhibition of Notch impaired regeneration of young muscle, whereas forced activation of Notch restored regenerative potential to old muscle. Thus, Notch signaling is a key determinant of muscle regenerative potential that declines with age.

1 Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305-5235, USA.
2 GRECC and Neurology Service, VA Palo Alto Health Care System, Palo Alto, CA 94304, USA.

* To whom correspondence should be addressed. E-mail: rando{at}stanford.edu

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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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M. F. Buas, S. Kabak, and T. Kadesch (2010)
J. Biol. Chem. 285, 1249-1258
   Abstract »    Full Text »    PDF »
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S. Gupta, S. Li, Md. J. Abedin, L. Wang, E. Schneider, B. Najafian, and M. Rosenberg (2010)
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   Abstract »    Full Text »    PDF »
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Y. Ono, V. F. Gnocchi, P. S. Zammit, and R. Nagatomi (2009)
J. Cell Sci. 122, 4427-4438
   Abstract »    Full Text »    PDF »
Notch-1 signalling is activated in brain arteriovenous malformations in humans.
Q. ZhuGe, M. Zhong, W. Zheng, G.-Y. Yang, X. Mao, L. Xie, G. Chen, Y. Chen, M. T. Lawton, W. L. Young, et al. (2009)
Brain 132, 3231-3241
   Abstract »    Full Text »    PDF »
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K. Powell (2009)
J. Cell Biol. 187, 4-5
   Full Text »    PDF »
Effects of aging on human skeletal muscle after immobilization and retraining.
C. Suetta, L. G. Hvid, L. Justesen, U. Christensen, K. Neergaard, L. Simonsen, N. Ortenblad, S. P. Magnusson, M. Kjaer, and P. Aagaard (2009)
J Appl Physiol 107, 1172-1180
   Abstract »    Full Text »    PDF »
Fibroblast growth factor 2-stimulated proliferation is lower in muscle precursor cells from old rats.
S. S. Jump, T. E. Childs, K. A. Zwetsloot, F. W. Booth, and S. J. Lees (2009)
Exp Physiol 94, 739-748
   Abstract »    Full Text »    PDF »
Mouse model of testosterone-induced muscle fiber hypertrophy: involvement of p38 mitogen-activated protein kinase-mediated Notch signaling.
D. Brown, A. P S. Hikim, E. L Kovacheva, and I. Sinha-Hikim (2009)
J. Endocrinol. 201, 129-139
   Abstract »    Full Text »    PDF »
Expression of growth-related genes in young and older human skeletal muscle following an acute stimulation of protein synthesis.
M. J. Drummond, M. Miyazaki, H. C. Dreyer, B. Pennings, S. Dhanani, E. Volpi, K. A. Esser, and B. B. Rasmussen (2009)
J Appl Physiol 106, 1403-1411
   Abstract »    Full Text »    PDF »
Regulation and Function of Skeletal Muscle Stem Cells.
M. Cerletti, J.L. Shadrach, S. Jurga, R. Sherwood, and A.J. Wagers (2009)
Cold Spring Harb Symp Quant Biol
   Abstract »    PDF »
Stem Cells Use Distinct Self-renewal Programs at Different Ages.
B.P. Levi and S.J. Morrison (2009)
Cold Spring Harb Symp Quant Biol
   Abstract »    PDF »
Control of the adaptive response of the heart to stress via the Notch1 receptor pathway.
A. Croquelois, A. A. Domenighetti, M. Nemir, M. Lepore, N. Rosenblatt-Velin, F. Radtke, and T. Pedrazzini (2008)
J. Exp. Med. 205, 3173-3185
   Abstract »    Full Text »    PDF »
Stem Cells, Their Niches and the Systemic Environment: An Aging Network.
D. Drummond-Barbosa (2008)
Genetics 180, 1787-1797
   Abstract »    Full Text »    PDF »
The role of Delta-like 1 shedding in muscle cell self-renewal and differentiation.
D. Sun, H. Li, and A. Zolkiewska (2008)
J. Cell Sci. 121, 3815-3823
   Abstract »    Full Text »    PDF »
Regulation of Cell Proliferation by Fast Myosin Light Chain 1 in Myoblasts Derived from Extraocular Muscle, Diaphragm and Gastrocnemius.
S.-Z. Zhang, H.-Q. Xie, Y. Xu, X.-Q. Li, R.-Q. Wei, W. Zhi, L. Deng, L. Qiu, and Z.-M. Yang (2008)
Exp Biol Med 233, 1374-1384
   Abstract »    Full Text »    PDF »
Age-dependent FOXO regulation of p27Kip1 expression via a conserved binding motif in rat muscle precursor cells.
S. J. Lees, T. E. Childs, and F. W. Booth (2008)
Am J Physiol Cell Physiol 295, C1238-C1246
   Abstract »    Full Text »    PDF »
All muscle satellite cells are equal, but are some more equal than others?.
P. S. Zammit (2008)
J. Cell Sci. 121, 2975-2982
   Abstract »    Full Text »    PDF »
Highlights of the 2007 Progeria Research Foundation Scientific Workshop: Progress in Translational Science.
L. B. Gordon, C. J. Harling-Berg, and F. G. Rothman (2008)
J Gerontol A Biol Sci Med Sci 63, 777-787
   Full Text »    PDF »
Aging and Disease as Modifiers of Efficacy of Cell Therapy.
S. Dimmeler and A. Leri (2008)
Circ. Res. 102, 1319-1330
   Abstract »    Full Text »    PDF »
Sca-1-Expressing Nonmyogenic Cells Contribute to Fibrosis in Aged Skeletal Muscle.
M. Hidestrand, S. Richards-Malcolm, C. M. Gurley, G. Nolen, B. Grimes, A. Waterstrat, G. V. Zant, and C. A. Peterson (2008)
J Gerontol A Biol Sci Med Sci 63, 566-579
   Abstract »    Full Text »    PDF »
Modulation of the dystrophin-associated protein complex in response to resistance training in young and older men.
D. J. Kosek and M. M. Bamman (2008)
J Appl Physiol 104, 1476-1484
   Abstract »    Full Text »    PDF »
Ageing-exaggerated proliferation of vascular smooth muscle cells is related to attenuation of Jagged1 expression in endothelial cells.
X. Wu, Q. Zhou, L. Huang, A. Sun, K. Wang, Y. Zou, and J. Ge (2008)
Cardiovasc Res 77, 800-808
   Abstract »    Full Text »    PDF »
High glucose induces adipogenic differentiation of muscle-derived stem cells.
P. Aguiari, S. Leo, B. Zavan, V. Vindigni, A. Rimessi, K. Bianchi, C. Franzin, R. Cortivo, M. Rossato, R. Vettor, et al. (2008)
PNAS 105, 1226-1231
   Abstract »    Full Text »    PDF »
Megf10 regulates the progression of the satellite cell myogenic program.
C. E. Holterman, F. Le Grand, S. Kuang, P. Seale, and M. A. Rudnicki (2007)
J. Cell Biol. 179, 911-922
   Abstract »    Full Text »    PDF »
Increased Wnt Signaling During Aging Alters Muscle Stem Cell Fate and Increases Fibrosis.
A. S. Brack, M. J. Conboy, S. Roy, M. Lee, C. J. Kuo, C. Keller, and T. A. Rando (2007)
Science 317, 807-810
   Abstract »    Full Text »    PDF »
Metabolic homeostasis and tissue renewal are dependent on {beta}1,6GlcNAc-branched N-glycans.
P. Cheung, J. Pawling, E. A Partridge, B. Sukhu, M. Grynpas, and J. W Dennis (2007)
Glycobiology 17, 828-837
   Abstract »    Full Text »    PDF »
Advances in signaling in vertebrate regeneration as a prelude to regenerative medicine.
C. L. Stoick-Cooper, R. T. Moon, and G. Weidinger (2007)
Genes & Dev. 21, 1292-1315
   Abstract »    Full Text »    PDF »
Stra13 regulates satellite cell activation by antagonizing Notch signaling.
H. Sun, L. Li, C. Vercherat, N. T. Gulbagci, S. Acharjee, J. Li, T.-K. Chung, T. H. Thin, and R. Taneja (2007)
J. Cell Biol. 177, 647-657
   Abstract »    Full Text »    PDF »
Gene expression profiling in the early phases of DMD: a constant molecular signature characterizes DMD muscle from early postnatal life throughout disease progression.
M. Pescatori, A. Broccolini, C. Minetti, E. Bertini, C. Bruno, A. D'amico, C. Bernardini, M. Mirabella, G. Silvestri, V. Giglio, et al. (2007)
FASEB J 21, 1210-1226
   Abstract »    Full Text »    PDF »
RBP-J (Rbpsuh) is essential to maintain muscle progenitor cells and to generate satellite cells.
E. Vasyutina, D. C. Lenhard, H. Wende, B. Erdmann, J. A. Epstein, and C. Birchmeier (2007)
PNAS 104, 4443-4448
   Abstract »    Full Text »    PDF »
The ubiquitin-protein ligase Nedd4 targets Notch1 in skeletal muscle and distinguishes the subset of atrophies caused by reduced muscle tension.
A. Koncarevic, R. W. Jackman, and S. C. Kandarian (2007)
FASEB J 21, 427-437
   Abstract »    Full Text »    PDF »
Fat accumulation with altered inflammation and regeneration in skeletal muscle of CCR2-/- mice following ischemic injury.
V. Contreras-Shannon, O. Ochoa, S. M. Reyes-Reyna, D. Sun, J. E. Michalek, W. A. Kuziel, L. M. McManus, and P. K. Shireman (2007)
Am J Physiol Cell Physiol 292, C953-C967
   Abstract »    Full Text »    PDF »
Premature myogenic differentiation and depletion of progenitor cells cause severe muscle hypotrophy in Delta1 mutants.
K. Schuster-Gossler, R. Cordes, and A. Gossler (2007)
PNAS 104, 537-542
   Abstract »    Full Text »    PDF »
Impaired Expression of Notch Signaling Genes in Aged Human Skeletal Muscle.
K. A. Carey, M. M. Farnfield, S. D. Tarquinio, and D. Cameron-Smith (2007)
J Gerontol A Biol Sci Med Sci 62, 9-17
   Abstract »    Full Text »    PDF »
Studies to Investigate the in Vivo Therapeutic Window of the {gamma}-Secretase Inhibitor N2-[(2S)-2-(3,5-Difluorophenyl)-2-hydroxyethanoyl]-N1-[(7S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl]-L-alaninamide (LY411,575) in the CRND8 Mouse.
L. A. Hyde, N. A. McHugh, J. Chen, Q. Zhang, D. Manfra, A. A. Nomeir, H. Josien, T. Bara, J. W. Clader, L. Zhang, et al. (2006)
J. Pharmacol. Exp. Ther. 319, 1133-1143
   Abstract »    Full Text »    PDF »
Modifying muscle mass - the endocrine perspective.
A M Solomon and P M G Bouloux (2006)
J. Endocrinol. 191, 349-360
   Abstract »    Full Text »    PDF »
The Skeletal Muscle Satellite Cell: The Stem Cell That Came in From the Cold.
P. S. Zammit, T. A. Partridge, and Z. Yablonka-Reuveni (2006)
Journal of Histochemistry & Cytochemistry 54, 1177-1191
   Abstract »    Full Text »    PDF »
Efficacy of myonuclear addition may explain differential myofiber growth among resistance-trained young and older men and women.
J. K. Petrella, J.-s. Kim, J. M. Cross, D. J. Kosek, and M. M. Bamman (2006)
Am J Physiol Endocrinol Metab 291, E937-E946
   Abstract »    Full Text »    PDF »
Efficacy of 3 days/wk resistance training on myofiber hypertrophy and myogenic mechanisms in young vs. older adults.
D. J. Kosek, J.-s. Kim, J. K. Petrella, J. M. Cross, and M. M. Bamman (2006)
J Appl Physiol 101, 531-544
   Abstract »    Full Text »    PDF »
Effects of Testosterone Supplementation on Skeletal Muscle Fiber Hypertrophy and Satellite Cells in Community-Dwelling Older Men.
I. Sinha-Hikim, M. Cornford, H. Gaytan, M. L. Lee, and S. Bhasin (2006)
J. Clin. Endocrinol. Metab. 91, 3024-3033
   Abstract »    Full Text »    PDF »
Muscle stem cells in development, regeneration, and disease..
X. Shi and D. J. Garry (2006)
Genes & Dev. 20, 1692-1708
   Abstract »    Full Text »    PDF »
Genes invoked in the ovarian transition to menopause.
A. Zimon, A. Erat, T. V. Wald, B. Bissell, A. Koulova, C. H. Choi, D. Bachvarov, R. H. Reindollar, and A. Usheva (2006)
Nucleic Acids Res. 34, 3279-3287
   Abstract »    Full Text »    PDF »
The satellite cell as a companion in skeletal muscle plasticity: currency, conveyance, clue, connector and colander.
J. E. Anderson (2006)
J. Exp. Biol. 209, 2276-2292
   Abstract »    Full Text »    PDF »
Distribution of myonuclei and microtubules in live muscle fibers of young, middle-aged, and old mice.
J. C. Bruusgaard, K. Liestol, and K. Gundersen (2006)
J Appl Physiol 100, 2024-2030
   Abstract »    Full Text »    PDF »
Vascular wall resident progenitor cells: a source for postnatal vasculogenesis.
E. Zengin, F. Chalajour, U. M. Gehling, W. D. Ito, H. Treede, H. Lauke, J. Weil, H. Reichenspurner, N. Kilic, and S. Ergun (2006)
Development 133, 1543-1551
   Abstract »    Full Text »    PDF »
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H. Shen, A. S. McElhinny, Y. Cao, P. Gao, J. Liu, R. Bronson, J. D. Griffin, and L. Wu (2006)
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   Abstract »    Full Text »    PDF »
Age-associated decrease in muscle precursor cell differentiation.
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   Abstract »    Full Text »    PDF »
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R. T. Hepple (2006)
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   Abstract »    Full Text »
Evidence that satellite cell decrement contributes to preferential decline in nuclear number from large fibres during murine age-related muscle atrophy.
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