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Science 302 (5651): 1751-1754

Copyright © 2003 by the American Association for the Advancement of Science

Regulation of Flowering Time by Histone Acetylation in Arabidopsis

Yuehui He, Scott D. Michaels, Richard M. Amasino*

Abstract: The Arabidopsis autonomous floral-promotion pathway promotes flowering independently of the photoperiod and vernalization pathways by repressing FLOWERING LOCUS C (FLC), a MADS-boxtranscription factor that blocks the transition from vegetative to reproductive development. Here, we report that FLOWERING LOCUS D (FLD), one of sixgenes in the autonomous pathway, encodes a plant homolog of a protein found in histone deacetylase complexes in mammals. Lesions in FLD result in hyperacetylation of histones in FLC chromatin, up-regulation of FLC expression, and extremely delayed flowering. Thus, the autonomous pathway regulates flowering in part by histone deacetylation. However, not all autonomous-pathway mutants exhibit FLC hyperacetylation, indicating that multiple means exist by which this pathway represses FLC expression.

Department of Biochemistry, University of Wisconsin, Madison, WI 53706, USA.

* To whom correspondence should be addressed. E-mail: amasino{at}biochem.wisc.edu


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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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K. Choi, S. Kim, S. Y. Kim, M. Kim, Y. Hyun, H. Lee, S. Choe, S.-G. Kim, S. Michaels, and I. Lee (2005)
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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I. R. Henderson, F. Liu, S. Drea, G. G. Simpson, and C. Dean (2005)
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   Abstract »    Full Text »    PDF »
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A. Loukoianov, L. Yan, A. Blechl, A. Sanchez, and J. Dubcovsky (2005)
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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C. Zhou, L. Zhang, J. Duan, B. Miki, and K. Wu (2005)
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   Abstract »    Full Text »    PDF »
Differential Regulation of FLOWERING LOCUS C Expression by Vernalization in Cabbage and Arabidopsis.
S.-I Lin, J.-G. Wang, S.-Y. Poon, C.-l. Su, S.-S. Wang, and T.-J. Chiou (2005)
Plant Physiology 137, 1037-1048
   Abstract »    Full Text »    PDF »
Quantitative trait locus mapping and DNA array hybridization identify an FLM deletion as a cause for natural flowering-time variation.
J. D. Werner, J. O. Borevitz, N. Warthmann, G. T. Trainer, J. R. Ecker, J. Chory, and D. Weigel (2005)
PNAS 102, 2460-2465
   Abstract »    Full Text »    PDF »
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J. Moon, H. Lee, M. Kim, and I. Lee (2005)
Plant Cell Physiol. 46, 292-299
   Abstract »    Full Text »    PDF »
Reversible Histone Acetylation and Deacetylation Mediate Genome-Wide, Promoter-Dependent and Locus-Specific Changes in Gene Expression During Plant Development.
L. Tian, M. P. Fong, J. J. Wang, N. E. Wei, H. Jiang, R. W. Doerge, and Z. J. Chen (2005)
Genetics 169, 337-345
   Abstract »    Full Text »    PDF »
Semirandom Sampling to Detect Differentiation-Related and Age-Related Epigenome Remodeling.
V. R. Russanova, T. H. Hirai, and B. H. Howard (2004)
J Gerontol A Biol Sci Med Sci 59, 1221-1233
   Abstract »    Full Text »    PDF »
siRNAs targeting an intronic transposon in the regulation of natural flowering behavior in Arabidopsis.
J. Liu, Y. He, R. Amasino, and X. Chen (2004)
Genes & Dev. 18, 2873-2878
   Abstract »    Full Text »    PDF »
PAF1-complex-mediated histone methylation of FLOWERING LOCUS C chromatin is required for the vernalization-responsive, winter-annual habit in Arabidopsis.
Y. He, M. R. Doyle, and R. M. Amasino (2004)
Genes & Dev. 18, 2774-2784
   Abstract »    Full Text »    PDF »
Epistatic interaction between Arabidopsis FRI and FLC flowering time genes generates a latitudinal cline in a life history trait.
A. L. Caicedo, J. R. Stinchcombe, K. M. Olsen, J. Schmitt, and M. D. Purugganan (2004)
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   Abstract »    Full Text »    PDF »
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R. Amasino (2004)
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   Full Text »    PDF »
Divergent Roles of a Pair of Homologous Jumonji/Zinc-Finger-Class Transcription Factor Proteins in the Regulation of Arabidopsis Flowering Time.
B. Noh, S.-H. Lee, H.-J. Kim, G. Yi, E.-A. Shin, M. Lee, K.-J. Jung, M. R. Doyle, R. M. Amasino, and Y.-S. Noh (2004)
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   Abstract »    Full Text »    PDF »
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T. C. Mockler, X. Yu, D. Shalitin, D. Parikh, T. P. Michael, J. Liou, J. Huang, Z. Smith, J. M. Alonso, J. R. Ecker, et al. (2004)
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