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Science 302 (5651): 1760-1765

Copyright © 2003 by the American Association for the Advancement of Science

Inflammatory Blockade Restores Adult Hippocampal Neurogenesis

Michelle L. Monje, Hiroki Toda, Theo D. Palmer*

Abstract: Cranial radiation therapy causes a progressive decline in cognitive function that is linked to impaired neurogenesis. Chronic inflammation accompanies radiation injury, suggesting that inflammatory processes may contribute to neural stem cell dysfunction. Here, we show that neuroinflammation alone inhibits neurogenesis and that inflammatory blockade with indomethacin, a common nonsteroidal anti-inflammatory drug, restores neurogenesis after endotoxin-induced inflammation and augments neurogenesis after cranial irradiation.

Stanford University, Department of Neurosurgery, MSLS P309, Mail Code 5487, 1201 Welch Road, Stanford, CA 94305–5487, USA.

* To whom correspondence should be addressed. E-mail: tpalmer{at}

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