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Science 302 (5651): 1765-1768

Copyright © 2003 by the American Association for the Advancement of Science

Spatiotemporal Rescue of Memory Dysfunction in Drosophila

Sean E. McGuire,1 Phuong T. Le,1 Alexander J. Osborn,3 Kunihiro Matsumoto,4 Ronald L. Davis1,2*

Abstract: We have developed a method for temporal and regional gene expression targeting (TARGET) in Drosophila and show the simultaneous spatial and temporal rescue of a memory defect. The transient expression of the rutabaga-encoded adenylyl cyclase in the mushroom bodies of the adult brain was necessary and sufficient to rescue the rutabaga memory deficit, which rules out a developmental brain defect in the etiology of this deficit and demonstrates an acute role for rutabaga in memory formation in these neurons. The TARGET system offers general utility in simultaneously addressing issues of when and where gene products are required.

1 Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA.
2 Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX 77030, USA.
3 Department of Molecular & Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.
4 Department of Molecular Biology, Graduate School of Science, Nagoya University, Nagoya 464 – 8602, Japan.

* To whom correspondence should be addressed. E-mail: rdavis{at}

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Inositol 1,4,5-Trisphosphate Receptor and dSTIM Function in Drosophila Insulin-Producing Neurons Regulates Systemic Intracellular Calcium Homeostasis and Flight.
N. Agrawal, G. Venkiteswaran, S. Sadaf, N. Padmanabhan, S. Banerjee, and G. Hasan (2010)
J. Neurosci. 30, 1301-1313
   Abstract »    Full Text »    PDF »
Attention-Like Deficit and Hyperactivity in a Drosophila Memory Mutant.
B. van Swinderen and B. Brembs (2010)
J. Neurosci. 30, 1003-1014
   Abstract »    Full Text »    PDF »
Dimerization Is Essential for 14-3-3{zeta} Stability and Function in Vivo.
G. Messaritou, S. Grammenoudi, and E. M. C. Skoulakis (2010)
J. Biol. Chem. 285, 1692-1700
   Abstract »    Full Text »    PDF »
Differential Effects of Tau on the Integrity and Function of Neurons Essential for Learning in Drosophila.
S. Kosmidis, S. Grammenoudi, K. Papanikolopoulou, and E. M. C. Skoulakis (2010)
J. Neurosci. 30, 464-477
   Abstract »    Full Text »    PDF »

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