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Science 302 (5651): 1765-1768

Copyright © 2003 by the American Association for the Advancement of Science

Spatiotemporal Rescue of Memory Dysfunction in Drosophila

Sean E. McGuire,1 Phuong T. Le,1 Alexander J. Osborn,3 Kunihiro Matsumoto,4 Ronald L. Davis1,2*

Abstract: We have developed a method for temporal and regional gene expression targeting (TARGET) in Drosophila and show the simultaneous spatial and temporal rescue of a memory defect. The transient expression of the rutabaga-encoded adenylyl cyclase in the mushroom bodies of the adult brain was necessary and sufficient to rescue the rutabaga memory deficit, which rules out a developmental brain defect in the etiology of this deficit and demonstrates an acute role for rutabaga in memory formation in these neurons. The TARGET system offers general utility in simultaneously addressing issues of when and where gene products are required.

1 Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA.
2 Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX 77030, USA.
3 Department of Molecular & Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.
4 Department of Molecular Biology, Graduate School of Science, Nagoya University, Nagoya 464 – 8602, Japan.

* To whom correspondence should be addressed. E-mail: rdavis{at}bcm.tmc.edu

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T. D. Southall, D. A. Elliott, and A. H. Brand (2008)
Cold Spring Harb Protoc 2008, pdb.top49
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Axonal Injury and Regeneration in the Adult Brain of Drosophila.
D. Ayaz, M. Leyssen, M. Koch, J. Yan, M. Srahna, V. Sheeba, K. J. Fogle, T. C. Holmes, and B. A. Hassan (2008)
J. Neurosci. 28, 6010-6021
   Abstract »    Full Text »    PDF »
Increased Dopamine Level Enhances Male-Male Courtship in Drosophila.
T. Liu, L. Dartevelle, C. Yuan, H. Wei, Y. Wang, J.-F. Ferveur, and A. Guo (2008)
J. Neurosci. 28, 5539-5546
   Abstract »    Full Text »    PDF »

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