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In vitro studies have indicated that reactive oxygen species(ROS) and the oxidation of signaling molecules are importantmediators of signal transduction. We have identified two pathwaysby which the altered redox chemistry of the clk-1 mutants ofCaenorhabditis elegans acts in vivo on germline development.One pathway depends on the oxidation of an analog of vertebratelow density lipoprotein (LDL) and acts on the germline throughthe Ack-related tyrosine kinase (ARK-1) kinase and inositoltrisphosphate (IP3) signaling. The other pathway is the oncogenicras signaling pathway, whose action on germline as well as vulvaldevelopment appears to be modulated by cytoplasmic ROS.
Department of Biology, McGill University, 1205 Avenue Docteur Penfield, Montréal, Québec, Canada, H3A 1B1.
Demethoxy-Q, An Intermediate of Coenzyme Q Biosynthesis, Fails to Support Respiration in Saccharomyces cerevisiae and Lacks Antioxidant Activity.
S. Padilla, T. Jonassen, M. A. Jimenez-Hidalgo, D. J. M. Fernandez-Ayala, G. Lopez-Lluch, B. Marbois, P. Navas, C. F. Clarke, and C. Santos-Ocana (2004)
J. Biol. Chem.
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Lack of Peroxisomal Catalase Causes a Progeric Phenotype in Caenorhabditis elegans.