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Abstract:
In the mouse olfactory system, each olfactory sensory neuron(OSN) expresses only one odorant receptor (OR) gene in a monoallelicand mutually exclusive manner. Such expression forms the geneticbasis for OR-instructed axonal projection of OSNs to the olfactorybulb of the brain during development. Here, we identify an upstreamcis-acting DNA region that activates the OR gene cluster inmouse and allows the expression of only one OR gene within thecluster. Deletion of the coding region of the expressed OR geneor a naturally occurring frame-shift mutation allows a secondOR gene to be expressed. We propose that stochastic activationof only one OR gene within the cluster and negative feedbackregulation by that OR gene product are necessary to ensure theone receptor–one neuron rule.
1 Department of Biophysics and Biochemistry, Graduate School of Science, University of Tokyo, Tokyo 113-0032, Japan. 2 PRESTO Programs, Japan Science and Technology Corporation, Kawaguchi, Saitama 332-0012, Japan. 3 CREST Programs, Japan Science and Technology Corporation, Kawaguchi, Saitama 332-0012, Japan. 4 Center for Animal Resources and Development, Kumamoto University, Kumamoto 862-0976, Japan. 5 Laboratory for Neurobiology of Synapse, RIKEN Brain Science Institute, Wako, Saitama 351-0198, Japan.
Developmental Pluripotency of the Nuclei of Neurons in the Cerebral Cortex of Juvenile Mice.
T. Osada, N. Tamamaki, S.-Y. Song, N. Kakazu, Y. Yamazaki, H. Makino, A. Sasaki, T. Hirayama, S. Hamada, K.-A. Nave, et al. (2005)
J. Neurosci.
25, 8368-8374
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Cyclic AMP Cascade Mediates the Inhibitory Odor Response of Isolated Toad Olfactory Receptor Neurons.
R. Madrid, R. Delgado, and J. Bacigalupo (2005)
J Neurophysiol
94, 1781-1788
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Elementary Response of Olfactory Receptor Neurons to Odorants.
Continuous and Overlapping Expression Domains of Odorant Receptor Genes in the Olfactory Epithelium Determine the Dorsal/Ventral Positioning of Glomeruli in the Olfactory Bulb.
K. Miyamichi, S. Serizawa, H. M. Kimura, and H. Sakano (2005)
J. Neurosci.
25, 3586-3592
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Mechanisms Determining the Dynamic Range of the Bullfrog Olfactory Receptor Cell.
{beta}1,3-N-Acetylglucosaminyltransferase 1 Glycosylation Is Required for Axon Pathfinding by Olfactory Sensory Neurons.
T. R. Henion, D. Raitcheva, R. Grosholz, F. Biellmann, W. C. Skarnes, T. Hennet, and G. A. Schwarting (2005)
J. Neurosci.
25, 1894-1903
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Functional Expression of Mammalian Odorant Receptors.
Negative Feedback Regulation Ensures the One Neuron-One Receptor Rule in the Mouse Olfactory System.
S. Serizawa, K. Miyamichi, and H. Sakano (2005)
Chem Senses
30, i99-i100
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Cellular Mechanisms of Olfactory Signal Transduction.
C. H. Wetzel, D. Brunert, and H. Hatt (2005)
Chem Senses
30, i321-i322
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Efficient Generation of Transgenic Mice with Intact Yeast Artificial Chromosomes by Intracytoplasmic Sperm Injection.
P. N. Moreira, P. Giraldo, P. Cozar, J. Pozueta, A. Jimenez, L. Montoliu, and A. Gutierrez-Adan (2004)
Biol Reprod
71, 1943-1947
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Selective Gene Expression in Multigene Families from Yeast to Mammals.
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