Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Subscribe

Logo for

Science 303 (5655): 197-202

Copyright © 2004 by the American Association for the Advancement of Science

Dendrite Development Regulated by CREST, a Calcium-Regulated Transcriptional Activator

Hiroyuki Aizawa,* Shu-Ching Hu,* Kathryn Bobb, Karthik Balakrishnan, Gulayse Ince, Inga Gurevich, Mitra Cowan, Anirvan Ghosh{dagger}{ddagger}

Abstract: The lasting effects of neuronal activity on brain development involve calcium-dependent gene expression. Using a strategy called transactivator trap, we cloned a calcium-responsive transactivator called CREST (for calcium-responsive transactivator). CREST is a SYT-related nuclear protein that interacts with adenosine 3',5'-monophosphate (cAMP) response element–binding protein (CREB)–binding protein (CBP) and is expressed in the developing brain. Mice that have a targeted disruption of the crest gene are viable but display defects in cortical and hippocampal dendrite development. Cortical neurons from crest mutant mice are compromised in calcium-dependent dendritic growth. Thus, calcium activation of CREST-mediated transcription helps regulate neuronal morphogenesis.

Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

Back to Top

* These authors contributed equally to this work.

{dagger} Present address: Division of Biology, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.

{ddagger} To whom correspondence should be addressed. E-mail: aghosh{at}ucsd.edu


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Mechanisms by which a CACNA1H mutation in epilepsy patients increases seizure susceptibility.
V.-S. Eckle, A. Shcheglovitov, I. Vitko, D. Dey, C. C. Yap, B. Winckler, and E. Perez-Reyes (2014)
J. Physiol. 592, 795-809
   Abstract »    Full Text »    PDF »
LMO4 Is Essential for Paraventricular Hypothalamic Neuronal Activity and Calcium Channel Expression to Prevent Hyperphagia.
T. Zaman, X. Zhou, N. R. Pandey, Z. Qin, K. Keyhanian, K. Wen, R. D. Courtney, A. F. R. Stewart, and H.-H. Chen (2014)
J. Neurosci. 34, 140-148
   Abstract »    Full Text »    PDF »
Molecular Mechanism of microRNA396 Mediating Pistil Development in Arabidopsis.
G. Liang, H. He, Y. Li, F. Wang, and D. Yu (2014)
Plant Physiology 164, 249-258
   Abstract »    Full Text »    PDF »
Cell-intrinsic drivers of dendrite morphogenesis.
S. V. Puram and A. Bonni (2013)
Development 140, 4657-4671
   Abstract »    Full Text »    PDF »
The LIM Domain Only 4 Protein Is a Metabolic Responsive Inhibitor of Protein Tyrosine Phosphatase 1B That Controls Hypothalamic Leptin Signaling.
N. R. Pandey, X. Zhou, Z. Qin, T. Zaman, M. Gomez-Smith, K. Keyhanian, H. Anisman, J. M. Brunel, A. F. R. Stewart, and H.-H. Chen (2013)
J. Neurosci. 33, 12647-12655
   Abstract »    Full Text »    PDF »
The Drosophila Transcription Factor Adf-1 (nalyot) Regulates Dendrite Growth by Controlling FasII and Staufen Expression Downstream of CaMKII and Neural Activity.
C. Timmerman, S. Suppiah, B. V. Gurudatta, J. Yang, C. Banerjee, D. J. Sandstrom, V. G. Corces, and S. Sanyal (2013)
J. Neurosci. 33, 11916-11931
   Abstract »    Full Text »    PDF »
Kinetic Analysis of npBAF to nBAF Switching Reveals Exchange of SS18 with CREST and Integration with Neural Developmental Pathways.
B. T. Staahl, J. Tang, W. Wu, A. Sun, A. D. Gitler, A. S. Yoo, and G. R. Crabtree (2013)
J. Neurosci. 33, 10348-10361
   Abstract »    Full Text »    PDF »
Hypoxic adaptation engages the CBP/CREST-induced coactivator complex of Creb-HIF-1{alpha} in transactivating murine neuroblastic glucose transporter.
S. Thamotharan, N. Raychaudhuri, M. Tomi, B.-C. Shin, and S. U. Devaskar (2013)
Am J Physiol Endocrinol Metab 304, E583-E598
   Abstract »    Full Text »    PDF »
Temporal coherency between receptor expression, neural activity and AP-1-dependent transcription regulates Drosophila motoneuron dendrite development.
F. Vonhoff, C. Kuehn, S. Blumenstock, S. Sanyal, and C. Duch (2013)
Development 140, 606-616
   Abstract »    Full Text »    PDF »
Involvement of the Ca2+-responsive transactivator in high glucose-induced {beta}-cell apoptosis.
X. Men, L. Peng, H. Wang, W. Zhang, S. Xu, Q. Fang, H. Liu, W. Yang, and J. Lou (2013)
J. Endocrinol. 216, 231-243
   Abstract »    Full Text »    PDF »
LIM Domain Only 4 (LMO4) Regulates Calcium-Induced Calcium Release and Synaptic Plasticity in the Hippocampus.
Z. Qin, X. Zhou, M. Gomez-Smith, N. R. Pandey, K. F. H. Lee, D. C. Lagace, J.-C. Beique, and H.-H. Chen (2012)
J. Neurosci. 32, 4271-4283
   Abstract »    Full Text »    PDF »
SIRT1 Deacetylates the DNA Methyltransferase 1 (DNMT1) Protein and Alters Its Activities.
L. Peng, Z. Yuan, H. Ling, K. Fukasawa, K. Robertson, N. Olashaw, J. Koomen, J. Chen, W. S. Lane, and E. Seto (2011)
Mol. Cell. Biol. 31, 4720-4734
   Abstract »    Full Text »    PDF »
BDNF-Promoted Increases in Proximal Dendrites Occur via CREB-Dependent Transcriptional Regulation of Cypin.
M. Kwon, J. R. Fernandez, G. F. Zegarek, S. B. Lo, and B. L. Firestein (2011)
J. Neurosci. 31, 9735-9745
   Abstract »    Full Text »    PDF »
Neuronal Activity-Regulated Gene Transcription in Synapse Development and Cognitive Function.
A. E. West and M. E. Greenberg (2011)
Cold Spring Harb Perspect Biol 3, a005744
   Abstract »    Full Text »    PDF »
Histone Deacetylase 9 (HDAC9) Regulates the Functions of the ATDC (TRIM29) Protein.
Z. Yuan, L. Peng, R. Radhakrishnan, and E. Seto (2010)
J. Biol. Chem. 285, 39329-39338
   Abstract »    Full Text »    PDF »
SMARCA2 and other genome-wide supported schizophrenia-associated genes: regulation by REST/NRSF, network organization and primate-specific evolution.
Y. Loe-Mie, A.-M. Lepagnol-Bestel, G. Maussion, A. Doron-Faigenboim, S. Imbeaud, H. Delacroix, L. Aggerbeck, T. Pupko, P. Gorwood, M. Simonneau, et al. (2010)
Hum. Mol. Genet. 19, 2841-2857
   Abstract »    Full Text »    PDF »
Endogenous Signaling through {alpha}7-Containing Nicotinic Receptors Promotes Maturation and Integration of Adult-Born Neurons in the Hippocampus.
N. R. Campbell, C. C. Fernandes, A. W. Halff, and D. K. Berg (2010)
J. Neurosci. 30, 8734-8744
   Abstract »    Full Text »    PDF »
The ATDC (TRIM29) Protein Binds p53 and Antagonizes p53-Mediated Functions.
Z. Yuan, A. Villagra, L. Peng, D. Coppola, M. Glozak, E. M. Sotomayor, J. Chen, W. S. Lane, and E. Seto (2010)
Mol. Cell. Biol. 30, 3004-3015
   Abstract »    Full Text »    PDF »
Diversity of Lysophosphatidic Acid Receptor-Mediated Intracellular Calcium Signaling in Early Cortical Neurogenesis.
A. E. Dubin, D. R. Herr, and J. Chun (2010)
J. Neurosci. 30, 7300-7309
   Abstract »    Full Text »    PDF »
A FOXO-Pak1 transcriptional pathway controls neuronal polarity.
L. de la Torre-Ubieta, B. Gaudilliere, Y. Yang, Y. Ikeuchi, T. Yamada, S. DiBacco, J. Stegmuller, U. Schuller, D. A. Salih, D. Rowitch, et al. (2010)
Genes & Dev. 24, 799-813
   Abstract »    Full Text »    PDF »
Molecules and mechanisms of dendrite development in Drosophila.
M. M. Corty, B. J. Matthews, and W. B. Grueber (2009)
Development 136, 1049-1061
   Abstract »    Full Text »    PDF »
TOX3 regulates calcium-dependent transcription in neurons.
S. H. Yuan, Z. Qiu, and A. Ghosh (2009)
PNAS 106, 2909-2914
   Abstract »    Full Text »    PDF »
Differential dendritic Ca2+ signalling in young and mature hippocampal granule cells.
G. Stocca, C. Schmidt-Hieber, and J. Bischofberger (2008)
J. Physiol. 586, 3795-3811
   Abstract »    Full Text »    PDF »
TRPC6 channels promote dendritic growth via the CaMKIV-CREB pathway.
Y. Tai, S. Feng, R. Ge, W. Du, X. Zhang, Z. He, and Y. Wang (2008)
J. Cell Sci. 121, 2301-2307
   Abstract »    Full Text »    PDF »
Erbin Controls Dendritic Morphogenesis by Regulating Localization of {delta}-Catenin.
J. Arikkath, I. Israely, Y. Tao, L. Mei, X. Liu, and L. F. Reichardt (2008)
J. Neurosci. 28, 7047-7056
   Abstract »    Full Text »    PDF »
Ca2+-Operated Transcriptional Networks: Molecular Mechanisms and In Vivo Models.
B. Mellstrom, M. Savignac, R. Gomez-Villafuertes, and J. R. Naranjo (2008)
Physiol Rev 88, 421-449
   Abstract »    Full Text »    PDF »
Transcription factor Sp4 regulates dendritic patterning during cerebellar maturation.
B. Ramos, B. Gaudilliere, A. Bonni, and G. Gill (2007)
PNAS 104, 9882-9887
   Abstract »    Full Text »    PDF »
Network activity-independent coordinated gene expression program for synapse assembly.
L. M. Valor, P. Charlesworth, L. Humphreys, C. N. G. Anderson, and S. G. N. Grant (2007)
PNAS 104, 4658-4663
   Abstract »    Full Text »    PDF »
Activity-Independent Regulation of Dendrite Patterning by Postsynaptic Density Protein PSD-95.
E. I. Charych, B. F. Akum, J. S. Goldberg, R. J. Jornsten, C. Rongo, J. Q. Zheng, and B. L. Firestein (2006)
J. Neurosci. 26, 10164-10176
   Abstract »    Full Text »    PDF »
Targeted disruption of the synovial sarcoma-associated SS18 gene causes early embryonic lethality and affects PPARBP expression.
D.R.H. de Bruijn, W.J.M. Peters, S.M. Chuva de Sousa Lopes, A.H.A. van Dijk, M.P. Willemse, R. Pfundt, P. de Boer, and A. Geurts van Kessel (2006)
Hum. Mol. Genet. 15, 2936-2944
   Abstract »    Full Text »    PDF »
Transcriptional regulation of neuronal phenotype in mammals.
Q. Ma (2006)
J. Physiol. 575, 379-387
   Abstract »    Full Text »    PDF »
Calcium Activation of the LMO4 Transcription Complex and Its Role in the Patterning of Thalamocortical Connections..
A. H. Kashani, Z. Qiu, L. Jurata, S.-K. Lee, S. Pfaff, S. Goebbels, K.-A. Nave, and A. Ghosh (2006)
J. Neurosci. 26, 8398-8408
   Abstract »    Full Text »    PDF »
Insulin-like growth factor-1 modulation of CaV1.3 calcium channels depends on Ca2+ release from IP3-sensitive stores and calcium/calmodulin kinase II phosphorylation of the alpha1 subunit EF hand..
L. Gao, L. A. C. Blair, G. D. Salinas, L. A. Needleman, and J. Marshall (2006)
J. Neurosci. 26, 6259-6268
   Abstract »    Full Text »    PDF »
Genome-wide analyses identify transcription factors required for proper morphogenesis of Drosophila sensory neuron dendrites.
J. Z. Parrish, M. D. Kim, L. Y. Jan, and Y. N. Jan (2006)
Genes & Dev. 20, 820-835
   Abstract »    Full Text »    PDF »
Dendrites Contain a Spacing Pattern.
A. B. Taylor and J. R. Fallon (2006)
J. Neurosci. 26, 1154-1163
   Abstract »    Full Text »    PDF »
A Novel Role for Snapin in Dendrite Patterning: Interaction with Cypin.
M. Chen, K. G. Lucas, B. F. Akum, G. Balasingam, T. M. Stawicki, J. M. Provost, G. M. Riefler, R. J. Jornsten, and B. L. Firestein (2005)
Mol. Biol. Cell 16, 5103-5114
   Abstract »    Full Text »    PDF »
Role of Hippocampal Cav1.2 Ca2+ Channels in NMDA Receptor-Independent Synaptic Plasticity and Spatial Memory.
S. Moosmang, N. Haider, N. Klugbauer, H. Adelsberger, N. Langwieser, J. Muller, M. Stiess, E. Marais, V. Schulla, L. Lacinova, et al. (2005)
J. Neurosci. 25, 9883-9892
   Abstract »    Full Text »    PDF »
A Multifunctional Domain of the Calcium-responsive Transactivator (CREST) That Inhibits Dendritic Growth in Cultured Neurons.
A. Pradhan and Y. Liu (2005)
J. Biol. Chem. 280, 24738-24743
   Abstract »    Full Text »    PDF »
A transcriptional coactivator, AtGIF1, is involved in regulating leaf growth and morphology in Arabidopsis.
J. H. Kim and H. Kende (2004)
PNAS 101, 13374-13379
   Abstract »    Full Text »    PDF »
NEUROSCIENCE: Calcium and CREST for Healthy Dendrites.
G. S. X. E. Jefferis, T. Komiyama, and L. Luo (2004)
Science 303, 179-181
   Abstract »    Full Text »    PDF »

To Advertise     Find Products


Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882