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Science 303 (5656): 359-363

Copyright © 2004 by the American Association for the Advancement of Science

Defining the Epithelial Stem Cell Niche in Skin

Tudorita Tumbar, Geraldine Guasch, Valentina Greco, Cedric Blanpain, William E. Lowry, Michael Rendl, Elaine Fuchs*

Abstract: Many adult regenerative cells divide infrequently but have high proliferative capacity. We developed a strategy to fluorescently label slow-cycling cells in a cell type–specific fashion. We used this method to purify the label-retaining cells (LRCs) that mark the skin stem cell (SC) niche. We found that these cells rarely divide within their niche but change properties abruptly when stimulated to exit. We determined their transcriptional profile, which, when compared to progeny and other SCs, defines the niche. Many of the >100 messenger RNAs preferentially expressed in the niche encode surface receptors and secreted proteins, enabling LRCs to signal and respond to their environment.

Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, Rockefeller University, New York, NY 10021, USA.

* To whom correspondence should be addressed. E-mail: fuchslb{at}rockefeller.edu


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Cancer Stem Cells and Aneuploid Populations within Developing Tumors Are the Major Determinants of Tumor Dormancy.
A. P. Kusumbe and S. A. Bapat (2009)
Cancer Res. 69, 9245-9253
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