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Science 303 (5656): 366-370

Copyright © 2004 by the American Association for the Advancement of Science

Transformation of Olfactory Representations in the Drosophila Antennal Lobe

Rachel I. Wilson, Glenn C. Turner, Gilles Laurent*

Abstract: Molecular genetics has revealed a precise stereotypy in the projection of primary olfactory sensory neurons onto secondary neurons. A major challenge is to understand how this mapping translates into odor responses in these second-order neurons. We investigated this question in Drosophila using whole-cell recordings in vivo. We observe that monomolecular odors generally elicit responses in large ensembles of antennal lobe neurons. Comparison of odor-evoked activity from afferents and postsynaptic neurons in the same glomerulus revealed that second-order neurons display broader tuning and more complex responses than their primary afferents. This indicates a major transformation of odor representations, implicating lateral interactions within the antennal lobe.

Division of Biology, 139-74, California Institute of Technology, Pasadena, CA 91125, USA.

* To whom correspondence should be addressed. E-mail: laurentg{at}caltech.edu.

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