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Science 303 (5658): 682-684

Copyright © 2004 by the American Association for the Advancement of Science

EGF-Like Growth Factors As Mediators of LH Action in the Ovulatory Follicle

Jy-Young Park, You-Qiang Su, Miyako Ariga, Evelyn Law, S.-L. Catherine Jin, Marco Conti*

Abstract: Before ovulation in mammals, a cascade of events resembling an inflammatory and/or tissue remodeling process is triggered by luteinizing hormone (LH) in the ovarian follicle. Many LH effects, however, are thought to be indirect because of the restricted expression of its receptor. Here, we demonstrate that LH stimulation induces the transient and sequential expression of the epidermal growth factor (EGF) family members amphiregulin, epiregulin, and beta-cellulin. Incubation of follicles with these growth factors recapitulates the morphological and biochemical events triggered by LH, including cumulus expansion and oocyte maturation. Thus, these EGF-related growth factors are paracrine mediators that propagate the LH signal throughout the follicle.

Division of Reproductive Biology and Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, CA 94305, USA.

* To whom correspondence should be addressed. E-mail: marco.conti{at}

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   Abstract »    Full Text »    PDF »
Maternal heparin-binding-EGF deficiency limits pregnancy success in mice.
H. Xie, H. Wang, S. Tranguch, R. Iwamoto, E. Mekada, F. J. DeMayo, J. P. Lydon, S. K. Das, and S. K. Dey (2007)
PNAS 104, 18315-18320
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