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Science 303 (5659): 853-856

Copyright © 2004 by the American Association for the Advancement of Science

Selective D2 Receptor Actions on the Functional Circuitry of Working Memory

Min Wang,* Susheel Vijayraghavan, Patricia S. Goldman-Rakic{dagger}

Abstract: Prefrontal neurons engaged by working memory tasks express a sequence of phasic and tonic activations linked to a train of sensory, mnemonic, and response-related events. Here, we report that the dopamine D2 receptor selectively modulates the neural activities associated with memory-guided saccades in oculomotor delayed-response tasks yet has little or no effect on the persistent mnemonic-related activity, which is instead modulated by D1 receptors. This associates the D2 receptor with a specific component of working memory circuitry and fractionates the modulatory effects of D1 and D2 receptors on the neural machinery of a cognitive process.

Department of Neurobiology, Yale University School of Medicine, New Haven, CT 06510, USA.

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{dagger} Deceased.

* To whom correspondence should be addressed. E-mail:{at}

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