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Science 303 (5661): 1195-1198

Copyright © 2004 by the American Association for the Advancement of Science

Regulation of Fasted Blood Glucose by Resistin

Ronadip R. Banerjee,1* Shamina M. Rangwala,1* Jennifer S. Shapiro,1 A. Sophie Rich,1 Ben Rhoades,1 Yong Qi,1 Juan Wang,1 Michael W. Rajala,2 Alessandro Pocai,2 Phillipp E. Scherer,2 Claire M. Steppan,1 Rexford S. Ahima,1 Silvana Obici,2 Luciano Rossetti,2 Mitchell A. Lazar1{dagger}

Abstract: The association between obesity and diabetes supports an endocrine role for the adipocyte in maintaining glucose homeostasis. Here we report that mice lacking the adipocyte hormone resistin exhibit low blood glucose levels after fasting, due to reduced hepatic glucose production. This is partly mediated by activation of adenosine monophosphate–activated protein kinase and decreased expression of gluconeogenic enzymes in the liver. The data thus support a physiological function for resistin in the maintenance of blood glucose during fasting. Remarkably, lack of resistin diminishes the increase in post-fast blood glucose normally associated with increased weight, suggesting a role for resistin in mediating hyperglycemia associated with obesity.

1 Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, and The Penn Diabetes Center, 611 CRB, 415 Curie Boulevard, Universityof Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.
2 Department of Medicine, Diabetes Research and Training Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA.

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* These authors contributed equally to this work.

{dagger} To whom correspondence should be addressed: E-mail: lazar{at}

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C. M. Steppan, J. Wang, E. L. Whiteman, M. J. Birnbaum, and M. A. Lazar (2005)
Mol. Cell. Biol. 25, 1569-1575
   Abstract »    Full Text »    PDF »
Resistin expression in 3T3-L1 adipocytes is reduced by arachidonic acid.
F. Haugen, N. Zahid, K. T. Dalen, K. Hollung, H. I. Nebb, and C. A. Drevon (2005)
J. Lipid Res. 46, 143-153
   Abstract »    Full Text »    PDF »
Resistin Promotes Smooth Muscle Cell Proliferation Through Activation of Extracellular Signal-Regulated Kinase 1/2 and Phosphatidylinositol 3-Kinase Pathways.
P. Calabro, I. Samudio, J. T. Willerson, and E. T.H. Yeh (2004)
Circulation 110, 3335-3340
   Abstract »    Full Text »    PDF »
Desnutrin, an Adipocyte Gene Encoding a Novel Patatin Domain-containing Protein, Is Induced by Fasting and Glucocorticoids: ECTOPIC EXPRESSION OF DESNUTRIN INCREASES TRIGLYCERIDE HYDROLYSIS.
J. A. Villena, S. Roy, E. Sarkadi-Nagy, K.-H. Kim, and H. S. Sul (2004)
J. Biol. Chem. 279, 47066-47075
   Abstract »    Full Text »    PDF »
Genetics of the APM1 Locus and Its Contribution to Type 2 Diabetes Susceptibility in French Caucasians.
F. Gibson and P. Froguel (2004)
Diabetes 53, 2977-2983
   Abstract »    Full Text »    PDF »
P. K. Saha, H. Kojima, J. Martinez-Botas, A. L. Sunehag, and L. Chan (2004)
J. Biol. Chem. 279, 35150-35158
   Abstract »    Full Text »    PDF »
Wnt10b Inhibits Development of White and Brown Adipose Tissues.
K. A. Longo, W. S. Wright, S. Kang, I. Gerin, S.-H. Chiang, P. C. Lucas, M. R. Opp, and O. A. MacDougald (2004)
J. Biol. Chem. 279, 35503-35509
   Abstract »    Full Text »    PDF »
The Direct Peroxisome Proliferator-activated Receptor Target Fasting-induced Adipose Factor (FIAF/PGAR/ANGPTL4) Is Present in Blood Plasma as a Truncated Protein That Is Increased by Fenofibrate Treatment.
S. Mandard, F. Zandbergen, N. S. Tan, P. Escher, D. Patsouris, W. Koenig, R. Kleemann, A. Bakker, F. Veenman, W. Wahli, et al. (2004)
J. Biol. Chem. 279, 34411-34420
   Abstract »    Full Text »    PDF »
Abnormal Glucose Homeostasis due to Chronic Hyperresistinemia.
S. M. Rangwala, A. S. Rich, B. Rhoades, J. S. Shapiro, S. Obici, L. Rossetti, and M. A. Lazar (2004)
Diabetes 53, 1937-1941
   Abstract »    Full Text »    PDF »
Regulation of Resistin Expression and Circulating Levels in Obesity, Diabetes, and Fasting.
M. W. Rajala, Y. Qi, H. R. Patel, N. Takahashi, R. Banerjee, U. B. Pajvani, M. K. Sinha, R. L. Gingerich, P. E. Scherer, and R. S. Ahima (2004)
Diabetes 53, 1671-1679
   Abstract »    Full Text »    PDF »
Disulfide-Dependent Multimeric Assembly of Resistin Family Hormones.
S. D. Patel, M. W. Rajala, L. Rossetti, P. E. Scherer, and L. Shapiro (2004)
Science 304, 1154-1158
   Abstract »    Full Text »    PDF »
Papers of Note.
Sci. Aging Knowl. Environ. 2004, nw7-7
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