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Science 303 (5665): 1810-1813

Copyright © 2004 by the American Association for the Advancement of Science

Organic Chemistry in Drug Discovery

Malcolm MacCoss1*, and Thomas A. Baillie2

Abstract: The role played by organic chemistry in the pharmaceutical industry continues to be one of the main drivers in the drug discovery process. However, the precise nature of that role is undergoing a visible change, not only because of the new synthetic methods and technologies now available to the synthetic and medicinal chemist, but also in several key areas, particularly in drug metabolism and chemical toxicology, as chemists deal with the ever more rapid turnaround of testing data that influences their day-to-day decisions.

1 Department of Basic Chemistry, Merck Research Laboratories, 126 East Lincoln Avenue, Rahway, NJ 07065, USA.
2 Department of Drug Metabolism, Merck Research Laboratories, Sumneytown Pike, West Point, PA 19486, USA.

* To whom correspondence should be addressed. E-mail: malcolm_maccoss{at}

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