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Trophic Action of Leptin on Hypothalamic Neurons That Regulate Feeding
Sebastien G. Bouret,
Shin J. Draper,
Richard B. Simerly*
Abstract:
In adult mammals, the adipocyte-derived hormone leptin actson the brain to reduce food intake by regulating the activityof neurons in the arcuate nucleus of the hypothalamus (ARH).Here, we report that neural projection pathways from the ARHare permanently disrupted in leptin-deficient (Lepob/Lepob)mice and leptin treatment in adulthood does not reverse theseneuroanatomical defects. However, treatment of Lepob/Lepob neonateswith exogenous leptin rescues the development of ARH projections,and leptin promotes neurite outgrowth from ARH neurons in vitro.These results suggest that leptin plays a neurotrophic roleduring the development of the hypothalamus and that this activityis restricted to a neonatal critical period that precedes leptin'sacute regulation of food intake in adults.
Division of Neuroscience, Oregon National Primate Research Center and Oregon Health and Science University, Beaverton, OR 97006, USA.
* To whom correspondence should be addressed. E-mail: simerlyr{at}ohsu.edu
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|Abstract »|Full Text »|PDF »
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|Abstract »|Full Text »|PDF »
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|Abstract »|Full Text »|PDF »
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|Abstract »|Full Text »|PDF »
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152, 3396-3408
|Abstract »|Full Text »|PDF »
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FASEB J
25, 3271-3278
|Abstract »|Full Text »|PDF »
Maternal prenatal undernutrition programs adipose tissue gene expression in adult male rat offspring under high-fat diet.
M.-A. Lukaszewski, S. Mayeur, I. Fajardy, F. Delahaye, I. Dutriez-Casteloot, V. Montel, A. Dickes-Coopman, C. Laborie, J. Lesage, D. Vieau, et al. (2011)
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|Abstract »|Full Text »|PDF »
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|Full Text »|PDF »
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|Abstract »|Full Text »|PDF »
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|Abstract »|Full Text »|PDF »
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|Abstract »|Full Text »|PDF »
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|Abstract »|Full Text »|PDF »
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|Abstract »|Full Text »|PDF »
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|Abstract »|Full Text »|PDF »
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|Abstract »|Full Text »|PDF »
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|Abstract »|Full Text »|PDF »
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151, 1598-1610
|Abstract »|Full Text »|PDF »
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|Abstract »|Full Text »|PDF »
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151, 702-713
|Abstract »|Full Text »|PDF »
Maternal and postweaning diet interaction alters hypothalamic gene expression and modulates response to a high-fat diet in male offspring.
K. C. Page, R. E. Malik, J. A. Ripple, and E. K. Anday (2009)
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297, R1049-R1057
|Abstract »|Full Text »|PDF »
The timing of "catch-up growth" affects metabolism and appetite regulation in male rats born with intrauterine growth restriction.
B. Coupe, I. Grit, D. Darmaun, and P. Parnet (2009)
Am J Physiol Regulatory Integrative Comp Physiol
297, R813-R824
|Abstract »|Full Text »|PDF »
Maternal nutritional history predicts obesity in adult offspring independent of postnatal diet.
M. H. Davenport and M. R. Cabrero (2009)
J. Physiol.
587, 3423-3424
|Full Text »|PDF »
Maternal obesity is necessary for programming effect of high-fat diet on offspring.
C. L. White, M. N. Purpera, and C. D. Morrison (2009)
Am J Physiol Regulatory Integrative Comp Physiol
296, R1464-R1472
|Abstract »|Full Text »|PDF »
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A. Gupta, M. Srinivasan, S. Thamadilok, and M. S Patel (2009)
J. Endocrinol.
200, 293-300
|Abstract »|Full Text »|PDF »
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K. W Williams, M. M Scott, and J. K Elmquist (2009)
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89, 985S-990S
|Abstract »|Full Text »|PDF »
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296, E462-E472
|Abstract »|Full Text »|PDF »
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E. C. Cottrell, R. L. Cripps, J. S. Duncan, P. Barrett, J. G. Mercer, A. Herwig, and S. E. Ozanne (2009)
Am J Physiol Regulatory Integrative Comp Physiol
296, R631-R639
|Abstract »|Full Text »|PDF »
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296, R537-R548
|Abstract »|Full Text »|PDF »
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G. J. Howie, D. M. Sloboda, T. Kamal, and M. H. Vickers (2009)
J. Physiol.
587, 905-915
|Abstract »|Full Text »|PDF »
Changes in satiety hormones and expression of genes involved in glucose and lipid metabolism in rats weaned onto diets high in fibre or protein reflect susceptibility to increased fat mass in adulthood.
A. D. Maurer, Q. Chen, C. McPherson, and R. A. Reimer (2009)
J. Physiol.
587, 679-691
|Abstract »|Full Text »|PDF »
Early Postnatal Nutrition Determines Somatotropic Function in Mice.
L. Kappeler, C. De Magalhaes Filho, P. Leneuve, J. Xu, N. Brunel, C. Chatziantoniou, Y. Le Bouc, and M. Holzenberger (2009)
Endocrinology
150, 314-323
|Abstract »|Full Text »|PDF »
Effect of high-fat diet during gestation, lactation, or postweaning on physiological and behavioral indexes in borderline hypertensive rats.
A. Mitra, K. M. Alvers, E. M. Crump, and N. E. Rowland (2009)
Am J Physiol Regulatory Integrative Comp Physiol
296, R20-R28
|Abstract »|Full Text »|PDF »
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L. Enthoven, M. S. Oitzl, N. Koning, M. van der Mark, and E. R. de Kloet (2008)
Endocrinology
149, 6366-6377
|Abstract »|Full Text »|PDF »
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Y.-C. L. Tung, M. Ma, S. Piper, A. Coll, S. O'Rahilly, and G. S. H. Yeo (2008)
J. Neurosci.
28, 12419-12426
|Abstract »|Full Text »|PDF »
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D. R. Grattan (2008)
Endocrinology
149, 5345-5347
|Full Text »|PDF »
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E. Velkoska, T. J. Cole, R. G. Dean, L. M. Burrell, and M. J. Morris (2008)
J. Nutr.
138, 1622-1627
|Abstract »|Full Text »|PDF »
Hyperghrelinemia Precedes Obesity in Prader-Willi Syndrome.
E. Feigerlova, G. Diene, F. Conte-Auriol, C. Molinas, I. Gennero, J.-P. Salles, C. Arnaud, and M. Tauber (2008)
J. Clin. Endocrinol. Metab.
93, 2800-2805
|Abstract »|Full Text »|PDF »
A high-carbohydrate diet in the immediate postnatal life of rats induces adaptations predisposing to adult-onset obesity.
M. Srinivasan, P. Mitrani, G. Sadhanandan, C. Dodds, S. Shbeir-ElDika, S. Thamotharan, H. Ghanim, P. Dandona, S. U Devaskar, and M. S Patel (2008)
J. Endocrinol.
197, 565-574
|Abstract »|Full Text »|PDF »
Improved Lactational Nutrition and Postnatal Growth Ameliorates Impairment of Glucose Tolerance by Uteroplacental Insufficiency in Male Rat Offspring.
A. L. Siebel, A. Mibus, M. J. De Blasio, K. T. Westcott, M. J. Morris, L. Prior, J. A. Owens, and M. E. Wlodek (2008)
Endocrinology
149, 3067-3076
|Abstract »|Full Text »|PDF »
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M. H. Vickers, P. D. Gluckman, A. H. Coveny, P. L. Hofman, W. S. Cutfield, A. Gertler, B. H. Breier, and M. Harris (2008)
Endocrinology
149, 1906-1913
|Abstract »|Full Text »|PDF »
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G. Stratigopoulos, S. L. Padilla, C. A. LeDuc, E. Watson, A. T. Hattersley, M. I. McCarthy, L. M. Zeltser, W. K. Chung, and R. L. Leibel (2008)
Am J Physiol Regulatory Integrative Comp Physiol
294, R1185-R1196
|Abstract »|Full Text »|PDF »
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S. G. Bouret (2008)
Endocrinology
149, 875-876
|Full Text »|PDF »
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F. Delahaye, C. Breton, P.-Y. Risold, M. Enache, I. Dutriez-Casteloot, C. Laborie, J. Lesage, and D. Vieau (2008)
Endocrinology
149, 470-475
|Abstract »|Full Text »|PDF »
Oral Supplementation with Physiological Doses of Leptin During Lactation in Rats Improves Insulin Sensitivity and Affects Food Preferences Later in Life.
J. Sanchez, T. Priego, M. Palou, A. Tobaruela, A. Palou, and C. Pico (2008)
Endocrinology
149, 733-740
|Abstract »|Full Text »|PDF »
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C. M. Patterson, A. A. Dunn-Meynell, and B. E. Levin (2008)
Am J Physiol Regulatory Integrative Comp Physiol
294, R290-R301
|Abstract »|Full Text »|PDF »
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Z. Guo, H. Jiang, X. Xu, W. Duan, and M. P. Mattson (2008)
J. Biol. Chem.
283, 1754-1763
|Abstract »|Full Text »|PDF »
Low expression of insulin signaling molecules impairs glucose uptake in adipocytes after early overnutrition.
A. L Rodrigues, E. P G De Souza, S. V Da Silva, D. S B Rodrigues, A. B Nascimento, C. Barja-Fidalgo, and M. S De Freitas (2007)
J. Endocrinol.
195, 485-494
|Abstract »|Full Text »|PDF »
Leptin Sensitivity in the Developing Rat Hypothalamus.
A.-S. Carlo, M. Pyrski, C. Loudes, A. Faivre-Baumann, J. Epelbaum, L. M. Williams, and W. Meyerhof (2007)
Endocrinology
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|Abstract »|Full Text »|PDF »
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|Abstract »|Full Text »|PDF »
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|Abstract »|Full Text »|PDF »
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|Abstract »|Full Text »|PDF »
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293, R581-R589
|Abstract »|Full Text »|PDF »
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148, 2251-2263
|Abstract »|Full Text »|PDF »
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C. J. Stocker, E. Wargent, J. O'Dowd, C. Cornick, J. R. Speakman, J. R. S. Arch, and M. A. Cawthorne (2007)
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292, R1810-R1818
|Abstract »|Full Text »|PDF »
Neonatal hyperleptinaemia programmes adrenal medullary function in adult rats: effects on cardiovascular parameters.
I. H. Trevenzoli, M. M. R. Valle, F. B. Machado, R. M. G. Garcia, M. C. F. Passos, P. C. Lisboa, and E. G. Moura (2007)
J. Physiol.
580, 629-637
|Abstract »|Full Text »|PDF »
Small for Gestational Age: Short Stature and Beyond.
P. Saenger, P. Czernichow, I. Hughes, and E. O. Reiter (2007)
Endocr. Rev.
28, 219-251
|Abstract »|Full Text »|PDF »
Determinants of Early Life Leptin Levels and Later Life Degenerative Outcomes.
D.-M. Alexe, G. Syridou, and E. Th. Petridou (2006)
Clin. Med. Res.
4, 326-335
|Abstract »|Full Text »|PDF »
Hyperphagia, Severe Obesity, Impaired Cognitive Function, and Hyperactivity Associated With Functional Loss of One Copy of the Brain-Derived Neurotrophic Factor (BDNF) Gene.
J. Gray, G. S.H. Yeo, J. J. Cox, J. Morton, A.-L. R. Adlam, J. M. Keogh, J. A. Yanovski, A. El Gharbawy, J. C. Han, Y.C. L. Tung, et al. (2006)
Diabetes
55, 3366-3371
|Abstract »|Full Text »|PDF »
Peripherally administered desacetyl {alpha}-MSH and {alpha}-MSH both influence postnatal rat growth and associated rat hypothalamic protein expression.
C.-S. J. Wu, D. R. Greenwood, J. M. Cooney, D. J. Jensen, M. A. Tatnell, G. J. S. Cooper, and K. G. Mountjoy (2006)
Am J Physiol Endocrinol Metab
291, E1372-E1380
|Abstract »|Full Text »|PDF »
Brain Adipocytokine Action and Metabolic Regulation.
R. S. Ahima, Y. Qi, N. S. Singhal, M. B. Jackson, and P. E. Scherer (2006)
Diabetes
55, S145-S154
|Abstract »|Full Text »|PDF »
Assessment and mechanism of variations in pubertal timing in internationally adopted children: a developmental hypothesis.
F Domine, A-S Parent, G Rasier, M-C Lebrethon, and J-P Bourguignon (2006)
Eur. J. Endocrinol.
155, S17-S25
|Abstract »|Full Text »|PDF »
Postnatal environment overrides genetic and prenatal factors influencing offspring obesity and insulin resistance.
J. N. Gorski, A. A. Dunn-Meynell, T. G. Hartman, and B. E. Levin (2006)
Am J Physiol Regulatory Integrative Comp Physiol
291, R768-R778
|Abstract »|Full Text »|PDF »
Metabolic imprinting: critical impact of the perinatal environment on the regulation of energy homeostasis.
