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Science 304 (5671): 743-746

Copyright © 2004 by the American Association for the Advancement of Science

Cofilin Promotes Actin Polymerization and Defines the Direction of Cell Motility

Mousumi Ghosh,1 Xiaoyan Song,1 Ghassan Mouneimne,1 Mazen Sidani,1 David S. Lawrence,2 John S. Condeelis1*

Abstract: A general caging method for proteins that are regulated by phosphorylation was used to study the in vivo biochemical action of cofilin and the subsequent cellular response. By acute and local activation of a chemically engineered, light-sensitive phosphocofilin mimic, we demonstrate that cofilin polymerizes actin, generates protrusions, and determines the direction of cell migration. We propose a role for cofilin that is distinct from its role as an actin-depolymerizing factor.

1 Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA.
2 Department of Biochemistry, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA.

* To whom correspondence should be addressed. E-mail: condeeli{at}

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Rapid actin monomer-insensitive depolymerization of Listeria actin comet tails by cofilin, coronin, and Aip1.
W. M. Brieher, H. Y. Kueh, B. A. Ballif, and T. J. Mitchison (2006)
J. Cell Biol. 175, 315-324
   Abstract »    Full Text »    PDF »
Prohibitin and Cofilin Are Intracellular Effectors of Transforming Growth Factor {beta} Signaling in Human Prostate Cancer Cells..
B. Zhu, K. Fukada, H. Zhu, and N. Kyprianou (2006)
Cancer Res. 66, 8640-8647
   Abstract »    Full Text »    PDF »
Oscillatory Increases in Alkalinity Anticipate Growth and May Regulate Actin Dynamics in Pollen Tubes of Lily.
A. Lovy-Wheeler, J. G. Kunkel, E. G. Allwood, P. J. Hussey, and P. K. Hepler (2006)
PLANT CELL 18, 2182-2193
   Abstract »    Full Text »    PDF »
Glia Maturation Factor-{gamma} Is Preferentially Expressed in Microvascular Endothelial and Inflammatory Cells and Modulates Actin Cytoskeleton Reorganization.
K. Ikeda, R. K. Kundu, S. Ikeda, M. Kobara, H. Matsubara, and T. Quertermous (2006)
Circ. Res. 99, 424-433
   Abstract »    Full Text »    PDF »
Initiation of cofilin activity in response to EGF is uncoupled from cofilin phosphorylation and dephosphorylation in carcinoma cells.
X. Song, X. Chen, H. Yamaguchi, G. Mouneimne, J. S. Condeelis, and R. J. Eddy (2006)
J. Cell Sci. 119, 2871-2881
   Abstract »    Full Text »    PDF »
The activity status of cofilin is directly related to invasion, intravasation, and metastasis of mammary tumors.
W. Wang, G. Mouneimne, M. Sidani, J. Wyckoff, X. Chen, A. Makris, S. Goswami, A. R. Bresnick, and J. S. Condeelis (2006)
J. Cell Biol. 173, 395-404
   Abstract »    Full Text »    PDF »
Enhancement of Actin-depolymerizing Factor/Cofilin-dependent Actin Disassembly by Actin-interacting Protein 1 Is Required for Organized Actin Filament Assembly in the Caenorhabditis elegans Body Wall Muscle.
K. Mohri, K. Ono, R. Yu, S. Yamashiro, and S. Ono (2006)
Mol. Biol. Cell 17, 2190-2199
   Abstract »    Full Text »    PDF »
Rho GEF Lsc is required for normal polarization, migration, and adhesion of formyl-peptide-stimulated neutrophils.
S. A. Francis, X. Shen, J. B. Young, P. Kaul, and D. J. Lerner (2006)
Blood 107, 1627-1635
   Abstract »    Full Text »    PDF »
Cocaine Increases Actin Cycling: Effects in the Reinstatement Model of Drug Seeking.
S. Toda, H.-W. Shen, J. Peters, S. Cagle, and P. W. Kalivas (2006)
J. Neurosci. 26, 1579-1587
   Abstract »    Full Text »    PDF »
Regulation of LIM-kinase 1 and cofilin in thrombin-stimulated platelets.
D. Pandey, P. Goyal, J. R. Bamburg, and W. Siess (2006)
Blood 107, 575-583
   Abstract »    Full Text »    PDF »
Proteomic Analysis Reveals Changes in the Liver Protein Pattern of Rats Exposed to Dietary Folate Deficiency.
A. Chanson, T. Sayd, E. Rock, C. Chambon, V. Sante-Lhoutellier, G. Potier de Courcy, and P. Brachet (2005)
J. Nutr. 135, 2524-2529
   Abstract »    Full Text »    PDF »
Spatial and temporal regulation of cofilin activity by LIM kinase and Slingshot is critical for directional cell migration.
M. Nishita, C. Tomizawa, M. Yamamoto, Y. Horita, K. Ohashi, and K. Mizuno (2005)
J. Cell Biol. 171, 349-359
   Abstract »    Full Text »    PDF »

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