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Science 304 (5672): 839-843

Copyright © 2004 by the American Association for the Advancement of Science

Independent Cellular Processes for Hippocampal Memory Consolidation and Reconsolidation

Jonathan L. C. Lee, Barry J. Everitt, Kerrie L. Thomas*{dagger}

Abstract: The idea that new memories undergo a time-dependent consolidation process after acquisition has received considerable experimental support. More controversial has been the demonstration that established memories, once recalled, become labile and sensitive to disruption, requiring "reconsolidation" to become permanent. By infusing antisense oligodeoxynucleotides into the hippocampus of rats, we show that consolidation and reconsolidation are doubly dissociable component processes of memory. Consolidation involves brain-derived neurotrophic factor (BDNF) but not the transcription factor Zif268, whereas reconsolidation recruits Zif268 but not BDNF. These findings confirm a requirement for BDNF specifically in memory consolidation and also resolve the role of Zif268 in brain plasticity, learning, and memory.

Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge CB2 3EB, UK.

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* Present address: Cardiff School of Biosciences, Cardiff University, Cardiff CF10 3US, UK.

{dagger} To whom correspondence should be addressed. E-mail: thomaskl5{at}

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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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C. A. J. Stern, L. Gazarini, A. C. Vanvossen, M. S. Hames, and L. J. Bertoglio (2014)
Learn. Mem. 21, 14-20
   Abstract »    Full Text »    PDF »
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Z. Penke, E. Morice, A. Veyrac, A. Gros, C. Chagneau, P. LeBlanc, N. Samson, K. Baumgartel, I. M. Mansuy, S. Davis, et al. (2013)
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   Abstract »    Full Text »    PDF »
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D. Carlino, M. De Vanna, and E. Tongiorgi (2013)
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   Abstract »    Full Text »    PDF »
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R. O. Sierra, L. F. Cassini, F. Santana, A. P. Crestani, J. M. Duran, J. Haubrich, L. de Oliveira Alvares, and J. A. Quillfeldt (2013)
Learn. Mem. 20, 379-387
   Abstract »    Full Text »    PDF »
Zif268/egr1 gene controls the selection, maturation and functional integration of adult hippocampal newborn neurons by learning.
A. Veyrac, A. Gros, E. Bruel-Jungerman, C. Rochefort, F. B. Kleine Borgmann, S. Jessberger, and S. Laroche (2013)
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   Abstract »    Full Text »    PDF »
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M. Giachero, S. G. Bustos, G. Calfa, and V. A. Molina (2013)
Learn. Mem. 20, 245-255
   Abstract »    Full Text »    PDF »
Enhanced noradrenergic activity potentiates fear memory consolidation and reconsolidation by differentially recruiting {alpha}1- and {beta}-adrenergic receptors.
L. Gazarini, C. A. J. Stern, A. P. Carobrez, and L. J. Bertoglio (2013)
Learn. Mem. 20, 210-219
   Abstract »    Full Text »    PDF »
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S. Datta and M. W. O'Malley (2013)
J. Neurosci. 33, 4561-4569
   Abstract »    Full Text »    PDF »
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M. J. Sekeres, V. Mercaldo, B. Richards, D. Sargin, V. Mahadevan, M. A. Woodin, P. W. Frankland, and S. A. Josselyn (2012)
J. Neurosci. 32, 17857-17868
   Abstract »    Full Text »    PDF »
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W. Wei, C. M. Coelho, X. Li, R. Marek, S. Yan, S. Anderson, D. Meyers, C. Mukherjee, G. Sbardella, S. Castellano, et al. (2012)
J. Neurosci. 32, 11930-11941
   Abstract »    Full Text »    PDF »
Asymmetrical roles of zinc fingers in dynamic DNA-scanning process by the inducible transcription factor Egr-1.
L. Zandarashvili, D. Vuzman, A. Esadze, Y. Takayama, D. Sahu, Y. Levy, and J. Iwahara (2012)
PNAS 109, E1724-E1732
   Abstract »    Full Text »    PDF »
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T. J. Jarome, J. L. Kwapis, C. T. Werner, R. G. Parsons, G. M. Gafford, and F. J. Helmstetter (2012)
Learn. Mem. 19, 300-306
   Abstract »    Full Text »    PDF »
Wiping Drug Memories.
A. L. Milton and B. J. Everitt (2012)
Science 336, 167-168
   Abstract »    Full Text »    PDF »
Time-Limited Consolidation and Task Interference: No Direct Link.
M. Been, B. Jans, and P. De Weerd (2011)
J. Neurosci. 31, 14944-14951
   Abstract »    Full Text »    PDF »
Extinction after retrieval: Effects on the associative and nonassociative components of remote contextual fear memory.
M. Costanzi, S. Cannas, D. Saraulli, C. Rossi-Arnaud, and V. Cestari (2011)
Learn. Mem. 18, 508-518
   Abstract »    Full Text »    PDF »
Persistent Long-Term Synaptic Plasticity Requires Activation of a New Signaling Pathway by Additional Stimuli.
J.-Y. Hu, O. Baussi, A. Levine, Y. Chen, and S. Schacher (2011)
J. Neurosci. 31, 8841-8850
   Abstract »    Full Text »    PDF »
Reconsolidation or Extinction: Transcription Factor Switch in the Determination of Memory Course after Retrieval.
V. de la Fuente, R. Freudenthal, and A. Romano (2011)
J. Neurosci. 31, 5562-5573
   Abstract »    Full Text »    PDF »
Repeatedly reactivated memories become more resistant to hippocampal damage.
H. Lehmann and K. C. McNamara (2011)
Learn. Mem. 18, 132-135
   Abstract »    Full Text »    PDF »
Region-Specific Involvement of BDNF Secretion and Synthesis in Conditioned Taste Aversion Memory Formation.
L. Ma, D.-D. Wang, T.-Y. Zhang, H. Yu, Y. Wang, S.-H. Huang, F. S. Lee, and Z.-Y. Chen (2011)
J. Neurosci. 31, 2079-2090
   Abstract »    Full Text »    PDF »
Early growth response gene 1 (Egr-1) is required for new and reactivated fear memories in the lateral amygdala.
S. A. Maddox, M. S. Monsey, and G. E. Schafe (2010)
Learn. Mem. 18, 24-38
   Abstract »    Full Text »    PDF »
The exclusive induction of extinction is gated by BDNF.
A. Kirtley and K. L. Thomas (2010)
Learn. Mem. 17, 612-619
   Abstract »    Full Text »    PDF »
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F. R. M. Theberge, A. L. Milton, D. Belin, J. L. C. Lee, and B. J. Everitt (2010)
Learn. Mem. 17, 444-453
   Abstract »    Full Text »    PDF »
A brief retraining regulates the persistence and lability of a long-term memory.
D. Levitan, R. Twitto, R. Levy, L. C. Lyons, and A. J. Susswein (2010)
Learn. Mem. 17, 402-406
   Abstract »    Full Text »    PDF »
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J. Kim, B. Song, I. Hong, J. Kim, J. Lee, S. Park, J. Yong Eom, C. J. Lee, S. Lee, and S. Choi (2010)
J. Neurosci. 30, 9631-9640
   Abstract »    Full Text »    PDF »
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F. Peng, H. Yao, X. Bai, X. Zhu, B. C. Reiner, M. Beazely, K. Funa, H. Xiong, and S. Buch (2010)
J. Biol. Chem. 285, 21615-21624
   Abstract »    Full Text »    PDF »
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H. Ageta, S. Ikegami, M. Miura, M. Masuda, R. Migishima, T. Hino, N. Takashima, A. Murayama, H. Sugino, M. Setou, et al. (2010)
Learn. Mem. 17, 176-185
   Abstract »    Full Text »    PDF »
Plastic modifications induced by object recognition memory processing.
J. R. Clarke, M. Cammarota, A. Gruart, I. Izquierdo, and J. M. Delgado-Garcia (2010)
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   Abstract »    Full Text »    PDF »
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P. Outka (2009)
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   Abstract »    PDF »
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R. E. Bernardi, A. E. Ryabinin, S. P. Berger, and K. M. Lattal (2009)
Learn. Mem. 16, 777-789
   Abstract »    Full Text »    PDF »
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B. D. Winters, M. C. Tucci, and M. DaCosta-Furtado (2009)
Learn. Mem. 16, 545-553
   Abstract »    Full Text »    PDF »
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P. Garcia-DeLaTorre, C. J. Rodriguez-Ortiz, J. L. Arreguin-Martinez, P. Cruz-Castaneda, and F. Bermudez-Rattoni (2009)
Learn. Mem. 16, 514-519
   Abstract »    Full Text »    PDF »
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J. M. Stafford and K. M. Lattal (2009)
Learn. Mem. 16, 494-503
   Abstract »    Full Text »    PDF »
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Y. Dudai (2009)
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   Abstract »    Full Text »    PDF »
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J. L.C. Lee, R. J. Gardner, V. J. Butler, and B. J. Everitt (2009)
Learn. Mem. 16, 82-85
   Abstract »    Full Text »    PDF »
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S. Duvarci, K. Nader, and J. E. LeDoux (2008)
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   Abstract »    Full Text »    PDF »
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Learn. Mem. 15, 643-648
   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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K. Hefner, N. Whittle, J. Juhasz, M. Norcross, R.-M. Karlsson, L. M. Saksida, T. J. Bussey, N. Singewald, and A. Holmes (2008)
J. Neurosci. 28, 8074-8085
   Abstract »    Full Text »    PDF »
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A. Hupbach, O. Hardt, R. Gomez, and L. Nadel (2008)
Learn. Mem. 15, 574-579
   Abstract »    Full Text »    PDF »
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N. Lasry, E. Levy, and J. Tremblay (2008)
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   Full Text »    PDF »
Activation of LVGCCs and CB1 receptors required for destabilization of reactivated contextual fear memories.
A. Suzuki, T. Mukawa, A. Tsukagoshi, P. W. Frankland, and S. Kida (2008)
Learn. Mem. 15, 426-433
   Abstract »    Full Text »    PDF »
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P. Bekinschtein, M. Cammarota, I. Izquierdo, and J. H. Medina (2008)
Neuroscientist 14, 147-156
   Abstract »    PDF »
Activation of Trk neurotrophin receptors by glucocorticoids provides a neuroprotective effect.
F. Jeanneteau, M. J. Garabedian, and M. V. Chao (2008)
PNAS 105, 4862-4867
   Abstract »    Full Text »    PDF »
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P. Bekinschtein, M. Cammarota, C. Katche, L. Slipczuk, J. I. Rossato, A. Goldin, I. Izquierdo, and J. H. Medina (2008)
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   Abstract »    Full Text »    PDF »
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M. Boccia, R. Freudenthal, M. Blake, V. de la Fuente, G. Acosta, C. Baratti, and A. Romano (2007)
J. Neurosci. 27, 13436-13445
   Abstract »    Full Text »    PDF »
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E. Bruel-Jungerman, S. Davis, and S. Laroche (2007)
Neuroscientist 13, 492-505
   Abstract »    PDF »
Transcriptional Regulation of Brain-Derived Neurotrophic Factor in the Amygdala during Consolidation of Fear Memory.
L.-C. Ou and P.-W. Gean (2007)
Mol. Pharmacol. 72, 350-358
   Abstract »    Full Text »    PDF »
Temporal requirement of C/EBP{beta} in the amygdala following reactivation but not acquisition of inhibitory avoidance.
M. H. Milekic, G. Pollonini, and C. M. Alberini (2007)
Learn. Mem. 14, 504-511
   Abstract »    Full Text »    PDF »
Role of matrix metalloproteinases in the acquisition and reconsolidation of cocaine-induced conditioned place preference.
T. E. Brown, M. R. Forquer, D. L. Cocking, H. T. Jansen, J. W. Harding, and B. A. Sorg (2007)
Learn. Mem. 14, 214-223
   Abstract »    Full Text »    PDF »
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S. Simo, L. Pujadas, M. F. Segura, A. L. Torre, J. A. Del Rio, J. M. Urena, J. X. Comella, and E. Soriano (2007)
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   Abstract »    Full Text »    PDF »
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J. I. Rossato, L. R.M. Bevilaqua, J. C. Myskiw, J. H. Medina, I. Izquierdo, and M. Cammarota (2007)
Learn. Mem. 14, 36-46
   Abstract »    Full Text »    PDF »
Translational Control via the Mammalian Target of Rapamycin Pathway Is Critical for the Formation and Stability of Long-Term Fear Memory in Amygdala Neurons.
R. G. Parsons, G. M. Gafford, and F. J. Helmstetter (2006)
J. Neurosci. 26, 12977-12983
   Abstract »    Full Text »    PDF »
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K. G. C. Hellemans, B. J. Everitt, and J. L. C. Lee (2006)
J. Neurosci. 26, 12694-12699
   Abstract »    Full Text »    PDF »
Ca2+/Calmodulin Kinase Kinase {alpha} Is Dispensable for Brain Development but Is Required for Distinct Memories in Male, though Not in Female, Mice.
K. Mizuno, L. Ris, A. Sanchez-Capelo, E. Godaux, and K. P. Giese (2006)
Mol. Cell. Biol. 26, 9094-9104
   Abstract »    Full Text »    PDF »
Long-Term Memory Deficits in Pavlovian Fear Conditioning in Ca2+/Calmodulin Kinase Kinase {alpha}-Deficient Mice.
F. Blaeser, M. J. Sanders, N. Truong, S. Ko, L. J. Wu, D. F. Wozniak, M. S. Fanselow, M. Zhuo, and T. A. Chatila (2006)
Mol. Cell. Biol. 26, 9105-9115
   Abstract »    Full Text »    PDF »
Cognitive enhancement with central thalamic electrical stimulation.
P. Shirvalkar, M. Seth, N. D. Schiff, and D. G. Herrera (2006)
PNAS 103, 17007-17012
   Abstract »    Full Text »    PDF »
Reconsolidation and Extinction of Conditioned Fear: Inhibition and Potentiation.
J. L. C. Lee, A. L. Milton, and B. J. Everitt (2006)
J. Neurosci. 26, 10051-10056
   Abstract »    Full Text »    PDF »
Postreactivation glucocorticoids impair recall of established fear memory..
W.-H. Cai, J. Blundell, J. Han, R. W. Greene, and C. M. Powell (2006)
J. Neurosci. 26, 9560-9566
   Abstract »    Full Text »    PDF »
Retrieval failure versus memory loss in experimental amnesia: Definitions and processes..
R. R. Miller and L. D. Matzel (2006)
Learn. Mem. 13, 491-497
   Abstract »    Full Text »    PDF »
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C. A. Miller and J. D. Sweatt (2006)
Learn. Mem. 13, 498-505
   Abstract »    Full Text »    PDF »
In memory of consolidation..
S. J. Sara and B. Hars (2006)
Learn. Mem. 13, 515-521
   Full Text »    PDF »
Fading in..
K. Nader and S.-H. Wang (2006)
Learn. Mem. 13, 530-535
   Abstract »    Full Text »    PDF »
Reconsolidation: A brief history, a retrieval view, and some recent issues..
D. C. Riccio, P. M. Millin, and A. R. Bogart (2006)
Learn. Mem. 13, 536-544
   Abstract »    Full Text »    PDF »
A meeting to remember: Meeting on Memory and Related Disorders.
G. P. Gasic, A. Barco, J. Avila, and J. Lerma (2006)
EMBO Rep. 7, 768-773
   Full Text »    PDF »
Aversive memory reactivation engages in the amygdala only some neurotransmitters involved in consolidation.
C. Bucherelli, E. Baldi, C. Mariottini, M. B. Passani, and P. Blandina (2006)
Learn. Mem. 13, 426-430
   Abstract »    Full Text »    PDF »
Retrieval induces hippocampal-dependent reconsolidation of spatial memory.
J. I. Rossato, L. R.M. Bevilaqua, J. H. Medina, I. Izquierdo, and M. Cammarota (2006)
Learn. Mem. 13, 431-440
   Abstract »    Full Text »    PDF »
Stability of recent and remote contextual fear memory.
P. W. Frankland, H.-K. Ding, E. Takahashi, A. Suzuki, S. Kida, and A. J. Silva (2006)
Learn. Mem. 13, 451-457
   Abstract »    Full Text »    PDF »
Understanding Consolidation through the Architecture of Memories.
E. M. Robertson and D. A. Cohen (2006)
Neuroscientist 12, 261-271
   Abstract »    PDF »
Lessons From a Crab: Molecular Mechanisms in Different Memory Phases of Chasmagnathus.
A. Romano, F. Locatelli, R. Freudenthal, E. Merlo, M. Feld, P. Ariel, D. Lemos, N. Federman, and M. S. Fustinana (2006)
Biol. Bull. 210, 280-288
   Abstract »    Full Text »    PDF »
Cue-induced cocaine seeking and relapse are reduced by disruption of drug memory reconsolidation..
J. L. C. Lee, A. L. Milton, and B. J. Everitt (2006)
J. Neurosci. 26, 5881-5887
   Abstract »    Full Text »    PDF »
An inhibitor of DNA recombination blocks memory consolidation, but not reconsolidation, in context fear conditioning..
M. Colon-Cesario, J. Wang, X. Ramos, H. G. Garcia, J. J. Davila, J. Laguna, C. Rosado, and S. Pena de Ortiz (2006)
J. Neurosci. 26, 5524-5533
   Abstract »    Full Text »    PDF »
Plasticity-associated gene Krox24/Zif268 is required for long-lasting behavioral effects of cocaine..
E. Valjent, B. Aubier, A.-G. Corbille, K. Brami-Cherrier, J. Caboche, P. Topilko, J.-A. Girault, and D. Herve (2006)
J. Neurosci. 26, 4956-4960
   Abstract »    Full Text »    PDF »
Post-retrieval effects of icv infusions of hemicholinium in mice are dependent on the age of the original memory..
M. M. Boccia, M. G. Blake, G. B. Acosta, and C. M. Baratti (2006)
Learn. Mem. 13, 376-381
   Abstract »    Full Text »    PDF »
Directly reactivated, but not indirectly reactivated, memories undergo reconsolidation in the amygdala.
J. Debiec, V. Doyere, K. Nader, and J. E. LeDoux (2006)
PNAS 103, 3428-3433
   Abstract »    Full Text »    PDF »
Inhibition of ERK pathway or protein synthesis during reexposure to drugs of abuse erases previously learned place preference.
E. Valjent, A.-G. Corbille, J. Bertran-Gonzalez, D. Herve, and J.-A. Girault (2006)
PNAS 103, 2932-2937
   Abstract »    Full Text »    PDF »
Amygdala Regulation of Immediate-Early Gene Expression in the Hippocampus Induced by Contextual Fear Conditioning.
N. C. Huff, M. Frank, K. Wright-Hardesty, D. Sprunger, P. Matus-Amat, E. Higgins, and J. W. Rudy (2006)
J. Neurosci. 26, 1616-1623
   Abstract »    Full Text »    PDF »
Anisomycin infused into the hippocampus fails to block "reconsolidation" but impairs extinction: The role of re-exposure duration.
A. E. Power, D. J. Berlau, J. L. McGaugh, and O. Steward (2006)
Learn. Mem. 13, 27-34
   Abstract »    Full Text »    PDF »
The Neuroplasticity-Associated Arc Gene Is a Direct Transcriptional Target of Early Growth Response (Egr) Transcription Factors.
L. Li, J. Carter, X. Gao, J. Whitehead, and W. G. Tourtellotte (2005)
Mol. Cell. Biol. 25, 10286-10300
   Abstract »    Full Text »    PDF »
Recalling an aversive experience by day-old chicks is not dependent on somatic protein synthesis.
R. Mileusnic, C. L. Lancashire, and S. P.R. Rose (2005)
Learn. Mem. 12, 615-619
   Abstract »    Full Text »    PDF »
Protein synthesis underlies post-retrieval memory consolidation to a restricted degree only when updated information is obtained.
C. J. Rodriguez-Ortiz, V. De la Cruz, R. Gutierrez, and F. Bermudez-Rattoni (2005)
Learn. Mem. 12, 533-537
   Abstract »    Full Text »    PDF »
Expression of the immediate-early gene-encoded protein Egr-1 (zif268) during in vitro classical conditioning.
M. Mokin and J. Keifer (2005)
Learn. Mem. 12, 144-149
   Abstract »    Full Text »    PDF »
Memory Reconsolidation Engages Only a Subset of Immediate-Early Genes Induced during Consolidation.
L. S. J. von Hertzen and K. P. Giese (2005)
J. Neurosci. 25, 1935-1942
   Abstract »    Full Text »    PDF »
Acquisition, Consolidation, Reconsolidation, and Extinction of Eyelid Conditioning Responses Require De Novo Protein Synthesis.
M. C. Inda, J. M. Delgado-Garcia, and A. M. Carrion (2005)
J. Neurosci. 25, 2070-2080
   Abstract »    Full Text »    PDF »
Consolidation and Reconsolidation of Incentive Learning in the Amygdala.
S.-H. Wang, S. B. Ostlund, K. Nader, and B. W. Balleine (2005)
J. Neurosci. 25, 830-835
   Abstract »    Full Text »    PDF »
Activation of the transcription factor NF-{kappa}B by retrieval is required for long-term memory reconsolidation.
E. Merlo, R. Freudenthal, H. Maldonado, and A. Romano (2005)
Learn. Mem. 12, 23-29
   Abstract »    Full Text »    PDF »
Memory Consolidation and Reconsolidation in the Rat Pup Require Protein Synthesis.
N. Gruest, P. Richer, and B. Hars (2004)
J. Neurosci. 24, 10488-10492
   Abstract »    Full Text »    PDF »
The Brain-Derived Neurotrophic Factor val66met Polymorphism and Variation in Human Cortical Morphology.
L. Pezawas, B. A. Verchinski, V. S. Mattay, J. H. Callicott, B. S. Kolachana, R. E. Straub, M. F. Egan, A. Meyer-Lindenberg, and D. R. Weinberger (2004)
J. Neurosci. 24, 10099-10102
   Abstract »    Full Text »    PDF »
Brain-Derived Neurotrophic Factor Plays a Critical Role in Contextual Fear Conditioning.
I. Y.C. Liu, W. E. Lyons, L. A. Mamounas, and R. F. Thompson (2004)
J. Neurosci. 24, 7958-7963
   Abstract »    Full Text »    PDF »
An egr-1 (zif268) Antisense Oligodeoxynucleotide Infused Into the Amygdala Disrupts Fear Conditioning.
S. Malkani, K. J. Wallace, M. P. Donley, and J. B. Rosen (2004)
Learn. Mem. 11, 617-624
   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »

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