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Science 304 (5672): 839-843

Copyright © 2004 by the American Association for the Advancement of Science

Independent Cellular Processes for Hippocampal Memory Consolidation and Reconsolidation

Jonathan L. C. Lee, Barry J. Everitt, Kerrie L. Thomas*{dagger}

Abstract: The idea that new memories undergo a time-dependent consolidation process after acquisition has received considerable experimental support. More controversial has been the demonstration that established memories, once recalled, become labile and sensitive to disruption, requiring "reconsolidation" to become permanent. By infusing antisense oligodeoxynucleotides into the hippocampus of rats, we show that consolidation and reconsolidation are doubly dissociable component processes of memory. Consolidation involves brain-derived neurotrophic factor (BDNF) but not the transcription factor Zif268, whereas reconsolidation recruits Zif268 but not BDNF. These findings confirm a requirement for BDNF specifically in memory consolidation and also resolve the role of Zif268 in brain plasticity, learning, and memory.

Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge CB2 3EB, UK.

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* Present address: Cardiff School of Biosciences, Cardiff University, Cardiff CF10 3US, UK.

{dagger} To whom correspondence should be addressed. E-mail: thomaskl5{at}cf.ac.uk


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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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J. I. Rossato, L. R.M. Bevilaqua, J. C. Myskiw, J. H. Medina, I. Izquierdo, and M. Cammarota (2007)
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    PDF »
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A. Romano, F. Locatelli, R. Freudenthal, E. Merlo, M. Feld, P. Ariel, D. Lemos, N. Federman, and M. S. Fustinana (2006)
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   Abstract »    Full Text »    PDF »
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E. Valjent, B. Aubier, A.-G. Corbille, K. Brami-Cherrier, J. Caboche, P. Topilko, J.-A. Girault, and D. Herve (2006)
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   Abstract »    Full Text »    PDF »
Post-retrieval effects of icv infusions of hemicholinium in mice are dependent on the age of the original memory..
M. M. Boccia, M. G. Blake, G. B. Acosta, and C. M. Baratti (2006)
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   Abstract »    Full Text »    PDF »
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Inhibition of ERK pathway or protein synthesis during reexposure to drugs of abuse erases previously learned place preference.
E. Valjent, A.-G. Corbille, J. Bertran-Gonzalez, D. Herve, and J.-A. Girault (2006)
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   Abstract »    Full Text »    PDF »
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N. C. Huff, M. Frank, K. Wright-Hardesty, D. Sprunger, P. Matus-Amat, E. Higgins, and J. W. Rudy (2006)
J. Neurosci. 26, 1616-1623
   Abstract »    Full Text »    PDF »
Anisomycin infused into the hippocampus fails to block "reconsolidation" but impairs extinction: The role of re-exposure duration.
A. E. Power, D. J. Berlau, J. L. McGaugh, and O. Steward (2006)
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   Abstract »    Full Text »    PDF »
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L. Li, J. Carter, X. Gao, J. Whitehead, and W. G. Tourtellotte (2005)
Mol. Cell. Biol. 25, 10286-10300
   Abstract »    Full Text »    PDF »
Recalling an aversive experience by day-old chicks is not dependent on somatic protein synthesis.
R. Mileusnic, C. L. Lancashire, and S. P.R. Rose (2005)
Learn. Mem. 12, 615-619
   Abstract »    Full Text »    PDF »
Protein synthesis underlies post-retrieval memory consolidation to a restricted degree only when updated information is obtained.
C. J. Rodriguez-Ortiz, V. De la Cruz, R. Gutierrez, and F. Bermudez-Rattoni (2005)
Learn. Mem. 12, 533-537
   Abstract »    Full Text »    PDF »
Expression of the immediate-early gene-encoded protein Egr-1 (zif268) during in vitro classical conditioning.
M. Mokin and J. Keifer (2005)
Learn. Mem. 12, 144-149
   Abstract »    Full Text »    PDF »
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L. S. J. von Hertzen and K. P. Giese (2005)
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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S.-H. Wang, S. B. Ostlund, K. Nader, and B. W. Balleine (2005)
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