Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Logo for

Science 305 (5681): 205-208

Copyright © 2004 by the American Association for the Advancement of Science

Therapeutic Vaccines for Chronic Infections

Brigitte Autran,* Guislaine Carcelain, Béhazine Combadiere, Patrice Debre

Abstract: Therapeutic vaccines aim to prevent severe complications of a chronic infection by reinforcing host defenses when some immune control, albeit insufficient, can already be demonstrated and when a conventional antimicrobial therapy either is not available or has limited efficacy. We focus on the rationale and challenges behind this still controversial strategy and provide examples from three major chronic infectious diseases— human immunodeficiency virus, hepatitis B virus, and human papillomavirus—for which the efficacy of therapeutic vaccines is currently being evaluated.

Laboratoire d'Immunologie Cellulaire and INSERM Unit 543, Centre Hospitalier Universitaire Pitié-Salpétrière, Université Pierre et Marie Curie, 75013 Paris, France.

* To whom correspondence should be addressed. E-mail: brigitte.autran{at}

Therapeutic Vaccination Expands and Improves the Function of the HIV-Specific Memory T-Cell Repertoire.
J. P. Casazza, K. A. Bowman, S. Adzaku, E. C. Smith, M. E. Enama, R. T. Bailer, D. A. Price, E. Gostick, I. J. Gordon, D. R. Ambrozak, et al. (2013)
The Journal of Infectious Disease 207, 1829-1840
   Abstract »    Full Text »    PDF »
Postexposure Subunit Vaccination against Chronic Enteric Mycobacterial Infection in a Natural Host.
W. Santema, V. Rutten, R. Segers, J. Poot, S. Hensen, H. Heesterbeek, and A. Koets (2013)
Infect. Immun. 81, 1990-1995
   Abstract »    Full Text »    PDF »
Could Therapeutic Vaccination of Cytomegalovirus-Seropositive Persons Prevent Reinfection and Congenital Virus Transmission?.
M. R. Schleiss (2011)
The Journal of Infectious Disease 203, 1513-1516
   Full Text »    PDF »
Delipidated Retroviruses as Potential Autologous Therapeutic Vaccines--A Pilot Experiment.
M. Kitabwalla, A. A. Ansari, F. Villinger, H. Akeefe, A. P. Conner, A. E. Mayne, and J. E. K. Hildreth (2008)
Experimental Biology and Medicine 233, 732-740
   Abstract »    Full Text »    PDF »
IL-10 blockade facilitates DNA vaccine-induced T cell responses and enhances clearance of persistent virus infection.
D. G. Brooks, A. M. Lee, H. Elsaesser, D. B. McGavern, and M. B.A. Oldstone (2008)
J. Exp. Med. 205, 533-541
   Abstract »    Full Text »    PDF »
Therapeutic vaccination reduces HIV sequence variability.
D. Hoffmann, J. Seebach, A. Cosma, F. D. Goebel, K. Strimmer, H. M. Schatzl, and V. Erfle (2008)
FASEB J 22, 437-444
   Abstract »    Full Text »    PDF »
B Subunit of Shiga Toxin-Based Vaccines Synergize with {alpha}-Galactosylceramide to Break Tolerance against Self Antigen and Elicit Antiviral Immunity.
O. Adotevi, B. Vingert, L. Freyburger, P. Shrikant, Y.-C. Lone, F. Quintin-Colonna, N. Haicheur, M. Amessou, A. Herbelin, P. Langlade-Demoyen, et al. (2007)
J. Immunol. 179, 3371-3379
   Abstract »    Full Text »    PDF »
Virus-Specific Cellular Immune Correlates of Survival in Vaccinated Monkeys after Simian Immunodeficiency Virus Challenge.
Y. Sun, J. E. Schmitz, A. P. Buzby, B. R. Barker, S. S. Rao, L. Xu, Z.-y. Yang, J. R. Mascola, G. J. Nabel, and N. L. Letvin (2006)
J. Virol. 80, 10950-10956
   Abstract »    Full Text »    PDF »
Expansion and Diversification of Virus-Specific T Cells following Immunization of Human Immunodeficiency Virus Type 1 (HIV-1)-Infected Individuals with a Recombinant Modified Vaccinia Virus Ankara/HIV-1 Gag Vaccine.
L. Dorrell, H. Yang, B. Ondondo, T. Dong, K. di Gleria, A. Suttill, C. Conlon, D. Brown, P. Williams, P. Bowness, et al. (2006)
J. Virol. 80, 4705-4716
   Abstract »    Full Text »    PDF »
Optimization of Codon Usage Enhances the Immunogenicity of a DNA Vaccine Encoding Mycobacterial Antigen Ag85B.
H.-J. Ko, S.-Y. Ko, Y.-J. Kim, E.-G. Lee, S.-N. Cho, and C.-Y. Kang (2005)
Infect. Immun. 73, 5666-5674
   Abstract »    Full Text »    PDF »
Low CD8 T-Cell Proliferative Potential and High Viral Load Limit the Effectiveness of Therapeutic Vaccination.
E. J. Wherry, J. N. Blattman, and R. Ahmed (2005)
J. Virol. 79, 8960-8968
   Abstract »    Full Text »    PDF »
Cutting Edge: The Prevalence of Regulatory T Cells in Lymphoid Tissue Is Correlated with Viral Load in HIV-Infected Patients.
J. Andersson, A. Boasso, J. Nilsson, R. Zhang, N. J. Shire, S. Lindback, G. M. Shearer, and C. A. Chougnet (2005)
J. Immunol. 174, 3143-3147
   Abstract »    Full Text »    PDF »

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882