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Science 305 (5681): 205-208

Copyright © 2004 by the American Association for the Advancement of Science

Therapeutic Vaccines for Chronic Infections

Brigitte Autran,* Guislaine Carcelain, Béhazine Combadiere, Patrice Debre

Abstract: Therapeutic vaccines aim to prevent severe complications of a chronic infection by reinforcing host defenses when some immune control, albeit insufficient, can already be demonstrated and when a conventional antimicrobial therapy either is not available or has limited efficacy. We focus on the rationale and challenges behind this still controversial strategy and provide examples from three major chronic infectious diseases— human immunodeficiency virus, hepatitis B virus, and human papillomavirus—for which the efficacy of therapeutic vaccines is currently being evaluated.

Laboratoire d'Immunologie Cellulaire and INSERM Unit 543, Centre Hospitalier Universitaire Pitié-Salpétrière, Université Pierre et Marie Curie, 75013 Paris, France.

* To whom correspondence should be addressed. E-mail: brigitte.autran{at}psl.ap-hop-paris.fr


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