Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Logo for

Science 305 (5692): 1972-1975

Copyright © 2004 by the American Association for the Advancement of Science

Recycling Endosomes Supply AMPA Receptors for LTP

Mikyoung Park,1* Esther C. Penick,3* Jeffrey G. Edwards,3 Julie A. Kauer,3 Michael D. Ehlers1,2{ddagger}

Abstract: Long-term potentiation (LTP) of synaptic strength, the most established cellular model of information storage in the brain, is expressed by an increase in the number of postsynaptic AMPA receptors. However, the source of AMPA receptors mobilized during LTP is unknown. We report that AMPA receptors are transported from recycling endosomes to the plasma membrane for LTP. Stimuli that triggered LTP promoted not only AMPA receptor insertion but also generalized recycling of cargo and membrane from endocytic compartments. Thus, recycling endosomes supply AMPA receptors for LTP and provide a mechanistic link between synaptic potentiation and membrane remodeling during synapse modification.

1 Department of Neurobiology, Duke University Medical Center, Box 3209, Durham, NC 27710, USA.
2 Department of Cell Biology, Department of Pharmacology and Cancer Biology, Department of Pathology, and Neuroproteomics Laboratory; Duke University Medical Center, Box 3209, Durham, NC 27710, USA.
3 Department of Molecular Pharmacology, Physiology, and Biotechnology, Brown University, Providence, RI 02912, USA.

Back to Top

* These authors contributed equally to this work.

{ddagger} To whom correspondence should be addressed. E-mail: ehlers{at}

Surface dynamics of GluN2B-NMDA receptors controls plasticity of maturing glutamate synapses.
J. P. Dupuis, L. Ladepeche, H. Seth, L. Bard, J. Varela, L. Mikasova, D. Bouchet, V. Rogemond, J. Honnorat, E. Hanse, et al. (2014)
EMBO J. 33, 842-861
   Abstract »    Full Text »    PDF »
Differential Regulation of GABAB Receptor Trafficking by Different Modes of N-methyl-D-aspartate (NMDA) Receptor Signaling.
S. Kantamneni, I. M. Gonzalez-Gonzalez, J. Luo, H. Cimarosti, S. C. Jacobs, N. Jaafari, and J. M. Henley (2014)
J. Biol. Chem. 289, 6681-6694
   Abstract »    Full Text »    PDF »
Pansynaptic Enlargement at Adult Cortical Connections Strengthened by Experience.
C. E. J. Cheetham, S. J. Barnes, G. Albieri, G. W. Knott, and G. T. Finnerty (2014)
Cereb Cortex 24, 521-531
   Abstract »    Full Text »    PDF »
Ghrelin triggers the synaptic incorporation of AMPA receptors in the hippocampus.
L. F. Ribeiro, T. Catarino, S. D. Santos, M. Benoist, J. F. van Leeuwen, J. A. Esteban, and A. L. Carvalho (2014)
PNAS 111, E149-E158
   Abstract »    Full Text »    PDF »
Moderate AMPA receptor clustering on the nanoscale can efficiently potentiate synaptic current.
L. P. Savtchenko and D. A. Rusakov (2013)
Phil Trans R Soc B 369, 20130167
   Abstract »    Full Text »    PDF »
Regulation of glutamate receptor internalization by the spine cytoskeleton is mediated by its PKA-dependent association with CPG2.
S. Loebrich, B. Djukic, Z. J. Tong, J. R. Cottrell, G. G. Turrigiano, and E. Nedivi (2013)
PNAS 110, E4548-E4556
   Abstract »    Full Text »    PDF »
Cell biology in neuroscience: The interplay between Hebbian and homeostatic synaptic plasticity.
N. Vitureira and Y. Goda (2013)
J. Cell Biol. 203, 175-186
   Abstract »    Full Text »    PDF »
Functions of Class V Myosins in Neurons.
J. A. Hammer III and W. Wagner (2013)
J. Biol. Chem. 288, 28428-28434
   Abstract »    Full Text »    PDF »
A recollection of mTOR signaling in learning and memory.
T. E. Graber, P. K. McCamphill, and W. S. Sossin (2013)
Learn. Mem. 20, 518-530
   Abstract »    Full Text »    PDF »
PICK1 interacts with PACSIN to regulate AMPA receptor internalization and cerebellar long-term depression.
V. Anggono, Y. Koc-Schmitz, J. Widagdo, J. Kormann, A. Quan, C.-M. Chen, P. J. Robinson, S.-Y. Choi, D. J. Linden, M. Plomann, et al. (2013)
PNAS 110, 13976-13981
   Abstract »    Full Text »    PDF »
Differential targeting of the dopamine transporter to recycling or degradative pathways during amphetamine- or PKC-regulated endocytosis in dopamine neurons.
W. C. Hong and S. G. Amara (2013)
FASEB J 27, 2995-3007
   Abstract »    Full Text »    PDF »
Essential Role for Synaptopodin in Dendritic Spine Plasticity of the Developing Hippocampus.
X.-l. Zhang, B. Poschel, C. Faul, C. Upreti, P. K. Stanton, and P. Mundel (2013)
J. Neurosci. 33, 12510-12518
   Abstract »    Full Text »    PDF »
Ral mediates activity-dependent growth of postsynaptic membranes via recruitment of the exocyst.
R. O. Teodoro, G. Pekkurnaz, A. Nasser, M. E. Higashi-Kovtun, M. Balakireva, I. G. McLachlan, J. Camonis, and T. L. Schwarz (2013)
EMBO J. 32, 2039-2055
   Abstract »    Full Text »    PDF »
Shank3-Rich2 Interaction Regulates AMPA Receptor Recycling and Synaptic Long-Term Potentiation.
F. Raynaud, A. Janossy, J. Dahl, F. Bertaso, J. Perroy, A. Varrault, M. Vidal, P. F. Worley, T. M. Boeckers, J. Bockaert, et al. (2013)
J. Neurosci. 33, 9699-9715
   Abstract »    Full Text »    PDF »
Cooperation of MICAL-L1, syndapin2, and phosphatidic acid in tubular recycling endosome biogenesis.
S. S. P. Giridharan, B. Cai, N. Vitale, N. Naslavsky, and S. Caplan (2013)
Mol. Biol. Cell 24, 1776-1790
   Abstract »    Full Text »    PDF »
BDNF-Dependent Recycling Facilitates TrkB Translocation to Postsynaptic Density during LTP via a Rab11-Dependent Pathway.
S.-H. Huang, J. Wang, W.-H. Sui, B. Chen, X.-Y. Zhang, J. Yan, Z. Geng, and Z.-Y. Chen (2013)
J. Neurosci. 33, 9214-9230
   Abstract »    Full Text »    PDF »
Kainate Receptor Post-translational Modifications Differentially Regulate Association with 4.1N to Control Activity-dependent Receptor Endocytosis.
B. A. Copits and G. T. Swanson (2013)
J. Biol. Chem. 288, 8952-8965
   Abstract »    Full Text »    PDF »
Enhanced Recruitment of Endosomal Na+/H+ Exchanger NHE6 into Dendritic Spines of Hippocampal Pyramidal Neurons during NMDA Receptor-Dependent Long-Term Potentiation.
E. C. Deane, A. E. Ilie, S. Sizdahkhani, M. Das Gupta, J. Orlowski, and R. A. McKinney (2013)
J. Neurosci. 33, 595-610
   Abstract »    Full Text »    PDF »
A Noncanonical Postsynaptic Transport Route for a GPCR Belonging to the Serotonin Receptor Family.
T. Liebmann, M. Kruusmagi, N. Sourial-Bassillious, A. Bondar, P. Svenningsson, M. Flajolet, P. Greengard, L. Scott, H. Brismar, and A. Aperia (2012)
J. Neurosci. 32, 17998-18008
   Abstract »    Full Text »    PDF »
Studying Signal Transduction in Single Dendritic Spines.
R. Yasuda (2012)
Cold Spring Harb Perspect Biol 4, a005611
   Abstract »    Full Text »    PDF »
The Balance between Receptor Recycling and Trafficking toward Lysosomes Determines Synaptic Strength during Long-Term Depression.
M. Fernandez-Monreal, T. C. Brown, M. Royo, and J. A. Esteban (2012)
J. Neurosci. 32, 13200-13205
   Abstract »    Full Text »    PDF »
PICK1 Mediates Transient Synaptic Expression of GluA2-Lacking AMPA Receptors during Glycine-Induced AMPA Receptor Trafficking.
N. Jaafari, J. M. Henley, and J. G. Hanley (2012)
J. Neurosci. 32, 11618-11630
   Abstract »    Full Text »    PDF »
Dynamic remodeling of scaffold interactions in dendritic spines controls synaptic excitability.
E. Moutin, F. Raynaud, J. Roger, E. Pellegrino, V. Homburger, F. Bertaso, V. Ollendorff, J. Bockaert, L. Fagni, and J. Perroy (2012)
J. Cell Biol. 198, 251-263
   Abstract »    Full Text »    PDF »
Synapses and Memory Storage.
M. Mayford, S. A. Siegelbaum, and E. R. Kandel (2012)
Cold Spring Harb Perspect Biol 4, a005751
   Abstract »    Full Text »    PDF »
Microscale AMPAR Reorganization and Dynamics of the Postsynaptic Density.
S. Jurado and S. Knafo (2012)
J. Neurosci. 32, 7103-7105
   Full Text »    PDF »
Palmitoylation of A-Kinase Anchoring Protein 79/150 Regulates Dendritic Endosomal Targeting and Synaptic Plasticity Mechanisms.
D. J. Keith, J. L. Sanderson, E. S. Gibson, K. M. Woolfrey, H. R. Robertson, K. Olszewski, R. Kang, A. El-Husseini, and M. L. Dell'Acqua (2012)
J. Neurosci. 32, 7119-7136
   Abstract »    Full Text »    PDF »
Identification of Two Functionally Distinct Endosomal Recycling Pathways for Dopamine D2 Receptor.
Y. Li, B. D. Roy, W. Wang, L. Zhang, L. Zhang, S. B. Sampson, Y. Yang, and D.-T. Lin (2012)
J. Neurosci. 32, 7178-7190
   Abstract »    Full Text »    PDF »
Photochemical Inactivation Analysis of Temporal Dynamics of Postsynaptic Native AMPA Receptors in Hippocampal Slices.
H. Kamiya (2012)
J. Neurosci. 32, 6517-6524
   Abstract »    Full Text »    PDF »
Disrupted surface cross-talk between NMDA and Ephrin-B2 receptors in anti-NMDA encephalitis.
L. Mikasova, P. De Rossi, D. Bouchet, F. Georges, V. Rogemond, A. Didelot, C. Meissirel, J. Honnorat, and L. Groc (2012)
Brain 135, 1606-1621
   Abstract »    Full Text »    PDF »
Axonal and dendritic synaptotagmin isoforms revealed by a pHluorin-syt functional screen.
C. Dean, F. M. Dunning, H. Liu, E. Bomba-Warczak, H. Martens, V. Bharat, S. Ahmed, and E. R. Chapman (2012)
Mol. Biol. Cell 23, 1715-1727
   Abstract »    Full Text »    PDF »
Protein Interacting with C Kinase 1 (PICK1) Reduces Reinsertion Rates of Interaction Partners Sorted to Rab11-dependent Slow Recycling Pathway.
K. L. Madsen, T. S. Thorsen, T. Rahbek-Clemmensen, J. Eriksen, and U. Gether (2012)
J. Biol. Chem. 287, 12293-12308
   Abstract »    Full Text »    PDF »
Small GTPase Rab17 Regulates Dendritic Morphogenesis and Postsynaptic Development of Hippocampal Neurons.
Y. Mori, T. Matsui, Y. Furutani, Y. Yoshihara, and M. Fukuda (2012)
J. Biol. Chem. 287, 8963-8973
   Abstract »    Full Text »    PDF »
RAB-6.2 and the retromer regulate glutamate receptor recycling through a retrograde pathway.
D. Zhang, N. R. Isack, D. R. Glodowski, J. Liu, C. C.-H. Chen, X. Z. S. Xu, B. D. Grant, and C. Rongo (2012)
J. Cell Biol. 196, 85-101
   Abstract »    Full Text »    PDF »
The Cell Biology of Synaptic Plasticity.
V. M. Ho, J.-A. Lee, and K. C. Martin (2011)
Science 334, 623-628
   Abstract »    Full Text »    PDF »
NCAM/Spectrin Complex Disassembly Results in PSD Perforation and Postsynaptic Endocytic Zone Formation.
D. Puchkov, I. Leshchyns'ka, A. G. Nikonenko, M. Schachner, and V. Sytnyk (2011)
Cereb Cortex 21, 2217-2232
   Abstract »    Full Text »    PDF »
Translocation of the Drosophila Transient Receptor Potential-like (TRPL) Channel Requires Both the N- and C-terminal Regions Together with Sustained Ca2+ Entry.
D. Richter, B. Katz, T. Oberacker, V. Tzarfaty, G. Belusic, B. Minke, and A. Huber (2011)
J. Biol. Chem. 286, 34234-34243
   Abstract »    Full Text »    PDF »
Regulation of dendritic spine growth through activity-dependent recruitment of the brain-enriched Na+/H+ exchanger NHE5.
G. H. Diering, F. Mills, S. X. Bamji, and M. Numata (2011)
Mol. Biol. Cell 22, 2246-2257
   Abstract »    Full Text »    PDF »
NMDA Receptor Activation Suppresses Microtubule Growth and Spine Entry.
L. C. Kapitein, K. W. Yau, S. M. Gouveia, W. A. van der Zwan, P. S. Wulf, N. Keijzer, J. Demmers, J. Jaworski, A. Akhmanova, and C. C. Hoogenraad (2011)
J. Neurosci. 31, 8194-8209
   Abstract »    Full Text »    PDF »
The palmitoyl transferase DHHC2 targets a dynamic membrane cycling pathway: regulation by a C-terminal domain.
J. Greaves, J. A. Carmichael, and L. H. Chamberlain (2011)
Mol. Biol. Cell 22, 1887-1895
   Abstract »    Full Text »    PDF »
Trafficking of AMPA Receptors at Plasma Membranes of Hippocampal Neurons.
J.-H. Tao-Cheng, V. T. Crocker, C. A. Winters, R. Azzam, J. Chludzinski, and T. S. Reese (2011)
J. Neurosci. 31, 4834-4843
   Abstract »    Full Text »    PDF »
Endocytic Recycling Proteins EHD1 and EHD2 Interact with Fer-1-like-5 (Fer1L5) and Mediate Myoblast Fusion.
A. D. Posey Jr, P. Pytel, K. Gardikiotes, A. R. Demonbreun, M. Rainey, M. George, H. Band, and E. M. McNally (2011)
J. Biol. Chem. 286, 7379-7388
   Abstract »    Full Text »    PDF »
Activity-Dependent Ubiquitination of the AMPA Receptor Subunit GluA2.
M. P. Lussier, Y. Nasu-Nishimura, and K. W. Roche (2011)
J. Neurosci. 31, 3077-3081
   Abstract »    Full Text »    PDF »
Activation of D1/D5 Dopamine Receptors Protects Neurons from Synapse Dysfunction Induced by Amyloid-{beta} Oligomers.
S. Jurgensen, L. L. Antonio, G. E. A. Mussi, J. Brito-Moreira, T. R. Bomfim, F. G. De Felice, E. R. Garrido-Sanabria, E. A. Cavalheiro, and S. T. Ferreira (2011)
J. Biol. Chem. 286, 3270-3276
   Abstract »    Full Text »    PDF »
Ras and Rap Signaling in Synaptic Plasticity and Mental Disorders.
R. L. Stornetta and J. J. Zhu (2011)
Neuroscientist 17, 54-78
   Abstract »    PDF »
The Deubiquitinating Enzyme USP-46 Negatively Regulates the Degradation of Glutamate Receptors to Control Their Abundance in the Ventral Nerve Cord of Caenorhabditis elegans.
J. R. Kowalski, C. L. Dahlberg, and P. Juo (2011)
J. Neurosci. 31, 1341-1354
   Abstract »    Full Text »    PDF »
MHC class I modulates NMDA receptor function and AMPA receptor trafficking.
L. Fourgeaud, C. M. Davenport, C. M. Tyler, T. T. Cheng, M. B. Spencer, and L. M. Boulanger (2010)
PNAS 107, 22278-22283
   Abstract »    Full Text »    PDF »
Neuronal Early Endosomes Require EHD1 for L1/NgCAM Trafficking.
Z. M. Lasiecka, C. C. Yap, S. Caplan, and B. Winckler (2010)
J. Neurosci. 30, 16485-16497
   Abstract »    Full Text »    PDF »
Role of Syntaxin 4 in Activity-Dependent Exocytosis and Synaptic Plasticity in Hippocampal Neurons.
P. Mohanasundaram and M. M. Shanmugam (2010)
Science Signaling 3, jc7
   Abstract »    Full Text »    PDF »
Calcium/Calmodulin Kinase II-Dependent Acetylcholine Receptor Cycling at the Mammalian Neuromuscular Junction In Vivo.
I. Martinez-Pena y Valenzuela, C. Mouslim, and M. Akaaboune (2010)
J. Neurosci. 30, 12455-12465
   Abstract »    Full Text »    PDF »
The myotubularin phosphatase MTMR4 regulates sorting from early endosomes.
M. J. Naughtin, D. A. Sheffield, P. Rahman, W. E. Hughes, R. Gurung, J. L. Stow, H. H. Nandurkar, J. M. Dyson, and C. A. Mitchell (2010)
J. Cell Sci. 123, 3071-3083
   Abstract »    Full Text »    PDF »
AMPA receptors are exocytosed in stimulated spines and adjacent dendrites in a Ras-ERK-dependent manner during long-term potentiation.
M. A. Patterson, E. M. Szatmari, and R. Yasuda (2010)
PNAS 107, 15951-15956
   Abstract »    Full Text »    PDF »
Rab11 and Its Effector Rab Coupling Protein Contribute to the Trafficking of {beta}1 Integrins during Axon Growth in Adult Dorsal Root Ganglion Neurons and PC12 Cells.
R. Eva, E. Dassie, P. T. Caswell, G. Dick, C. ffrench-Constant, J. C. Norman, and J. W. Fawcett (2010)
J. Neurosci. 30, 11654-11669
   Abstract »    Full Text »    PDF »
Coupled Activity-Dependent Trafficking of Synaptic SK2 Channels and AMPA Receptors.
M. T. Lin, R. Lujan, M. Watanabe, M. Frerking, J. Maylie, and J. P. Adelman (2010)
J. Neurosci. 30, 11726-11734
   Abstract »    Full Text »    PDF »
Regulation of AMPA Receptor Trafficking and Function by Glycogen Synthase Kinase 3.
J. Wei, W. Liu, and Z. Yan (2010)
J. Biol. Chem. 285, 26369-26376
   Abstract »    Full Text »    PDF »
Persistence of Coordinated Long-Term Potentiation and Dendritic Spine Enlargement at Mature Hippocampal CA1 Synapses Requires N-Cadherin.
O. Bozdagi, X.-b. Wang, J. S. Nikitczuk, T. R. Anderson, E. B. Bloss, G. L. Radice, Q. Zhou, D. L. Benson, and G. W. Huntley (2010)
J. Neurosci. 30, 9984-9989
   Abstract »    Full Text »    PDF »
Perisynaptic GluR2-lacking AMPA receptors control the reversibility of synaptic and spines modifications.
Y. Yang, X.-b. Wang, and Q. Zhou (2010)
PNAS 107, 11999-12004
   Abstract »    Full Text »    PDF »
Plasma membrane insertion of the AMPA receptor GluA2 subunit is regulated by NSF binding and Q/R editing of the ion pore.
Y. Araki, D.-T. Lin, and R. L. Huganir (2010)
PNAS 107, 11080-11085
   Abstract »    Full Text »    PDF »
AMPA receptor subunits define properties of state-dependent synaptic plasticity.
M. R. Emond, J. M. Montgomery, M. L. Huggins, J. E. Hanson, L. Mao, R. L. Huganir, and D. V. Madison (2010)
J. Physiol. 588, 1929-1946
   Abstract »    Full Text »    PDF »
N-cadherin-dependent neuron-neuron interaction is required for the maintenance of activity-induced dendrite growth.
Z.-J. Tan, Y. Peng, H.-L. Song, J.-J. Zheng, and X. Yu (2010)
PNAS 107, 9873-9878
   Abstract »    Full Text »    PDF »
Actin in dendritic spines: connecting dynamics to function.
P. Hotulainen and C. C. Hoogenraad (2010)
J. Cell Biol. 189, 619-629
   Abstract »    Full Text »    PDF »
Alterations of EHD1/EHD4 Protein Levels Interfere with L1/NgCAM Endocytosis in Neurons and Disrupt Axonal Targeting.
C. C. C. Yap, Z. M. Lasiecka, S. Caplan, and B. Winckler (2010)
J. Neurosci. 30, 6646-6657
   Abstract »    Full Text »    PDF »
Aberrant Rab11-Dependent Trafficking of the Neuronal Glutamate Transporter EAAC1 Causes Oxidative Stress and Cell Death in Huntington's Disease.
X. Li, A. Valencia, E. Sapp, N. Masso, J. Alexander, P. Reeves, K. B. Kegel, N. Aronin, and M. DiFiglia (2010)
J. Neurosci. 30, 4552-4561
   Abstract »    Full Text »    PDF »
The Stress Hormone Corticosterone Increases Synaptic {alpha}-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors via Serum- and Glucocorticoid-inducible Kinase (SGK) Regulation of the GDI-Rab4 Complex.
W. Liu, E. Y. Yuen, and Z. Yan (2010)
J. Biol. Chem. 285, 6101-6108
   Abstract »    Full Text »    PDF »
Contribution of the Global Subunit Structure and Stargazin on the Maturation of AMPA Receptors.
N. F. Shanks, T. Maruo, A. N. Farina, M. H. Ellisman, and T. Nakagawa (2010)
J. Neurosci. 30, 2728-2740
   Abstract »    Full Text »    PDF »
Potassium Channel Silencing by Constitutive Endocytosis and Intracellular Sequestration.
S. Feliciangeli, M. P. Tardy, G. Sandoz, F. C. Chatelain, R. Warth, J. Barhanin, S. Bendahhou, and F. Lesage (2010)
J. Biol. Chem. 285, 4798-4805
   Abstract »    Full Text »    PDF »
SNAP-25 Is a Target of Protein Kinase C Phosphorylation Critical to NMDA Receptor Trafficking.
C. G. Lau, Y. Takayasu, A. Rodenas-Ruano, A. V. Paternain, J. Lerma, M. V. L. Bennett, and R. S. Zukin (2010)
J. Neurosci. 30, 242-254
   Abstract »    Full Text »    PDF »
Plasticity between Neuronal Pairs in Layer 4 of Visual Cortex Varies with Synapse State.
I. Saez and M. J. Friedlander (2009)
J. Neurosci. 29, 15286-15298
   Abstract »    Full Text »    PDF »
Myosin-Va-interacting protein, RILPL2, controls cell shape and neuronal morphogenesis via Rac signaling.
M.-F. Lise, D. P. Srivastava, P. Arstikaitis, R. L. Lett, R. Sheta, V. Viswanathan, P. Penzes, T. P. O'Connor, and A. El-Husseini (2009)
J. Cell Sci. 122, 3810-3821
   Abstract »    Full Text »    PDF »
Ubiquitin-dependent lysosomal targeting of GABAA receptors regulates neuronal inhibition.
I. L. Arancibia-Carcamo, E. Y. Yuen, J. Muir, M. J. Lumb, G. Michels, R. S. Saliba, T. G. Smart, Z. Yan, J. T. Kittler, and S. J. Moss (2009)
PNAS 106, 17552-17557
   Abstract »    Full Text »    PDF »
Spine Modifications Associated with Long-Term Potentiation.
Y. Yang and Q. Zhou (2009)
Neuroscientist 15, 464-476
   Abstract »    PDF »
Axonal Targeting of Trk Receptors via Transcytosis Regulates Sensitivity to Neurotrophin Responses.
M. Ascano, A. Richmond, P. Borden, and R. Kuruvilla (2009)
J. Neurosci. 29, 11674-11685
   Abstract »    Full Text »    PDF »
Mechanism underlying activity-dependent insertion of TrkB into the neuronal surface.
L. Zhao, A.-L. Sheng, S.-H. Huang, Y.-X. Yin, B. Chen, X.-Z. Li, Y. Zhang, and Z.-Y. Chen (2009)
J. Cell Sci. 122, 3123-3136
   Abstract »    Full Text »    PDF »
Uncoordinated 119 Protein Controls Trafficking of Lck via the Rab11 Endosome and Is Critical for Immunological Synapse Formation.
M. M. Gorska, Q. Liang, Z. Karim, and R. Alam (2009)
J. Immunol. 183, 1675-1684
   Abstract »    Full Text »    PDF »
Regulation of Postsynaptic Structure and Function by an A-Kinase Anchoring Protein-Membrane-Associated Guanylate Kinase Scaffolding Complex.
H. R. Robertson, E. S. Gibson, T. A. Benke, and M. L. Dell'Acqua (2009)
J. Neurosci. 29, 7929-7943
   Abstract »    Full Text »    PDF »
Eps15 Homology Domain 1-associated Tubules Contain Phosphatidylinositol-4-Phosphate and Phosphatidylinositol-(4,5)-Bisphosphate and Are Required for Efficient Recycling.
M. Jovic, F. Kieken, N. Naslavsky, P. L. Sorgen, and S. Caplan (2009)
Mol. Biol. Cell 20, 2731-2743
   Abstract »    Full Text »    PDF »
Transducing Neuronal Activity into Dendritic Spine Morphology: New Roles for p38 MAP Kinase and N-cadherin.
H. Sugiura, H. Tanaka, S. Yasuda, T. Takemiya, and K. Yamagata (2009)
Neuroscientist 15, 90-104
   Abstract »    PDF »
Extracellular proteolysis by matrix metalloproteinase-9 drives dendritic spine enlargement and long-term potentiation coordinately.
X.-b. Wang, O. Bozdagi, J. S. Nikitczuk, Z. W. Zhai, Q. Zhou, and G. W. Huntley (2008)
PNAS 105, 19520-19525
   Abstract »    Full Text »    PDF »
Left-right asymmetry of the hippocampal synapses with differential subunit allocation of glutamate receptors.
Y. Shinohara, H. Hirase, M. Watanabe, M. Itakura, M. Takahashi, and R. Shigemoto (2008)
PNAS 105, 19498-19503
   Abstract »    Full Text »    PDF »
Monomeric IgG Is Neuroprotective via Enhancing Microglial Recycling Endocytosis and TNF-{alpha}.
R. E. Hulse, W. G. Swenson, P. E. Kunkler, D. M. White, and R. P. Kraig (2008)
J. Neurosci. 28, 12199-12211
   Abstract »    Full Text »    PDF »
Janus-faced trafficking at glutamatergic synapses.
M. D. Ehlers (2008)
PNAS 105, 17215-17216
   Full Text »    PDF »
Region-Specific Changes in the Subcellular Distribution of AMPA Receptor GluR1 Subunit in the Rat Ventral Tegmental Area after Acute or Chronic Morphine Administration.
D. A. Lane, A. A. Lessard, J. Chan, E. E. O. Colago, Y. Zhou, S. D. Schlussman, M. J. Kreek, and V. M. Pickel (2008)
J. Neurosci. 28, 9670-9681
   Abstract »    Full Text »    PDF »
Regulation of D6 chemokine scavenging activity by ligand- and Rab11-dependent surface up-regulation.
R. Bonecchi, E. M. Borroni, A. Anselmo, A. Doni, B. Savino, M. Mirolo, M. Fabbri, V. R. Jala, B. Haribabu, A. Mantovani, et al. (2008)
Blood 112, 493-503
   Abstract »    Full Text »    PDF »
Recycling endosomes supply cardiac pacemaker channels for regulated surface expression.
N. Hardel, N. Harmel, G. Zolles, B. Fakler, and N. Klocker (2008)
Cardiovasc Res 79, 52-60
   Abstract »    Full Text »    PDF »
UNC-108/Rab2 Regulates Postendocytic Trafficking in Caenorhabditis elegans.
D. K. Chun, J. M. McEwen, M. Burbea, and J. M. Kaplan (2008)
Mol. Biol. Cell 19, 2682-2695
   Abstract »    Full Text »    PDF »
Recruitment of Calcium-Permeable AMPA Receptors during Synaptic Potentiation Is Regulated by CaM-Kinase I.
E. S. Guire, M. C. Oh, T. R. Soderling, and V. A. Derkach (2008)
J. Neurosci. 28, 6000-6009
   Abstract »    Full Text »    PDF »
Spine Expansion and Stabilization Associated with Long-Term Potentiation.
Y. Yang, X.-b. Wang, M. Frerking, and Q. Zhou (2008)
J. Neurosci. 28, 5740-5751
   Abstract »    Full Text »    PDF »
Rapid Tumor Necrosis Factor {alpha}-Induced Exocytosis of Glutamate Receptor 2-Lacking AMPA Receptors to Extrasynaptic Plasma Membrane Potentiates Excitotoxicity.
D. Leonoudakis, P. Zhao, and E. C. Beattie (2008)
J. Neurosci. 28, 2119-2130
   Abstract »    Full Text »    PDF »
The somatodendritic endosomal regulator NEEP21 facilitates axonal targeting of L1/NgCAM.
C. C. Yap, D. Wisco, P. Kujala, Z. M. Lasiecka, J. T. Cannon, M. C. Chang, H. Hirling, J. Klumperman, and B. Winckler (2008)
J. Cell Biol. 180, 827-842
   Abstract »    Full Text »    PDF »
Differential Trafficking of AMPA and NMDA Receptors during Long-Term Potentiation in Awake Adult Animals.
J. M. Williams, D. Guevremont, S. E. Mason-Parker, C. Luxmanan, W. P. Tate, and W. C. Abraham (2007)
J. Neurosci. 27, 14171-14178
   Abstract »    Full Text »    PDF »
GluR1 Links Structural and Functional Plasticity at Excitatory Synapses.
C. D. Kopec, E. Real, H. W. Kessels, and R. Malinow (2007)
J. Neurosci. 27, 13706-13718
   Abstract »    Full Text »    PDF »
PICK1 and Phosphorylation of the Glutamate Receptor 2 (GluR2) AMPA Receptor Subunit Regulates GluR2 Recycling after NMDA Receptor-Induced Internalization.
D.-T. Lin and R. L. Huganir (2007)
J. Neurosci. 27, 13903-13908
   Abstract »    Full Text »    PDF »
Regulation of spine morphology and spine density by NMDA receptor signaling in vivo.
S. K. Ultanir, J.-E. Kim, B. J. Hall, T. Deerinck, M. Ellisman, and A. Ghosh (2007)
PNAS 104, 19553-19558
   Abstract »    Full Text »    PDF »

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882