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Science 305 (5692): 1972-1975

Copyright © 2004 by the American Association for the Advancement of Science

Recycling Endosomes Supply AMPA Receptors for LTP

Mikyoung Park,1* Esther C. Penick,3* Jeffrey G. Edwards,3 Julie A. Kauer,3 Michael D. Ehlers1,2{ddagger}

Abstract: Long-term potentiation (LTP) of synaptic strength, the most established cellular model of information storage in the brain, is expressed by an increase in the number of postsynaptic AMPA receptors. However, the source of AMPA receptors mobilized during LTP is unknown. We report that AMPA receptors are transported from recycling endosomes to the plasma membrane for LTP. Stimuli that triggered LTP promoted not only AMPA receptor insertion but also generalized recycling of cargo and membrane from endocytic compartments. Thus, recycling endosomes supply AMPA receptors for LTP and provide a mechanistic link between synaptic potentiation and membrane remodeling during synapse modification.

1 Department of Neurobiology, Duke University Medical Center, Box 3209, Durham, NC 27710, USA.
2 Department of Cell Biology, Department of Pharmacology and Cancer Biology, Department of Pathology, and Neuroproteomics Laboratory; Duke University Medical Center, Box 3209, Durham, NC 27710, USA.
3 Department of Molecular Pharmacology, Physiology, and Biotechnology, Brown University, Providence, RI 02912, USA.

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* These authors contributed equally to this work.

{ddagger} To whom correspondence should be addressed. E-mail: ehlers{at}neuro.duke.edu


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E. S. Guire, M. C. Oh, T. R. Soderling, and V. A. Derkach (2008)
J. Neurosci. 28, 6000-6009
   Abstract »    Full Text »    PDF »
Spine Expansion and Stabilization Associated with Long-Term Potentiation.
Y. Yang, X.-b. Wang, M. Frerking, and Q. Zhou (2008)
J. Neurosci. 28, 5740-5751
   Abstract »    Full Text »    PDF »
Rapid Tumor Necrosis Factor {alpha}-Induced Exocytosis of Glutamate Receptor 2-Lacking AMPA Receptors to Extrasynaptic Plasma Membrane Potentiates Excitotoxicity.
D. Leonoudakis, P. Zhao, and E. C. Beattie (2008)
J. Neurosci. 28, 2119-2130
   Abstract »    Full Text »    PDF »
The somatodendritic endosomal regulator NEEP21 facilitates axonal targeting of L1/NgCAM.
C. C. Yap, D. Wisco, P. Kujala, Z. M. Lasiecka, J. T. Cannon, M. C. Chang, H. Hirling, J. Klumperman, and B. Winckler (2008)
J. Cell Biol. 180, 827-842
   Abstract »    Full Text »    PDF »
Differential Trafficking of AMPA and NMDA Receptors during Long-Term Potentiation in Awake Adult Animals.
J. M. Williams, D. Guevremont, S. E. Mason-Parker, C. Luxmanan, W. P. Tate, and W. C. Abraham (2007)
J. Neurosci. 27, 14171-14178
   Abstract »    Full Text »    PDF »
GluR1 Links Structural and Functional Plasticity at Excitatory Synapses.
C. D. Kopec, E. Real, H. W. Kessels, and R. Malinow (2007)
J. Neurosci. 27, 13706-13718
   Abstract »    Full Text »    PDF »
PICK1 and Phosphorylation of the Glutamate Receptor 2 (GluR2) AMPA Receptor Subunit Regulates GluR2 Recycling after NMDA Receptor-Induced Internalization.
D.-T. Lin and R. L. Huganir (2007)
J. Neurosci. 27, 13903-13908
   Abstract »    Full Text »    PDF »
Regulation of spine morphology and spine density by NMDA receptor signaling in vivo.
S. K. Ultanir, J.-E. Kim, B. J. Hall, T. Deerinck, M. Ellisman, and A. Ghosh (2007)
PNAS 104, 19553-19558
   Abstract »    Full Text »    PDF »

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