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Science 306 (5696): 640-643

Copyright © 2004 by the American Association for the Advancement of Science

Systems Biology and New Technologies Enable Predictive and Preventative Medicine

Leroy Hood,1* James R. Heath,2,3 Michael E. Phelps,3 Biaoyang Lin1

Abstract: Systems approaches to disease are grounded in the idea that disease-perturbed protein and gene regulatory networks differ from their normal counterparts; we have been pursuing the possibility that these differences may be reflected by multiparameter measurements of the blood. Such concepts are transforming current diagnostic and therapeutic approaches to medicine and, together with new technologies, will enable a predictive and preventive medicine that will lead to personalized medicine.

1 Institute for Systems Biology, Seattle, WA, USA.
2 Department of Chemistry, California Institute of Technology, Pasadena, CA, USA.
3 Department of Molecular and Medical Pharmacology, The David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, CA, USA.

* To whom correspondence should be addressed. E-mail: lhood{at}

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