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Science 306 (5696): 644-647

Copyright © 2004 by the American Association for the Advancement of Science

Gene Order and Dynamic Domains

Steven T. Kosak1, and Mark Groudine1,2*

Abstract: When considering the daunting complexity of eukaryotic genomes, some comfort can be found in the fact that the human genome may contain only 30,000 to 40,000 genes. Moreover, growing evidence suggests that genomes may be organized in such a way as to take advantage of space. A gene's location in the linear DNA sequence and its position in the three-dimensional nucleus can both be important in its regulation. Contrary to prevailing notions in this postgenomic era, the bacteriophage {lambda}, a paragon of simplicity, may still have a few things to teach us with respect to these facets of nonrandom genomes.

1 Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109, USA.
2 Department of Radiation Oncology, University of Washington School of Medicine, Seattle, WA 98195, USA.

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Note added in proof: A recent study has provided evidence for the colocalization of coregulated genes on the same chromosome (35).

* To whom correspondence should be addressed. E-mail: markg{at}

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