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Common and Distinct Elements in Cellular Signaling via EGF and FGF Receptors
Joseph Schlessinger*
Abstract:
Signaling pathways that are activated by epidermal growth factor(EGF) or fibroblast growth factor (FGF) receptors have beenidentified and compared (detailed Connections Maps are availableat Science's Signal Transduction Knowledge Environment). Bothreceptors stimulate a similar complement of intracellular signalingpathways. However, whereas activated EGF receptors (EGFRs) functionas the main platform for recruitment of signaling proteins,signaling through the FGF receptors (FGFRs) is mediated primarilyby assembly of a multidocking protein complex. Moreover, FGFRsignaling is subject to additional intracellular and extracellularcontrol mechanisms that do not affect EGFR signaling. The differentialcircuitry of the intracellular networks that are activated byEGFR and FGFR may affect signal specificity and physiologicalresponses.
Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06520, USA.
* To whom correspondence should be addressed. E-mail: joseph.schlessinger{at}yale.edu
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