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Science 306 (5701): 1509-1511

Copyright © 2004 by the American Association for the Advancement of Science

Jekyll and Hyde in the Microbial World

Dagmar M. Truckses, Lindsay S. Garrenton, Jeremy Thorner*

Abstract: Fungi are nonmotile organisms that obtain carbon from compounds in their immediate surroundings. Confronted with nutrient limitation, the yeast Saccharomyces cerevisiae undergoes a dimorphic transition, switching from spherical cells to filaments of adherent, elongated cells that can invade the substratum. A complex web of sensing mechanisms and cooperation among signaling networks (including a mitogen-activated protein kinase cascade, cyclic adenosine monophosphate–dependent protein kinase, and 5'–adenosine monophosphate–activated protein kinase) elicits the appropriate changes in physiology, cell cycle progression, cell polarity, and gene expression to achieve this differentiation. Highly related signaling processes control filamentation and virulence of many human fungal pathogens.

Division of Biochemistry and Molecular Biology, Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720–3202, USA.

* To whom correspondence should be addressed. E-mail: jeremy{at}

Combined computational and experimental analysis reveals mitogen-activated protein kinase-mediated feedback phosphorylation as a mechanism for signaling specificity.
N. Hao, N. Yildirim, M. J. Nagiec, S. C. Parnell, B. Errede, H. G. Dohlman, and T. C. Elston (2012)
Mol. Biol. Cell 23, 3899-3910
   Abstract »    Full Text »    PDF »
The Membrane Mucin Msb2 Regulates Invasive Growth and Plant Infection in Fusarium oxysporum.
E. Perez-Nadales and A. Di Pietro (2011)
PLANT CELL 23, 1171-1185
   Abstract »    Full Text »    PDF »
Single-Cell Analysis Reveals That Insulation Maintains Signaling Specificity Between Two Yeast MAPK Pathways with Common Components.
J. C. Patterson, E. S. Klimenko, and J. Thorner (2010)
Science Signaling 3, ra75
   Abstract »    Full Text »    PDF »
Systematic Epistasis Analysis of the Contributions of Protein Kinase A- and Mitogen-Activated Protein Kinase-Dependent Signaling to Nutrient Limitation-Evoked Responses in the Yeast Saccharomyces cerevisiae.
R. E. Chen and J. Thorner (2010)
Genetics 185, 855-870
   Abstract »    Full Text »    PDF »
Roles of the Snf1-Activating Kinases during Nitrogen Limitation and Pseudohyphal Differentiation in Saccharomyces cerevisiae.
M. Orlova, H. Ozcetin, L. Barrett, and S. Kuchin (2010)
Eukaryot. Cell 9, 208-214
   Abstract »    Full Text »    PDF »
Pheromone Signaling Pathways in Yeast.
H. G. Dohlman and J. E. Slessareva (2006)
Sci. STKE 2006, cm6
   Abstract »    Full Text »    PDF »
Systems Biology of AGC Kinases in Fungi.
A. Sobko (2006)
Sci. STKE 2006, re9
   Abstract »    Full Text »    PDF »
Analysis of Mitogen-Activated Protein Kinase Signaling Specificity in Response to Hyperosmotic Stress: Use of an Analog-Sensitive HOG1 Allele.
P. J. Westfall and J. Thorner (2006)
Eukaryot. Cell 5, 1215-1228
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The RA Domain of Ste50 Adaptor Protein Is Required for Delivery of Ste11 to the Plasma Membrane in the Filamentous Growth Signaling Pathway of the Yeast Saccharomyces cerevisiae.
D. M. Truckses, J. E. Bloomekatz, and J. Thorner (2006)
Mol. Cell. Biol. 26, 912-928
   Abstract »    Full Text »    PDF »
Pheromone Signaling Mechanisms in Yeast: A Prototypical Sex Machine.
Y. Wang and H. G. Dohlman (2004)
Science 306, 1508-1509
   Abstract »    Full Text »    PDF »

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