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Science 306 (5702): 1786-1789

Copyright © 2004 by the American Association for the Advancement of Science

Lysosomal Glycosphingolipid Recognition by NKT Cells

Dapeng Zhou,1* Jochen Mattner,1 Carlos Cantu, III,2 Nicolas Schrantz,2 Ning Yin,3 Ying Gao,3 Yuval Sagiv,1 Kelly Hudspeth,1 Yun-Ping Wu,4 Tadashi Yamashita,4 Susann Teneberg,5 Dacheng Wang,6 Richard L. Proia,4 Steven B Levery,7 Paul B. Savage,3 Luc Teyton,2 Albert Bendelac1*

Abstract: NKT cells represent a distinct lineage of T cells that coexpress a conserved {alpha}ß T cell receptor (TCR) and natural killer (NK) receptors. Although the TCR of NKT cells is characteristically autoreactive to CD1d, a lipid-presenting molecule, endogenous ligands for these cells have not been identified. We show that a lysosomal glycosphingolipid of previously unknown function, isoglobotrihexosylceramide (iGb3), is recognized both by mouse and human NKT cells. Impaired generation of lysosomal iGb3 in mice lacking ß-hexosaminidase b results in severe NKT cell deficiency, suggesting that this lipid also mediates development of NKT cells in the mouse. We suggest that expression of iGb3 in peripheral tissues may be involved in controlling NKT cell responses to infections and malignancy and in autoimmunity.

1 University of Chicago, Department of Pathology, Chicago, IL 60637, USA.
2 The Scripps Research Institute, Department of Immunology, La Jolla, CA 92037, USA.
3 Brigham Young University, Department of Chemistry and Biochemistry, Provo, UT 84602–5700, USA.
4 Genetics of Development and Disease Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD 20892, USA.
5 Institute of Medical Biochemistry, Göteborg University, SE 405 30 Göteborg, Sweden.
6 Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.
7 Department of Chemistry, University of New Hampshire, Durham, NH 03824–3598, USA.

* To whom correspondence should be addressed. E-mail: dzhou{at} (D.Z.) and abendela{at} (A.B.)

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R. Bedel, R. Berry, T. Mallevaey, J. L. Matsuda, J. Zhang, D. I. Godfrey, J. Rossjohn, J. W. Kappler, P. Marrack, and L. Gapin (2014)
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Blockade of invariant TCR-CD1d interaction specifically inhibits antibody production against blood group A carbohydrates.
H. Tazawa, T. Irei, Y. Tanaka, Y. Igarashi, H. Tashiro, and H. Ohdan (2013)
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   Abstract »    Full Text »    PDF »
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D. Ly, A. G. Kasmar, T.-Y. Cheng, A. de Jong, S. Huang, S. Roy, A. Bhatt, R. P. van Summeren, J. D. Altman, W. R. Jacobs Jr., et al. (2013)
J. Exp. Med. 210, 729-741
   Abstract »    Full Text »    PDF »
Role for lysosomal phospholipase A2 in iNKT cell-mediated CD1d recognition.
C. Paduraru, J. S. Bezbradica, A. Kunte, R. Kelly, J. A. Shayman, N. Veerapen, L. R. Cox, G. S. Besra, and P. Cresswell (2013)
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   Abstract »    Full Text »    PDF »
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Z.-H. Tang, S. Liang, J. Potter, X. Jiang, H.-Q. Mao, and Z. Li (2013)
J. Immunol. 190, 1788-1796
   Abstract »    Full Text »    PDF »
The bovine CD1D gene has an unusual gene structure and is expressed but cannot present {alpha}-galactosylceramide with a C26 fatty acid.
T. K. A. Nguyen, A. P. Koets, M. Vordermeier, P. J. Jervis, L. R. Cox, S. P. Graham, W. J. Santema, D. B. Moody, S. van Calenbergh, D. M. Zajonc, et al. (2013)
Int. Immunol. 25, 91-98
   Abstract »    Full Text »    PDF »
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D. Li, A. Hong, Q. Lu, G. F. Gao, B. Jin, G. R. Screaton, and X.-N. Xu (2012)
Int. Immunol. 24, 729-737
   Abstract »    Full Text »    PDF »
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S. Porubsky, A. O. Speak, M. Salio, R. Jennemann, M. Bonrouhi, R. Zafarulla, Y. Singh, J. Dyson, B. Luckow, A. Lehuen, et al. (2012)
J. Immunol. 189, 3007-3017
   Abstract »    Full Text »    PDF »
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D. Cala-De Paepe, E. Layre, G. Giacometti, L. F. Garcia-Alles, L. Mori, D. Hanau, G. de Libero, H. de la Salle, G. Puzo, and M. Gilleron (2012)
J. Biol. Chem. 287, 31494-31502
   Abstract »    Full Text »    PDF »
Dendritic Cell Sphingosine 1-Phosphate Receptor-3 Regulates Th1-Th2 Polarity in Kidney Ischemia-Reperfusion Injury.
A. Bajwa, L. Huang, H. Ye, K. Dondeti, S. Song, D. L. Rosin, K. R. Lynch, P. I. Lobo, L. Li, and M. D. Okusa (2012)
J. Immunol. 189, 2584-2596
   Abstract »    Full Text »    PDF »
High expression of lactotriaosylceramide, a differentiation-associated glycosphingolipid, in the bone marrow of acute myeloid leukemia patients.
Z. Wang, L. Wen, X. Ma, Z. Chen, Y. Yu, J. Zhu, Y. Wang, Z. Liu, H. Liu, D. Wu, et al. (2012)
Glycobiology 22, 930-938
   Abstract »    Full Text »    PDF »
Lysophospholipid presentation by CD1d and recognition by a human Natural Killer T-cell receptor.
J. Lopez-Sagaseta, L. V. Sibener, J. E. Kung, J. Gumperz, and E. J. Adams (2012)
EMBO J. 31, 2047-2059
   Abstract »    Full Text »    PDF »
Significance of para-esophageal lymph nodes in food or aeroallergen-induced iNKT cell-mediated experimental eosinophilic esophagitis.
P. Rajavelu, M. Rayapudi, M. Moffitt, A. Mishra, and A. Mishra (2012)
Am J Physiol Gastrointest Liver Physiol 302, G645-G654
   Abstract »    Full Text »    PDF »
Structural and Functional Characterization of a Novel Nonglycosidic Type I NKT Agonist with Immunomodulatory Properties.
J. Kerzerho, E. D. Yu, C. M. Barra, E. Alari-Pahisa, E. Girardi, Y. Harrak, P. Lauzurica, A. Llebaria, D. M. Zajonc, O. Akbari, et al. (2012)
J. Immunol. 188, 2254-2265
   Abstract »    Full Text »    PDF »
Mutation of a Positively Charged Cytoplasmic Motif within CD1d Results in Multiple Defects in Antigen Presentation to NKT Cells.
J. H. Shin, J.-Y. Park, Y. H. Shin, H. Lee, Y.-K. Park, S. Jung, and S.-H. Park (2012)
J. Immunol. 188, 2235-2243
   Abstract »    Full Text »    PDF »
Evidence for the divergence of innate and adaptive T-cell precursors before commitment to the {alpha}{beta} and {gamma}{delta} lineages.
J. Kisielow, L. Tortola, J. Weber, K. Karjalainen, and M. Kopf (2011)
Blood 118, 6591-6600
   Abstract »    Full Text »    PDF »
V{beta}2 natural killer T cell antigen receptor-mediated recognition of CD1d-glycolipid antigen.
O. Patel, D. G. Pellicci, A. P. Uldrich, L. C. Sullivan, M. Bhati, M. McKnight, S. K. Richardson, A. R. Howell, T. Mallevaey, J. Zhang, et al. (2011)
PNAS 108, 19007-19012
   Abstract »    Full Text »    PDF »
Critical Roles of RasGRP1 for Invariant NKT Cell Development.
S. Shen, Y. Chen, B. K. Gorentla, J. Lu, J. C. Stone, and X.-P. Zhong (2011)
J. Immunol. 187, 4467-4473
   Abstract »    Full Text »    PDF »
Identification of Self-lipids Presented by CD1c and CD1d Proteins.
N. A. Haig, Z. Guan, D. Li, A. McMichael, C. R. H. Raetz, and X.-N. Xu (2011)
J. Biol. Chem. 286, 37692-37701
   Abstract »    Full Text »    PDF »
Cutting Edge: Structural Basis for the Recognition of {beta}-Linked Glycolipid Antigens by Invariant NKT Cells.
E. D. Yu, E. Girardi, J. Wang, and D. M. Zajonc (2011)
J. Immunol. 187, 2079-2083
   Abstract »    Full Text »    PDF »
CD1b tetramers bind {alpha}{beta} T cell receptors to identify a mycobacterial glycolipid-reactive T cell repertoire in humans.
A. G. Kasmar, I. van Rhijn, T.-Y. Cheng, M. Turner, C. Seshadri, A. Schiefner, R. C. Kalathur, J. W. Annand, A. de Jong, J. Shires, et al. (2011)
J. Exp. Med. 208, 1741-1747
   Abstract »    Full Text »    PDF »
Characterization of human invariant natural killer T cells expressing FoxP3.
P. Engelmann, K. Farkas, J. Kis, G. Richman, Z. Zhang, C. W. Liew, M. Borowiec, M. A. Niewczas, H. Jalahej, and T. Orban (2011)
Int. Immunol. 23, 473-484
   Abstract »    Full Text »    PDF »
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S. Joyce, E. Girardi, and D. M. Zajonc (2011)
J. Immunol. 187, 1081-1089
   Abstract »    Full Text »    PDF »
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M. G. Constantinides, D. Picard, A. K. Savage, and A. Bendelac (2011)
J. Immunol. 187, 309-315
   Abstract »    Full Text »    PDF »
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B. Nakken, T. Varga, I. Szatmari, L. Szeles, A. Gyongyosi, P. A. Illarionov, B. Dezso, P. Gogolak, E. Rajnavolgyi, and L. Nagy (2011)
J. Immunol. 187, 240-247
   Abstract »    Full Text »    PDF »
PLZF induces an intravascular surveillance program mediated by long-lived LFA-1-ICAM-1 interactions.
S. Y. Thomas, S. T. Scanlon, K. G. Griewank, M. G. Constantinides, A. K. Savage, K. A. Barr, F. Meng, A. D. Luster, and A. Bendelac (2011)
J. Exp. Med. 208, 1179-1188
   Abstract »    Full Text »    PDF »
T cell receptor signal strength in Treg and iNKT cell development demonstrated by a novel fluorescent reporter mouse.
A. E. Moran, K. L. Holzapfel, Y. Xing, N. R. Cunningham, J. S. Maltzman, J. Punt, and K. A. Hogquist (2011)
J. Exp. Med. 208, 1279-1289
   Abstract »    Full Text »    PDF »
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Q. Chen, K. L. Mosovsky, and A. C. Ross (2011)
Clin. Vaccine Immunol. 18, 1015-1020
   Abstract »    Full Text »    PDF »
Transcription factor Bcl11b controls selection of invariant natural killer T-cells by regulating glycolipid presentation in double-positive thymocytes.
D. I. Albu, J. VanValkenburgh, N. Morin, D. Califano, N. A. Jenkins, N. G. Copeland, P. Liu, and D. Avram (2011)
PNAS 108, 6211-6216
   Abstract »    Full Text »    PDF »
Role of SLAM in NKT Cell Development Revealed by Transgenic Complementation in NOD Mice.
M. A. Jordan, J. M. Fletcher, R. Jose, S. Chowdhury, N. Gerlach, J. Allison, and A. G. Baxter (2011)
J. Immunol. 186, 3953-3965
   Abstract »    Full Text »    PDF »
Diverse Endogenous Antigens for Mouse NKT Cells: Self-Antigens That Are Not Glycosphingolipids.
B. Pei, A. O. Speak, D. Shepherd, T. Butters, V. Cerundolo, F. M. Platt, and M. Kronenberg (2011)
J. Immunol. 186, 1348-1360
   Abstract »    Full Text »    PDF »
Calreticulin Controls the Rate of Assembly of CD1d Molecules in the Endoplasmic Reticulum.
Y. Zhu, W. Zhang, N. Veerapen, G. Besra, and P. Cresswell (2010)
J. Biol. Chem. 285, 38283-38292
   Abstract »    Full Text »    PDF »
Adenosine A2A receptors induced on iNKT and NK cells reduce pulmonary inflammation and injury in mice with sickle cell disease.
K. L. Wallace and J. Linden (2010)
Blood 116, 5010-5020
   Abstract »    Full Text »    PDF »
The invariant NKT cell subset in anti-viral defenses: a dark horse in anti-influenza immunity?.
R. R. Kulkarni, S. M. Haeryfar, and S. Sharif (2010)
J. Leukoc. Biol. 88, 635-643
   Abstract »    Full Text »    PDF »
Development of Spontaneous Anergy in Invariant Natural Killer T Cells in a Mouse Model of Dyslipidemia.
N. A. Braun, Y. V. Mendez-Fernandez, R. Covarrubias, S. A. Porcelli, P. B. Savage, H. Yagita, L. Van Kaer, and A. S. Major (2010)
Arterioscler Thromb Vasc Biol 30, 1758-1765
   Abstract »    Full Text »    PDF »
Multi-system disorders of glycosphingolipid and ganglioside metabolism.
Y.-H. Xu, S. Barnes, Y. Sun, and G. A. Grabowski (2010)
J. Lipid Res. 51, 1643-1675
   Abstract »    Full Text »    PDF »
Dietary fatty acids modulate antigen presentation to hepatic NKT cells in nonalcoholic fatty liver disease.
J. Hua, X. Ma, T. Webb, J. J. Potter, M. Oelke, and Z. Li (2010)
J. Lipid Res. 51, 1696-1703
   Abstract »    Full Text »    PDF »
Oligoclonality and innate-like features in the TCR repertoire of type II NKT cells reactive to a {beta}-linked self-glycolipid.
P. Arrenberg, R. Halder, Y. Dai, I. Maricic, and V. Kumar (2010)
PNAS 107, 10984-10989
   Abstract »    Full Text »    PDF »
PLZF Induces the Spontaneous Acquisition of Memory/Effector Functions in T Cells Independently of NKT Cell-Related Signals.
D. Kovalovsky, E. S. Alonzo, O. U. Uche, M. Eidson, K. E. Nichols, and D. B. Sant'Angelo (2010)
J. Immunol. 184, 6746-6755
   Abstract »    Full Text »    PDF »
Activation state and intracellular trafficking contribute to the repertoire of endogenous glycosphingolipids presented by CD1d.
K. Muindi, M. Cernadas, G. F. M. Watts, L. Royle, D. C. A. Neville, R. A. Dwek, G. S. Besra, P. M. Rudd, T. D. Butters, and M. B. Brenner (2010)
PNAS 107, 3052-3057
   Abstract »    Full Text »    PDF »
Commensal Microbiota and CD8+ T Cells Shape the Formation of Invariant NKT Cells.
B. Wei, G. Wingender, D. Fujiwara, D. Y. Chen, M. McPherson, S. Brewer, J. Borneman, M. Kronenberg, and J. Braun (2010)
J. Immunol. 184, 1218-1226
   Abstract »    Full Text »    PDF »
The specialized iNKT cell system recognizes glycolipid antigens and bridges the innate and acquired immune systems with potential applications for cancer therapy.
M. Taniguchi, T. Tashiro, N. Dashtsoodol, N. Hongo, and H. Watarai (2010)
Int. Immunol. 22, 1-6
   Abstract »    Full Text »    PDF »
Direct CD1d-Mediated Stimulation of APC IL-12 Production and Protective Immune Response to Virus Infection In Vivo.
S. C. Yue, M. Nowak, A. Shaulov-Kask, R. Wang, D. Yue, S. P. Balk, and M. A. Exley (2010)
J. Immunol. 184, 268-276
   Abstract »    Full Text »    PDF »
Adaptability of the semi-invariant natural killer T-cell receptor towards structurally diverse CD1d-restricted ligands.
W. C. Florence, C. Xia, L. E. Gordy, W. Chen, Y. Zhang, J. Scott-Browne, Y. Kinjo, K. O. A. Yu, S. Keshipeddy, D. G. Pellicci, et al. (2009)
EMBO J. 28, 3579-3590
   Abstract »    Full Text »    PDF »
EBV-Induced Human CD8+ NKT Cells Suppress Tumorigenesis by EBV-Associated Malignancies.
H. Yuling, X. Ruijing, L. Li, J. Xiang, Z. Rui, W. Yujuan, Z. Lijun, D. Chunxian, T. Xinti, X. Wei, et al. (2009)
Cancer Res. 69, 7935-7944
   Abstract »    Full Text »    PDF »
Human NKT cells promote monocyte differentiation into suppressive myeloid antigen-presenting cells.
S. Hegde, E. Jankowska-Gan, D. A. Roenneburg, J. Torrealba, W. J. Burlingham, and J. E. Gumperz (2009)
J. Leukoc. Biol. 86, 757-768
   Abstract »    Full Text »    PDF »
Molecular and immunogenic features of myelin lipids: incitants or modulators of multiple sclerosis?.
M Podbielska and E. Hogan (2009)
Multiple Sclerosis Journal 15, 1011-1029
   Abstract »    PDF »
NKT cells mediate pulmonary inflammation and dysfunction in murine sickle cell disease through production of IFN-{gamma} and CXCR3 chemokines.
K. L. Wallace, M. A. Marshall, S. I. Ramos, J. A. Lannigan, J. J. Field, R. M. Strieter, and J. Linden (2009)
Blood 114, 667-676
   Abstract »    Full Text »    PDF »
Activation of invariant NKT cells confers protection against Chlamydia trachomatis-induced arthritis.
M. S. Bharhani, B. Chiu, K.-S. Na, and R. D. Inman (2009)
Int. Immunol. 21, 859-870
   Abstract »    Full Text »    PDF »
CD1c bypasses lysosomes to present a lipopeptide antigen with 12 amino acids.
I. Van Rhijn, D. C. Young, A. De Jong, J. Vazquez, T.-Y. Cheng, R. Talekar, D. C. Barral, L. Leon, M. B. Brenner, J. T. Katz, et al. (2009)
J. Exp. Med. 206, 1409-1422
   Abstract »    Full Text »    PDF »
Intrathymic proliferation wave essential for V{alpha}14+ natural killer T cell development depends on c-Myc.
M. Dose, B. P. Sleckman, J. Han, A. L. Bredemeyer, A. Bendelac, and F. Gounari (2009)
PNAS 106, 8641-8646
   Abstract »    Full Text »    PDF »
NKT Cell Subsets Mediate Differential Proatherogenic Effects in ApoE-/- Mice.
K. To, A. Agrotis, G. Besra, A. Bobik, and B.-H. Toh (2009)
Arterioscler Thromb Vasc Biol 29, 671-677
   Abstract »    Full Text »    PDF »
PD-1/PD-L Blockade Prevents Anergy Induction and Enhances the Anti-Tumor Activities of Glycolipid-Activated Invariant NKT Cells.
V. V. Parekh, S. Lalani, S. Kim, R. Halder, M. Azuma, H. Yagita, V. Kumar, L. Wu, and L. Van Kaer (2009)
J. Immunol. 182, 2816-2826
   Abstract »    Full Text »    PDF »
Importance of NKT Cells in Resistance to Herpes Simplex Virus, Fate of Virus-Infected Neurons, and Level of Latency in Mice.
B. Grubor-Bauk, J. L. Arthur, and G. Mayrhofer (2008)
J. Virol. 82, 11073-11083
   Abstract »    Full Text »    PDF »
Enhanced Early Expansion and Maturation of Semi-Invariant NK T Cells Inhibited Autoimmune Pathogenesis in Congenic Nonobese Diabetic Mice.
A. Ueno, J. Wang, L. Cheng, J. S. Im, Y. Shi, S. A. Porcelli, and Y. Yang (2008)
J. Immunol. 181, 6789-6796
   Abstract »    Full Text »    PDF »
Natural killer T-cell autoreactivity leads to a specialized activation state.
X. Wang, X. Chen, L. Rodenkirch, W. Simonson, S. Wernimont, R. M. Ndonye, N. Veerapen, D. Gibson, A. R. Howell, G. S. Besra, et al. (2008)
Blood 112, 4128-4138
   Abstract »    Full Text »    PDF »
{beta}-Glycosphingolipids-mediated lipid raft alteration is associated with redistribution of NKT cells and increased intrahepatic CD8+ T lymphocyte trapping.
G. Lalazar, A. Ben Ya'acov, N. Eliakim-Raz, D. M. Livovsky, O. Pappo, S. Preston, L. Zolotarov, and Y. Ilan (2008)
J. Lipid Res. 49, 1884-1893
   Abstract »    Full Text »    PDF »
Congenic Analysis of the NKT Cell Control Gene Nkt2 Implicates the Peroxisomal Protein Pxmp4.
J. M. Fletcher, M. A. Jordan, S. L. Snelgrove, R. M. Slattery, F. D. Dufour, K. Kyparissoudis, G. S. Besra, D. I. Godfrey, and A. G. Baxter (2008)
J. Immunol. 181, 3400-3412
   Abstract »    Full Text »    PDF »
Invariant NKT Cells Regulate Experimental Autoimmune Encephalomyelitis and Infiltrate the Central Nervous System in a CD1d-Independent Manner.
L. T. Mars, A.-S. Gautron, J. Novak, L. Beaudoin, J. Diana, R. S. Liblau, and A. Lehuen (2008)
J. Immunol. 181, 2321-2329
   Abstract »    Full Text »    PDF »
IFN-{gamma}-Producing Human Invariant NKT Cells Promote Tumor-Associated Antigen-Specific Cytotoxic T Cell Responses.
M. Moreno, J. W. Molling, S. von Mensdorff-Pouilly, R. H. M. Verheijen, E. Hooijberg, D. Kramer, A. W. Reurs, A. J. M. van den Eertwegh, B. M. E. von Blomberg, R. J. Scheper, et al. (2008)
J. Immunol. 181, 2446-2454
   Abstract »    Full Text »    PDF »
Influence of a Non-NK Complex Region of Chromosome 6 on CD4+ Invariant NK T Cell Homeostasis.
D. Vallois, M.-C. Gagnerault, P. Avner, U. C. Rogner, C. Boitard, K. Benlagha, A. Herbelin, and F. Lepault (2008)
J. Immunol. 181, 1753-1759
   Abstract »    Full Text »    PDF »
IL-2 triggers specific signaling pathways in human NKT cells leading to the production of pro- and anti-inflammatory cytokines.
S. Bessoles, F. Fouret, S. Dudal, G. S. Besra, F. Sanchez, and V. Lafont (2008)
J. Leukoc. Biol. 84, 224-233
   Abstract »    Full Text »    PDF »
Activation-induced NKT cell hyporesponsiveness protects from {alpha}-galactosylceramide hepatitis and is independent of active transregulatory factors.
M. Biburger and G. Tiegs (2008)
J. Leukoc. Biol. 84, 264-279
   Abstract »    Full Text »    PDF »
IL-15 Expands Unconventional CD8{alpha}{alpha}NK1.1+ T Cells but Not V{alpha}14J{alpha}18+ NKT Cells.
M. Terabe, Y. Tagaya, Q. Zhu, L. Granger, M. Roederer, T. A. Waldmann, and J. A. Berzofsky (2008)
J. Immunol. 180, 7276-7286
   Abstract »    Full Text »    PDF »
MR1 uses an endocytic pathway to activate mucosal-associated invariant T cells.
S. Huang, S. Gilfillan, S. Kim, B. Thompson, X. Wang, A. J. Sant, D. H. Fremont, O. Lantz, and T. H. Hansen (2008)
J. Exp. Med. 205, 1201-1211
   Abstract »    Full Text »    PDF »
Dendritic Cell Differentiation State and Their Interaction with NKT Cells Determine Th1/Th2 Differentiation in the Murine Model of Leishmania major Infection.
C. Wiethe, A. Debus, M. Mohrs, A. Steinkasserer, M. Lutz, and A. Gessner (2008)
J. Immunol. 180, 4371-4381
   Abstract »    Full Text »    PDF »
Aberrant Genetic Control of Invariant TCR-Bearing NKT Cell Function in New Zealand Mouse Strains: Possible Involvement in Systemic Lupus Erythematosus Pathogenesis.
K. Tsukamoto, M. Ohtsuji, W. Shiroiwa, Q. Lin, K. Nakamura, H. Tsurui, Y. Jiang, K. Sudo, H. Nishimura, T. Shirai, et al. (2008)
J. Immunol. 180, 4530-4539
   Abstract »    Full Text »    PDF »
The vitamin D receptor is required for iNKT cell development.
S. Yu and M. T. Cantorna (2008)
PNAS 105, 5207-5212
   Abstract »    Full Text »    PDF »
NKT Cells in Tumor Immunity: Opposing Subsets Define a New Immunoregulatory Axis.
J. A. Berzofsky and M. Terabe (2008)
J. Immunol. 180, 3627-3635
   Abstract »    Full Text »    PDF »
Involvement of Secretory and Endosomal Compartments in Presentation of an Exogenous Self-Glycolipid to Type II NKT Cells.
K. C. Roy, I. Maricic, A. Khurana, T. R. F. Smith, R. C. Halder, and V. Kumar (2008)
J. Immunol. 180, 2942-2950
   Abstract »    Full Text »    PDF »
Cutting Edge: Activation by Innate Cytokines or Microbial Antigens Can Cause Arrest of Natural Killer T Cell Patrolling of Liver Sinusoids.
P. Velazquez, T. O. Cameron, Y. Kinjo, N. Nagarajan, M. Kronenberg, and M. L. Dustin (2008)
J. Immunol. 180, 2024-2028
   Abstract »    Full Text »    PDF »
A Critical Role of Costimulation during Intrathymic Development of Invariant NK T Cells.
Y. Chung, R. Nurieva, E. Esashi, Y.-H. Wang, D. Zhou, L. Gapin, and C. Dong (2008)
J. Immunol. 180, 2276-2283
   Abstract »    Full Text »    PDF »
Sensitive detection of isoglobo and globo series tetraglycosylceramides in human thymus by ion trap mass spectrometry.
Y. Li, S. Teneberg, P. Thapa, A. Bendelac, S. B. Levery, and D. Zhou (2008)
Glycobiology 18, 158-165
   Abstract »    Full Text »    PDF »
Sensitive quantitation of isoglobotriaosylceramide in the presence of isobaric components using electrospray ionization-ion trap mass spectrometry.
Y. Li, D. Zhou, C. Xia, P. G. Wang, and S. B. Levery (2008)
Glycobiology 18, 166-176
   Abstract »    Full Text »    PDF »
Role of NKT cells in the digestive system. IV. The role of canonical natural killer T cells in mucosal immunity and inflammation.
G. Wingender and M. Kronenberg (2008)
Am J Physiol Gastrointest Liver Physiol 294, G1-G8
   Abstract »    Full Text »    PDF »
S1P1 receptor expression regulates emergence of NKT cells in peripheral tissues.
M. L. Allende, D. Zhou, D. N. Kalkofen, S. Benhamed, G. Tuymetova, C. Borowski, A. Bendelac, and R. L. Proia (2008)
FASEB J 22, 307-315
   Abstract »    Full Text »    PDF »
Modulation of human natural killer T cell ligands on TLR-mediated antigen-presenting cell activation.
M. Salio, A. O. Speak, D. Shepherd, P. Polzella, P. A. Illarionov, N. Veerapen, G. S. Besra, F. M. Platt, and V. Cerundolo (2007)
PNAS 104, 20490-20495
   Abstract »    Full Text »    PDF »
Critical Role for CXC Chemokine Ligand 16 (SR-PSOX) in Th1 Response Mediated by NKT Cells.
T. Shimaoka, K.-i. Seino, N. Kume, M. Minami, C. Nishime, M. Suematsu, T. Kita, M. Taniguchi, K. Matsushima, and S. Yonehara (2007)
J. Immunol. 179, 8172-8179
   Abstract »    Full Text »    PDF »
Modulation of CD1d-restricted NKT cell responses by CD4.
X. Chen, X. Wang, G. S. Besra, and J. E. Gumperz (2007)
J. Leukoc. Biol. 82, 1455-1465
   Abstract »    Full Text »    PDF »
Role of NKT Cells in the Digestive System. III. Role of NKT cells in intestinal immunity.
S. Zeissig, A. Kaser, S. K. Dougan, E. E. S. Nieuwenhuis, and R. S. Blumberg (2007)
Am J Physiol Gastrointest Liver Physiol 293, G1101-G1105
   Abstract »    Full Text »    PDF »
Non-classical major histocompatibility complex proteins as determinants of tumour immunosurveillance.
A. Q. Gomes, D. V. Correia, and B. Silva-Santos (2007)
EMBO Rep. 8, 1024-1030
   Abstract »    Full Text »    PDF »
Invariant NKT Cells Biased for IL-5 Production Act as Crucial Regulators of Inflammation.
K. Sakuishi, S. Oki, M. Araki, S. A. Porcelli, S. Miyake, and T. Yamamura (2007)
J. Immunol. 179, 3452-3462
   Abstract »    Full Text »    PDF »
A Y Chromosome-Linked Factor Impairs NK T Development.
J. D. Wesley, M. S. Tessmer, C. Paget, F. Trottein, and L. Brossay (2007)
J. Immunol. 179, 3480-3487
   Abstract »    Full Text »    PDF »
A Single Early Activation of Invariant NK T Cells Confers Long-Term Protection against Collagen-Induced Arthritis in a Ligand-Specific Manner.
K. Coppieters, K. Van Beneden, P. Jacques, P. Dewint, A. Vervloet, B. Vander Cruyssen, S. Van Calenbergh, G. Chen, R. W. Franck, G. Verbruggen, et al. (2007)
J. Immunol. 179, 2300-2309
   Abstract »    Full Text »    PDF »
CD4 engagement by CD1d potentiates activation of CD4+ invariant NKT cells.
A. Thedrez, C. de Lalla, S. Allain, L. Zaccagnino, S. Sidobre, C. Garavaglia, G. Borsellino, P. Dellabona, M. Bonneville, E. Scotet, et al. (2007)
Blood 110, 251-258
   Abstract »    Full Text »    PDF »
Distinct Endosomal Trafficking Requirements for Presentation of Autoantigens and Exogenous Lipids by Human CD1d Molecules.
X. Chen, X. Wang, J. M. Keaton, F. Reddington, P. A. Illarionov, G. S. Besra, and J. E. Gumperz (2007)
J. Immunol. 178, 6181-6190
   Abstract »    Full Text »    PDF »
Identification of an IL-17-producing NK1.1neg iNKT cell population involved in airway neutrophilia.
M.-L. Michel, A. C. Keller, C. Paget, M. Fujio, F. Trottein, P. B. Savage, C.-H. Wong, E. Schneider, M. Dy, and M. C. Leite-de-Moraes (2007)
J. Exp. Med. 204, 995-1001
   Abstract »    Full Text »    PDF »

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