Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Subscribe

Logo for

Science 306 (5704): 2093-2097

Copyright © 2004 by the American Association for the Advancement of Science

Hemoxygenase-2 Is an Oxygen Sensor for a Calcium-Sensitive Potassium Channel

Sandile E. J. Williams,1,5 Phillippa Wootton,1 Helen S. Mason,1,5 Jonathan Bould,2 David E. Iles,3 Daniela Riccardi,5 Chris Peers,4 Paul J. Kemp1,5*

Abstract: Modulation of calcium-sensitive potassium (BK) channels by oxygen is important in several mammalian tissues, and in the carotid body it is crucial to respiratory control. However, the identity of the oxygen sensor remains unknown. We demonstrate that hemoxygenase-2 (HO-2) is part of the BK channel complex and enhances channel activity in normoxia. Knockdown of HO-2 expression reduced channel activity, and carbon monoxide, a product of HO-2 activity, rescued this loss of function. Inhibition of BK channels by hypoxia was dependent on HO-2 expression and was augmented by HO-2 stimulation. Furthermore, carotid body cells demonstrated HO-2–dependent hypoxic BK channel inhibition, which indicates that HO-2 is an oxygen sensor that controls channel activity during oxygen deprivation.

1 School of Biomedical Sciences, University of Leeds, Leeds LS2 9JT, UK.
2 School of Chemistry, University of Leeds, Leeds LS2 9JT, UK.
3 School of Biology, University of Leeds, Leeds LS2 9JT, UK.
4 School of Medicine, University of Leeds, Leeds LS2 9JT, UK.
5 Cardiff School of Biosciences, Museum Avenue, Cardiff University, Cardiff, CF10 3US, UK.

* To whom correspondence should be addressed. E-mail: KempPJ{at}Cardiff.ac.uk


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Gasotransmitter Regulation of Ion Channels: A Key Step in O2 Sensing By the Carotid Body.
N. R. Prabhakar and C. Peers (2014)
Physiology 29, 49-57
   Abstract »    Full Text »    PDF »
A new method to detect rapid oxygen changes around cells: How quickly do calcium channels sense oxygen in cardiomyocytes?.
J. A. Scaringi, A. O. Rosa, M. Morad, and L. Cleemann (2013)
J Appl Physiol 115, 1855-1861
   Abstract »    Full Text »    PDF »
Heme Sensor Proteins.
H. M. Girvan and A. W. Munro (2013)
J. Biol. Chem. 288, 13194-13203
   Abstract »    Full Text »    PDF »
Sensing hypoxia: physiology, genetics and epigenetics.
N. R. Prabhakar (2013)
J. Physiol. 591, 2245-2257
   Abstract »    Full Text »    PDF »
Carbon monoxide stimulates Ca2+-dependent big-conductance K channels in the cortical collecting duct.
Z. Wang, P. Yue, D.-H. Lin, and W.-H. Wang (2013)
Am J Physiol Renal Physiol 304, F543-F552
   Abstract »    Full Text »    PDF »
H2S, a gasotransmitter for oxygen sensing in carotid body. Focus on "Endogenous H2S is required for hypoxic sensing by carotid body glomus cells".
K. A. Smith and J. X.- J. Yuan (2012)
Am J Physiol Cell Physiol 303, C911-C912
   Full Text »    PDF »
Role of Cysteine Residues in Heme Binding to Human Heme Oxygenase-2 Elucidated by Two-dimensional NMR Spectroscopy.
F. Varfaj, J. N. Lampe, and P. R. Ortiz de Montellano (2012)
J. Biol. Chem. 287, 35181-35191
   Abstract »    Full Text »    PDF »
Hypoxic regulation of cardiac Ca2+ channel: possible role of haem oxygenase.
A. O. Rosa, S. Movafagh, L. Cleemann, and M. Morad (2012)
J. Physiol. 590, 4223-4237
   Abstract »    Full Text »    PDF »
The human carotid body transcriptome with focus on oxygen sensing and inflammation - a comparative analysis.
S. Mkrtchian, J. Kahlin, A. Ebberyd, C. Gonzalez, D. Sanchez, A. Balbir, E. W. Kostuk, M. Shirahata, M. J. Fagerlund, and L. I. Eriksson (2012)
J. Physiol. 590, 3807-3819
   Abstract »    Full Text »    PDF »
Regulation of endothelial BK channels by heme oxygenase-derived carbon monoxide and caveolin-1.
M. A. Riddle and B. R. Walker (2012)
Am J Physiol Cell Physiol 303, C92-C101
   Abstract »    Full Text »    PDF »
Hypoxic regulation of the cerebral microcirculation is mediated by a carbon monoxide-sensitive hydrogen sulfide pathway.
T. Morikawa, M. Kajimura, T. Nakamura, T. Hishiki, T. Nakanishi, Y. Yukutake, Y. Nagahata, M. Ishikawa, K. Hattori, T. Takenouchi, et al. (2012)
PNAS 109, 1293-1298
   Abstract »    Full Text »    PDF »
Hypoxic Pulmonary Vasoconstriction.
J. T. Sylvester, L. A. Shimoda, P. I. Aaronson, and J. P. T. Ward (2012)
Physiol Rev 92, 367-520
   Abstract »    Full Text »    PDF »
Suppression of a Neocortical Potassium Channel Activity by Intracellular Amyloid-{beta} and Its Rescue with Homer1a.
K. Yamamoto, Y. Ueta, L. Wang, R. Yamamoto, N. Inoue, K. Inokuchi, A. Aiba, H. Yonekura, and N. Kato (2011)
J. Neurosci. 31, 11100-11109
   Abstract »    Full Text »    PDF »
Carbon monoxide as an endogenous vascular modulator.
C. W. Leffler, H. Parfenova, and J. H. Jaggar (2011)
Am J Physiol Heart Circ Physiol 301, H1-H11
   Abstract »    Full Text »    PDF »
Carbon monoxide: an emerging regulator of ion channels.
W. J. Wilkinson and P. J. Kemp (2011)
J. Physiol. 589, 3055-3062
   Abstract »    Full Text »    PDF »
Uncoupling Charge Movement from Channel Opening in Voltage-gated Potassium Channels by Ruthenium Complexes.
A. Jara-Oseguera, I. G. Ishida, G. E. Rangel-Yescas, N. Espinosa-Jalapa, J. A. Perez-Guzman, D. Elias-Vinas, R. Le Lagadec, T. Rosenbaum, and L. D. Islas (2011)
J. Biol. Chem. 286, 16414-16425
   Abstract »    Full Text »    PDF »
Carbon monoxide protects against oxidant-induced apoptosis via inhibition of Kv2.1.
M. L. Dallas, J. P. Boyle, C. J. Milligan, R. Sayer, T. L. Kerrigan, C. McKinstry, P. Lu, J. Mankouri, M. Harris, J. L. Scragg, et al. (2011)
FASEB J 25, 1519-1530
   Abstract »    Full Text »    PDF »
The Yeast Homolog of Heme Oxygenase-1 Affords Cellular Antioxidant Protection via the Transcriptional Regulation of Known Antioxidant Genes.
E. J. Collinson, S. Wimmer-Kleikamp, S. K. Gerega, Y. H. Yang, C. R. Parish, I. W. Dawes, and R. Stocker (2011)
J. Biol. Chem. 286, 2205-2214
   Abstract »    Full Text »    PDF »
The coordinated increased expression of biliverdin reductase and heme oxygenase-2 promotes cardiomyocyte survival: a reductase-based peptide counters {beta}-adrenergic receptor ligand-mediated cardiac dysfunction.
B. Ding, P. E. M. Gibbs, P. S. Brookes, and M. D. Maines (2011)
FASEB J 25, 301-313
   Abstract »    Full Text »    PDF »
Long-term exposure to high-altitude chronic hypoxia during gestation induces neonatal pulmonary hypertension at sea level.
E. A. Herrera, R. A. Riquelme, G. Ebensperger, R. V. Reyes, C. E. Ulloa, G. Cabello, B. J. Krause, J. T. Parer, D. A. Giussani, and A. J. Llanos (2010)
Am J Physiol Regulatory Integrative Comp Physiol 299, R1676-R1684
   Abstract »    Full Text »    PDF »
Ca2+-Activated K+ Channels: From Protein Complexes to Function.
H. Berkefeld, B. Fakler, and U. Schulte (2010)
Physiol Rev 90, 1437-1459
   Abstract »    Full Text »    PDF »
TRPC6 channels and their binding partners in podocytes: role in glomerular filtration and pathophysiology.
S. E. Dryer and J. Reiser (2010)
Am J Physiol Renal Physiol 299, F689-F701
   Abstract »    Full Text »    PDF »
Genetic Evidence for High-Altitude Adaptation in Tibet.
T. S. Simonson, Y. Yang, C. D. Huff, H. Yun, G. Qin, D. J. Witherspoon, Z. Bai, F. R. Lorenzo, J. Xing, L. B. Jorde, et al. (2010)
Science 329, 72-75
   Abstract »    Full Text »    PDF »
Identification of a Thiol/Disulfide Redox Switch in the Human BK Channel That Controls Its Affinity for Heme and CO.
L. Yi, J. T. Morgan, and S. W. Ragsdale (2010)
J. Biol. Chem. 285, 20117-20127
   Abstract »    Full Text »    PDF »
H2S mediates O2 sensing in the carotid body.
Y.-J. Peng, J. Nanduri, G. Raghuraman, D. Souvannakitti, M. M. Gadalla, G. K. Kumar, S. H. Snyder, and N. R. Prabhakar (2010)
PNAS 107, 10719-10724
   Abstract »    Full Text »    PDF »
The Ventilatory Response to Hypoxia in Mammals: Mechanisms, Measurement, and Analysis.
L. J. Teppema and A. Dahan (2010)
Physiol Rev 90, 675-754
   Abstract »    Full Text »    PDF »
Chemoreceptor Hypersensitivity, Sympathetic Excitation, and Overexpression of ASIC and TASK Channels Before the Onset of Hypertension in SHR.
Z.-Y. Tan, Y. Lu, C. A. Whiteis, A. E. Simms, J. F.R. Paton, M. W. Chapleau, and F. M. Abboud (2010)
Circ. Res. 106, 536-545
   Abstract »    Full Text »    PDF »
Nitric Oxide-Dependent Bone Marrow Progenitor Mobilization by Carbon Monoxide Enhances Endothelial Repair After Vascular Injury.
B. Wegiel, D. J. Gallo, K. G. Raman, J. M. Karlsson, B. Ozanich, B. Y. Chin, E. Tzeng, S. Ahmad, A. Ahmed, C. J. Baty, et al. (2010)
Circulation 121, 537-548
   Abstract »    Full Text »    PDF »
{alpha}5{beta}1 Integrin Engagement Increases Large Conductance, Ca2+-activated K+ Channel Current and Ca2+ Sensitivity through c-src-mediated Channel Phosphorylation.
Y. Yang, X. Wu, P. Gui, J. Wu, J.-Z. Sheng, S. Ling, A. P. Braun, G. E. Davis, and M. J. Davis (2010)
J. Biol. Chem. 285, 131-141
   Abstract »    Full Text »    PDF »
Hypoxemia induces expression of heme oxygenase-1 and heme oxygenase-2 proteins in the mouse myocardium.
F. Han, K. Takeda, M. Ono, F. Date, K. Ishikawa, S. Yokoyama, Y. Shinozawa, K. Furuyama, and S. Shibahara (2010)
J. Biochem. 147, 143-151
   Abstract »    Full Text »    PDF »
Identification of subdomains in NADPH oxidase-4 critical for the oxygen-dependent regulation of TASK-1 K+ channels.
S. J. Park, Y.-S. Chun, K. S. Park, S. J. Kim, S.-O. Choi, H.-L. Kim, and J.-W. Park (2009)
Am J Physiol Cell Physiol 297, C855-C864
   Abstract »    Full Text »    PDF »
Heme oxygenase-1 induction modulates hypoxic pulmonary vasoconstriction through upregulation of ecSOD.
M. Ahmad, X. Zhao, M. R. Kelly, S. Kandhi, O. Perez, N. G. Abraham, and M. S. Wolin (2009)
Am J Physiol Heart Circ Physiol 297, H1453-H1461
   Abstract »    Full Text »    PDF »
Heme oxygenase-1-dependent central cardiorespiratory adaptations to chronic hypoxia in mice.
J. Sunderram, J. Semmlow, S. Thakker-Varia, M. Bhaumik, O. Hoang-Le, and J. A. Neubauer (2009)
Am J Physiol Regulatory Integrative Comp Physiol 297, R300-R312
   Abstract »    Full Text »    PDF »
An oxygen-sensitive mechanism in regulation of epithelial sodium channel.
S. Wang, S. Publicover, and Y. Gu (2009)
PNAS 106, 2957-2962
   Abstract »    Full Text »    PDF »
Modulation of BKCa Channel Gating by Endogenous Signaling Molecules.
S. Hou, S. H. Heinemann, and T. Hoshi (2009)
Physiology 24, 26-35
   Abstract »    Full Text »    PDF »
Heme oxygenase is necessary for the excitatory response of cultured neonatal rat rostral ventrolateral medulla neurons to hypoxia.
D. D'Agostino, E. Mazza Jr., and J. A. Neubauer (2009)
Am J Physiol Regulatory Integrative Comp Physiol 296, R102-R118
   Abstract »    Full Text »    PDF »
MaxiK potassium channels in the function of chemoreceptor cells of the rat carotid body.
A. Gomez-Nino, A. Obeso, J. A. Baranda, J. Santo-Domingo, J. R. Lopez-Lopez, and C. Gonzalez (2009)
Am J Physiol Cell Physiol 297, C715-C722
   Abstract »    Full Text »    PDF »
Carotid body oxygen sensing.
J. Lopez-Barneo, P. Ortega-Saenz, R. Pardal, A. Pascual, and J. I. Piruat (2008)
Eur. Respir. J. 32, 1386-1398
   Abstract »    Full Text »    PDF »
A Prolyl-hydroxylase Inhibitor, Ethyl-3,4-dihydroxybenzoate, Induces Haem Oxygenase-1 Expression in Human Cells Through a Mechanism Independent of Hypoxia-inducible Factor-1{alpha}.
B. Li, K. Takeda, S. Yokoyama, and S. Shibahara (2008)
J. Biochem. 144, 643-654
   Abstract »    Full Text »    PDF »
Carbon Monoxide Inhibits L-type Ca2+ Channels via Redox Modulation of Key Cysteine Residues by Mitochondrial Reactive Oxygen Species.
J. L. Scragg, M. L. Dallas, J. A. Wilkinson, G. Varadi, and C. Peers (2008)
J. Biol. Chem. 283, 24412-24419
   Abstract »    Full Text »    PDF »
Downregulation of carbon monoxide as well as nitric oxide contributes to peripheral chemoreflex hypersensitivity in heart failure rabbits.
Y. Ding, Y.-L. Li, and H. D. Schultz (2008)
J Appl Physiol 105, 14-23
   Abstract »    Full Text »    PDF »
The RCK1 high-affinity Ca2+ sensor confers carbon monoxide sensitivity to Slo1 BK channels.
S. Hou, R. Xu, S. H. Heinemann, and T. Hoshi (2008)
PNAS 105, 4039-4043
   Abstract »    Full Text »    PDF »
Pharmacological and Clinical Aspects of Heme Oxygenase.
N. G. Abraham and A. Kappas (2008)
Pharmacol. Rev. 60, 79-127
   Abstract »    Full Text »    PDF »
Carbon monoxide: a novel pulmonary artery vasodilator in neonatal llamas of the Andean altiplano.
E. A. Herrera, R. V. Reyes, D. A. Giussani, R. A. Riquelme, E. M. Sanhueza, G. Ebensperger, P. Casanello, N. Mendez, R. Ebensperger, E. Sepulveda-Kattan, et al. (2008)
Cardiovasc Res 77, 197-201
   Abstract »    Full Text »    PDF »
Acid-Sensing Ion Channels Contribute to Transduction of Extracellular Acidosis in Rat Carotid Body Glomus Cells.
Z.-Y. Tan, Y. Lu, C. A. Whiteis, C. J. Benson, M. W. Chapleau, and F. M. Abboud (2007)
Circ. Res. 101, 1009-1019
   Abstract »    Full Text »    PDF »
Carbon monoxide and Ca2+-activated K+ channels in cerebral arteriolar responses to glutamate and hypoxia in newborn pigs.
A. Kanu and C. W. Leffler (2007)
Am J Physiol Heart Circ Physiol 293, H3193-H3200
   Abstract »    Full Text »    PDF »
Evidence That the Heme Regulatory Motifs in Heme Oxygenase-2 Serve as a Thiol/Disulfide Redox Switch Regulating Heme Binding.
L. Yi and S. W. Ragsdale (2007)
J. Biol. Chem. 282, 21056-21067
   Abstract »    Full Text »    PDF »
Hypoxia reduces KCa channel activity by inducing Ca2+ spark uncoupling in cerebral artery smooth muscle cells.
G. Zhao, A. Adebiyi, Q. Xi, and J. H. Jaggar (2007)
Am J Physiol Cell Physiol 292, C2122-C2128
   Abstract »    Full Text »    PDF »
AMP-activated Protein Kinase Mediates Carotid Body Excitation by Hypoxia.
C. N. Wyatt, K. J. Mustard, S. A. Pearson, M. L Dallas, L. Atkinson, P. Kumar, C. Peers, D. G. Hardie, and A. M. Evans (2007)
J. Biol. Chem. 282, 8092-8098
   Abstract »    Full Text »    PDF »
A search for genes that may confer divergent morphology and function in the carotid body between two strains of mice.
A. Balbir, H. Lee, M. Okumura, S. Biswal, R. S. Fitzgerald, and M. Shirahata (2007)
Am J Physiol Lung Cell Mol Physiol 292, L704-L715
   Abstract »    Full Text »    PDF »
A noncanonical SH3 domain binding motif links BK channels to the actin cytoskeleton via the SH3 adapter cortactin.
L. Tian, L. Chen, H. McClafferty, C. A. Sailer, P. Ruth, H.-G. Knaus, and M. J. Shipston (2006)
FASEB J 20, 2588-2590
   Abstract »    Full Text »    PDF »
Interaction between endogenously produced carbon monoxide and nitric oxide in regulation of renal afferent arterioles.
F. T. Botros and L. G. Navar (2006)
Am J Physiol Heart Circ Physiol 291, H2772-H2778
   Abstract »    Full Text »    PDF »
Acute Oxygen Sensing in Heme Oxygenase-2 Null Mice.
P. Ortega-Saenz, A. Pascual, R. Gomez-Diaz, and J. Lopez-Barneo (2006)
J. Gen. Physiol. 128, 405-411
   Abstract »    Full Text »    PDF »
Translational Control of Collagen Prolyl 4-Hydroxylase-{alpha}(I) Gene Expression under Hypoxia.
M. Fahling, R. Mrowka, A. Steege, G. Nebrich, A. Perlewitz, P. B. Persson, and B. J. Thiele (2006)
J. Biol. Chem. 281, 26089-26101
   Abstract »    Full Text »    PDF »
AMP-activated protein kinase underpins hypoxic pulmonary vasoconstriction and carotid body excitation by hypoxia in mammals.
A. M. Evans (2006)
Exp Physiol 91, 821-827
   Abstract »    Full Text »    PDF »
Detecting acute changes in oxygen: will the real sensor please stand up?.
P. J. Kemp (2006)
Exp Physiol 91, 829-834
   Abstract »    Full Text »    PDF »
Oxygen sensors in hypoxic pulmonary vasoconstriction.
N. Weissmann, N. Sommer, R. T. Schermuly, H. A. Ghofrani, W. Seeger, and F. Grimminger (2006)
Cardiovasc Res 71, 620-629
   Abstract »    Full Text »    PDF »
The carbonic anhydrase inhibitors methazolamide and acetazolamide have different effects on the hypoxic ventilatory response in the anaesthetized cat.
L. J. Teppema, H. Bijl, B. M. Gourabi, and A. Dahan (2006)
J. Physiol. 574, 565-572
   Abstract »    Full Text »    PDF »
The good, the bad and the ugly in oxygen-sensing: ROS, cytochromes and prolyl-hydroxylases.
T. Acker, J. Fandrey, and H. Acker (2006)
Cardiovasc Res 71, 195-207
   Abstract »    Full Text »    PDF »
Carbon monoxide released by CORM-3 inhibits human platelets by a mechanism independent of soluble guanylate cyclase.
S. Chlopicki, R. Olszanecki, E. Marcinkiewicz, M. Lomnicka, and R. Motterlini (2006)
Cardiovasc Res 71, 393-401
   Abstract »    Full Text »    PDF »
AMP-activated protein kinase and the regulation of Ca2+ signalling in O2-sensing cells.
A. M. Evans (2006)
J. Physiol. 574, 113-123
   Abstract »    Full Text »    PDF »
Inhibition of cellular respiration by endogenously produced carbon monoxide.
G. D'Amico, F. Lam, T. Hagen, and S. Moncada (2006)
J. Cell Sci. 119, 2291-2298
   Abstract »    Full Text »    PDF »
Adenosine stimulates depolarization and rise in cytoplasmic [Ca2+] in type I cells of rat carotid bodies.
F. Xu, J. Xu, F. W. Tse, and A. Tse (2006)
Am J Physiol Cell Physiol 290, C1592-C1598
   Abstract »    Full Text »    PDF »
Antioxidants reverse depression of the hypoxic ventilatory response by acetazolamide in man.
L. J. Teppema, H. Bijl, R. R. Romberg, and A. Dahan (2006)
J. Physiol. 572, 849-856
   Abstract »    Full Text »    PDF »
Heme Oxygenase-1/Carbon Monoxide: From Basic Science to Therapeutic Applications.
S. W. Ryter, J. Alam, and A. M. K. Choi (2006)
Physiol Rev 86, 583-650
   Abstract »    Full Text »    PDF »
Carbon monoxide and hydrogen sulfide: gaseous messengers in cerebrovascular circulation.
C. W. Leffler, H. Parfenova, J. H. Jaggar, and R. Wang (2006)
J Appl Physiol 100, 1065-1076
   Abstract »    Full Text »    PDF »
MaxiK channel partners: physiological impact.
R. Lu, A. Alioua, Y. Kumar, M. Eghbali, E. Stefani, and L. Toro (2006)
J. Physiol. 570, 65-72
   Abstract »    Full Text »    PDF »
O2 sensing at the mammalian carotid body: why multiple O2 sensors and multiple transmitters?.
N. R Prabhakar (2006)
Exp Physiol 91, 17-23
   Abstract »    Full Text »    PDF »
Does AMP-activated Protein Kinase Couple Inhibition of Mitochondrial Oxidative Phosphorylation by Hypoxia to Calcium Signaling in O2-sensing Cells?.
A. M. Evans, K. J. W. Mustard, C. N. Wyatt, C. Peers, M. Dipp, P. Kumar, N. P. Kinnear, and D. G. Hardie (2005)
J. Biol. Chem. 280, 41504-41511
   Abstract »    Full Text »    PDF »
Carbon Monoxide From Heme Oxygenase-2 Is a Tonic Regulator Against NO-Dependent Vasodilatation in the Adult Rat Cerebral Microcirculation.
M. Ishikawa, M. Kajimura, T. Adachi, K. Maruyama, N. Makino, N. Goda, T. Yamaguchi, E. Sekizuka, and M. Suematsu (2005)
Circ. Res. 97, e104-e114
   Abstract »    Full Text »    PDF »
A cysteine-rich motif confers hypoxia sensitivity to mammalian large conductance voltage- and Ca-activated K (BK) channel {alpha}-subunits.
C. E. McCartney, H. McClafferty, J.-M. Huibant, E. G. Rowan, M. J. Shipston, and I. C. M. Rowe (2005)
PNAS 102, 17870-17876
   Abstract »    Full Text »    PDF »
Carbon Monoxide: Endogenous Production, Physiological Functions, and Pharmacological Applications.
L. Wu and R. Wang (2005)
Pharmacol. Rev. 57, 585-630
   Abstract »    Full Text »    PDF »
Effect of p47phox gene deletion on ROS production and oxygen sensing in mouse carotid body chemoreceptor cells.
L. He, B. Dinger, K. Sanders, J. Hoidal, A. Obeso, L. Stensaas, S. Fidone, and C. Gonzalez (2005)
Am J Physiol Lung Cell Mol Physiol 289, L916-L924
   Abstract »    Full Text »    PDF »
O2- and H2O2-dependent Verdoheme Degradation by Heme Oxygenase: REACTION MECHANISMS AND POTENTIAL PHYSIOLOGICAL ROLES OF THE DUAL PATHWAY DEGRADATION.
T. Matsui, A. Nakajima, H. Fujii, K. M. Matera, C. T. Migita, T. Yoshida, and M. Ikeda-Saito (2005)
J. Biol. Chem. 280, 36833-36840
   Abstract »    Full Text »    PDF »
On the peripheral and central chemoreception and control of breathing: an emerging role of ATP.
A. V Gourine (2005)
J. Physiol. 568, 715-724
   Abstract »    Full Text »    PDF »
Heme Is a Carbon Monoxide Receptor for Large-Conductance Ca2+-Activated K+ Channels.
J. H. Jaggar, A. Li, H. Parfenova, J. Liu, E. S. Umstot, A. M. Dopico, and C. W. Leffler (2005)
Circ. Res. 97, 805-812
   Abstract »    Full Text »    PDF »
Heme Regulates Allosteric Activation of the Slo1 BK Channel.
F. T. Horrigan, S. H. Heinemann, and T. Hoshi (2005)
J. Gen. Physiol. 126, 7-21
   Abstract »    Full Text »    PDF »
Multiple Facets of Maxi-K+ Channels: The Heme Connection.
J. Lopez-Barneo and A. Castellano (2005)
J. Gen. Physiol. 126, 1-5
   Full Text »    PDF »
CELL BIOLOGY: Oxygen Sensing: It's a Gas!.
T. Hoshi and S. Lahiri (2004)
Science 306, 2050-2051
   Abstract »    Full Text »    PDF »

To Advertise     Find Products


Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882