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Science 306 (5705): 2255-2257

Copyright © 2004 by the American Association for the Advancement of Science

Mouse Brain Organization Revealed Through Direct Genome-Scale TF Expression Analysis

Paul A. Gray,1,3*{dagger} Hui Fu,2,3* Ping Luo,1,3* Qing Zhao,4 Jing Yu,5 Annette Ferrari,3 Toyoaki Tenzen,5 Dong-in Yuk,4 Eric F. Tsung,6{ddagger} Zhaohui Cai,6 John A. Alberta,3 Le-ping Cheng,1,3 Yang Liu,1,3 Jan M. Stenman,5 M. Todd Valerius,5 Nathan Billings,4 Haesun A. Kim,2,3§ Michael E. Greenberg,1,8 Andrew P. McMahon,5 David H. Rowitch,4,7 Charles D. Stiles,2,3|| Qiufu Ma1,3||

Abstract: In the developing brain, transcription factors (TFs) direct the formation of a diverse array of neurons and glia. We identifed 1445 putative TFs in the mouse genome. We used in situ hybridization to map the expression of over 1000 of these TFs and TF-coregulator genes in the brains of developing mice. We found that 349 of these genes showed restricted expression patterns that were adequate to describe the anatomical organization of the brain. We provide a comprehensive inventory of murine TFs and their expression patterns in a searchable brain atlas database.

1 Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.
2 Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, MA 02115, USA.
3 Department of Cancer Biology, Dana-Farber Cancer Institute, 1 Jimmy Fund Way, Boston, MA 02115, USA.
4 Department of Pediatric Oncology, Dana-Farber Cancer Institute, 1 Jimmy Fund Way, Boston, MA 02115, USA.
5 Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA.
6 Informatics Program, Children's Hospital, Boston, MA 02115, USA.
7 Division of Newborn Medicine, Children's Hospital, Boston, MA 02115, USA.
8 Division of Neuroscience, Children's Hospital, Boston, MA 02115, USA.

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* These authors contributed equally to this work.

{dagger} Present address: Molecular Neurobiology Laboratory, The Salk Institute, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA.

{ddagger} Present address: Department of Biology, Boston College, 140 Commonwealth Avenue, Chestnut Hill, MA 02467, USA.

§ Present address: Department of Biological Sciences, Rutgers University, 101 Warren Street, Newark, NJ 07102 USA.

|| To whom correspondence should be addressed. E-mail: Qiufu_Ma{at} (Q.M.); Charles_Stiles{at} (C.D.S.)

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C. Gubelmann, S. M. Waszak, A. Isakova, W. Holcombe, K. Hens, A. Iagovitina, J.-D. Feuz, S. K. Raghav, J. Simicevic, and B. Deplancke (2014)
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   Abstract »    Full Text »    PDF »
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O. Symmons, V. V. Uslu, T. Tsujimura, S. Ruf, S. Nassari, W. Schwarzer, L. Ettwiller, and F. Spitz (2014)
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   Abstract »    Full Text »    PDF »
Evolutionarily Dynamic Alternative Splicing of GPR56 Regulates Regional Cerebral Cortical Patterning.
B.-I. Bae, I. Tietjen, K. D. Atabay, G. D. Evrony, M. B. Johnson, E. Asare, P. P. Wang, A. Y. Murayama, K. Im, S. N. Lisgo, et al. (2014)
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   Abstract »    Full Text »    PDF »
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F. Zhang, A. Bhattacharya, J. C. Nelson, N. Abe, P. Gordon, C. Lloret-Fernandez, M. Maicas, N. Flames, R. S. Mann, D. A. Colon-Ramos, et al. (2014)
Development 141, 422-435
   Abstract »    Full Text »    PDF »
TFcheckpoint: a curated compendium of specific DNA-binding RNA polymerase II transcription factors.
K. Chawla, S. Tripathi, L. Thommesen, A. Laegreid, and M. Kuiper (2013)
Bioinformatics 29, 2519-2520
   Abstract »    Full Text »    PDF »
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H. Ehmann, H. Hartwich, C. Salzig, N. Hartmann, M. Clement-Ziza, K. Ushakov, K. B. Avraham, O. R. P. Bininda-Emonds, A. K. Hartmann, P. Lang, et al. (2013)
J. Biol. Chem. 288, 25865-25879
   Abstract »    Full Text »    PDF »
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K. A. Krautkramer, A. K. Linnemann, D. A. Fontaine, A. L. Whillock, T. W. Harris, G. J. Schleis, N. A. Truchan, L. Marty-Santos, J. A. Lavine, O. Cleaver, et al. (2013)
Am J Physiol Endocrinol Metab 305, E600-E610
   Abstract »    Full Text »    PDF »
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S. Tripathi, K. R. Christie, R. Balakrishnan, R. Huntley, D. P. Hill, L. Thommesen, J. A. Blake, M. Kuiper, and A. Laegreid (2013)
Database 2013, bat062
   Abstract »    Full Text »    PDF »
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J. Dalal, J. H. Roh, S. E. Maloney, A. Akuffo, S. Shah, H. Yuan, B. Wamsley, W. B. Jones, C. d. G. Strong, P. A. Gray, et al. (2013)
Genes & Dev. 27, 565-578
   Abstract »    Full Text »    PDF »
Bone morphogenic protein signalling suppresses differentiation of pluripotent cells by maintaining expression of E-Cadherin.
M. Malaguti, P. A. Nistor, G. Blin, A. Pegg, X. Zhou, and S. Lowell (2013)
eLife Sci 2, e01197
   Abstract »    Full Text »    PDF »
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P. Formosa-Jordan, M. Ibanes, S. Ares, and J. M. Frade (2012)
Development 139, 2321-2329
   Abstract »    Full Text »    PDF »
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L. Zhang, N.-N. Song, J.-Y. Chen, Y. Huang, H. Li, and Y.-Q. Ding (2012)
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   Abstract »    Full Text »    PDF »
Identification of molecular compartments and genetic circuitry in the developing mammalian kidney.
J. Yu, M. T. Valerius, M. Duah, K. Staser, J. K. Hansard, J.-j. Guo, J. McMahon, J. Vaughan, D. Faria, K. Georgas, et al. (2012)
Development 139, 1863-1873
   Abstract »    Full Text »    PDF »
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J. Hu, T. Huang, T. Li, Z. Guo, and L. Cheng (2012)
J. Neurosci. 32, 5362-5373
   Abstract »    Full Text »    PDF »
Quantifying the white blood cell transcriptome as an accessible window to the multiorgan transcriptome.
I. S. Kohane and V. I. Valtchinov (2012)
Bioinformatics 28, 538-545
   Abstract »    Full Text »    PDF »
Cardiovascular defects in a mouse model of HOXA1 syndrome.
N. Makki and M. R. Capecchi (2012)
Hum. Mol. Genet. 21, 26-31
   Abstract »    Full Text »    PDF »
The Leucine Zipper Putative Tumor Suppressor 2 Protein LZTS2 Regulates Kidney Development.
Y. Peng, C. Clark, R. Luong, W. H. Tu, J. Lee, D. T. Johnson, A. Das, T. J. Carroll, and Z. Sun (2011)
J. Biol. Chem. 286, 40331-40342
   Abstract »    Full Text »    PDF »
Serum Response Factor Is Required for Cortical Axon Growth But Is Dispensable for Neurogenesis and Neocortical Lamination.
P. P. Y. Lu and N. Ramanan (2011)
J. Neurosci. 31, 16651-16664
   Abstract »    Full Text »    PDF »
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K. Watanabe, H. Takebayashi, A. K. Bepari, S. Esumi, Y. Yanagawa, and N. Tamamaki (2011)
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   Abstract »    Full Text »    PDF »
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B. R. Somalinga, G. A. Miller, H. T. Malik, W. C. Wigley, and P. J. Thomas (2011)
J Biomol Screen 16, 974-985
   Abstract »    Full Text »    PDF »
Towards resolving the transcription factor network controlling myelin gene expression.
D. L. Fulton, E. Denarier, H. C. Friedman, W. W. Wasserman, and A. C. Peterson (2011)
Nucleic Acids Res. 39, 7974-7991
   Abstract »    Full Text »    PDF »
Development, Maturation, and Necessity of Transcription Factors in the Mouse Suprachiasmatic Nucleus.
C. VanDunk, L. A. Hunter, and P. A. Gray (2011)
J. Neurosci. 31, 6457-6467
   Abstract »    Full Text »    PDF »
Combined transcriptome analysis of fetal human and mouse cerebral cortex exposed to alcohol.
K. Hashimoto-Torii, Y. I. Kawasawa, A. Kuhn, and P. Rakic (2011)
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   Abstract »    Full Text »    PDF »
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E. Potvin, L. Beuret, J.-F. Cadrin-Girard, M. Carter, S. Roy, M. Tremblay, and J. Charron (2010)
Mol. Cell. Biol. 30, 5348-5363
   Abstract »    Full Text »    PDF »
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P. A. Gray, J. A. Hayes, G. Y. Ling, I. Llona, S. Tupal, M. C. D. Picardo, S. E. Ross, T. Hirata, J. G. Corbin, J. Eugenin, et al. (2010)
J. Neurosci. 30, 14883-14895
   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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N. Wakabayashi, S. Shin, S. L. Slocum, E. S. Agoston, J. Wakabayashi, M.-K. Kwak, V. Misra, S. Biswal, M. Yamamoto, and T. W. Kensler (2010)
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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D. Didiano, L. Cochella, B. Tursun, and O. Hobert (2010)
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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H. Fu, J. Cai, H. Clevers, E. Fast, S. Gray, R. Greenberg, M. K. Jain, Q. Ma, M. Qiu, D. H. Rowitch, et al. (2009)
J. Neurosci. 29, 11399-11408
   Abstract »    Full Text »    PDF »
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X. Han, X. Wu, W.-Y. Chung, T. Li, A. Nekrutenko, N. S. Altman, G. Chen, and H. Ma (2009)
PNAS 106, 12741-12746
   Abstract »    Full Text »    PDF »
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S. P.J. Fancy, S. E. Baranzini, C. Zhao, D.-I. Yuk, K.-A. Irvine, S. Kaing, N. Sanai, R. J.M. Franklin, and D. H. Rowitch (2009)
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   Abstract »    Full Text »    PDF »
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T. Y. Vue, K. Bluske, A. Alishahi, L. L. Yang, N. Koyano-Nakagawa, B. Novitch, and Y. Nakagawa (2009)
J. Neurosci. 29, 4484-4497
   Abstract »    Full Text »    PDF »
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E. Theodorou, G. Dalembert, C. Heffelfinger, E. White, S. Weissman, L. Corcoran, and M. Snyder (2009)
Genes & Dev. 23, 575-588
   Abstract »    Full Text »    PDF »
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E. Valen, G. Pascarella, A. Chalk, N. Maeda, M. Kojima, C. Kawazu, M. Murata, H. Nishiyori, D. Lazarevic, D. Motti, et al. (2009)
Genome Res. 19, 255-265
   Abstract »    Full Text »    PDF »
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B. Deplancke (2009)
Briefings in Functional Genomics 8, 12-27
   Abstract »    Full Text »    PDF »
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D. B. Sparrow, E. Guillen-Navarro, D. Fatkin, and S. L. Dunwoodie (2008)
Hum. Mol. Genet. 17, 3761-3766
   Abstract »    Full Text »    PDF »
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D. S. Kim, T. Matsuda, and C. L. Cepko (2008)
J. Neurosci. 28, 7748-7764
   Abstract »    Full Text »    PDF »
c-Rel, an NF-{kappa}B family transcription factor, is required for hippocampal long-term synaptic plasticity and memory formation.
H. J. Ahn, C. M. Hernandez, J. M. Levenson, F. D. Lubin, H.-C. Liou, and J. D. Sweatt (2008)
Learn. Mem. 15, 539-549
   Abstract »    Full Text »    PDF »
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J. Hauser, J. Saarikettu, and T. Grundstrom (2008)
Mol. Biol. Cell 19, 2509-2519
   Abstract »    Full Text »    PDF »
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P. A. Gray (2008)
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   Abstract »    Full Text »    PDF »
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J. Rajagopal, T. J. Carroll, J. S. Guseh, S. A. Bores, L. J. Blank, W. J. Anderson, J. Yu, Q. Zhou, A. P. McMahon, and D. A. Melton (2008)
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   Abstract »    Full Text »    PDF »
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A. P. McMahon, B. J. Aronow, D. R. Davidson, J. A. Davies, K. W. Gaido, S. Grimmond, J. L. Lessard, M. H. Little, S. S. Potter, E. L. Wilder, et al. (2008)
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   Abstract »    Full Text »    PDF »
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I. Appolloni, F. Calzolari, G. Corte, R. Perris, and P. Malatesta (2008)
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   Abstract »    Full Text »    PDF »
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J. Neurosci. 27, 14078-14088
   Abstract »    Full Text »    PDF »
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U. Schuller, Q. Zhao, S. A. Godinho, V. M. Heine, R. H. Medema, D. Pellman, and D. H. Rowitch (2007)
Mol. Cell. Biol. 27, 8259-8270
   Abstract »    Full Text »    PDF »
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M. Alberstein, M. Amit, K. Vaknin, A. O'Donnell, C. Farhy, Y. Lerenthal, N. Shomron, O. Shaham, A. D. Sharrocks, R. Ashery-Padan, et al. (2007)
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   Abstract »    Full Text »    PDF »
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S. M. Sunkin and J. G. Hohmann (2007)
Hum. Mol. Genet. 16, R209-R219
   Abstract »    Full Text »    PDF »
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W. Zhong and P. W. Sternberg (2007)
Development 134, 3227-3238
   Abstract »    Full Text »    PDF »
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A. Watakabe, N. Ichinohe, S. Ohsawa, T. Hashikawa, Y. Komatsu, K. S. Rockland, and T. Yamamori (2007)
Cereb Cortex 17, 1918-1933
   Abstract »    Full Text »    PDF »
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V. Vermeirssen, M. I. Barrasa, C. A. Hidalgo, J. A. B. Babon, R. Sequerra, L. Doucette-Stamm, A.-L. Barabasi, and A. J.M. Walhout (2007)
Genome Res. 17, 1061-1071
   Abstract »    Full Text »    PDF »
Deconvoluting the intestine: molecular evidence for a major role of the mesenchyme in the modulation of signaling cross talk.
X. Li, B. B. Madison, W. Zacharias, A. Kolterud, D. States, and D. L. Gumucio (2007)
Physiol Genomics 29, 290-301
   Abstract »    Full Text »    PDF »
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V. E. Abraira, N. Hyun, A. F. Tucker, D. E. Coling, M. C. Brown, C. Lu, G. R. Hoffman, and L. V. Goodrich (2007)
J. Neurosci. 27, 4273-4282
   Abstract »    Full Text »    PDF »
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T. E. Reddy, B. E. Shakhnovich, D. S. Roberts, S. J. Russek, and C. DeLisi (2007)
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   Abstract »    Full Text »    PDF »
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C. M. Smith, J. H. Finger, T. F. Hayamizu, I. J. McCright, J. T. Eppig, J. A. Kadin, J. E. Richardson, and M. Ringwald (2007)
Nucleic Acids Res. 35, D618-D623
   Abstract »    Full Text »    PDF »
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F. Flamant, J. D. Baxter, D. Forrest, S. Refetoff, H. Samuels, T. S. Scanlan, B. Vennstrom, and J. Samarut (2006)
Pharmacol. Rev. 58, 705-711
   Full Text »    PDF »
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M. Y. Choi, A. I. Romer, M. Hu, M. Lepourcelet, A. Mechoor, A. Yesilaltay, M. Krieger, P. A. Gray, and R. A. Shivdasani (2006)
Development 133, 4119-4129
   Abstract »    Full Text »    PDF »
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G. Alvarez-Bolado and G. Eichele (2006)
J. Physiol. 575, 347-352
   Abstract »    Full Text »    PDF »
Transcriptional regulation of neuronal phenotype in mammals.
Q. Ma (2006)
J. Physiol. 575, 379-387
   Abstract »    Full Text »    PDF »
Tetracycline-controlled transgenic targeting from the SCL locus directs conditional expression to erythrocytes, megakaryocytes, granulocytes, and c-kit-expressing lineage-negative hematopoietic cells.
E. Bockamp, C. Antunes, M. Maringer, R. Heck, K. Presser, S. Beilke, S. Ohngemach, R. Alt, M. Cross, R. Sprengel, et al. (2006)
Blood 108, 1533-1541
   Abstract »    Full Text »    PDF »
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G. Chua, Q. D. Morris, R. Sopko, M. D. Robinson, O. Ryan, E. T. Chan, B. J. Frey, B. J. Andrews, C. Boone, and T. R. Hughes (2006)
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   Abstract »    Full Text »    PDF »
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J. Z. Parrish, M. D. Kim, L. Y. Jan, and Y. N. Jan (2006)
Genes & Dev. 20, 820-835
   Abstract »    Full Text »    PDF »
Natural variation and genetic covariance in adult hippocampal neurogenesis.
G. Kempermann, E. J. Chesler, L. Lu, R. W. Williams, and F. H. Gage (2006)
PNAS 103, 780-785
   Abstract »    Full Text »    PDF »
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T. M. Beres, T. Masui, G. H. Swift, L. Shi, R. M. Henke, and R. J. MacDonald (2006)
Mol. Cell. Biol. 26, 117-130
   Abstract »    Full Text »    PDF »
Zfp312 is required for subcortical axonal projections and dendritic morphology of deep-layer pyramidal neurons of the cerebral cortex.
J.-G. Chen, M.-R. Rasin, K. Y. Kwan, and N. Sestan (2005)
PNAS 102, 17792-17797
   Abstract »    Full Text »    PDF »
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N. Nakayama, J. M. Arroyo, J. Simorowski, B. May, R. Martienssen, and V. F. Irish (2005)
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   Abstract »    Full Text »    PDF »
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A. Bulfone, P. Carotenuto, A. Faedo, V. Aglio, L. Garzia, A. M. Bello, A. Basile, A. Andre, M. Cocchia, O. Guardiola, et al. (2005)
J. Neurosci. 25, 7586-7600
   Abstract »    Full Text »    PDF »
oPOSSUM: identification of over-represented transcription factor binding sites in co-expressed genes.
S. J. Ho Sui, J. R. Mortimer, D. J. Arenillas, J. Brumm, C. J. Walsh, B. P. Kennedy, and W. W. Wasserman (2005)
Nucleic Acids Res. 33, 3154-3164
   Abstract »    Full Text »    PDF »

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