Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Logo for

Science 307 (5707): 269-273

Copyright © 2005 by the American Association for the Advancement of Science

Stat3 Dimerization Regulated by Reversible Acetylation of a Single Lysine Residue

Zheng-long Yuan,1,3 Ying-jie Guan,1,3 Devasis Chatterjee,2 Y. Eugene Chin1,3*

Abstract: Upon cytokine treatment, members of the signal transducers and activators of transcription (STAT) family of proteins are phosphorylated on tyrosine and serine sites within the carboxyl-terminal region in cells. We show that in response to cytokine treatment, Stat3 is also acetylated on a single lysine residue, Lys685. Histone acetyltransferase p300–mediated Stat3 acetylation on Lys685 was reversible by type I histone deacetylase (HDAC). Use of a prostate cancer cell line (PC3) that lacks Stat3 and PC3 cells expressing wild-type Stat3 or a Stat3 mutant containing a Lys685-to-Arg substitution revealed that Lys685 acetylation was critical for Stat3 to form stable dimers required for cytokine-stimulated DNA binding and transcriptional regulation, to enhance transcription of cell growth–related genes, and to promote cell cycle progression in response to treatment with oncostatin M.

1 Department of Surgery, Brown University Medical School–Rhode Island Hospital, Providence, RI 02903, USA.
2 Department of Medicine, Brown University Medical School–Rhode Island Hospital, Providence, RI 02903, USA.
3 Department of Molecular Biology, Cell Biology and Biochemistry, Brown University Medical School–Rhode Island Hospital, Providence, RI 02903, USA.

* To whom correspondence should be addressed. E-mail: y_eugene_chin{at}

Histone deacetylase isoforms regulate innate immune responses by deacetylating mitogen-activated protein kinase phosphatase-1.
Y. Jeong, R. Du, X. Zhu, S. Yin, J. Wang, H. Cui, W. Cao, and C. J. Lowenstein (2014)
J. Leukoc. Biol. 95, 651-659
   Abstract »    Full Text »    PDF »
SH2B1{beta} Interacts with STAT3 and Enhances Fibroblast Growth Factor 1-Induced Gene Expression during Neuronal Differentiation.
Y.-J. Chang, K.-W. Chen, C.-J. Chen, M.-H. Lin, Y.-J. Sun, J.-L. Lee, I.-M. Chiu, and L. Chen (2014)
Mol. Cell. Biol. 34, 1003-1019
   Abstract »    Full Text »    PDF »
Histone Deacetylase 2 (HDAC2) Protein-dependent Deacetylation of Mortality Factor 4-like 1 (MORF4L1) Protein Enhances Its Homodimerization.
Y. Chen, J. Li, S. Dunn, S. Xiong, W. Chen, Y. Zhao, B. B. Chen, R. K. Mallampalli, and C. Zou (2014)
J. Biol. Chem. 289, 7092-7098
   Abstract »    Full Text »    PDF »
mMAPS: A Flow-Proteometric Technique to Analyze Protein-Protein Interactions in Individual Signaling Complexes.
C.-K. Chou, H.-H. Lee, P.-H. Tsou, C.-T. Chen, J.-M. Hsu, H. Yamaguchi, Y.-N. Wang, H.-J. Lee, J. L. Hsu, J.-F. Lee, et al. (2014)
Science Signaling 7, rs1
   Abstract »    Full Text »    PDF »
XPO1 (CRM1) Inhibition Represses STAT3 Activation to Drive a Survivin-Dependent Oncogenic Switch in Triple-Negative Breast Cancer.
Y. Cheng, M. P. Holloway, K. Nguyen, D. McCauley, Y. Landesman, M. G. Kauffman, S. Shacham, and R. A. Altura (2014)
Mol. Cancer Ther. 13, 675-686
   Abstract »    Full Text »    PDF »
Histone Deacetylases: A Saga of Perturbed Acetylation Homeostasis in Cancer.
S. Parbin, S. Kar, A. Shilpi, D. Sengupta, M. Deb, S. K. Rath, and S. K. Patra (2014)
Journal of Histochemistry & Cytochemistry 62, 11-33
   Abstract »    Full Text »    PDF »
SIRT1 regulates adaptive response of the growth hormone--insulin-like growth factor-I axis under fasting conditions in liver.
M. Yamamoto, G. Iguchi, H. Fukuoka, K. Suda, H. Bando, M. Takahashi, H. Nishizawa, S. Seino, and Y. Takahashi (2013)
PNAS 110, 14948-14953
   Abstract »    Full Text »    PDF »
Systematic identification of Class I HDAC substrates.
T. Li, B. Song, Z. Wu, M. Lu, and W.-G. Zhu (2013)
Brief Bioinform
   Abstract »    Full Text »    PDF »
STAT3 silencing inhibits glioma single cell infiltration and tumor growth.
M. Priester, E. Copanaki, V. Vafaizadeh, S. Hensel, C. Bernreuther, M. Glatzel, V. Seifert, B. Groner, D. Kogel, and J. Weissenberger (2013)
Neuro Oncology 15, 840-852
   Abstract »    Full Text »    PDF »
Inhibition of HDAC2 Protects the Retina From Ischemic Injury.
J. Fan, O. Alsarraf, M. Dahrouj, K. A. Platt, C. J. Chou, D. S. Rice, and C. E. Crosson (2013)
Invest. Ophthalmol. Vis. Sci. 54, 4072-4080
   Abstract »    Full Text »    PDF »
Small-Molecule Inhibitors of Acetyltransferase p300 Identified by High-Throughput Screening Are Potent Anticancer Agents.
H. Yang, C. E. Pinello, J. Luo, D. Li, Y. Wang, L. Y. Zhao, S. C. Jahn, S. A. Saldanha, J. Planck, K. R. Geary, et al. (2013)
Mol. Cancer Ther. 12, 610-620
   Abstract »    Full Text »    PDF »
Circadian acetylome reveals regulation of mitochondrial metabolic pathways.
S. Masri, V. R. Patel, K. L. Eckel-Mahan, S. Peleg, I. Forne, A. G. Ladurner, P. Baldi, A. Imhof, and P. Sassone-Corsi (2013)
PNAS 110, 3339-3344
   Abstract »    Full Text »    PDF »
STAT3 Protein Up-regulates G{alpha}-interacting Vesicle-associated Protein (GIV)/Girdin Expression, and GIV Enhances STAT3 Activation in a Positive Feedback Loop during Wound Healing and Tumor Invasion/Metastasis.
Y. Dunkel, A. Ong, D. Notani, Y. Mittal, M. Lam, X. Mi, and P. Ghosh (2012)
J. Biol. Chem. 287, 41667-41683
   Abstract »    Full Text »    PDF »
The Sin3a repressor complex is a master regulator of STAT transcriptional activity.
L. Icardi, R. Mori, V. Gesellchen, S. Eyckerman, L. De Cauwer, J. Verhelst, K. Vercauteren, X. Saelens, P. Meuleman, G. Leroux-Roels, et al. (2012)
PNAS 109, 12058-12063
   Abstract »    Full Text »    PDF »
Novel Interactions between NFATc1 (Nuclear Factor of Activated T Cells c1) and STAT-3 (Signal Transducer and Activator of Transcription-3) Mediate G Protein-coupled Receptor Agonist, Thrombin-induced Biphasic Expression of Cyclin D1, with First Phase Influencing Cell Migration and Second Phase Directing Cell Proliferation.
V. Kundumani-Sridharan, D. Van Quyen, J. Subramani, N. K. Singh, Y. E. Chin, and G. N. Rao (2012)
J. Biol. Chem. 287, 22463-22482
   Abstract »    Full Text »    PDF »
Acetylated STAT3 is crucial for methylation of tumor-suppressor gene promoters and inhibition by resveratrol results in demethylation.
H. Lee, P. Zhang, A. Herrmann, C. Yang, H. Xin, Z. Wang, D. S. B. Hoon, S. J. Forman, R. Jove, A. D. Riggs, et al. (2012)
PNAS 109, 7765-7769
   Abstract »    Full Text »    PDF »
Editorial: HDAC inhibition begets more MDSCs.
P. Reddy (2012)
J. Leukoc. Biol. 91, 679-681
   Full Text »    PDF »
Histone deacetylase inhibition facilitates GM-CSF-mediated expansion of myeloid-derived suppressor cells in vitro and in vivo.
B. R. Rosborough, A. Castellaneta, S. Natarajan, A. W. Thomson, and H. R. Turnquist (2012)
J. Leukoc. Biol. 91, 701-709
   Abstract »    Full Text »    PDF »
Extracellular Signal-Regulated Kinase Mitogen-Activated Protein Kinase-Dependent SOCS-3 Gene Induction Requires c-Jun, Signal Transducer and Activator of Transcription 3, and Specificity Protein 3 Transcription Factors.
J. Wiejak, J. Dunlop, S. Gao, G. Borland, and S. J. Yarwood (2012)
Mol. Pharmacol. 81, 657-668
   Abstract »    Full Text »    PDF »
Inhibition of Histone Deacetylases Preserves Myocardial Performance and Prevents Cardiac Remodeling through Stimulation of Endogenous Angiomyogenesis.
L. Zhang, X. Qin, Y. Zhao, L. Fast, S. Zhuang, P. Liu, G. Cheng, and T. C. Zhao (2012)
J. Pharmacol. Exp. Ther. 341, 285-293
   Abstract »    Full Text »    PDF »
Targeting the Interleukin-6/Jak/Stat Pathway in Human Malignancies.
P. Sansone and J. Bromberg (2012)
J. Clin. Oncol. 30, 1005-1014
   Abstract »    Full Text »    PDF »
Opposed regulation of type I IFN-induced STAT3 and ISGF3 transcriptional activities by histone deacetylases (HDACS) 1 and 2.
L. Icardi, S. Lievens, R. Mori, J. Piessevaux, L. De Cauwer, K. De Bosscher, and J. Tavernier (2012)
FASEB J 26, 240-249
   Abstract »    Full Text »    PDF »
Endoplasmic Reticulum Stress Inhibits STAT3-Dependent Suppression of Hepatic Gluconeogenesis via Dephosphorylation and Deacetylation.
K. Kimura, T. Yamada, M. Matsumoto, Y. Kido, T. Hosooka, S.-i. Asahara, T. Matsuda, T. Ota, H. Watanabe, Y. Sai, et al. (2012)
Diabetes 61, 61-73
   Abstract »    Full Text »    PDF »
MiR-365: a mechanosensitive microRNA stimulates chondrocyte differentiation through targeting histone deacetylase 4.
Y.-J. Guan, X. Yang, L. Wei, and Q. Chen (2011)
FASEB J 25, 4457-4466
   Abstract »    Full Text »    PDF »
Caveolin-1 Upregulation Mediates Suppression of Primary Breast Tumor Growth and Brain Metastases by Stat3 Inhibition.
W.-T. Chiu, H.-T. Lee, F.-J. Huang, K. D. Aldape, J. Yao, P. S. Steeg, C.-Y. Chou, Z. Lu, K. Xie, and S. Huang (2011)
Cancer Res. 71, 4932-4943
   Abstract »    Full Text »    PDF »
Increased Acetylation in the DNA-binding Domain of TR4 Nuclear Receptor by the Coregulator ARA55 Leads to Suppression of TR4 Transactivation.
S. Xie, J. Ni, Y.-F. Lee, S. Liu, G. Li, C.-R. Shyr, and C. Chang (2011)
J. Biol. Chem. 286, 21129-21136
   Abstract »    Full Text »    PDF »
Negative Regulation of STAT3 Protein-mediated Cellular Respiration by SIRT1 Protein.
M. Bernier, R. K. Paul, A. Martin-Montalvo, M. Scheibye-Knudsen, S. Song, H.-J. He, S. M. Armour, B. P. Hubbard, V. A. Bohr, L. Wang, et al. (2011)
J. Biol. Chem. 286, 19270-19279
   Abstract »    Full Text »    PDF »
Valproic Acid Antagonizes the Capacity of Other Histone Deacetylase Inhibitors To Activate the Epstein-Barr Virus Lytic Cycle.
D. Daigle, L. Gradoville, D. Tuck, V. Schulz, R. Wang'ondu, J. Ye, K. Gorres, and G. Miller (2011)
J. Virol. 85, 5628-5643
   Abstract »    Full Text »    PDF »
Cytokine-induced Paracrystals Prolong the Activity of Signal Transducers and Activators of Transcription (STAT) and Provide a Model for the Regulation of Protein Solubility by Small Ubiquitin-like Modifier (SUMO).
M. Droescher, A. Begitt, A. Marg, M. Zacharias, and U. Vinkemeier (2011)
J. Biol. Chem. 286, 18731-18746
   Abstract »    Full Text »    PDF »
pp32, an INHAT component, is a transcription machinery recruiter for maximal induction of IFN-stimulated genes.
S. Kadota and K. Nagata (2011)
J. Cell Sci. 124, 892-899
   Abstract »    Full Text »    PDF »
STAT3-dependent effects of IL-22 in human keratinocytes are counterregulated by sirtuin 1 through a direct inhibition of STAT3 acetylation.
R. Sestito, S. Madonna, C. Scarponi, F. Cianfarani, C. M. Failla, A. Cavani, G. Girolomoni, and C. Albanesi (2011)
FASEB J 25, 916-927
   Abstract »    Full Text »    PDF »
CPLA 1.0: an integrated database of protein lysine acetylation.
Z. Liu, J. Cao, X. Gao, Y. Zhou, L. Wen, X. Yang, X. Yao, J. Ren, and Y. Xue (2011)
Nucleic Acids Res. 39, D1029-D1034
   Abstract »    Full Text »    PDF »
Reversible methylation of promoter-bound STAT3 by histone-modifying enzymes.
J. Yang, J. Huang, M. Dasgupta, N. Sears, M. Miyagi, B. Wang, M. R. Chance, X. Chen, Y. Du, Y. Wang, et al. (2010)
PNAS 107, 21499-21504
   Abstract »    Full Text »    PDF »
Acetylation Directs Survivin Nuclear Localization to Repress STAT3 Oncogenic Activity.
H. Wang, M. P. Holloway, L. Ma, Z. A. Cooper, M. Riolo, A. Samkari, K. S. J. Elenitoba-Johnson, Y. E. Chin, and R. A. Altura (2010)
J. Biol. Chem. 285, 36129-36137
   Abstract »    Full Text »    PDF »
Acetylation modulates prolactin receptor dimerization.
L. Ma, J.-s. Gao, Y. Guan, X. Shi, H. Zhang, M. K. Ayrapetov, Z. Zhang, L. Xu, Y.-M. Hyun, M. Kim, et al. (2010)
PNAS 107, 19314-19319
   Abstract »    Full Text »    PDF »
Inhibition of Histone Deacetylase Protects the Retina from Ischemic Injury.
C. E. Crosson, S. K. Mani, S. Husain, O. Alsarraf, and D. R. Menick (2010)
Invest. Ophthalmol. Vis. Sci. 51, 3639-3645
   Abstract »    Full Text »    PDF »
The nuclear factor-{kappa}B-interleukin-6 signalling pathway mediating vascular inflammation.
A. R. Brasier (2010)
Cardiovasc Res 86, 211-218
   Abstract »    Full Text »    PDF »
Protein Acetylation in the Cardiorenal Axis: The Promise of Histone Deacetylase Inhibitors.
E. W. Bush and T. A. McKinsey (2010)
Circ. Res. 106, 272-284
   Abstract »    Full Text »    PDF »
Histone Deacetylase Inhibitors in Cancer Therapy.
A. A. Lane and B. A. Chabner (2009)
J. Clin. Oncol. 27, 5459-5468
   Abstract »    Full Text »    PDF »
Notch Signal Activates Hypoxia Pathway through HES1-Dependent SRC/Signal Transducers and Activators of Transcription 3 Pathway.
J. H. Lee, J. Suk, J. Park, S. B. Kim, S. S. Kwak, J. W. Kim, C. H. Lee, B. Byun, J. K. Ahn, and C. O. Joe (2009)
Mol. Cancer Res. 7, 1663-1671
   Abstract »    Full Text »    PDF »
SysPTM: A Systematic Resource for Proteomic Research on Post-translational Modifications.
H. Li, X. Xing, G. Ding, Q. Li, C. Wang, L. Xie, R. Zeng, and Y. Li (2009)
Mol. Cell. Proteomics 8, 1839-1849
   Abstract »    Full Text »    PDF »
SirT1 knockdown in liver decreases basal hepatic glucose production and increases hepatic insulin responsiveness in diabetic rats.
D. M. Erion, S. Yonemitsu, Y. Nie, Y. Nagai, M. P. Gillum, J. J. Hsiao, T. Iwasaki, R. Stark, D. Weismann, X. X. Yu, et al. (2009)
PNAS 106, 11288-11293
   Abstract »    Full Text »    PDF »
Apratoxin A Reversibly Inhibits the Secretory Pathway by Preventing Cotranslational Translocation.
Y. Liu, B. K. Law, and H. Luesch (2009)
Mol. Pharmacol. 76, 91-104
   Abstract »    Full Text »    PDF »
Acetylation and activation of STAT3 mediated by nuclear translocation of CD44.
J.-L. Lee, M.-J. Wang, and J.-Y. Chen (2009)
J. Cell Biol. 185, 949-957
   Abstract »    Full Text »    PDF »
Cutting Edge: Negative Regulation of Dendritic Cells through Acetylation of the Nonhistone Protein STAT-3.
Y. Sun, Y. E. Chin, E. Weisiger, C. Malter, I. Tawara, T. Toubai, E. Gatza, P. Mascagni, C. A. Dinarello, and P. Reddy (2009)
J. Immunol. 182, 5899-5903
   Abstract »    Full Text »    PDF »
A phosphorylation-acetylation switch regulates STAT1 signaling.
O. H. Kramer, S. K. Knauer, G. Greiner, E. Jandt, S. Reichardt, K.-H. Guhrs, R. H. Stauber, F. D. Bohmer, and T. Heinzel (2009)
Genes & Dev. 23, 223-235
   Abstract »    Full Text »    PDF »
T-Bet Dependent Removal of Sin3A-Histone Deacetylase Complexes at the Ifng Locus Drives Th1 Differentiation.
S. Chang, P. L. Collins, and T. M. Aune (2008)
J. Immunol. 181, 8372-8381
   Abstract »    Full Text »    PDF »
The STAT3 NH2-terminal Domain Stabilizes Enhanceosome Assembly by Interacting with the p300 Bromodomain.
T. Hou, S. Ray, C. Lee, and A. R. Brasier (2008)
J. Biol. Chem. 283, 30725-30734
   Abstract »    Full Text »    PDF »
Structural and Functional Analysis of the Human HDAC4 Catalytic Domain Reveals a Regulatory Structural Zinc-binding Domain.
M. J. Bottomley, P. Lo Surdo, P. Di Giovine, A. Cirillo, R. Scarpelli, F. Ferrigno, P. Jones, P. Neddermann, R. De Francesco, C. Steinkuhler, et al. (2008)
J. Biol. Chem. 283, 26694-26704
   Abstract »    Full Text »    PDF »
PCSK9 is required for the disposal of non-acetylated intermediates of the nascent membrane protein BACE1.
M. C. Jonas, C. Costantini, and L. Puglielli (2008)
EMBO Rep. 9, 916-922
   Abstract »    Full Text »    PDF »
Vorinostat inhibits STAT6-mediated TH2 cytokine and TARC production and induces cell death in Hodgkin lymphoma cell lines.
D. Buglio, G. V. Georgakis, S. Hanabuchi, K. Arima, N. M. Khaskhely, Y.-J. Liu, and A. Younes (2008)
Blood 112, 1424-1433
   Abstract »    Full Text »    PDF »
Requirement of histone deacetylase1 (HDAC1) in signal transducer and activator of transcription 3 (STAT3) nucleocytoplasmic distribution.
S. Ray, C. Lee, T. Hou, I. Boldogh, and A. R. Brasier (2008)
Nucleic Acids Res. 36, 4510-4520
   Abstract »    Full Text »    PDF »
Acetylation of mitogen-activated protein kinase phosphatase-1 inhibits Toll-like receptor signaling.
W. Cao, C. Bao, E. Padalko, and C. J. Lowenstein (2008)
J. Exp. Med. 205, 1491-1503
   Abstract »    Full Text »    PDF »
Inverse Association between Raf Kinase Inhibitory Protein and Signal Transducers and Activators of Transcription 3 Expression in Gastric Adenocarcinoma Patients: Implications for Clinical Outcome.
D. Chatterjee, E. Sabo, R. Tavares, and M. B. Resnick (2008)
Clin. Cancer Res. 14, 2994-3001
   Abstract »    Full Text »    PDF »
Inhibition of histone deacetylases triggers pharmacologic preconditioning effects against myocardial ischemic injury.
T. C. Zhao, G. Cheng, L. X. Zhang, Y. T. Tseng, and J. F. Padbury (2007)
Cardiovasc Res 76, 473-481
   Abstract »    Full Text »    PDF »
Kruppel-like Factor 4 Is Acetylated by p300 and Regulates Gene Transcription via Modulation of Histone Acetylation.
P. M. Evans, W. Zhang, X. Chen, J. Yang, K. K. Bhakat, and C. Liu (2007)
J. Biol. Chem. 282, 33994-34002
   Abstract »    Full Text »    PDF »
Reduced Body Size and Decreased Intestinal Tumor Rates in HDAC2-Mutant Mice.
S. Zimmermann, F. Kiefer, M. Prudenziati, C. Spiller, J. Hansen, T. Floss, W. Wurst, S. Minucci, and M. Gottlicher (2007)
Cancer Res. 67, 9047-9054
   Abstract »    Full Text »    PDF »
Histone Deacetylase Inhibitors: Overview and Perspectives.
M. Dokmanovic, C. Clarke, and P. A. Marks (2007)
Mol. Cancer Res. 5, 981-989
   Abstract »    Full Text »    PDF »
JAK-STAT Signaling: From Interferons to Cytokines.
C. Schindler, D. E. Levy, and T. Decker (2007)
J. Biol. Chem. 282, 20059-20063
   Full Text »    PDF »
Epstein-Barr virus induces a distinct form of DNA-bound STAT1 compared with that found in interferon-stimulated B lymphocytes.
J. McLaren, M. Rowe, and P. Brennan (2007)
J. Gen. Virol. 88, 1876-1886
   Abstract »    Full Text »    PDF »
Metabolism, cytoskeleton and cellular signalling in the grip of protein N{epsilon} - and O-acetylation.
X.-J. Yang and S. Gregoire (2007)
EMBO Rep. 8, 556-562
   Abstract »    Full Text »    PDF »
Unphosphorylated STAT3 accumulates in response to IL-6 and activates transcription by binding to NF{kappa}B.
J. Yang, X. Liao, M. K. Agarwal, L. Barnes, P. E. Auron, and G. R. Stark (2007)
Genes & Dev. 21, 1396-1408
   Abstract »    Full Text »    PDF »
An RNA-binding protein {alpha}CP-1 is involved in the STAT3-mediated suppression of NF-{kappa}B transcriptional activity.
H. Nishinakamura, Y. Minoda, K. Saeki, K. Koga, G. Takaesu, M. Onodera, A. Yoshimura, and T. Kobayashi (2007)
Int. Immunol. 19, 609-619
   Abstract »    Full Text »    PDF »
FOXP3 interactions with histone acetyltransferase and class II histone deacetylases are required for repression.
B. Li, A. Samanta, X. Song, K. T. Iacono, K. Bembas, R. Tao, S. Basu, J. L. Riley, W. W. Hancock, Y. Shen, et al. (2007)
PNAS 104, 4571-4576
   Abstract »    Full Text »    PDF »
Histone Deacetylase 3 Interacts with and Deacetylates Myocyte Enhancer Factor 2.
S. Gregoire, L. Xiao, J. Nie, X. Zhang, M. Xu, J. Li, J. Wong, E. Seto, and X.-J. Yang (2007)
Mol. Cell. Biol. 27, 1280-1295
   Abstract »    Full Text »    PDF »
Histone deacetylase inhibitors suppress IFN{alpha}-induced up-regulation of promyelocytic leukemia protein.
J. Vlasakova, Z. Novakova, L. Rossmeislova, M. Kahle, P. Hozak, and Z. Hodny (2007)
Blood 109, 1373-1380
   Abstract »    Full Text »    PDF »
Kinetic and Mass Spectrometric Analysis of p300 Histone Acetyltransferase Domain Autoacetylation.
B. Karanam, L. Jiang, L. Wang, N. L. Kelleher, and P. A. Cole (2006)
J. Biol. Chem. 281, 40292-40301
   Abstract »    Full Text »    PDF »
Stat1 and SUMO modification.
L. Song, S. Bhattacharya, A. A. Yunus, C. D. Lima, and C. Schindler (2006)
Blood 108, 3237-3244
   Abstract »    Full Text »    PDF »
Antitumor Effects of a Novel Phenylbutyrate-Based Histone Deacetylase Inhibitor, (S)-HDAC-42, in Prostate Cancer.
S. K. Kulp, C.-S. Chen, D.-S. Wang, C.-Y. Chen, and C.-S. Chen (2006)
Clin. Cancer Res. 12, 5199-5206
   Abstract »    Full Text »    PDF »
Differential Gene Regulation by Selective Association of Transcriptional Coactivators and bZIP DNA-Binding Domains.
B. Miotto and K. Struhl (2006)
Mol. Cell. Biol. 26, 5969-5982
   Abstract »    Full Text »    PDF »
J. W. Darnowski, F. A. Goulette, Y.-j. Guan, D. Chatterjee, Z.-F. Yang, L. P. Cousens, and Y. E. Chin (2006)
J. Biol. Chem. 281, 17707-17717
   Abstract »    Full Text »    PDF »
STAT3 as a Downstream Mediator of Trk Signaling and Functions.
Y. P. Ng, Z. H. Cheung, and N. Y. Ip (2006)
J. Biol. Chem. 281, 15636-15644
   Abstract »    Full Text »    PDF »
Stat3 activation of NF-{kappa}B p100 processing involves CBP/p300-mediated acetylation.
N. Nadiminty, W. Lou, S. O. Lee, X. Lin, D. L. Trump, and A. C. Gao (2006)
PNAS 103, 7264-7269
   Abstract »    Full Text »    PDF »
Histone deacetylase 3 binds to and regulates the GCMa transcription factor.
H.-C. Chuang, C.-W. Chang, G.-D. Chang, T.-P. Yao, and H. Chen (2006)
Nucleic Acids Res. 34, 1459-1469
   Abstract »    Full Text »    PDF »
G{beta}{gamma} Binds Histone Deacetylase 5 (HDAC5) and Inhibits Its Transcriptional Co-repression Activity.
B. D. Spiegelberg and H. E. Hamm (2005)
J. Biol. Chem. 280, 41769-41776
   Abstract »    Full Text »    PDF »
Histone Acetylation-independent Effect of Histone Deacetylase Inhibitors on Akt through the Reshuffling of Protein Phosphatase 1 Complexes.
C.-S. Chen, S.-C. Weng, P.-H. Tseng, H.-P. Lin, and C.-S. Chen (2005)
J. Biol. Chem. 280, 38879-38887
   Abstract »    Full Text »    PDF »
RNA Interference-directed Knockdown of Urokinase Plasminogen Activator and Urokinase Plasminogen Activator Receptor Inhibits Prostate Cancer Cell Invasion, Survival, and Tumorigenicity in Vivo.
S. M. Pulukuri, C. S. Gondi, S. S. Lakka, A. Jutla, N. Estes, M. Gujrati, and J. S. Rao (2005)
J. Biol. Chem. 280, 36529-36540
   Abstract »    Full Text »    PDF »
Modification of the Stat1 SH2 Domain Broadly Improves Interferon Efficacy in Proportion to p300/CREB-binding Protein Coactivator Recruitment.
Y. Zhang, K. Takami, M. S. Lo, G. Huang, Q. Yu, W. T. Roswit, and M. J. Holtzman (2005)
J. Biol. Chem. 280, 34306-34315
   Abstract »    Full Text »    PDF »
mSin3A corepressor regulates diverse transcriptional networks governing normal and neoplastic growth and survival.
J.-H. Dannenberg, G. David, S. Zhong, J. van der Torre, W. H. Wong, and R. A. DePinho (2005)
Genes & Dev. 19, 1581-1595
   Abstract »    Full Text »    PDF »
CELL SIGNALING: Stat Acetylation-A Key Facet of Cytokine Signaling?.
J. J. O'Shea, Y. Kanno, X. Chen, and D. E. Levy (2005)
Science 307, 217-218
   Abstract »    Full Text »    PDF »

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882